DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-1474228)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005387	ADAMTS1	Q9UHI8	3.4.24.-	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-5173214 R-HSA-5173214 Reactome Name: O-glycosylation of TSR domain-containing proteins See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5173105 R-HSA-5173105 Reactome Name: O-linked glycosylation See in Reactome	Extracellular matrix organization Metabolism of proteins	R-HSA-1592310 ( R-HSA-1474228 ) R-HSA-1592310 Reaction Name: Aggrecan degradation by ADAMTSs See in Reactome R-HSA-5173005 ( R-HSA-5173214 ) R-HSA-5173005 Reaction Name: B3GALTL transfers glucose to O-fucosyl-proteins See in Reactome R-HSA-5173192 ( R-HSA-5173214 ) R-HSA-5173192 Reaction Name: POFUT2 transfers fucose to TSR domain-containing proteins See in Reactome
MONDO:0006928	CAPN5	O15484	3.4.22.-	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-8848658 ( R-HSA-1474228 ) R-HSA-8848658 Reaction Name: CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins See in Reactome
MONDO:0007088	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0008090	ELANE	P08246	3.4.21.37	R-HSA-5620971 R-HSA-5620971 Reactome Name: Pyroptosis See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6803157 R-HSA-6803157 Reactome Name: Antimicrobial peptides See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System Programmed Cell Death Extracellular matrix organization	R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-2482180 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2482180 Reaction Name: Collagen type VIII degradation by ELANE See in Reactome R-HSA-2514823 ( R-HSA-1474228 ) R-HSA-2514823 Reaction Name: Fibrillin-1 degradation by ELANE See in Reactome R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6813659 ( R-HSA-6803157 ) R-HSA-6813659 Reaction Name: ELANE, CTSG or PRTN3 binds bacteria See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9710106 ( R-HSA-5620971 ) R-HSA-9710106 Reaction Name: ELANE cleaves GSDMD See in Reactome
MONDO:0008243	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0008664	CAPN5	O15484	3.4.22.-	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-8848658 ( R-HSA-1474228 ) R-HSA-8848658 Reaction Name: CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins See in Reactome
MONDO:0008788	TMPRSS6	Q8IU80	3.4.21.-	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-1458433 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1458433 Reaction Name: Collagen type I degradation by MMP14 See in Reactome R-HSA-1474196 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474196 Reaction Name: Collagen type II degradation by MMP14 See in Reactome R-HSA-1474210 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474210 Reaction Name: Collagen type III degradation by MMP14 See in Reactome R-HSA-2514790 ( R-HSA-1474228 ) R-HSA-2514790 Reaction Name: Elastin degradation by MMP14 See in Reactome R-HSA-2514831 ( R-HSA-1474228 ) R-HSA-2514831 Reaction Name: Fibrillin-1 degradation by MMP14 See in Reactome R-HSA-2533874 ( R-HSA-1474228 ) R-HSA-2533874 Reaction Name: Laminin-511 degradation by MMP14 See in Reactome R-HSA-2533950 ( R-HSA-1474228 ) R-HSA-2533950 Reaction Name: Fibronectin degradation by MMP14, TMPRSS6 See in Reactome R-HSA-3791155 ( R-HSA-1474228 ) R-HSA-3791155 Reaction Name: Laminin-322 degradation by MMP14 See in Reactome R-HSA-3828025 ( R-HSA-1474228 ) R-HSA-3828025 Reaction Name: DCN (decorin) degradation by MMP14 See in Reactome
MONDO:0009009	PLG	P00747	3.4.21.7	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-75205 R-HSA-75205 Reactome Name: Dissolution of Fibrin Clot See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome	R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Extracellular matrix organization Hemostasis Signal Transduction	R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-158721 ( R-HSA-75205 ) R-HSA-158721 Reaction Name: histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen See in Reactome R-HSA-158722 ( R-HSA-75205 ) R-HSA-158722 Reaction Name: histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen See in Reactome R-HSA-158744 ( R-HSA-75205 ) R-HSA-158744 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin See in Reactome R-HSA-158747 ( R-HSA-75205 ) R-HSA-158747 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) See in Reactome R-HSA-158750 ( R-HSA-75205 ) R-HSA-158750 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin See in Reactome R-HSA-158756 ( R-HSA-75205 ) R-HSA-158756 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen See in Reactome R-HSA-158766 ( R-HSA-75205 ) R-HSA-158766 Reaction Name: fibrin multimer, crosslinked -> fibrin digestion products (plasmin) See in Reactome R-HSA-158784 ( R-HSA-75205 ) R-HSA-158784 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen See in Reactome R-HSA-158893 ( R-HSA-75205 ) R-HSA-158893 Reaction Name: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin See in Reactome R-HSA-158925 ( R-HSA-75205 ) R-HSA-158925 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) See in Reactome R-HSA-158941 ( R-HSA-75205 ) R-HSA-158941 Reaction Name: plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein See in Reactome R-HSA-158942 ( R-HSA-75205 ) R-HSA-158942 Reaction Name: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR See in Reactome R-HSA-158982 ( R-HSA-75205 ) R-HSA-158982 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1602458 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602458 Reaction Name: Activation of proMMP10 See in Reactome R-HSA-1602488 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-381461 ( R-HSA-381426 ) R-HSA-381461 Reaction Name: Plasmin proteolyzes IGF:IGFBP-3:ALS See in Reactome R-HSA-382061 ( R-HSA-186797 ) R-HSA-382061 Reaction Name: Extracellular processing of novel PDGFs See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome
MONDO:0009597	MMP13	P45452	3.4.24.-	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Extracellular matrix organization	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1474197 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474197 Reaction Name: Collagen type II degradation by MMP1,3,8,13,PRSS2 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564117 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564117 Reaction Name: Collagen type XIV degradation by MMP9,13 See in Reactome R-HSA-1564184 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564184 Reaction Name: Collagen type IX degradation by MMP3,13 See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602488 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604732 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604732 Reaction Name: Autocatalytic activation of proMMP13 See in Reactome R-HSA-1604741 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604741 Reaction Name: Initial activation of proMMP13 by MMP14 (MT1-MMP) See in Reactome R-HSA-1604752 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604752 Reaction Name: Initial activation of proMMP13 by MMP3 See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2484882 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2484882 Reaction Name: Collagen type X degradation by MMP3, 13 See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534160 ( R-HSA-1474228 ) R-HSA-2534160 Reaction Name: HSPG2 (perlecan) degradation by MMP13, CTSS See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-8940007 ( R-HSA-8941332 ) R-HSA-8940007 Reaction Name: MMP13 gene expression is stimulated by RUNX2:CBFB See in Reactome R-HSA-8942302 ( R-HSA-1474228 ) R-HSA-8942302 Reaction Name: MMP13 cleaves OPTC See in Reactome
MONDO:0009675	CAPN3	P20807	3.4.22.54	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-8848658 ( R-HSA-1474228 ) R-HSA-8848658 Reaction Name: CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins See in Reactome
MONDO:0009676	CAPN3	P20807	3.4.22.54	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-8848658 ( R-HSA-1474228 ) R-HSA-8848658 Reaction Name: CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins See in Reactome
MONDO:0009728	ADAMTS9	Q9P2N4	3.4.24.-	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-5173214 R-HSA-5173214 Reactome Name: O-glycosylation of TSR domain-containing proteins See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5173105 R-HSA-5173105 Reactome Name: O-linked glycosylation See in Reactome	Extracellular matrix organization Metabolism of proteins	R-HSA-1592310 ( R-HSA-1474228 ) R-HSA-1592310 Reaction Name: Aggrecan degradation by ADAMTSs See in Reactome R-HSA-5173005 ( R-HSA-5173214 ) R-HSA-5173005 Reaction Name: B3GALTL transfers glucose to O-fucosyl-proteins See in Reactome R-HSA-5173192 ( R-HSA-5173214 ) R-HSA-5173192 Reaction Name: POFUT2 transfers fucose to TSR domain-containing proteins See in Reactome
MONDO:0009804	BMP1	P13497	3.4.24.19	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome	Transport of small molecules Extracellular matrix organization	R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-2002428 ( R-HSA-1650814 ) R-HSA-2002428 Reaction Name: Removal of fibrillar collagen N-propeptides See in Reactome R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2022090; R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2022090; R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0009809	MMP2	P08253	3.4.24.24	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1592278 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592278 Reaction Name: Autocatalytic activation of proMMP2 See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-8940554 ( R-HSA-1474228 ) R-HSA-8940554 Reaction Name: MMP2 cleaves OPTC See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0009940	CTSK	P43235	3.4.22.38	R-HSA-8939242 R-HSA-8939242 Reactome Name: RUNX1 regulates transcription of genes involved in differentiation of keratinocytes See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-1679131 R-HSA-1679131 Reactome Name: Trafficking and processing of endosomal TLR See in Reactome R-HSA-2132295 R-HSA-2132295 Reactome Name: MHC class II antigen presentation See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8878171 R-HSA-8878171 Reactome Name: Transcriptional regulation by RUNX1 See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Extracellular matrix organization	R-HSA-1592362 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592362 Reaction Name: Activation of proMMP7 by MMP3 See in Reactome R-HSA-1604752 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604752 Reaction Name: Initial activation of proMMP13 by MMP3 See in Reactome R-HSA-1678920 ( R-HSA-1679131 ) R-HSA-1678920 Reaction Name: TLR processing at low pH See in Reactome R-HSA-2130349 ( R-HSA-2132295 ) R-HSA-2130349 Reaction Name: Generation of CLIP from lip10 See in Reactome R-HSA-2130504 ( R-HSA-2132295 ) R-HSA-2130504 Reaction Name: Cleavage of lip22 to lip10 See in Reactome R-HSA-2130706 ( R-HSA-2132295 ) R-HSA-2130706 Reaction Name: MHC class II antigen processing See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2471621 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2471621 Reaction Name: Endostatin degradation by cathepsins See in Reactome R-HSA-2514772 ( R-HSA-1474228 ) R-HSA-2514772 Reaction Name: Fibrillin-1 degradation by MMP3, CTSK, CTSL2 See in Reactome R-HSA-8938121 ( R-HSA-8939242 ) R-HSA-8938121 Reaction Name: SERPINB13 binds CTSK See in Reactome
MONDO:0010201	MMP14	P50281	3.4.24.80	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-1458433 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1458433 Reaction Name: Collagen type I degradation by MMP14 See in Reactome R-HSA-1474196 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474196 Reaction Name: Collagen type II degradation by MMP14 See in Reactome R-HSA-1474210 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474210 Reaction Name: Collagen type III degradation by MMP14 See in Reactome R-HSA-1592349 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592349 Reaction Name: MMP14 (MT1-MMP) binds TIMP2 See in Reactome R-HSA-1602466 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602466 Reaction Name: Activation of MT-MMPs by FURIN See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604741 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604741 Reaction Name: Initial activation of proMMP13 by MMP14 (MT1-MMP) See in Reactome R-HSA-1605825 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1605825 Reaction Name: MT-MMPs are sorted to the plasma membrane See in Reactome R-HSA-2514790 ( R-HSA-1474228 ) R-HSA-2514790 Reaction Name: Elastin degradation by MMP14 See in Reactome R-HSA-2514831 ( R-HSA-1474228 ) R-HSA-2514831 Reaction Name: Fibrillin-1 degradation by MMP14 See in Reactome R-HSA-2533874 ( R-HSA-1474228 ) R-HSA-2533874 Reaction Name: Laminin-511 degradation by MMP14 See in Reactome R-HSA-2533950 ( R-HSA-1474228 ) R-HSA-2533950 Reaction Name: Fibronectin degradation by MMP14, TMPRSS6 See in Reactome R-HSA-2533965 ( R-HSA-1474228 ) R-HSA-2533965 Reaction Name: NID1 degradation by MMP14, MMP15 See in Reactome R-HSA-2534240 ( R-HSA-1474228 ) R-HSA-2534240 Reaction Name: HSPG2 (perlecan) degradation by MMP14, MMP15 See in Reactome R-HSA-3791155 ( R-HSA-1474228 ) R-HSA-3791155 Reaction Name: Laminin-322 degradation by MMP14 See in Reactome R-HSA-3828025 ( R-HSA-1474228 ) R-HSA-3828025 Reaction Name: DCN (decorin) degradation by MMP14 See in Reactome
MONDO:0010829	HTRA1	Q92743	3.4.21.-	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-8855825 ( R-HSA-1474228 ) R-HSA-8855825 Reaction Name: HTRA1 hydrolyzes ACAN (Aggrecan) See in Reactome
MONDO:0010857	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0011027	CAPN10	Q9HC96	3.4.22.-	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-8848658 ( R-HSA-1474228 ) R-HSA-8848658 Reaction Name: CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins See in Reactome
MONDO:0011198	MMP13	P45452	3.4.24.-	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Extracellular matrix organization	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1474197 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474197 Reaction Name: Collagen type II degradation by MMP1,3,8,13,PRSS2 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564117 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564117 Reaction Name: Collagen type XIV degradation by MMP9,13 See in Reactome R-HSA-1564184 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564184 Reaction Name: Collagen type IX degradation by MMP3,13 See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602488 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604732 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604732 Reaction Name: Autocatalytic activation of proMMP13 See in Reactome R-HSA-1604741 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604741 Reaction Name: Initial activation of proMMP13 by MMP14 (MT1-MMP) See in Reactome R-HSA-1604752 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604752 Reaction Name: Initial activation of proMMP13 by MMP3 See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2484882 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2484882 Reaction Name: Collagen type X degradation by MMP3, 13 See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534160 ( R-HSA-1474228 ) R-HSA-2534160 Reaction Name: HSPG2 (perlecan) degradation by MMP13, CTSS See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-8940007 ( R-HSA-8941332 ) R-HSA-8940007 Reaction Name: MMP13 gene expression is stimulated by RUNX2:CBFB See in Reactome R-HSA-8942302 ( R-HSA-1474228 ) R-HSA-8942302 Reaction Name: MMP13 cleaves OPTC See in Reactome
MONDO:0011743	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0011751	MMP1	P03956	3.4.24.7	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-210991 R-HSA-210991 Reactome Name: Basigin interactions See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Hemostasis	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1474197 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474197 Reaction Name: Collagen type II degradation by MMP1,3,8,13,PRSS2 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564169 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564169 Reaction Name: Collagen type VIII degradation by MMP1 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602473 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602473 Reaction Name: Autocatalytic activation of MMP1 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-375135 ( R-HSA-1474228; R-HSA-210991 ) R-HSA-375135 Reaction Name: Basigin binds Matrix metalloproteinase-1 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome
MONDO:0011913	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0012419	HTRA1	Q92743	3.4.21.-	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-8855825 ( R-HSA-1474228 ) R-HSA-8855825 Reaction Name: HTRA1 hydrolyzes ACAN (Aggrecan) See in Reactome
MONDO:0012687	MMP19	Q99542	3.4.24.-	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-2537499 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2537499 Reaction Name: Gelatin degradation by MMP19 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791319 ( R-HSA-1474228 ) R-HSA-3791319 Reaction Name: NID1 degradation by MMP19 See in Reactome
MONDO:0012926	MMP20	O60882	3.4.24.-	R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome
MONDO:0013113	MMP9	P14780	3.4.24.35	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1433374 ( R-HSA-1433557 ) R-HSA-1433374 Reaction Name: Processing of SCF isoform 1 See in Reactome R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564117 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564117 Reaction Name: Collagen type XIV degradation by MMP9,13 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602454 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602454 Reaction Name: proMMP9 binds TIMP1 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604722 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604722 Reaction Name: Activation of proMMP9 by proteases See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2168982 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168982 Reaction Name: Collagen type XVI degradation by MMP9 See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-3827958 ( R-HSA-1474228 ) R-HSA-3827958 Reaction Name: E-cadherin degradation by MMP9, KLK7 See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0013123	TLL1	O43897	3.4.24.-	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0013371	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013398	PSEN1	P49768	3.4.23.-	R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-193692 R-HSA-193692 Reactome Name: Regulated proteolysis of p75NTR See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-205043 R-HSA-205043 Reactome Name: NRIF signals cell death from the nucleus See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-9017802 R-HSA-9017802 Reactome Name: Noncanonical activation of NOTCH3 See in Reactome R-HSA-1251985 R-HSA-1251985 Reactome Name: Nuclear signaling by ERBB4 See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-204998 R-HSA-204998 Reactome Name: Cell death signalling via NRAGE, NRIF and NADE See in Reactome R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-193704 R-HSA-193704 Reactome Name: p75 NTR receptor-mediated signalling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-1236394 R-HSA-1236394 Reactome Name: Signaling by ERBB4 See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1251997 ( R-HSA-1251985 ) R-HSA-1251997 Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex See in Reactome R-HSA-157353 ( R-HSA-2122948 ) R-HSA-157353 Reaction Name: NEXT1 is cleaved to produce NICD1 See in Reactome R-HSA-157640 ( R-HSA-2979096 ) R-HSA-157640 Reaction Name: NEXT2 is cleaved to produce NICD2 See in Reactome R-HSA-193682 ( R-HSA-193692 ) R-HSA-193682 Reaction Name: gamma-secretase cleaves the p75NTR transmembrane domain See in Reactome R-HSA-1980109 ( R-HSA-2122948 ) R-HSA-1980109 Reaction Name: Cleavage of CNTN1:NOTCH1 complex releases NICD1 See in Reactome R-HSA-1980112 ( R-HSA-2122948 ) R-HSA-1980112 Reaction Name: Cleavage of DNER:NOTCH1 complex releases NICD1 See in Reactome R-HSA-205112 ( R-HSA-205043 ) R-HSA-205112 Reaction Name: gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 See in Reactome R-HSA-2534206 ( R-HSA-1474228 ) R-HSA-2534206 Reaction Name: E-cadherin degradation by PS1:NCSTN (Gamma-secretase) See in Reactome R-HSA-2974731 ( R-HSA-2979096 ) R-HSA-2974731 Reaction Name: Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 See in Reactome R-HSA-3928656 ( R-HSA-3928665 ) R-HSA-3928656 Reaction Name: gamma-secretase cleaves EPHB2 See in Reactome R-HSA-6798739 ( R-HSA-6798695 ) R-HSA-6798739 Reaction Name: Exocytosis of azurophil granule membrane proteins See in Reactome R-HSA-9013361 ( R-HSA-9013507 ) R-HSA-9013361 Reaction Name: NEXT3 is cleaved to produce NICD3 See in Reactome R-HSA-9017817 ( R-HSA-9013507; R-HSA-9017802 ) R-HSA-9017817 Reaction Name: Gamma-secretase cleaves YBX1:NOTCH3 See in Reactome R-HSA-9604294 ( R-HSA-9013700 ) R-HSA-9604294 Reaction Name: Gamma-secretase cleaves NOTCH4 See in Reactome
MONDO:0013765	MMP3	P08254	3.4.24.17	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Extracellular matrix organization Signal Transduction	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1474197 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474197 Reaction Name: Collagen type II degradation by MMP1,3,8,13,PRSS2 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1564184 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564184 Reaction Name: Collagen type IX degradation by MMP3,13 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592362 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592362 Reaction Name: Activation of proMMP7 by MMP3 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604731 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604731 Reaction Name: Autocatalytic activation of MMP3 See in Reactome R-HSA-1604752 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604752 Reaction Name: Initial activation of proMMP13 by MMP3 See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2179402 ( R-HSA-2179392 ) R-HSA-2179402 Reaction Name: Active MMP3 can cleave pro-HBEGF to form active HBEGF See in Reactome R-HSA-2179413 ( R-HSA-2179392 ) R-HSA-2179413 Reaction Name: Activated PKC-alpha activate MMP3 See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2484882 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2484882 Reaction Name: Collagen type X degradation by MMP3, 13 See in Reactome R-HSA-2514772 ( R-HSA-1474228 ) R-HSA-2514772 Reaction Name: Fibrillin-1 degradation by MMP3, CTSK, CTSL2 See in Reactome R-HSA-2533970 ( R-HSA-1474228 ) R-HSA-2533970 Reaction Name: NID1 degradation by MMP3, 7 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-4086205 ( R-HSA-1474228 ) R-HSA-4086205 Reaction Name: OPN (osteopontin) degradation by MMP3, MMP7 See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0013924	BMP1	P13497	3.4.24.19	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome	Transport of small molecules Extracellular matrix organization	R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-2002428 ( R-HSA-1650814 ) R-HSA-2002428 Reaction Name: Removal of fibrillar collagen N-propeptides See in Reactome R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2022090; R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2022090; R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0014195	ADAMTS18	Q8TE60	3.4.24.-	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-5173214 R-HSA-5173214 Reactome Name: O-glycosylation of TSR domain-containing proteins See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-5173105 R-HSA-5173105 Reactome Name: O-linked glycosylation See in Reactome	Extracellular matrix organization Metabolism of proteins	R-HSA-1592310 ( R-HSA-1474228 ) R-HSA-1592310 Reaction Name: Aggrecan degradation by ADAMTSs See in Reactome R-HSA-5173005 ( R-HSA-5173214 ) R-HSA-5173005 Reaction Name: B3GALTL transfers glucose to O-fucosyl-proteins See in Reactome R-HSA-5173192 ( R-HSA-5173214 ) R-HSA-5173192 Reaction Name: POFUT2 transfers fucose to TSR domain-containing proteins See in Reactome
