DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-159763)

Number of enzymes:	5
Number of disease:	15
Number of reactomes:	15
Number of reactions:	66

Search results (Reactome ID: R-HSA-159763)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0002049	F10	P00742	3.4.21.6	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140686 ( R-HSA-140875 ) R-HSA-140686 Reaction Name: factor Va + factor Xa -> Va:Xa complex (prothrombinase) See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140736 ( R-HSA-140834 ) R-HSA-140736 Reaction Name: factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) See in Reactome R-HSA-140769 ( R-HSA-140834 ) R-HSA-140769 Reaction Name: factor VII -> factor VIIa See in Reactome R-HSA-140777 ( R-HSA-140834 ) R-HSA-140777 Reaction Name: factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) See in Reactome R-HSA-140825 ( R-HSA-140834 ) R-HSA-140825 Reaction Name: TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-159733 ( R-HSA-159782 ) R-HSA-159733 Reaction Name: Furin cleaves pro-factor X to factor X See in Reactome R-HSA-159757 ( R-HSA-159763 ) R-HSA-159757 Reaction Name: Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159819 ( R-HSA-159740 ) R-HSA-159819 Reaction Name: GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) See in Reactome R-HSA-9015111 ( R-HSA-140875 ) R-HSA-9015111 Reaction Name: Factor Xa inhibitors binds Xa See in Reactome R-HSA-9015122 ( R-HSA-140875 ) R-HSA-9015122 Reaction Name: Factor Xa inhibitors bind Va:Xa See in Reactome
MONDO:0008316	PROC	P04070	3.4.21.69	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-141026 ( R-HSA-140875 ) R-HSA-141026 Reaction Name: Activated protein C cleaves factor Va to factor Vi intermediate form See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159762 ( R-HSA-159763 ) R-HSA-159762 Reaction Name: Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159771 ( R-HSA-159782 ) R-HSA-159771 Reaction Name: Furin cleaves pro-protein C to protein C See in Reactome R-HSA-159795 ( R-HSA-159740 ) R-HSA-159795 Reaction Name: GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) See in Reactome R-HSA-5591040 ( R-HSA-140875 ) R-HSA-5591040 Reaction Name: Activated protein C cleaves Factor Va intermediate form for Factor Va See in Reactome R-HSA-5591052 ( R-HSA-140875 ) R-HSA-5591052 Reaction Name: PROCR binds Protein C See in Reactome R-HSA-5591086 ( R-HSA-140875 ) R-HSA-5591086 Reaction Name: SERPINA5 binds activated protein C See in Reactome R-HSA-5603467 ( R-HSA-140875 ) R-HSA-5603467 Reaction Name: Activated protein C is released from PROCR See in Reactome R-HSA-5604929 ( R-HSA-140875 ) R-HSA-5604929 Reaction Name: Activated protein C binds Protein S See in Reactome R-HSA-5606996 ( R-HSA-140875 ) R-HSA-5606996 Reaction Name: Soluble PROCR binds activated protein C See in Reactome R-HSA-5607002 ( R-HSA-140875 ) R-HSA-5607002 Reaction Name: Activated protein C cleaves factor VIIIa See in Reactome R-HSA-5607058 ( R-HSA-140875 ) R-HSA-5607058 Reaction Name: Activated protein C:PROCR binds F2R See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0008559	F2	P00734	3.4.21.5	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-375276 R-HSA-375276 Reactome Name: Peptide ligand-binding receptors See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-500792 R-HSA-500792 Reactome Name: GPCR ligand binding See in Reactome R-HSA-373076 R-HSA-373076 Reactome Name: Class A/1 (Rhodopsin-like receptors) See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114697 ( R-HSA-456926 ) R-HSA-114697 Reaction Name: Activated thrombin (factor IIa) cleaves PAR3,4, activating them See in Reactome R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140791 ( R-HSA-140875 ) R-HSA-140791 Reaction Name: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-140870 ( R-HSA-140875 ) R-HSA-140870 Reaction Name: thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin See in Reactome R-HSA-140872 ( R-HSA-140875 ) R-HSA-140872 Reaction Name: thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-141046 ( R-HSA-140875 ) R-HSA-141046 Reaction Name: activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159728 ( R-HSA-159782 ) R-HSA-159728 Reaction Name: Furin cleaves pro-prothrombin to prothrombin See in Reactome R-HSA-159826 ( R-HSA-159740 ) R-HSA-159826 Reaction Name: GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) See in Reactome R-HSA-159843 ( R-HSA-159763 ) R-HSA-159843 Reaction Name: Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-379048 ( R-HSA-416476 ) R-HSA-379048 Reaction Name: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 See in Reactome R-HSA-381446 ( R-HSA-381426 ) R-HSA-381446 Reaction Name: Thrombin proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-389463 ( R-HSA-375276 ) R-HSA-389463 Reaction Name: Proteinase-activated receptors can bind thrombin See in Reactome R-HSA-429529 ( R-HSA-76009 ) R-HSA-429529 Reaction Name: Thrombin binding to GP1b:IX:V See in Reactome R-HSA-5578883 ( R-HSA-140875 ) R-HSA-5578883 Reaction Name: Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) See in Reactome R-HSA-5602080 ( R-HSA-140875 ) R-HSA-5602080 Reaction Name: Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. See in Reactome R-HSA-749448 ( R-HSA-416476 ) R-HSA-749448 Reaction Name: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq See in Reactome R-HSA-749452 ( R-HSA-416476 ) R-HSA-749452 Reaction Name: The Ligand:GPCR:Gq complex dissociates See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9015379 ( R-HSA-140837 ) R-HSA-9015379 Reaction Name: Factor IIa inhibitors (compounds) binds IIa See in Reactome R-HSA-9603302 ( R-HSA-140837 ) R-HSA-9603302 Reaction Name: Factor IIa inhibitors (peptide) binds IIa See in Reactome R-HSA-9708859 ( R-HSA-456926 ) R-HSA-9708859 Reaction Name: Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it See in Reactome
MONDO:0009211	F7	P08709	3.4.21.21	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-1368108 R-HSA-1368108 Reactome Name: BMAL1:CLOCK,NPAS2 activates circadian gene expression See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome	R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Circadian Clock Metabolism of proteins Hemostasis	R-HSA-140736 ( R-HSA-140834 ) R-HSA-140736 Reaction Name: factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) See in Reactome R-HSA-140748 ( R-HSA-140834 ) R-HSA-140748 Reaction Name: tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex See in Reactome R-HSA-140769 ( R-HSA-140834 ) R-HSA-140769 Reaction Name: factor VII -> factor VIIa See in Reactome R-HSA-140777 ( R-HSA-140834 ) R-HSA-140777 Reaction Name: factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) See in Reactome R-HSA-140783 ( R-HSA-140834 ) R-HSA-140783 Reaction Name: tissue factor (TF) + factor VII (F7) -> TF:F7 complex See in Reactome R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-140825 ( R-HSA-140834 ) R-HSA-140825 Reaction Name: TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa See in Reactome R-HSA-159761 ( R-HSA-159740 ) R-HSA-159761 Reaction Name: GGCX gamma-carboxylates F7(21-466) (pro-factor VII) See in Reactome R-HSA-159783 ( R-HSA-159763 ) R-HSA-159783 Reaction Name: Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159868 ( R-HSA-159782 ) R-HSA-159868 Reaction Name: Furin cleaves pro-factor VII to factor VII See in Reactome R-HSA-549428 ( R-HSA-1368108 ) R-HSA-549428 Reaction Name: Expression of FACTOR VII (F7) See in Reactome
MONDO:0009212	F10	P00742	3.4.21.6	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140686 ( R-HSA-140875 ) R-HSA-140686 Reaction Name: factor Va + factor Xa -> Va:Xa complex (prothrombinase) See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140736 ( R-HSA-140834 ) R-HSA-140736 Reaction Name: factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) See in Reactome R-HSA-140769 ( R-HSA-140834 ) R-HSA-140769 Reaction Name: factor VII -> factor VIIa See in Reactome R-HSA-140777 ( R-HSA-140834 ) R-HSA-140777 Reaction Name: factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) See in Reactome R-HSA-140825 ( R-HSA-140834 ) R-HSA-140825 Reaction Name: TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-159733 ( R-HSA-159782 ) R-HSA-159733 Reaction Name: Furin cleaves pro-factor X to factor X See in Reactome R-HSA-159757 ( R-HSA-159763 ) R-HSA-159757 Reaction Name: Gamma-carboxy pro-factor X transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159819 ( R-HSA-159740 ) R-HSA-159819 Reaction Name: GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain) See in Reactome R-HSA-9015111 ( R-HSA-140875 ) R-HSA-9015111 Reaction Name: Factor Xa inhibitors binds Xa See in Reactome R-HSA-9015122 ( R-HSA-140875 ) R-HSA-9015122 Reaction Name: Factor Xa inhibitors bind Va:Xa See in Reactome
