MONDO:0000087 |
MONDO:0000087
Disease Name: polymicrogyria
Orphanet id: Orphanet:35981
All associated enzymes in DAR:
AKT3
. The disease is also associated to other non-enzyme proteins (not in DAR).
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0001056 |
ERBB2 |
P04626 |
2.7.10.1
|
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-1251932
R-HSA-1251932
Reactome Name: PLCG1 events in ERBB2 signaling
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1306955
R-HSA-1306955
Reactome Name: GRB7 events in ERBB2 signaling
See in Reactome
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-9652282
R-HSA-9652282
Reactome Name: Drug-mediated inhibition of ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-1227986
R-HSA-6785631
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-9675108
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-373755
R-HSA-422475
R-HSA-73857
R-HSA-5684996
R-HSA-400685
R-HSA-1266738
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
|
Gene expression (Transcription)
Signal Transduction
Developmental Biology
|
R-HSA-1250189
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250488
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250488
Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1251922
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1251922
Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2
See in Reactome
R-HSA-1251944
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1306953
(
R-HSA-1227986;
R-HSA-1306955
)
R-HSA-1306953
Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306963
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306963
Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306969
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306969
Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1358792
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
Reaction Name: RNF41 ubiquitinates activated ERBB3
See in Reactome
R-HSA-1358798
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358798
Reaction Name: RNF41 binds neuregulin-activated ERBB3
See in Reactome
R-HSA-1918092
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918092
Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1918095
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918095
Reaction Name: CUL5 mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-373750
(
R-HSA-416572
)
R-HSA-373750
Reaction Name: SEMA4D interacts with Plexin-B1:ErbB2
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-416594
(
R-HSA-416572
)
R-HSA-416594
Reaction Name: LARG and PDZ-RhoGEF binds to Plexin-B1
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864105
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864105
Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers
See in Reactome
R-HSA-8864125
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864125
Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
See in Reactome
R-HSA-8864466
(
R-HSA-8866910
)
R-HSA-8864466
Reaction Name: TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression
See in Reactome
R-HSA-9652264
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9652277
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9665726
(
R-HSA-1227986;
R-HSA-9652282
)
|
MONDO:0002407 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005148 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-165158
)
R-HSA-109702
(
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005233 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-165158
)
R-HSA-109702
(
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005335 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-165158
)
R-HSA-109702
(
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0007573 |
ERBB3 |
P21860 |
2.7.10.1
|
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1306955
R-HSA-1306955
Reactome Name: GRB7 events in ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-6785631
R-HSA-1227986
R-HSA-1236394
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-5684996
R-HSA-162582
|
Signal Transduction
|
R-HSA-1247497
(
R-HSA-1227986
)
R-HSA-1250189
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1306953
(
R-HSA-1227986;
R-HSA-1306955
)
R-HSA-1306953
Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1358790
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
Reaction Name: RNF41 ubiquitinates activated ERBB3
See in Reactome
R-HSA-1358798
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358798
Reaction Name: RNF41 binds neuregulin-activated ERBB3
See in Reactome
R-HSA-1358801
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358801
Reaction Name: ERBB3 binds RNF41 ubiquitin ligase
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1977958
(
R-HSA-1236394
)
R-HSA-1977958
Reaction Name: ERBB4 forms heterodimers with ERBB3
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
|
MONDO:0008170 |
ERBB2 |
P04626 |
2.7.10.1
|
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-1251932
R-HSA-1251932
Reactome Name: PLCG1 events in ERBB2 signaling
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1306955
R-HSA-1306955
Reactome Name: GRB7 events in ERBB2 signaling
See in Reactome
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-9652282
R-HSA-9652282
Reactome Name: Drug-mediated inhibition of ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-1227986
R-HSA-6785631
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-9675108
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-373755
R-HSA-422475
R-HSA-73857
R-HSA-5684996
R-HSA-400685
R-HSA-1266738
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
|
Gene expression (Transcription)
Signal Transduction
Developmental Biology
|
R-HSA-1250189
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250488
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250488
Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1251922
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1251922
Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2
See in Reactome
R-HSA-1251944
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1306953
(
R-HSA-1227986;
R-HSA-1306955
)
R-HSA-1306953
Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306963
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306963
Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306969
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306969
Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1358792
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
Reaction Name: RNF41 ubiquitinates activated ERBB3
See in Reactome
R-HSA-1358798
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358798
Reaction Name: RNF41 binds neuregulin-activated ERBB3
See in Reactome
R-HSA-1918092
