DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-1632852)

Number of enzymes:	2
Number of disease:	14
Number of reactomes:	13
Number of reactions:	26

Search results (Reactome ID: R-HSA-1632852)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005012	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0005036	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0005335	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0005611	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0008048	MTMR14	Q8NCE2	3.1.3.-	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome	R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome	Metabolism Autophagy	R-HSA-1675994 ( R-HSA-1660499 ) R-HSA-1675994 Reaction Name: PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-1676203 ( R-HSA-1660499 ) R-HSA-1676203 Reaction Name: PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane See in Reactome R-HSA-5679206 ( R-HSA-1632852 ) R-HSA-5679206 Reaction Name: MTMR14, MTMR3 dephosphorylate PI3P See in Reactome
MONDO:0014716	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0017101	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0017102	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0017884	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0018177	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0020492	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0021100	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0021230	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0032908	MTOR	P42345	2.7.11.1	R-HSA-1632852 R-HSA-1632852 Reactome Name: Macroautophagy See in Reactome R-HSA-380972 R-HSA-380972 Reactome Name: Energy dependent regulation of mTOR by LKB1-AMPK See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6804757 R-HSA-6804757 Reactome Name: Regulation of TP53 Degradation See in Reactome R-HSA-165159 R-HSA-165159 Reactome Name: MTOR signalling See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome R-HSA-3371571 R-HSA-3371571 Reactome Name: HSF1-dependent transactivation See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-5628897 R-HSA-5628897 Reactome Name: TP53 Regulates Metabolic Genes See in Reactome R-HSA-166208 R-HSA-166208 Reactome Name: mTORC1-mediated signalling See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-9612973 R-HSA-9612973 Reactome Name: Autophagy See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-6806003 R-HSA-6806003 Reactome Name: Regulation of TP53 Expression and Degradation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Autophagy Gene expression (Transcription) Immune System Cellular responses to stimuli Signal Transduction	R-HSA-165680 ( R-HSA-165159 ) R-HSA-165680 Reaction Name: Formation of active mTORC1 complex See in Reactome R-HSA-165692 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165692 Reaction Name: Phosphorylation of 4E-BP1 by activated mTORC1 See in Reactome R-HSA-165718 ( R-HSA-165159; R-HSA-166208 ) R-HSA-165718 Reaction Name: mTORC1 phosphorylation of RPS6KB1 (S6K) See in Reactome R-HSA-198640 ( R-HSA-1257604; R-HSA-389357; R-HSA-5218920 ) R-HSA-198640 Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473 See in Reactome R-HSA-377186 ( R-HSA-165159 ) R-HSA-377186 Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40) See in Reactome R-HSA-380979 ( R-HSA-165159; R-HSA-380972; R-HSA-5628897 ) R-HSA-380979 Reaction Name: RHEB in mTORC1:RHEB:GTP hydrolyses GTP See in Reactome R-HSA-447074 ( R-HSA-165159; R-HSA-380972 ) R-HSA-447074 Reaction Name: AMPK phosphorylates Raptor in the mTORC1 complex See in Reactome R-HSA-5082405 ( R-HSA-3371571 ) R-HSA-5082405 Reaction Name: Phosphorylation of HSF1 at Ser326 induces transactivation See in Reactome R-HSA-5653968 ( R-HSA-165159 ) R-HSA-5653968 Reaction Name: Ragulator:Rag dimers:SLC38A9 bind mTORC1 See in Reactome R-HSA-5672010 ( R-HSA-1632852 ) R-HSA-5672010 Reaction Name: Active MTORC1 phosphorylates ULK1 See in Reactome R-HSA-5672017 ( R-HSA-1632852 ) R-HSA-5672017 Reaction Name: Rheb in the MTORC1 complex hydrolyses GTP See in Reactome R-HSA-5672817 ( R-HSA-1632852 ) R-HSA-5672817 Reaction Name: Active MTORC1 binds the ULK1 complex See in Reactome R-HSA-5672824 ( R-HSA-165159 ) R-HSA-5672824 Reaction Name: Phosphorylated AKT1S1:mTORC1 binds YWHAB See in Reactome R-HSA-5672828 ( R-HSA-165159 ) R-HSA-5672828 Reaction Name: mTORC1 phosphorylates AKT1S1 See in Reactome R-HSA-5672843 ( R-HSA-165159 ) R-HSA-5672843 Reaction Name: AKT1S1 (PRAS40) binds mTORC1 See in Reactome R-HSA-5673768 ( R-HSA-1632852 ) R-HSA-5673768 Reaction Name: p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex See in Reactome R-HSA-5675790 ( R-HSA-1632852 ) R-HSA-5675790 Reaction Name: MTORC1 dissociates from ULK complex See in Reactome R-HSA-6795290 ( R-HSA-6804757 ) R-HSA-6795290 Reaction Name: TORC2 complex phosphorylates SGK1 See in Reactome R-HSA-8944454 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944454 Reaction Name: mTORC1 phosphorylates MAF1 See in Reactome R-HSA-8944457 ( R-HSA-1257604; R-HSA-8943724 ) R-HSA-8944457 Reaction Name: MAF1 translocates to the nucleus See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome