DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-1502540)

Number of enzymes:	2
Number of disease:	4
Number of reactomes:	47
Number of reactions:	92

Search results (Reactome ID: R-HSA-1502540)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009327	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0013403	ACVR2B	Q13705	2.7.11.30	R-HSA-1433617 R-HSA-1433617 Reactome Name: Regulation of signaling by NODAL See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-1181149 ( R-HSA-1502540 ) R-HSA-1181149 Reaction Name: ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin See in Reactome R-HSA-1181153 ( R-HSA-1502540 ) R-HSA-1181153 Reaction Name: Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B See in Reactome R-HSA-1181155 ( R-HSA-1181150 ) R-HSA-1181155 Reaction Name: The NODAL Receptor binds NODAL ligands See in Reactome R-HSA-1181156 ( R-HSA-1181150 ) R-HSA-1181156 Reaction Name: Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL See in Reactome R-HSA-1181351 ( R-HSA-1181150; R-HSA-1433617 ) R-HSA-1181351 Reaction Name: LEFTY binds the EGF-CFC coreceptor in the NODAL receptor See in Reactome R-HSA-1181355 ( R-HSA-1181150 ) R-HSA-1181355 Reaction Name: Phosphorylation of R-SMAD2/3 by NODAL receptor See in Reactome R-HSA-1225894 ( R-HSA-1181150 ) R-HSA-1225894 Reaction Name: Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL See in Reactome R-HSA-1549526 ( R-HSA-1502540 ) R-HSA-1549526 Reaction Name: Phosphorylation of SMAD2,3 by Activin:Activin Receptor See in Reactome R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome R-HSA-2470483 ( R-HSA-1502540 ) R-HSA-2470483 Reaction Name: Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C See in Reactome R-HSA-2470508 ( R-HSA-1502540 ) R-HSA-2470508 Reaction Name: ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin See in Reactome
MONDO:0016225	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome
MONDO:0033669	MAPK1	P28482	2.7.11.24	R-HSA-2559585 R-HSA-2559585 Reactome Name: Oncogene Induced Senescence See in Reactome R-HSA-445144 R-HSA-445144 Reactome Name: Signal transduction by L1 See in Reactome R-HSA-2871796 R-HSA-2871796 Reactome Name: FCERI mediated MAPK activation See in Reactome R-HSA-111995 R-HSA-111995 Reactome Name: phospho-PLA2 pathway See in Reactome R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-198753 R-HSA-198753 Reactome Name: ERK/MAPK targets See in Reactome R-HSA-9634638 R-HSA-9634638 Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-8940973 R-HSA-8940973 Reactome Name: RUNX2 regulates osteoblast differentiation See in Reactome R-HSA-170968 R-HSA-170968 Reactome Name: Frs2-mediated activation See in Reactome R-HSA-437239 R-HSA-437239 Reactome Name: Recycling pathway of L1 See in Reactome R-HSA-444257 R-HSA-444257 Reactome Name: RSK activation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-1295596 R-HSA-1295596 Reactome Name: Spry regulation of FGF signaling See in Reactome R-HSA-982772 R-HSA-982772 Reactome Name: Growth hormone receptor signaling See in Reactome R-HSA-9634635 R-HSA-9634635 Reactome Name: Estrogen-stimulated signaling through PRKCZ See in Reactome R-HSA-2559582 R-HSA-2559582 Reactome Name: Senescence-Associated Secretory Phenotype (SASP) See in Reactome R-HSA-5654726 R-HSA-5654726 Reactome Name: Negative regulation of FGFR1 signaling See in Reactome R-HSA-5654727 R-HSA-5654727 Reactome Name: Negative regulation of FGFR2 signaling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-2173796 R-HSA-2173796 Reactome Name: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription See in Reactome R-HSA-112409 R-HSA-112409 Reactome Name: RAF-independent MAPK1/3 activation See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-5675221 R-HSA-5675221 Reactome Name: Negative regulation of MAPK pathway See in Reactome R-HSA-450341 R-HSA-450341 Reactome Name: Activation of the AP-1 family of transcription factors See in Reactome R-HSA-5674499 R-HSA-5674499 Reactome Name: Negative feedback regulation of MAPK pathway See in Reactome R-HSA-74749 R-HSA-74749 