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918092
Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1918095
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918095
Reaction Name: CUL5 mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-373750
(
R-HSA-416572
)
R-HSA-373750
Reaction Name: SEMA4D interacts with Plexin-B1:ErbB2
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-416594
(
R-HSA-416572
)
R-HSA-416594
Reaction Name: LARG and PDZ-RhoGEF binds to Plexin-B1
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864105
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864105
Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers
See in Reactome
R-HSA-8864125
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864125
Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
See in Reactome
R-HSA-8864466
(
R-HSA-8866910
)
R-HSA-8864466
Reaction Name: TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression
See in Reactome
R-HSA-9652264
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9652277
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9665726
(
R-HSA-1227986;
R-HSA-9652282
)
|
MONDO:0008170 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0008318 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0008903 |
MONDO:0008903
Disease Name: lung cancer
OMIM id: OMIM:614210
All associated enzymes in DAR:
ERBB2
MAP3K8
PIK3CA
ERBB2 |
P04626 |
2.7.10.1
|
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-1251932
R-HSA-1251932
Reactome Name: PLCG1 events in ERBB2 signaling
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1306955
R-HSA-1306955
Reactome Name: GRB7 events in ERBB2 signaling
See in Reactome
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-9652282
R-HSA-9652282
Reactome Name: Drug-mediated inhibition of ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-1227986
R-HSA-6785631
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-9675108
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-373755
R-HSA-422475
R-HSA-73857
R-HSA-5684996
R-HSA-400685
R-HSA-1266738
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
|
Gene expression (Transcription)
Signal Transduction
Developmental Biology
|
R-HSA-1250189
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250488
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250488
Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1251922
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1251922
Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2
See in Reactome
R-HSA-1251944
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1306953
(
R-HSA-1227986;
R-HSA-1306955
)
R-HSA-1306953
Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306963
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306963
Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306969
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306969
Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1358792
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
Reaction Name: RNF41 ubiquitinates activated ERBB3
See in Reactome
R-HSA-1358798
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358798
Reaction Name: RNF41 binds neuregulin-activated ERBB3
See in Reactome
R-HSA-1918092
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918092
Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1918095
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918095
Reaction Name: CUL5 mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-373750
(
R-HSA-416572
)
R-HSA-373750
Reaction Name: SEMA4D interacts with Plexin-B1:ErbB2
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-416594
(
R-HSA-416572
)
R-HSA-416594
Reaction Name: LARG and PDZ-RhoGEF binds to Plexin-B1
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864105
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864105
Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers
See in Reactome
R-HSA-8864125
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864125
Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
See in Reactome
R-HSA-8864466
(
R-HSA-8866910
)
R-HSA-8864466
Reaction Name: TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression
See in Reactome
R-HSA-9652264
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9652277
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9665726
(
R-HSA-1227986;
R-HSA-9652282
)
|
MONDO:0009050 |
USP8 |
P40818 |
3.4.19.12
|
R-HSA-6807004
R-HSA-6807004
Reactome Name: Negative regulation of MET activity
See in Reactome
R-HSA-4641263
R-HSA-4641263
Reactome Name: Regulation of FZD by ubiquitination
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
|
R-HSA-6806834
R-HSA-195721
R-HSA-5688426
R-HSA-392499
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1358795
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358795
Reaction Name: Deubiquitination of RNF41 by P-USP8
See in Reactome
R-HSA-1358797
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358797
Reaction Name: Ubiquitinated RNF41 binds P-USP8
See in Reactome
R-HSA-4641236
(
R-HSA-4641263
)
R-HSA-4641236
Reaction Name: USP8 deubiquitinates FZD to potentiate WNT signaling
See in Reactome
R-HSA-5690196
(
R-HSA-5689880
)
R-HSA-6782628
(
R-HSA-5689880
)
R-HSA-6782628
Reaction Name: USP8 deubiquitinates STAM2:HGS
See in Reactome
R-HSA-8875443
(
R-HSA-6807004
)
|
MONDO:0009416 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-165158
)
R-HSA-109702
(
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0011240 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0011868 |
ERBB3 |
P21860 |
2.7.10.1
|
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1306955
R-HSA-1306955
Reactome Name: GRB7 events in ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-6785631
R-HSA-1227986
R-HSA-1236394
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-5684996
R-HSA-162582
|
Signal Transduction
|
R-HSA-1247497
(
R-HSA-1227986
)
R-HSA-1250189
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1306953
(
R-HSA-1227986;
R-HSA-1306955
)
R-HSA-1306953
Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1358790
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
Reaction Name: RNF41 ubiquitinates activated ERBB3
See in Reactome
R-HSA-1358798
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358798
Reaction Name: RNF41 binds neuregulin-activated ERBB3
See in Reactome
R-HSA-1358801
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358801
Reaction Name: ERBB3 binds RNF41 ubiquitin ligase
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1977958
(
R-HSA-1236394
)
R-HSA-1977958
Reaction Name: ERBB4 forms heterodimers with ERBB3
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
|