MONDO:0014234	ADAM10	O14672	3.4.24.81	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-157629 ( R-HSA-2979096 ) R-HSA-157629 Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2 See in Reactome R-HSA-157632 ( R-HSA-2122948 ) R-HSA-157632 Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 See in Reactome R-HSA-177946 ( R-HSA-177929 ) R-HSA-177946 Reaction Name: Pro-EGF is cleaved to form mature EGF See in Reactome R-HSA-2168960 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168960 Reaction Name: Collagen type XVII ectodomain shedding See in Reactome R-HSA-3928660 ( R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4224014 ( R-HSA-1474228 ) R-HSA-4224014 Reaction Name: E-cadherin degradation by ADAM10, ADAM15 See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9010034 ( R-HSA-977225 ) R-HSA-9010034 Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770) See in Reactome R-HSA-9010074 ( R-HSA-977225 ) R-HSA-9010074 Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane See in Reactome R-HSA-9010113 ( R-HSA-977225 ) R-HSA-9010113 Reaction Name: ADAM10:Zn2+ binds TSPANs See in Reactome R-HSA-9013284 ( R-HSA-9013507 ) R-HSA-9013284 Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3 See in Reactome R-HSA-9604264 ( R-HSA-9013700 ) R-HSA-9604264 Reaction Name: ADAM10 cleaves NOTCH4 See in Reactome
MONDO:0014265	ADAM10	O14672	3.4.24.81	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-9013507 R-HSA-9013507 Reactome Name: NOTCH3 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9013700 R-HSA-9013700 Reactome Name: NOTCH4 Activation and Transmission of Signal to the Nucleus See in Reactome R-HSA-977225 R-HSA-977225 Reactome Name: Amyloid fiber formation See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2122948 R-HSA-2122948 Reactome Name: Activated NOTCH1 Transmits Signal to the Nucleus See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-2979096 R-HSA-2979096 Reactome Name: NOTCH2 Activation and Transmission of Signal to the Nucleus See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-9012852 R-HSA-9012852 Reactome Name: Signaling by NOTCH3 See in Reactome R-HSA-1980145 R-HSA-1980145 Reactome Name: Signaling by NOTCH2 See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-9013694 R-HSA-9013694 Reactome Name: Signaling by NOTCH4 See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-157629 ( R-HSA-2979096 ) R-HSA-157629 Reaction Name: NOTCH2-ligand complex is cleaved to produce NEXT2 See in Reactome R-HSA-157632 ( R-HSA-2122948 ) R-HSA-157632 Reaction Name: Complex of NOTCH1 with its ligand is cleaved to produce NEXT1 See in Reactome R-HSA-177946 ( R-HSA-177929 ) R-HSA-177946 Reaction Name: Pro-EGF is cleaved to form mature EGF See in Reactome R-HSA-2168960 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168960 Reaction Name: Collagen type XVII ectodomain shedding See in Reactome R-HSA-3928660 ( R-HSA-3928665 ) R-HSA-3928660 Reaction Name: ADAM10 cleaves EFNAs See in Reactome R-HSA-4224014 ( R-HSA-1474228 ) R-HSA-4224014 Reaction Name: E-cadherin degradation by ADAM10, ADAM15 See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome R-HSA-9010034 ( R-HSA-977225 ) R-HSA-9010034 Reaction Name: ADAM10:Zn2+:TSPANs cleaves APP(18-770) See in Reactome R-HSA-9010074 ( R-HSA-977225 ) R-HSA-9010074 Reaction Name: ADAM10:Zn2+:TSPANs translocates from ER lumen to plasma membrane See in Reactome R-HSA-9010113 ( R-HSA-977225 ) R-HSA-9010113 Reaction Name: ADAM10:Zn2+ binds TSPANs See in Reactome R-HSA-9013284 ( R-HSA-9013507 ) R-HSA-9013284 Reaction Name: NOTCH3-ligand complex is cleaved to produce NEXT3 See in Reactome R-HSA-9604264 ( R-HSA-9013700 ) R-HSA-9604264 Reaction Name: ADAM10 cleaves NOTCH4 See in Reactome
MONDO:0014827	CAPN1	P07384	3.4.22.52	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-6809371 R-HSA-6809371 Reactome Name: Formation of the cornified envelope See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-6805567 R-HSA-6805567 Reactome Name: Keratinization See in Reactome	Extracellular matrix organization Immune System Developmental Biology	R-HSA-2534260 ( R-HSA-1474228 ) R-HSA-2534260 Reaction Name: E-cadherin degradation by caspase-3 and calpain-1 See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8848658 ( R-HSA-1474228 ) R-HSA-8848658 Reaction Name: CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins See in Reactome R-HSA-8934819 ( R-HSA-6809371 ) R-HSA-8934819 Reaction Name: Cytoplasmic proteases cleave Profilaggrin producing Filaggrin See in Reactome
