Number of enzymes: | 1 |
Number of disease: | 1 |
Number of reactomes: | 28 |
Number of reactions: | 69 |
DiseaseID | Gene | UniProt | EC numbers | Reactomes | Expanded Reactomes | Reactome roots | Reactions |
---|---|---|---|---|---|---|---|
MONDO:0032697 | PPP2CA | P67775 | 3.1.3.16 |
R-HSA-2467813 R-HSA-198753 R-HSA-2995383 R-HSA-4641262 R-HSA-4641262Reactome Name: Disassembly of the destruction complex and recruitment of AXIN to the membraneSee in Reactome R-HSA-180024 R-HSA-2500257 R-HSA-2465910 R-HSA-9648025 R-HSA-389513 R-HSA-196299 R-HSA-69231 R-HSA-432142 R-HSA-113501 R-HSA-113501Reactome Name: Inhibition of replication initiation of damaged DNA by RB1/E2F1See in Reactome R-HSA-141444Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalSee in Reactome R-HSA-1295596 R-HSA-9634600 R-HSA-9634600Reactome Name: Regulation of glycolysis by fructose 2,6-bisphosphate metabolismSee in Reactome R-HSA-163685 R-HSA-69273 R-HSA-5675221 R-HSA-163767 R-HSA-163767Reactome Name: PP2A-mediated dephosphorylation of key metabolic factorsSee in Reactome R-HSA-975957 R-HSA-975957Reactome Name: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)See in Reactome R-HSA-202670 R-HSA-68877 |
R-HSA-937061 R-HSA-3700989 R-HSA-975871 R-HSA-70326 R-HSA-449147 R-HSA-6806003 R-HSA-418594 R-HSA-181438 R-HSA-166016 R-HSA-194315 R-HSA-5654732 R-HSA-1280215 R-HSA-195258 R-HSA-9006925 R-HSA-1430728 R-HSA-1257604 R-HSA-1640170 R-HSA-5684996 R-HSA-1280218 R-HSA-5673001 R-HSA-199418 R-HSA-450282 R-HSA-168142 R-HSA-71387 R-HSA-2555396 R-HSA-212436 R-HSA-74160 R-HSA-168164 R-HSA-5654726 R-HSA-5654727 R-HSA-69620 R-HSA-69236 R-HSA-69278 R-HSA-198725 R-HSA-198725Reactome Name: Nuclear Events (kinase and transcription factor activation)See in Reactome R-HSA-418346 R-HSA-388396 R-HSA-166166 R-HSA-388841 R-HSA-73857 R-HSA-5654743 R-HSA-69275 R-HSA-5654741 R-HSA-453279 R-HSA-168188 R-HSA-168181 R-HSA-190236 R-HSA-141424 R-HSA-168256 R-HSA-8953854 R-HSA-168249 R-HSA-168179 R-HSA-168138 R-HSA-453274 R-HSA-68886 R-HSA-70171 R-HSA-9006934 R-HSA-68882 R-HSA-2995410 R-HSA-9716542 R-HSA-168898 R-HSA-187037 R-HSA-5633007 R-HSA-450294 R-HSA-195721 R-HSA-166520 R-HSA-372790 R-HSA-5654738 R-HSA-69206 R-HSA-5654736 R-HSA-111885 R-HSA-5654733 R-HSA-168176 R-HSA-109582 R-HSA-975155 R-HSA-166058 R-HSA-975138 R-HSA-975138Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationSee in Reactome R-HSA-5683057 R-HSA-113510 R-HSA-927802 R-HSA-69618 R-HSA-162582 R-HSA-68875 |
Metabolism Cell Cycle Gene expression (Transcription) Immune System Metabolism of RNA Hemostasis Signal Transduction |
R-HSA-113503
(
R-HSA-113501
) R-HSA-1295599 ( R-HSA-1295596 ) R-HSA-1295609 ( R-HSA-1295596 ) R-HSA-1295613 ( R-HSA-1295596 ) R-HSA-1295622 ( R-HSA-1295596 ) R-HSA-1295632 ( R-HSA-1295596 ) R-HSA-1363274 ( R-HSA-69231 ) R-HSA-1363276 ( R-HSA-69231 ) R-HSA-141409 ( R-HSA-141444 ) R-HSA-141422 ( R-HSA-141444 ) R-HSA-141422Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1See in Reactome R-HSA-141439 ( R-HSA-141444 ) R-HSA-1549564 ( R-HSA-1295596 ) R-HSA-163688 ( R-HSA-163685; R-HSA-163767 ) R-HSA-163689 ( R-HSA-163685; R-HSA-163767 ) R-HSA-163750 ( R-HSA-163685; R-HSA-163767; R-HSA-9634600 ) R-HSA-163769 ( R-HSA-163685 ) R-HSA-1638803 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638821 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-164056 ( R-HSA-163685; R-HSA-163767 ) R-HSA-195251 ( R-HSA-195253 ) R-HSA-195275 ( R-HSA-195253 ) R-HSA-195275Reaction Name: Phosphorylation of APC component of the destruction complexSee in Reactome R-HSA-195280Reaction Name: Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complexSee in Reactome R-HSA-195283Reaction Name: Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3See in Reactome R-HSA-195300 ( R-HSA-195253; R-HSA-196299 ) R-HSA-195300Reaction Name: Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3See in Reactome R-HSA-195304Reaction Name: Association of beta-catenin with the destruction complexSee in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-201685 ( R-HSA-4641262 ) R-HSA-201790 ( R-HSA-180024 ) R-HSA-2130279 ( R-HSA-195253 ) R-HSA-2130279Reaction Name: Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complexSee in Reactome R-HSA-2130282Reaction Name: Degradation of ubiquitinated beta catenin by the proteasomeSee in Reactome R-HSA-2130286Reaction Name: Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)See in Reactome R-HSA-2467809 ( R-HSA-2467813 ) R-HSA-2467811 ( R-HSA-2467813 ) R-HSA-2468287 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2484822 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2995388 ( R-HSA-2995383 ) R-HSA-3601585 ( R-HSA-4641262 ) R-HSA-3601585Reaction Name: PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complexSee in Reactome R-HSA-388809 ( R-HSA-389513 ) R-HSA-388833 ( R-HSA-389513 ) R-HSA-389532 ( R-HSA-389513 ) R-HSA-390329 ( R-HSA-389513 ) R-HSA-4088141 ( R-HSA-69273 ) R-HSA-432143 ( R-HSA-432142 ) R-HSA-5229343 ( R-HSA-195253 ) R-HSA-5666129 ( R-HSA-5663220 ) R-HSA-5666160 ( R-HSA-5663220 ) R-HSA-5666169 ( R-HSA-5663220 ) R-HSA-5666169Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2See in Reactome R-HSA-5672961 ( R-HSA-5673000 ) R-HSA-5675431 ( R-HSA-5675221 ) R-HSA-6792863 ( R-HSA-6804757 ) R-HSA-6792871 ( R-HSA-6804757 ) R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811504 ( R-HSA-6811558 ) R-HSA-8856945 ( R-HSA-69273 ) R-HSA-8856951 ( R-HSA-69273 ) R-HSA-8857925 ( R-HSA-6811558 ) R-HSA-8857925Reaction Name: Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307See in Reactome R-HSA-927813Reaction Name: p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2ASee in Reactome R-HSA-927836 ( R-HSA-975957 ) R-HSA-934559 ( R-HSA-1295596 ) R-HSA-9648114 ( R-HSA-68877; R-HSA-9648025 ) R-HSA-9667965 ( R-HSA-2995383 ) |