DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-1369062)

Number of enzymes:	9
Number of disease:	17
Number of reactomes:	9
Number of reactions:	19

Search results (Reactome ID: R-HSA-1369062)

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DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0001071	ABCD1	P33897	3.1.2.- 7.6.2.-	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-9603798 R-HSA-9603798 Reactome Name: Class I peroxisomal membrane protein import See in Reactome R-HSA-2046105 R-HSA-2046105 Reactome Name: Linoleic acid (LA) metabolism See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Protein localization Transport of small molecules Metabolism	R-HSA-2046087 ( R-HSA-2046106 ) R-HSA-2046087 Reaction Name: Translocation of tetracosahexaenoyl-CoA to peroxisomes See in Reactome R-HSA-2046093 ( R-HSA-2046105 ) R-HSA-2046093 Reaction Name: Translocation of tetracosapentaenoyl-CoA to peroxisomes See in Reactome R-HSA-382575 ( R-HSA-1369062 ) R-HSA-382575 Reaction Name: ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix See in Reactome R-HSA-382613 ( R-HSA-1369062 ) R-HSA-382613 Reaction Name: PEX-19 docks ABCD1/D2/D3 to peroximal membrane See in Reactome R-HSA-390393 ( R-HSA-390247 ) R-HSA-390393 Reaction Name: Peroxisomal uptake of very long-chain fatty acyl CoA See in Reactome R-HSA-9603775 ( R-HSA-9603798 ) R-HSA-9603775 Reaction Name: PEX3:PEX19:class I PMP dissociates See in Reactome R-HSA-9603784 ( R-HSA-9603798 ) R-HSA-9603784 Reaction Name: PEX19:class I PMP binds PEX3 See in Reactome R-HSA-9603804 ( R-HSA-9603798 ) R-HSA-9603804 Reaction Name: PEX19 binds class I peroxisomal membrane proteins See in Reactome
MONDO:0007610	ABCA5	Q8WWZ7	7.6.2.-	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome	R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-8848053 ( R-HSA-1369062 ) R-HSA-8848053 Reaction Name: ABCA5 transports CHOL from lysosomal lumen to cytosol See in Reactome
MONDO:0009410	ABCD1	P33897	3.1.2.- 7.6.2.-	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-9603798 R-HSA-9603798 Reactome Name: Class I peroxisomal membrane protein import See in Reactome R-HSA-2046105 R-HSA-2046105 Reactome Name: Linoleic acid (LA) metabolism See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Protein localization Transport of small molecules Metabolism	R-HSA-2046087 ( R-HSA-2046106 ) R-HSA-2046087 Reaction Name: Translocation of tetracosahexaenoyl-CoA to peroxisomes See in Reactome R-HSA-2046093 ( R-HSA-2046105 ) R-HSA-2046093 Reaction Name: Translocation of tetracosapentaenoyl-CoA to peroxisomes See in Reactome R-HSA-382575 ( R-HSA-1369062 ) R-HSA-382575 Reaction Name: ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix See in Reactome R-HSA-382613 ( R-HSA-1369062 ) R-HSA-382613 Reaction Name: PEX-19 docks ABCD1/D2/D3 to peroximal membrane See in Reactome R-HSA-390393 ( R-HSA-390247 ) R-HSA-390393 Reaction Name: Peroxisomal uptake of very long-chain fatty acyl CoA See in Reactome R-HSA-9603775 ( R-HSA-9603798 ) R-HSA-9603775 Reaction Name: PEX3:PEX19:class I PMP dissociates See in Reactome R-HSA-9603784 ( R-HSA-9603798 ) R-HSA-9603784 Reaction Name: PEX19:class I PMP binds PEX3 See in Reactome R-HSA-9603804 ( R-HSA-9603798 ) R-HSA-9603804 Reaction Name: PEX19 binds class I peroxisomal membrane proteins See in Reactome
MONDO:0009443	ABCA12	Q86UK0	7.6.2.1	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome	R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-5682285 ( R-HSA-1369062 ) R-HSA-5682285 Reaction Name: ABCA12 transports lipids from cytosol to extracellular region See in Reactome
MONDO:0010247	ABCD1	P33897	3.1.2.- 7.6.2.-	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-390247 R-HSA-390247 Reactome Name: Beta-oxidation of very long chain fatty acids See in Reactome R-HSA-2046106 R-HSA-2046106 Reactome Name: alpha-linolenic acid (ALA) metabolism See in Reactome R-HSA-9603798 R-HSA-9603798 Reactome Name: Class I peroxisomal membrane protein import See in Reactome R-HSA-2046105 R-HSA-2046105 Reactome Name: Linoleic acid (LA) metabolism See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-390918 R-HSA-390918 Reactome Name: Peroxisomal lipid metabolism See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-2046104 R-HSA-2046104 Reactome Name: alpha-linolenic (omega3) and linoleic (omega6) acid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-8978868 R-HSA-8978868 Reactome Name: Fatty acid metabolism See in Reactome	Protein localization Transport of small molecules Metabolism	R-HSA-2046087 ( R-HSA-2046106 ) R-HSA-2046087 Reaction Name: Translocation of tetracosahexaenoyl-CoA to peroxisomes See in Reactome R-HSA-2046093 ( R-HSA-2046105 ) R-HSA-2046093 Reaction Name: Translocation of tetracosapentaenoyl-CoA to peroxisomes See in Reactome R-HSA-382575 ( R-HSA-1369062 ) R-HSA-382575 Reaction Name: ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix See in Reactome R-HSA-382613 ( R-HSA-1369062 ) R-HSA-382613 Reaction Name: PEX-19 docks ABCD1/D2/D3 to peroximal membrane See in Reactome R-HSA-390393 ( R-HSA-390247 ) R-HSA-390393 Reaction Name: Peroxisomal uptake of very long-chain fatty acyl CoA See in Reactome R-HSA-9603775 ( R-HSA-9603798 ) R-HSA-9603775 Reaction Name: PEX3:PEX19:class I PMP dissociates See in Reactome R-HSA-9603784 ( R-HSA-9603798 ) R-HSA-9603784 Reaction Name: PEX19:class I PMP binds PEX3 See in Reactome R-HSA-9603804 ( R-HSA-9603798 ) R-HSA-9603804 Reaction Name: PEX19 binds class I peroxisomal membrane proteins See in Reactome
MONDO:0012153	ABCA7	Q8IZY2	7.6.2.1	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome	R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Transport of small molecules	R-HSA-382553 ( R-HSA-1369062 ) R-HSA-382553 Reaction Name: ABCA7:Apo1A-mediated phospholipid efflux See in Reactome
MONDO:0012582	ABCA3	Q99758	7.6.2.2 7.6.2.1	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-5683826 R-HSA-5683826 Reactome Name: Surfactant metabolism See in Reactome	R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Metabolism of proteins Transport of small molecules	R-HSA-5683714 ( R-HSA-1369062; R-HSA-5683826 ) R-HSA-5683714 Reaction Name: ABCA3 transports PC, PG from ER membrane to lamellar body See in Reactome
MONDO:0012672	ABCG8	Q9H221	7.6.2.-	R-HSA-9029569 R-HSA-9029569 Reactome Name: NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux See in Reactome R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome	R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9024446 R-HSA-9024446 Reactome Name: NR1H2 and NR1H3-mediated signaling See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome	Signal Transduction Transport of small molecules	R-HSA-265783 ( R-HSA-1369062 ) R-HSA-265783 Reaction Name: ABCG5:ABCG8 transports sterols from cytosol to extracellular region See in Reactome R-HSA-9029591 ( R-HSA-9029569 ) R-HSA-9029591 Reaction Name: Expression of ABCG8 regulated by NR1H2 or NR1H3 See in Reactome
MONDO:0014564	ABCD3	P28288	3.1.2.- 7.6.2.-	R-HSA-9603798 R-HSA-9603798 Reactome Name: Class I peroxisomal membrane protein import See in Reactome R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome	R-HSA-9609507 R-HSA-9609507 Reactome Name: Protein localization See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Protein localization Transport of small molecules Signal Transduction	R-HSA-382575 ( R-HSA-1369062 ) R-HSA-382575 Reaction Name: ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix See in Reactome R-HSA-382613 ( R-HSA-1369062 ) R-HSA-382613 Reaction Name: PEX-19 docks ABCD1/D2/D3 to peroximal membrane See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9603775 ( R-HSA-9603798 ) R-HSA-9603775 Reaction Name: PEX3:PEX19:class I PMP dissociates See in Reactome R-HSA-9603784 ( R-HSA-9603798 ) R-HSA-9603784 Reaction Name: PEX19:class I PMP binds PEX3 See in Reactome R-HSA-9603804 ( R-HSA-9603798 ) R-HSA-9603804 Reaction Name: PEX19 binds class I peroxisomal membrane proteins See in Reactome
MONDO:0015052	ABCA3	Q99758	7.6.2.2 7.6.2.1	R-HSA-1369062 R-HSA-1369062 Reactome Name: ABC transporters in lipid homeostasis See in Reactome R-HSA-5683826 R-HSA-5683826 Reactome Name: Surfactant metabolism See in Reactome	R-HSA-382556 R-HSA-382556 Reactome Name: ABC-family proteins mediated transport See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome	Metabolism of proteins Transport of small molecules	R-HSA-5683714 ( R-HSA-1369062; R-HSA-5683826 ) R-HSA-5683714 Reaction Name: ABCA3 transports PC, PG from ER membrane to lamellar body See in Reactome

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