MONDO:0010432	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0010602	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0012860	PROC	P04070	3.4.21.69	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-141026 ( R-HSA-140875 ) R-HSA-141026 Reaction Name: Activated protein C cleaves factor Va to factor Vi intermediate form See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159762 ( R-HSA-159763 ) R-HSA-159762 Reaction Name: Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159771 ( R-HSA-159782 ) R-HSA-159771 Reaction Name: Furin cleaves pro-protein C to protein C See in Reactome R-HSA-159795 ( R-HSA-159740 ) R-HSA-159795 Reaction Name: GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) See in Reactome R-HSA-5591040 ( R-HSA-140875 ) R-HSA-5591040 Reaction Name: Activated protein C cleaves Factor Va intermediate form for Factor Va See in Reactome R-HSA-5591052 ( R-HSA-140875 ) R-HSA-5591052 Reaction Name: PROCR binds Protein C See in Reactome R-HSA-5591086 ( R-HSA-140875 ) R-HSA-5591086 Reaction Name: SERPINA5 binds activated protein C See in Reactome R-HSA-5603467 ( R-HSA-140875 ) R-HSA-5603467 Reaction Name: Activated protein C is released from PROCR See in Reactome R-HSA-5604929 ( R-HSA-140875 ) R-HSA-5604929 Reaction Name: Activated protein C binds Protein S See in Reactome R-HSA-5606996 ( R-HSA-140875 ) R-HSA-5606996 Reaction Name: Soluble PROCR binds activated protein C See in Reactome R-HSA-5607002 ( R-HSA-140875 ) R-HSA-5607002 Reaction Name: Activated protein C cleaves factor VIIIa See in Reactome R-HSA-5607058 ( R-HSA-140875 ) R-HSA-5607058 Reaction Name: Activated protein C:PROCR binds F2R See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0013361	F2	P00734	3.4.21.5	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-375276 R-HSA-375276 Reactome Name: Peptide ligand-binding receptors See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-500792 R-HSA-500792 Reactome Name: GPCR ligand binding See in Reactome R-HSA-373076 R-HSA-373076 Reactome Name: Class A/1 (Rhodopsin-like receptors) See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114697 ( R-HSA-456926 ) R-HSA-114697 Reaction Name: Activated thrombin (factor IIa) cleaves PAR3,4, activating them See in Reactome R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140791 ( R-HSA-140875 ) R-HSA-140791 Reaction Name: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-140870 ( R-HSA-140875 ) R-HSA-140870 Reaction Name: thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin See in Reactome R-HSA-140872 ( R-HSA-140875 ) R-HSA-140872 Reaction Name: thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-141046 ( R-HSA-140875 ) R-HSA-141046 Reaction Name: activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159728 ( R-HSA-159782 ) R-HSA-159728 Reaction Name: Furin cleaves pro-prothrombin to prothrombin See in Reactome R-HSA-159826 ( R-HSA-159740 ) R-HSA-159826 Reaction Name: GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) See in Reactome R-HSA-159843 ( R-HSA-159763 ) R-HSA-159843 Reaction Name: Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-379048 ( R-HSA-416476 ) R-HSA-379048 Reaction Name: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 See in Reactome R-HSA-381446 ( R-HSA-381426 ) R-HSA-381446 Reaction Name: Thrombin proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-389463 ( R-HSA-375276 ) R-HSA-389463 Reaction Name: Proteinase-activated receptors can bind thrombin See in Reactome R-HSA-429529 ( R-HSA-76009 ) R-HSA-429529 Reaction Name: Thrombin binding to GP1b:IX:V See in Reactome R-HSA-5578883 ( R-HSA-140875 ) R-HSA-5578883 Reaction Name: Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) See in Reactome R-HSA-5602080 ( R-HSA-140875 ) R-HSA-5602080 Reaction Name: Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. See in Reactome R-HSA-749448 ( R-HSA-416476 ) R-HSA-749448 Reaction Name: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq See in Reactome R-HSA-749452 ( R-HSA-416476 ) R-HSA-749452 Reaction Name: The Ligand:GPCR:Gq complex dissociates See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9015379 ( R-HSA-140837 ) R-HSA-9015379 Reaction Name: Factor IIa inhibitors (compounds) binds IIa See in Reactome R-HSA-9603302 ( R-HSA-140837 ) R-HSA-9603302 Reaction Name: Factor IIa inhibitors (peptide) binds IIa See in Reactome R-HSA-9708859 ( R-HSA-456926 ) R-HSA-9708859 Reaction Name: Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it See in Reactome
