R-HSA-376172
R-HSA-445144
R-HSA-418885
R-HSA-418885
Reactome Name: DCC mediated attractive signaling
See in Reactome
R-HSA-9619229
R-HSA-9619229
Reactome Name: Activation of RAC1 downstream of NMDARs
See in Reactome
R-HSA-428540
R-HSA-428543
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-399954
R-HSA-399954
Reactome Name: Sema3A PAK dependent Axon repulsion
See in Reactome
R-HSA-9032845
R-HSA-9032845
Reactome Name: Activated NTRK2 signals through CDK5
See in Reactome
R-HSA-8849471
R-HSA-8849471
Reactome Name: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
See in Reactome
R-HSA-5663213
R-HSA-5663213
Reactome Name: RHO GTPases Activate WASPs and WAVEs
See in Reactome
R-HSA-6798695
R-HSA-983231
R-HSA-983231
Reactome Name: Factors involved in megakaryocyte development and platelet production
See in Reactome
R-HSA-193648
R-HSA-193648
Reactome Name: NRAGE signals death through JNK
See in Reactome
R-HSA-5625900
R-HSA-5625740
R-HSA-9032759
R-HSA-1257604
R-HSA-2871796
R-HSA-2871796
Reactome Name: FCERI mediated MAPK activation
See in Reactome
R-HSA-389359
R-HSA-5627123
R-HSA-399955
R-HSA-399955
Reactome Name: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
See in Reactome
R-HSA-5626467
R-HSA-4420097
R-HSA-5663220
R-HSA-2029482
R-HSA-2029482
Reactome Name: Regulation of actin dynamics for phagocytic cup formation
See in Reactome
R-HSA-5687128
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1433557
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-2424491
R-HSA-9013149
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-8875555
R-HSA-3928665
R-HSA-3928665
Reactome Name: EPH-ephrin mediated repulsion of cells
See in Reactome
R-HSA-3928664
R-HSA-416550
R-HSA-416550
Reactome Name: Sema4D mediated inhibition of cell attachment and migration
See in Reactome
R-HSA-4086400
R-HSA-3928662
R-HSA-3928662
Reactome Name: EPHB-mediated forward signaling
See in Reactome
R-HSA-5625970
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
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R-HSA-376176
R-HSA-9012999
R-HSA-168256
R-HSA-194315
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-193704
R-HSA-193704
Reactome Name: p75 NTR receptor-mediated signalling
See in Reactome
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-8848021
R-HSA-1280218
R-HSA-1266738
R-HSA-400685
R-HSA-166520
R-HSA-194138
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9675108
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-112316
R-HSA-8875878
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-373760
R-HSA-9032500
R-HSA-9032500
Reactome Name: Activated NTRK2 signals through FYN
See in Reactome
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-3858494
R-HSA-3858494
Reactome Name: Beta-catenin independent WNT signaling
See in Reactome
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-168249
R-HSA-195258
R-HSA-199991
R-HSA-73887
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006115
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-2682334
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-5653656
R-HSA-6806834
R-HSA-195721
R-HSA-2172127
R-HSA-204998
R-HSA-204998
Reactome Name: Cell death signalling via NRAGE, NRIF and NADE
See in Reactome
R-HSA-373755
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-109582
R-HSA-162582
R-HSA-373752
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R-HSA-1011598
(
R-HSA-983231
)
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1433415
(
R-HSA-1433557
)
R-HSA-2029451
(
R-HSA-2029482
)
R-HSA-2029454
(
R-HSA-2029482
)
R-HSA-2029456
(
R-HSA-2029482;
R-HSA-5627123
)
R-HSA-2029465
(
R-HSA-2029482;
R-HSA-4420097;
R-HSA-5663213
)
R-HSA-2029465
Reaction Name: RAC1:GTP and PIP3 bind WAVE Regulatory Complex (WRC)
See in Reactome
R-HSA-2029466
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029466
Reaction Name: (WASPs, WAVE):G-actin:ARP2/3 binds F-actin
See in Reactome
R-HSA-2029467
(
R-HSA-2029482
)
R-HSA-2029467
Reaction Name: Activation of RAC1 by CRKII:DOCK180:ELMO