MONDO:0015177	MMP13	P45452	3.4.24.-	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-8941332 R-HSA-8941332 Reactome Name: RUNX2 regulates genes involved in cell migration See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Extracellular matrix organization	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1474197 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474197 Reaction Name: Collagen type II degradation by MMP1,3,8,13,PRSS2 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564117 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564117 Reaction Name: Collagen type XIV degradation by MMP9,13 See in Reactome R-HSA-1564184 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564184 Reaction Name: Collagen type IX degradation by MMP3,13 See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602488 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604732 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604732 Reaction Name: Autocatalytic activation of proMMP13 See in Reactome R-HSA-1604741 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604741 Reaction Name: Initial activation of proMMP13 by MMP14 (MT1-MMP) See in Reactome R-HSA-1604752 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604752 Reaction Name: Initial activation of proMMP13 by MMP3 See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2484882 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2484882 Reaction Name: Collagen type X degradation by MMP3, 13 See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534160 ( R-HSA-1474228 ) R-HSA-2534160 Reaction Name: HSPG2 (perlecan) degradation by MMP13, CTSS See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-8940007 ( R-HSA-8941332 ) R-HSA-8940007 Reaction Name: MMP13 gene expression is stimulated by RUNX2:CBFB See in Reactome R-HSA-8942302 ( R-HSA-1474228 ) R-HSA-8942302 Reaction Name: MMP13 cleaves OPTC See in Reactome
MONDO:0017791	BMP1	P13497	3.4.24.19	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-8963896 R-HSA-8963896 Reactome Name: HDL assembly See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8963898 R-HSA-8963898 Reactome Name: Plasma lipoprotein assembly See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome	Transport of small molecules Extracellular matrix organization	R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-2002428 ( R-HSA-1650814 ) R-HSA-2002428 Reaction Name: Removal of fibrillar collagen N-propeptides See in Reactome R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2022090; R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2022090; R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0018298	MMP2	P08253	3.4.24.24	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Metabolism of proteins Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1454822 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454822 Reaction Name: Collagen type I degradation by MMP1,2,8,13, PRSS2 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564143 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564143 Reaction Name: Collagen type X degradation by MMP1,2 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1592278 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592278 Reaction Name: Autocatalytic activation of proMMP2 See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604359 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604359 Reaction Name: Initial activation of proMMP2 by MMP1, 7 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-381435 ( R-HSA-381426 ) R-HSA-381435 Reaction Name: Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-8940554 ( R-HSA-1474228 ) R-HSA-8940554 Reaction Name: MMP2 cleaves OPTC See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome
MONDO:0018298	MMP14	P50281	3.4.24.80	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-1458433 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1458433 Reaction Name: Collagen type I degradation by MMP14 See in Reactome R-HSA-1474196 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474196 Reaction Name: Collagen type II degradation by MMP14 See in Reactome R-HSA-1474210 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474210 Reaction Name: Collagen type III degradation by MMP14 See in Reactome R-HSA-1592349 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592349 Reaction Name: MMP14 (MT1-MMP) binds TIMP2 See in Reactome R-HSA-1602466 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602466 Reaction Name: Activation of MT-MMPs by FURIN See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604741 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604741 Reaction Name: Initial activation of proMMP13 by MMP14 (MT1-MMP) See in Reactome R-HSA-1605825 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1605825 Reaction Name: MT-MMPs are sorted to the plasma membrane See in Reactome R-HSA-2514790 ( R-HSA-1474228 ) R-HSA-2514790 Reaction Name: Elastin degradation by MMP14 See in Reactome R-HSA-2514831 ( R-HSA-1474228 ) R-HSA-2514831 Reaction Name: Fibrillin-1 degradation by MMP14 See in Reactome R-HSA-2533874 ( R-HSA-1474228 ) R-HSA-2533874 Reaction Name: Laminin-511 degradation by MMP14 See in Reactome R-HSA-2533950 ( R-HSA-1474228 ) R-HSA-2533950 Reaction Name: Fibronectin degradation by MMP14, TMPRSS6 See in Reactome R-HSA-2533965 ( R-HSA-1474228 ) R-HSA-2533965 Reaction Name: NID1 degradation by MMP14, MMP15 See in Reactome R-HSA-2534240 ( R-HSA-1474228 ) R-HSA-2534240 Reaction Name: HSPG2 (perlecan) degradation by MMP14, MMP15 See in Reactome R-HSA-3791155 ( R-HSA-1474228 ) R-HSA-3791155 Reaction Name: Laminin-322 degradation by MMP14 See in Reactome R-HSA-3828025 ( R-HSA-1474228 ) R-HSA-3828025 Reaction Name: DCN (decorin) degradation by MMP14 See in Reactome
MONDO:0018832	HTRA1	Q92743	3.4.21.-	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-8855825 ( R-HSA-1474228 ) R-HSA-8855825 Reaction Name: HTRA1 hydrolyzes ACAN (Aggrecan) See in Reactome