MONDO:0013728	F2	P00734	3.4.21.5	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-76009 R-HSA-76009 Reactome Name: Platelet Aggregation (Plug Formation) See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-375276 R-HSA-375276 Reactome Name: Peptide ligand-binding receptors See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome	R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-500792 R-HSA-500792 Reactome Name: GPCR ligand binding See in Reactome R-HSA-373076 R-HSA-373076 Reactome Name: Class A/1 (Rhodopsin-like receptors) See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Hemostasis Signal Transduction	R-HSA-114697 ( R-HSA-456926 ) R-HSA-114697 Reaction Name: Activated thrombin (factor IIa) cleaves PAR3,4, activating them See in Reactome R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140664 ( R-HSA-140875 ) R-HSA-140664 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140700 ( R-HSA-140875 ) R-HSA-140700 Reaction Name: prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) See in Reactome R-HSA-140791 ( R-HSA-140875 ) R-HSA-140791 Reaction Name: activated thrombin (factor IIa) + antithrombin III:heparin -> thrombin:antithrombin III:heparin See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-140870 ( R-HSA-140875 ) R-HSA-140870 Reaction Name: thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin See in Reactome R-HSA-140872 ( R-HSA-140875 ) R-HSA-140872 Reaction Name: thrombin:cleaved SERPINC1:SERPINC1 activators -> thrombin:cleaved SERPINC1 + SERPINC1 activators See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-141046 ( R-HSA-140875 ) R-HSA-141046 Reaction Name: activated thrombin (factor IIa) + thrombomodulin -> activated thrombin:thrombomodulin See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159728 ( R-HSA-159782 ) R-HSA-159728 Reaction Name: Furin cleaves pro-prothrombin to prothrombin See in Reactome R-HSA-159826 ( R-HSA-159740 ) R-HSA-159826 Reaction Name: GGCX gamma-carboxylates F2(25-622) (pro-prothrombin) See in Reactome R-HSA-159843 ( R-HSA-159763 ) R-HSA-159843 Reaction Name: Gamma-carboxy pro-prothrombin transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-379048 ( R-HSA-416476 ) R-HSA-379048 Reaction Name: Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 See in Reactome R-HSA-381446 ( R-HSA-381426 ) R-HSA-381446 Reaction Name: Thrombin proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-389463 ( R-HSA-375276 ) R-HSA-389463 Reaction Name: Proteinase-activated receptors can bind thrombin See in Reactome R-HSA-429529 ( R-HSA-76009 ) R-HSA-429529 Reaction Name: Thrombin binding to GP1b:IX:V See in Reactome R-HSA-5578883 ( R-HSA-140875 ) R-HSA-5578883 Reaction Name: Heparin cofactor 2 (SERPIND1) binds activated thrombin (factor IIa) See in Reactome R-HSA-5602080 ( R-HSA-140875 ) R-HSA-5602080 Reaction Name: Protease nexin-1 (PN1) is a specific and extremely efficient inhibitor of thrombin. See in Reactome R-HSA-749448 ( R-HSA-416476 ) R-HSA-749448 Reaction Name: Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq See in Reactome R-HSA-749452 ( R-HSA-416476 ) R-HSA-749452 Reaction Name: The Ligand:GPCR:Gq complex dissociates See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9015379 ( R-HSA-140837 ) R-HSA-9015379 Reaction Name: Factor IIa inhibitors (compounds) binds IIa See in Reactome R-HSA-9603302 ( R-HSA-140837 ) R-HSA-9603302 Reaction Name: Factor IIa inhibitors (peptide) binds IIa See in Reactome R-HSA-9708859 ( R-HSA-456926 ) R-HSA-9708859 Reaction Name: Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it See in Reactome
MONDO:0015715	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0015716	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0015717	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0015788	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome
MONDO:0026768	F9	P00740	3.4.21.22	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-140834 R-HSA-140834 Reactome Name: Extrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140823 ( R-HSA-140834 ) R-HSA-140823 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) See in Reactome R-HSA-158164 ( R-HSA-140837 ) R-HSA-158164 Reaction Name: factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) See in Reactome R-HSA-158278 ( R-HSA-140837 ) R-HSA-158278 Reaction Name: factor VIIIa + factor IXa -> factor VIIIa:factor IXa See in Reactome R-HSA-158333 ( R-HSA-140837 ) R-HSA-158333 Reaction Name: factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst) See in Reactome R-HSA-159796 ( R-HSA-159782 ) R-HSA-159796 Reaction Name: Furin cleaves pro-factor IX to factor IX See in Reactome R-HSA-159803 ( R-HSA-159740 ) R-HSA-159803 Reaction Name: GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX) See in Reactome R-HSA-159836 ( R-HSA-159763 ) R-HSA-159836 Reaction Name: Gamma-carboxy pro-factor IX transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-5607023 ( R-HSA-140837 ) R-HSA-5607023 Reaction Name: factor IXa associates with cell membrane See in Reactome R-HSA-9670673 ( R-HSA-140837 ) R-HSA-9670673 Reaction Name: FIX is secreted See in Reactome