Reactome Name: Signal attenuation See in Reactome R-HSA-375165 R-HSA-375165 Reactome Name: NCAM signaling for neurite out-growth See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-5674135 R-HSA-5674135 Reactome Name: MAP2K and MAPK activation See in Reactome R-HSA-202670 R-HSA-202670 Reactome Name: ERKs are inactivated See in Reactome R-HSA-879415 R-HSA-879415 Reactome Name: Advanced glycosylation endproduct receptor signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-162658 R-HSA-162658 Reactome Name: Golgi Cisternae Pericentriolar Stack Reorganization See in Reactome R-HSA-456926 R-HSA-456926 Reactome Name: Thrombin signalling through proteinase activated receptors (PARs) See in Reactome R-HSA-5654732 R-HSA-5654732 Reactome Name: Negative regulation of FGFR3 signaling See in Reactome R-HSA-112411 R-HSA-112411 Reactome Name: MAPK1 (ERK2) activation See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-3371453 R-HSA-3371453 Reactome Name: Regulation of HSF1-mediated heat shock response See in Reactome	R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-438064 R-HSA-438064 Reactome Name: Post NMDA receptor activation events See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-112316 R-HSA-112316 Reactome Name: Neuronal System See in Reactome R-HSA-112314 R-HSA-112314 Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission See in Reactome R-HSA-112315 R-HSA-112315 Reactome Name: Transmission across Chemical Synapses See in Reactome R-HSA-373760 R-HSA-373760 Reactome Name: L1CAM interactions See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-442755 R-HSA-442755 Reactome Name: Activation of NMDA receptors and postsynaptic events See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-3371556 R-HSA-3371556 Reactome Name: Cellular response to heat stress See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-442742 R-HSA-442742 Reactome Name: CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling See in Reactome R-HSA-450282 R-HSA-450282 Reactome Name: MAPK targets/ Nuclear events mediated by MAP kinases See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-169893 R-HSA-169893 Reactome Name: Prolonged ERK activation events See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-68875 R-HSA-68875 Reactome Name: Mitotic Prophase See in Reactome R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-187687 R-HSA-187687 Reactome Name: Signalling to ERKs See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-5654741 R-HSA-5654741 Reactome Name: Signaling by FGFR3 See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-5654736 R-HSA-5654736 Reactome Name: Signaling by FGFR1 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Developmental Biology Neuronal System Immune System Programmed Cell Death Gene expression (Transcription) Cellular responses to stimuli Hemostasis Signal Transduction	R-HSA-109822 ( R-HSA-74749 ) R-HSA-109822 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 See in Reactome R-HSA-109823 ( R-HSA-74749 ) R-HSA-109823 Reaction Name: MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 See in Reactome R-HSA-109858 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109858 Reaction Name: MAP2K2 binds MAPK1 See in Reactome R-HSA-109862 ( R-HSA-112409; R-HSA-112411; R-HSA-445144 ) R-HSA-109862 Reaction Name: MAP2K2 phosphorylates MAPK1 See in Reactome R-HSA-109864 ( R-HSA-112409; R-HSA-112411 ) R-HSA-109864 Reaction Name: Dissociation of p-T,Y-MAPK1:p-S,T-MAP2K2 See in Reactome R-HSA-111898 ( R-HSA-111995 ) R-HSA-111898 Reaction Name: Phosphorylation of cPLA2 by ERK-2 See in Reactome R-HSA-1168459 ( R-HSA-982772 ) R-HSA-1168459 Reaction Name: Lyn activates ERK See in Reactome R-HSA-1295634 ( R-HSA-1295596; R-HSA-5654726; R-HSA-5654727; R-HSA-5654732; R-HSA-5654733 ) R-HSA-1295634 Reaction Name: SPRY2 is serine phosphorylated in response to MAPK activation See in Reactome R-HSA-168053 ( R-HSA-450341 ) R-HSA-168053 Reaction Name: Phosphorylated MAPKs phosphorylate ATF-2 See in Reactome R-HSA-173488 ( R-HSA-1181150; R-HSA-1502540; R-HSA-2173796 ) R-HSA-173488 Reaction Name: The SMAD2/3:SMAD4 complex transfers to the nucleus See in Reactome R-HSA-198731 ( R-HSA-198753; R-HSA-8939211; R-HSA-9634638 ) R-HSA-198731 Reaction Name: ERK1/2 activates ELK1 See in Reactome R-HSA-198746 ( R-HSA-198753; R-HSA-2559582; R-HSA-881907 ) R-HSA-198746 Reaction Name: ERK1/2/5 activate RSK1/2/3 See in Reactome R-HSA-198756 ( R-HSA-198753; R-HSA-375165 ) R-HSA-198756 Reaction Name: ERK1/2 phosphorylates MSK1 See in Reactome R-HSA-199959 ( R-HSA-198753; R-HSA-202670 ) R-HSA-199959 Reaction Name: ERKs are inactivated by protein phosphatase 2A See in Reactome R-HSA-2029469 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2029469 Reaction Name: p-ERK phosphorylates WAVEs and ABI See in Reactome R-HSA-203797 ( R-HSA-198753; R-HSA-202670 ) R-HSA-203797 Reaction Name: ERKs are inactivated by dual-specific phosphatases (DUSPs) See in Reactome R-HSA-2422927 ( R-HSA-162658 ) R-HSA-2422927 Reaction Name: MAPK3-3 or MAPK1 phosphorylate GORASP2 See in Reactome R-HSA-3132737 ( R-HSA-2559585 ) R-HSA-3132737 Reaction Name: MAPKs phosphorylate ETS1 and ETS2 See in Reactome R-HSA-3209160 ( R-HSA-2559585 ) R-HSA-3209160 Reaction Name: Activated ERKs phosphorylate ERF See in Reactome R-HSA-3209177 ( R-HSA-2559585 ) R-HSA-3209177 Reaction Name: ERF binds ETS2 promoter See in Reactome R-HSA-3223236 ( R-HSA-2559580 ) R-HSA-3223236 Reaction Name: RAS signaling and prolonged interferon-beta stimulation promote generation of reactive oxygen species (ROS) See in Reactome R-HSA-3371531 ( R-HSA-3371453 ) R-HSA-3371531 Reaction Name: Constitutive phosphorylation by pERK1/2 See in Reactome R-HSA-3857329 ( R-HSA-2559582 ) R-HSA-3857329 Reaction Name: MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB See in Reactome R-HSA-418158 ( R-HSA-456926 ) R-HSA-418158 Reaction Name: SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) See in Reactome R-HSA-418163 ( R-HSA-456926 ) R-HSA-418163 Reaction Name: Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) See in Reactome R-HSA-418170 ( R-HSA-456926 ) R-HSA-418170 Reaction Name: F2R:ARRB1 binds MAPKs, SRC-1 See in Reactome R-HSA-418176 ( R-HSA-456926 ) R-HSA-418176 Reaction Name: F2R:ARRB2 binds MAPKs, SRC-1 See in Reactome R-HSA-418200 ( R-HSA-456926 ) R-HSA-418200 Reaction Name: SRC-1 bound to ARRB2 is not activated See in Reactome R-HSA-445079 ( R-HSA-437239 ) R-HSA-445079 Reaction Name: Phosphorylation of L1 by ERK See in Reactome R-HSA-450325 ( R-HSA-2559580; R-HSA-2871796; R-HSA-450341 ) R-HSA-450325 Reaction Name: c-FOS activation by phospho ERK1/2 See in Reactome R-HSA-5654560 ( R-HSA-5654726 ) R-HSA-5654560 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. See in Reactome R-HSA-5654562 ( R-HSA-5654727 ) R-HSA-5654562 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2 See in Reactome R-HSA-5654565 ( R-HSA-5654732 ) R-HSA-5654565 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2. See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5672972 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672972 Reaction Name: MAP2Ks and MAPKs bind to the activated RAF complex See in Reactome R-HSA-5672973 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672973 Reaction Name: MAP2Ks phosphorylate MAPKs See in Reactome R-HSA-5672978 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672978 Reaction Name: RAF phosphorylates MAP2K dimer See in Reactome R-HSA-5672980 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5672980 Reaction Name: Dissociation of RAS:RAF complex See in Reactome R-HSA-5674130 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674130 Reaction Name: MAP2Ks and MAPKs are phosphorylated at the endosome membrane See in Reactome R-HSA-5674132 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674132 Reaction Name: WDR83:LAMTOR2:LAMTOR3 binds MAPK components See in Reactome R-HSA-5674366 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674366 Reaction Name: IL17RD binds p-2S MAP2Ks and MAPKs See in Reactome R-HSA-5674373 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-5674373 Reaction Name: MAP2Ks phosphorylate MAPK at the Golgi membrane See in Reactome R-HSA-5674385 ( R-HSA-112409; R-HSA-170968; R-HSA-5673001 ) R-HSA-5674385 Reaction Name: p-T,Y MAPKs dimerize See in Reactome R-HSA-5674387 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5674387 Reaction Name: Phosphorylated MAPKs translocate into the nucleus See in Reactome R-HSA-5674496 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5674496 Reaction Name: Activated MAPKs phosphorylate MAP2K1 See in Reactome R-HSA-5675194 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675194 Reaction Name: Activated MAPK phosphorylates RAF1 See in Reactome R-HSA-5675198 ( R-HSA-5673001; R-HSA-5674499; R-HSA-5675221 ) R-HSA-5675198 Reaction Name: Activated MAPKs phosphorylate BRAF See in Reactome R-HSA-5675206 ( R-HSA-112409; R-HSA-5673001 ) R-HSA-5675206 Reaction Name: PEA15 binds MAPK monomers and dimers See in Reactome R-HSA-5675373 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675373 Reaction Name: Nuclear DUSPs dephosphorylate MAPKs See in Reactome R-HSA-5675376 ( R-HSA-112409; R-HSA-5673001; R-HSA-5675221 ) R-HSA-5675376 Reaction Name: Cytosolic DUSPs dephosphorylate MAPKs See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-6811454 ( R-HSA-6811558 ) R-HSA-6811454 Reaction Name: MAPKs phosphorylate PP2A See in Reactome R-HSA-6811472 ( R-HSA-6811558 ) R-HSA-6811472 Reaction Name: IER3 recruits MAPKs to PP2A-B56-beta,gamma See in Reactome R-HSA-879362 ( R-HSA-879415 ) R-HSA-879362 Reaction Name: AGER binds ERK1/2 See in Reactome R-HSA-8944047 ( R-HSA-8943724 ) R-HSA-8944047 Reaction Name: JUN binds the PTEN gene promoter See in Reactome R-HSA-9009208 ( R-HSA-8940973 ) R-HSA-9009208 Reaction Name: Activated ERKs phosphorylate RUNX2 See in Reactome R-HSA-9032751 ( R-HSA-8939211 ) R-HSA-9032751 Reaction Name: Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3 See in Reactome R-HSA-9610152 ( R-HSA-170968 ) R-HSA-9610152 Reaction Name: Activated BRAF recruits MAP2Ks and MAPKs to the endosome See in Reactome R-HSA-9610153 ( R-HSA-170968 ) R-HSA-9610153 Reaction Name: Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF See in Reactome R-HSA-9610154 ( R-HSA-170968 ) R-HSA-9610154 Reaction Name: Dissociation of phosphorylated MAP2Ks and MAPKs See in Reactome R-HSA-9610156 ( R-HSA-170968 ) R-HSA-9610156 Reaction Name: MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF See in Reactome R-HSA-9610166 ( R-HSA-170968 ) R-HSA-9610166 Reaction Name: p-T,Y MAPK dimers translocate to nucleus See in Reactome R-HSA-9619843 ( R-HSA-444257 ) R-HSA-9619843 Reaction Name: ERKs phosphorylate RSKs See in Reactome R-HSA-9626832 ( R-HSA-5668599 ) R-HSA-9626832 Reaction Name: MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 See in Reactome R-HSA-9627089 ( R-HSA-9627069 ) R-HSA-9627089 Reaction Name: CASP9 is phosphorylated at T125 See in Reactome R-HSA-9632873 ( R-HSA-8939211; R-HSA-9634638 ) R-HSA-9632873 Reaction Name: p-S10 CDKN1B translocates to the cytosol See in Reactome R-HSA-9632910 ( R-HSA-8939211; R-HSA-9634635 ) R-HSA-9632910 Reaction Name: ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus See in Reactome R-HSA-9635739 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635739 Reaction Name: PTPN7 dephosphorylates p-T,Y-MAPKs See in Reactome R-HSA-9635743 ( R-HSA-5673001; R-HSA-5675221 ) R-HSA-9635743 Reaction Name: PTPN7 binds p-T,Y-MAPK See in Reactome R-HSA-9657599 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657599 Reaction Name: Dual mechanism MAP2K inhibitors bind MAP2Ks See in Reactome R-HSA-9657603 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657603 Reaction Name: Dual mechanism MAPK inhibitors bind MAPKs See in Reactome R-HSA-9657606 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657606 Reaction Name: Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks See in Reactome R-HSA-9657608 ( R-HSA-5673001; R-HSA-5674135 ) R-HSA-9657608 Reaction Name: Single mechanism MAPK inhibitors bind phosphorylated MAPK See in Reactome