MONDO:0019623	PLG	P00747	3.4.21.7	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-75205 R-HSA-75205 Reactome Name: Dissolution of Fibrin Clot See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome	R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Extracellular matrix organization Hemostasis Signal Transduction	R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-158721 ( R-HSA-75205 ) R-HSA-158721 Reaction Name: histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen See in Reactome R-HSA-158722 ( R-HSA-75205 ) R-HSA-158722 Reaction Name: histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen See in Reactome R-HSA-158744 ( R-HSA-75205 ) R-HSA-158744 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin See in Reactome R-HSA-158747 ( R-HSA-75205 ) R-HSA-158747 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) See in Reactome R-HSA-158750 ( R-HSA-75205 ) R-HSA-158750 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin See in Reactome R-HSA-158756 ( R-HSA-75205 ) R-HSA-158756 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen See in Reactome R-HSA-158766 ( R-HSA-75205 ) R-HSA-158766 Reaction Name: fibrin multimer, crosslinked -> fibrin digestion products (plasmin) See in Reactome R-HSA-158784 ( R-HSA-75205 ) R-HSA-158784 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen See in Reactome R-HSA-158893 ( R-HSA-75205 ) R-HSA-158893 Reaction Name: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin See in Reactome R-HSA-158925 ( R-HSA-75205 ) R-HSA-158925 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) See in Reactome R-HSA-158941 ( R-HSA-75205 ) R-HSA-158941 Reaction Name: plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein See in Reactome R-HSA-158942 ( R-HSA-75205 ) R-HSA-158942 Reaction Name: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR See in Reactome R-HSA-158982 ( R-HSA-75205 ) R-HSA-158982 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1602458 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602458 Reaction Name: Activation of proMMP10 See in Reactome R-HSA-1602488 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-381461 ( R-HSA-381426 ) R-HSA-381461 Reaction Name: Plasmin proteolyzes IGF:IGFBP-3:ALS See in Reactome R-HSA-382061 ( R-HSA-186797 ) R-HSA-382061 Reaction Name: Extracellular processing of novel PDGFs See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome
MONDO:0020434	TLL1	O43897	3.4.24.-	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0020437	TLL1	O43897	3.4.24.-	R-HSA-1650814 R-HSA-1650814 Reactome Name: Collagen biosynthesis and modifying enzymes See in Reactome R-HSA-2214320 R-HSA-2214320 Reactome Name: Anchoring fibril formation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-2243919 R-HSA-2243919 Reactome Name: Crosslinking of collagen fibrils See in Reactome	R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome	Extracellular matrix organization	R-HSA-2002440 ( R-HSA-1650814 ) R-HSA-2002440 Reaction Name: Removal of fibrillar collagen C-propeptides See in Reactome R-HSA-2022141 ( R-HSA-2243919 ) R-HSA-2022141 Reaction Name: Prolysyl oxidase activation See in Reactome R-HSA-2214330 ( R-HSA-2214320 ) R-HSA-2214330 Reaction Name: Cleavage of collagen VII NC2 region by BMP1 See in Reactome R-HSA-3814820 ( R-HSA-1474228 ) R-HSA-3814820 Reaction Name: HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1 See in Reactome
MONDO:0029133	CAPN3	P20807	3.4.22.54	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-8848658 ( R-HSA-1474228 ) R-HSA-8848658 Reaction Name: CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins See in Reactome
MONDO:0042490	ELANE	P08246	3.4.21.37	R-HSA-5620971 R-HSA-5620971 Reactome Name: Pyroptosis See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6803157 R-HSA-6803157 Reactome Name: Antimicrobial peptides See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System Programmed Cell Death Extracellular matrix organization	R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-2482180 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2482180 Reaction Name: Collagen type VIII degradation by ELANE See in Reactome R-HSA-2514823 ( R-HSA-1474228 ) R-HSA-2514823 Reaction Name: Fibrillin-1 degradation by ELANE See in Reactome R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6813659 ( R-HSA-6803157 ) R-HSA-6813659 Reaction Name: ELANE, CTSG or PRTN3 binds bacteria See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9710106 ( R-HSA-5620971 ) R-HSA-9710106 Reaction Name: ELANE cleaves GSDMD See in Reactome
MONDO:0044339	MMP9	P14780	3.4.24.35	R-HSA-3928665 R-HSA-3928665 Reactome Name: EPH-ephrin mediated repulsion of cells See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Immune System Extracellular matrix organization Signal Transduction Developmental Biology	R-HSA-1433374 ( R-HSA-1433557 ) R-HSA-1433374 Reaction Name: Processing of SCF isoform 1 See in Reactome R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454791 ( R-HSA-1474228 ) R-HSA-1454791 Reaction Name: MMP2, MMP7, MMP9 bind CD44 See in Reactome R-HSA-1474213 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474213 Reaction Name: Collagen type III degradation by MMP1,8,9,13 See in Reactome R-HSA-1564112 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564112 Reaction Name: Collagen type VI degradation by MMP2,9,11 See in Reactome R-HSA-1564117 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564117 Reaction Name: Collagen type XIV degradation by MMP9,13 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564164 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564164 Reaction Name: Collagen type V degradation by MMP2,9,10 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1602454 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602454 Reaction Name: proMMP9 binds TIMP1 See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604722 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604722 Reaction Name: Activation of proMMP9 by proteases See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2168982 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168982 Reaction Name: Collagen type XVI degradation by MMP9 See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2485148 ( R-HSA-1474228 ) R-HSA-2485148 Reaction Name: Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-3827958 ( R-HSA-1474228 ) R-HSA-3827958 Reaction Name: E-cadherin degradation by MMP9, KLK7 See in Reactome R-HSA-3928657 ( R-HSA-3928665 ) R-HSA-3928657 Reaction Name: MMP2,9 cleave EPHB See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-8943959 ( R-HSA-1474228 ) R-HSA-8943959 Reaction Name: MMP2, MMP9 cleave SCUBE3 See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome

Number of enzymes:	24
Number of disease:	46
Number of reactomes:	39
Number of reactions:	155

Search summary (Reactome ID: R-HSA-1474228)

Search results (Reactome ID: R-HSA-1474228)

MONDO:0005387

R-HSA-1474228

R-HSA-5173214

R-HSA-597592

R-HSA-1474244

R-HSA-392499

R-HSA-5173105

R-HSA-1592310

R-HSA-5173005

R-HSA-5173192

MONDO:0006928

R-HSA-1474228

R-HSA-1474244

R-HSA-8848658

MONDO:0007088

R-HSA-9013507

R-HSA-193692

R-HSA-3928665

R-HSA-1474228

R-HSA-205043

R-HSA-9013700

R-HSA-6798695

R-HSA-2122948

R-HSA-9017802

R-HSA-1251985

R-HSA-2979096

R-HSA-204998

R-HSA-1980143

R-HSA-9012852

R-HSA-1980145

R-HSA-168249

R-HSA-168256

R-HSA-9675108

R-HSA-9013694

R-HSA-157118

R-HSA-1474244

R-HSA-9006934

R-HSA-162582

R-HSA-193704

R-HSA-73887

R-HSA-1236394

R-HSA-422475

R-HSA-2682334

R-HSA-1266738

R-HSA-1251997

R-HSA-157353

R-HSA-157640

R-HSA-193682

R-HSA-1980109

R-HSA-1980112

R-HSA-205112

R-HSA-2534206

R-HSA-2974731

R-HSA-3928656

R-HSA-6798739

R-HSA-9013361

R-HSA-9017817

R-HSA-9604294

MONDO:0008090

R-HSA-5620971

R-HSA-977606

R-HSA-1474228

R-HSA-1442490

R-HSA-1592389

R-HSA-6803157

R-HSA-6798695

R-HSA-168249

R-HSA-168256

R-HSA-5218859

R-HSA-5357801

R-HSA-1474244

R-HSA-166658

R-HSA-1566962

R-HSA-1592270

R-HSA-1592316

R-HSA-1592398

R-HSA-1604712

R-HSA-2482180