See in Reactome
R-HSA-2029469
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2029469
Reaction Name: p-ERK phosphorylates WAVEs and ABI
See in Reactome
R-HSA-205039
(
R-HSA-193648
)
R-HSA-205039
Reaction Name: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
See in Reactome
R-HSA-205136
(
R-HSA-193648
)
R-HSA-205136
Reaction Name: GTP-bound RAC contributes to JNK activation
See in Reactome
R-HSA-2130194
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2197690
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-2316352
(
R-HSA-1445148
)
R-HSA-2316352
Reaction Name: SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424476
(
R-HSA-2424491
)
R-HSA-2730840
(
R-HSA-2871796
)
R-HSA-2730856
(
R-HSA-2871796
)
R-HSA-2730889
(
R-HSA-2871796
)
R-HSA-2730889
Reaction Name: Recruitment of PAK to the membrane by binding active RAC1
See in Reactome
R-HSA-376123
(
R-HSA-376172
)
R-HSA-376123
Reaction Name: DSCAM associates with Rac1-GTP:pPAK1
See in Reactome
R-HSA-3858475
(
R-HSA-4086400
)
R-HSA-389348
(
R-HSA-389359
)
R-HSA-389788
(
R-HSA-389359;
R-HSA-5687128
)
R-HSA-389788
Reaction Name: Activation of PAKs by RAC1 and CDC42
See in Reactome
R-HSA-3928612
(
R-HSA-3928662
)
R-HSA-3928612
Reaction Name: KALRN exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928619
(
R-HSA-3928662
)
R-HSA-3928620
(
R-HSA-3928662
)
R-HSA-3928625
(
R-HSA-3928664
)
R-HSA-3928628
(
R-HSA-3928665
)
R-HSA-3928628
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-3928633
(
R-HSA-3928664
)
R-HSA-3928633
Reaction Name: bPIX exchanges GTP for GDP on RAC, activating it
See in Reactome
R-HSA-3928640
(
R-HSA-3928664
)
R-HSA-3928641
(
R-HSA-3928664
)
R-HSA-3928642
(
R-HSA-3928665
)
R-HSA-3928642
Reaction Name: TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-399928
(
R-HSA-399955
)
R-HSA-399928
Reaction Name: Recruitment of Rnd1 to Plexin A
See in Reactome
R-HSA-399930
(
R-HSA-399954
)
R-HSA-399935
(
R-HSA-399955
)
R-HSA-399935
Reaction Name: Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
See in Reactome
R-HSA-399938
(
R-HSA-399955
)
R-HSA-399939
(
R-HSA-399954
)
R-HSA-399941
(
R-HSA-399955
)
R-HSA-399952
(
R-HSA-399954
)
R-HSA-399952
Reaction Name: Phosphorylation of LIMK-1 by PAK
See in Reactome
R-HSA-400682
(
R-HSA-416550
)
R-HSA-400682
Reaction Name: Active Rac1 interacts with Plexin-B1:Sema4D
See in Reactome
R-HSA-4093336
(
R-HSA-3928662
)
R-HSA-4093336
Reaction Name: p-TIAM1 exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-418856
(
R-HSA-418885
)
R-HSA-418865
(
R-HSA-418885
)
R-HSA-418865
Reaction Name: Recruitment of ABLIM to the plasma membrane
See in Reactome
R-HSA-428522
(
R-HSA-428543
)
R-HSA-428535
(
R-HSA-428540
)
R-HSA-442273
(
R-HSA-114604
)
R-HSA-442273
Reaction Name: VAV1 is a GEF for Rho/Rac family GTPases
See in Reactome
R-HSA-442291
(
R-HSA-114604
)
R-HSA-442291
Reaction Name: VAV2 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442314
(
R-HSA-114604
)
R-HSA-442314
Reaction Name: VAV3 is a GEF for Rho/Rac family kinases
See in Reactome
R-HSA-442592
(
R-HSA-2029482;
R-HSA-5663213
)
R-HSA-442592
Reaction Name: WASPs or WAVEs activate the ARP2/3 complex
See in Reactome
R-HSA-445064
(
R-HSA-445144
)
R-HSA-445072
(
R-HSA-445144
)
R-HSA-445072
Reaction Name: Interaction of PAK1 with Rac1-GTP
See in Reactome
R-HSA-451347
(
R-HSA-376172
)
R-HSA-451366
(
R-HSA-376172
)
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218839
(
R-HSA-4420097
)
R-HSA-5218839
Reaction Name: DOCK180:ELMO exchanges GTP for GDP, activating RAC1
See in Reactome
R-HSA-5218841
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R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5218850
(
R-HSA-4420097
)
R-HSA-5218850
Reaction Name: VAV exchanges GTP for GDP on RAC1, activating it
See in Reactome
R-HSA-5357445
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357472
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5357483
(
R-HSA-4420097;
R-HSA-5218920
)
R-HSA-5623622
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R-HSA-5625740
