DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-156581)

Number of enzymes:	5
Number of disease:	7
Number of reactomes:	7
Number of reactions:	13

Search results (Reactome ID: R-HSA-156581)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005090	COMT	P21964	2.1.1.6	R-HSA-379398 R-HSA-379398 Reactome Name: Enzymatic degradation of Dopamine by monoamine oxidase See in Reactome R-HSA-379397 R-HSA-379397 Reactome Name: Enzymatic degradation of dopamine by COMT See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-379401 R-HSA-379401 Reactome Name: Dopamine clearance from the synaptic cleft See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-112311 R-HSA-112311 Reactome Name: Neurotransmitter clearance See in Reactome	Metabolism Neuronal System	R-HSA-175983 ( R-HSA-156581 ) R-HSA-175983 Reaction Name: COMT transfer CH3 from AdoMet to 3,4DHBNZ See in Reactome R-HSA-379387 ( R-HSA-379397 ) R-HSA-379387 Reaction Name: COMT transfers Met to DA to form 3MT See in Reactome R-HSA-379464 ( R-HSA-379398 ) R-HSA-379464 Reaction Name: COMT transfers Met to DOPAC to form HVA See in Reactome R-HSA-9679775 ( R-HSA-379397 ) R-HSA-9679775 Reaction Name: COMT binds COMT Inhibitors See in Reactome
MONDO:0005290	AHCY	P23526	3.3.1.1	R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-2408508 R-HSA-2408508 Reactome Name: Metabolism of ingested SeMet, Sec, MeSec into H2Se See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome	Metabolism	R-HSA-174401 ( R-HSA-156581; R-HSA-1614635 ) R-HSA-174401 Reaction Name: AHCY:NAD+ tetramer hydrolyses AdoHcy See in Reactome R-HSA-2408532 ( R-HSA-2408508 ) R-HSA-2408532 Reaction Name: AdeSeHCys is hydrolysed to SeHCys by AHCY See in Reactome
MONDO:0009354	MTRR	Q9UBK8	1.16.1.8	R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-196741 R-HSA-196741 Reactome Name: Cobalamin (Cbl, vitamin B12) transport and metabolism See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome	Metabolism	R-HSA-174374 ( R-HSA-156581; R-HSA-1614635; R-HSA-196741 ) R-HSA-174374 Reaction Name: MTR transfers CH3 from MeCbl to HCYS See in Reactome R-HSA-3149518 ( R-HSA-196741 ) R-HSA-3149518 Reaction Name: MTRR reduces cob(II)alamin to meCbl See in Reactome R-HSA-3149539 ( R-HSA-196741 ) R-HSA-3149539 Reaction Name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin See in Reactome R-HSA-3204318 ( R-HSA-196741 ) R-HSA-3204318 Reaction Name: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR See in Reactome
MONDO:0009607	MAT1A	Q00266	2.5.1.6	R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-2408508 R-HSA-2408508 Reactome Name: Metabolism of ingested SeMet, Sec, MeSec into H2Se See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome	Metabolism	R-HSA-174391 ( R-HSA-156581; R-HSA-1614635 ) R-HSA-174391 Reaction Name: MAT1A multimers transfer Ado from ATP to L-Met See in Reactome R-HSA-2408551 ( R-HSA-2408508 ) R-HSA-2408551 Reaction Name: SeMet is converted to AdoSeMet by MAT See in Reactome
MONDO:0009609	MTR	Q99707	2.1.1.13	R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-196741 R-HSA-196741 Reactome Name: Cobalamin (Cbl, vitamin B12) transport and metabolism See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-174374 ( R-HSA-156581; R-HSA-1614635; R-HSA-196741 ) R-HSA-174374 Reaction Name: MTR transfers CH3 from MeCbl to HCYS See in Reactome R-HSA-3149518 ( R-HSA-196741 ) R-HSA-3149518 Reaction Name: MTRR reduces cob(II)alamin to meCbl See in Reactome R-HSA-3149539 ( R-HSA-196741 ) R-HSA-3149539 Reaction Name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin See in Reactome R-HSA-3204318 ( R-HSA-196741 ) R-HSA-3204318 Reaction Name: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome
MONDO:0011120	MTR	Q99707	2.1.1.13	R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-196741 R-HSA-196741 Reactome Name: Cobalamin (Cbl, vitamin B12) transport and metabolism See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism Signal Transduction	R-HSA-174374 ( R-HSA-156581; R-HSA-1614635; R-HSA-196741 ) R-HSA-174374 Reaction Name: MTR transfers CH3 from MeCbl to HCYS See in Reactome R-HSA-3149518 ( R-HSA-196741 ) R-HSA-3149518 Reaction Name: MTRR reduces cob(II)alamin to meCbl See in Reactome R-HSA-3149539 ( R-HSA-196741 ) R-HSA-3149539 Reaction Name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin See in Reactome R-HSA-3204318 ( R-HSA-196741 ) R-HSA-3204318 Reaction Name: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome
MONDO:0011120	MTRR	Q9UBK8	1.16.1.8	R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-196741 R-HSA-196741 Reactome Name: Cobalamin (Cbl, vitamin B12) transport and metabolism See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-196849 R-HSA-196849 Reactome Name: Metabolism of water-soluble vitamins and cofactors See in Reactome	Metabolism	R-HSA-174374 ( R-HSA-156581; R-HSA-1614635; R-HSA-196741 ) R-HSA-174374 Reaction Name: MTR transfers CH3 from MeCbl to HCYS See in Reactome R-HSA-3149518 ( R-HSA-196741 ) R-HSA-3149518 Reaction Name: MTRR reduces cob(II)alamin to meCbl See in Reactome R-HSA-3149539 ( R-HSA-196741 ) R-HSA-3149539 Reaction Name: MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin See in Reactome R-HSA-3204318 ( R-HSA-196741 ) R-HSA-3204318 Reaction Name: cob(II)alamin is transferred from MMACHC:MMADHC:cob(II)alamin to MTRR:MTR See in Reactome
MONDO:0013404	AHCY	P23526	3.3.1.1	R-HSA-1614635 R-HSA-1614635 Reactome Name: Sulfur amino acid metabolism See in Reactome R-HSA-2408508 R-HSA-2408508 Reactome Name: Metabolism of ingested SeMet, Sec, MeSec into H2Se See in Reactome R-HSA-156581 R-HSA-156581 Reactome Name: Methylation See in Reactome	R-HSA-211859 R-HSA-211859 Reactome Name: Biological oxidations See in Reactome R-HSA-71291 R-HSA-71291 Reactome Name: Metabolism of amino acids and derivatives See in Reactome R-HSA-2408522 R-HSA-2408522 Reactome Name: Selenoamino acid metabolism See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-156580 R-HSA-156580 Reactome Name: Phase II - Conjugation of compounds See in Reactome	Metabolism	R-HSA-174401 ( R-HSA-156581; R-HSA-1614635 ) R-HSA-174401 Reaction Name: AHCY:NAD+ tetramer hydrolyses AdoHcy See in Reactome R-HSA-2408532 ( R-HSA-2408508 ) R-HSA-2408532 Reaction Name: AdeSeHCys is hydrolysed to SeHCys by AHCY See in Reactome