)
R-HSA-5623622
Reaction Name: RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
See in Reactome
R-HSA-5623632
(
R-HSA-5625740
)
R-HSA-5623632
Reaction Name: RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
See in Reactome
R-HSA-5623667
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R-HSA-5625740
)
R-HSA-5625901
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R-HSA-5625900
)
R-HSA-5625901
Reaction Name: CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-5625959
(
R-HSA-5625970
)
R-HSA-5625959
Reaction Name: Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
See in Reactome
R-HSA-5626469
(
R-HSA-5626467
)
R-HSA-5626469
Reaction Name: GTP-bound RAC1 and CDC42 bind IQGAPs
See in Reactome
R-HSA-5626507
(
R-HSA-5626467
)
R-HSA-5626507
Reaction Name: IQGAPs bind F-actin, which is inhibited by calmodulin
See in Reactome
R-HSA-5626549
(
R-HSA-5626467
)
R-HSA-5627775
(
R-HSA-5627123;
R-HSA-5687128
)
R-HSA-5627775
Reaction Name: Autophosphorylation of PAK1,2,3
See in Reactome
R-HSA-5663232
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R-HSA-5663220
)
R-HSA-5665659
(
R-HSA-5663220
)
R-HSA-5665659
Reaction Name: RAC1:GTP:FMNL1 binds profilin:G-actin
See in Reactome
R-HSA-5665802
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R-HSA-5663220
)
R-HSA-5665802
Reaction Name: SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin
See in Reactome
R-HSA-5665809
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R-HSA-5663220
)
R-HSA-5665809
Reaction Name: SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments
See in Reactome
R-HSA-5668714
(
R-HSA-5668599
)
R-HSA-5668718
(
R-HSA-5668599
)
R-HSA-5668718
Reaction Name: NOX1 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668731
(
R-HSA-5668599
)
R-HSA-5668731
Reaction Name: NOX3 complex:RAC1:GTP generates superoxide from oxygen
See in Reactome
R-HSA-5668735
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R-HSA-5668599
)
R-HSA-5671919
(
R-HSA-5625900
)
R-HSA-5671919
Reaction Name: Activated CIT phosphorylates MRLCs
See in Reactome
R-HSA-5671970
(
R-HSA-5625900
)
R-HSA-5671970
Reaction Name: Activated CIT binds KIF14 and PRC1
See in Reactome
R-HSA-5671993
(
R-HSA-5625900
)
R-HSA-5672083
(
R-HSA-5625970
)
R-HSA-5672304
(
R-HSA-5626467
)
R-HSA-5672304
Reaction Name: IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
See in Reactome
R-HSA-5672329
(
R-HSA-5626467
)
R-HSA-5672329
Reaction Name: IQGAP1 binds CLIP1 and microtubules
See in Reactome
R-HSA-6798743
(
R-HSA-6798695
)
R-HSA-6798743
Reaction Name: Exocytosis of secretory granule membrane proteins
See in Reactome
R-HSA-6800426
(
R-HSA-6798695
)
R-HSA-6800426
Reaction Name: Exocytosis of ficolin-rich granule membrane proteins
See in Reactome
R-HSA-8848618
(
R-HSA-8849471
)
R-HSA-8848618
Reaction Name: Activation of RAC1 by the PXN:CRK complex
See in Reactome
R-HSA-8875591
(
R-HSA-8875555
)
R-HSA-8951586
(
R-HSA-4420097
)
R-HSA-8951586
Reaction Name: p-VAV family:PIP3 binds RAC1:GDP
See in Reactome
R-HSA-8981443
(
R-HSA-5625900
)
R-HSA-8981443
Reaction Name: CIT-3 binds activated RHOA, RHOB, RHOC and RAC1
See in Reactome
R-HSA-8981926
(
R-HSA-5627123
)
R-HSA-8981931
(
R-HSA-5627123
)
R-HSA-9013143
(
R-HSA-9013149
)
R-HSA-9013144
(
R-HSA-9013149
)
R-HSA-9013144
Reaction Name: RAC1 GAPs stimulate RAC1 GTPase activity
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9013147
(
R-HSA-9013149
)
R-HSA-9013147
Reaction Name: RAC1 GDIs block activation of RAC1
See in Reactome
R-HSA-9032798
(
R-HSA-9032759
)
R-HSA-9033292
(
R-HSA-9032845
)
R-HSA-9033292
Reaction Name: NTRK2 and CDK5 promote activation of RAC1 by TIAM1
See in Reactome
R-HSA-9619803
(
R-HSA-9619229
)
R-HSA-9691168
(
R-HSA-9013149
)
R-HSA-9691168
Reaction Name: RAC1 translocates to the endoplasmic reticulum membrane
See in Reactome
R-HSA-9691174
(
R-HSA-9013149
)
R-HSA-9691174
Reaction Name: RAC1 binds effectors at the ER membrane
See in Reactome
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