MONDO:0014048 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0014407 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0016419 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0016642 |
AKT1 |
P31749 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-203615
R-HSA-389513
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-9604323
R-HSA-9604323
Reactome Name: Negative regulation of NOTCH4 signaling
See in Reactome
R-HSA-1257604
R-HSA-450385
R-HSA-450385
Reactome Name: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
See in Reactome
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-6785807
R-HSA-6785807
Reactome Name: Interleukin-4 and Interleukin-13 signaling
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
R-HSA-8849469
R-HSA-8849469
Reactome Name: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-354192
R-HSA-165159
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-450604
R-HSA-450604
Reactome Name: KSRP (KHSRP) binds and destabilizes mRNA
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-8848021
R-HSA-449147
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-157118
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-5357801
R-HSA-1430728
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-1640170
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-73857
R-HSA-76009
R-HSA-76009
Reactome Name: Platelet Aggregation (Plug Formation)
See in Reactome
R-HSA-5633007
R-HSA-212436
R-HSA-74160
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-1280218
R-HSA-69278
R-HSA-389356
R-HSA-388396
R-HSA-162582
R-HSA-450531
R-HSA-450531
Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-8953854
R-HSA-199991
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-8939211
R-HSA-9013694
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5653656
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-8978934
R-HSA-69206
R-HSA-6807070
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-69242
R-HSA-9614085
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109582
R-HSA-109581
|
Immune System
Programmed Cell Death
Metabolism
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Metabolism of RNA
Vesicle-mediated transport
Hemostasis
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202137
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-377186
(
R-HSA-165159
)
R-HSA-377186
Reaction Name: Activated Akt1 phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-432110
(
R-HSA-354192
)
R-HSA-432110
Reaction Name: Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
See in Reactome
R-HSA-450490
(
R-HSA-450385
)
R-HSA-450490
Reaction Name: Protein Kinase B/Akt phosphorylates BRF1
See in Reactome
R-HSA-450499
(
R-HSA-450604
)
R-HSA-450499
Reaction Name: Protein Kinase B (AKT) phosphorylates KSRP
See in Reactome
R-HSA-6790041
(
R-HSA-6785807
)
R-HSA-6790041
Reaction Name: Expression of STAT3-upregulated cytosolic proteins
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-6811504
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-6811504
Reaction Name: AKT1 dephosphorylation by PP2A-B56-beta,gamma
See in Reactome
R-HSA-8848751
(
R-HSA-8849469
)
R-HSA-8848758
(
R-HSA-8849469
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9604328
(
R-HSA-9604323
)
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0018309 |
ERBB2 |
P04626 |
2.7.10.1
|
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-1251932
R-HSA-1251932
Reactome Name: PLCG1 events in ERBB2 signaling
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1306955
R-HSA-1306955
Reactome Name: GRB7 events in ERBB2 signaling
See in Reactome
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-9652282
R-HSA-9652282
Reactome Name: Drug-mediated inhibition of ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-1227986
R-HSA-6785631
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-9675108
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-373755
R-HSA-422475
R-HSA-73857
R-HSA-5684996
R-HSA-400685
R-HSA-1266738
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
|
Gene expression (Transcription)
Signal Transduction
Developmental Biology
|
R-HSA-1250189
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250488
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250488
Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1251922
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1251922
Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2
See in Reactome
R-HSA-1251944
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1306953
(
R-HSA-1227986;
R-HSA-1306955
)
R-HSA-1306953
Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306963
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306963
Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306969
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306969
Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1358792
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
Reaction Name: RNF41 ubiquitinates activated ERBB3
See in Reactome
R-HSA-1358798
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358798
Reaction Name: RNF41 binds neuregulin-activated ERBB3
See in Reactome
R-HSA-1918092
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918092
Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1918095
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918095
Reaction Name: CUL5 mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-373750
(
R-HSA-416572
)
R-HSA-373750
Reaction Name: SEMA4D interacts with Plexin-B1:ErbB2
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-416594
(
R-HSA-416572
)
R-HSA-416594
Reaction Name: LARG and PDZ-RhoGEF binds to Plexin-B1
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864105
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864105
Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers
See in Reactome
R-HSA-8864125
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864125
Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
See in Reactome
R-HSA-8864466
(
R-HSA-8866910
)
R-HSA-8864466
Reaction Name: TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression
See in Reactome
R-HSA-9652264
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9652277
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9665726
(
R-HSA-1227986;
R-HSA-9652282
)
|
MONDO:0018309 |
ERBB3 |
P21860 |
2.7.10.1
|
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1306955
R-HSA-1306955
Reactome Name: GRB7 events in ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-6785631
R-HSA-1227986
R-HSA-1236394
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-5684996
R-HSA-162582
|
Signal Transduction
|
R-HSA-1247497
(
R-HSA-1227986
)
R-HSA-1250189
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1306953
(
R-HSA-1227986;
R-HSA-1306955
)
R-HSA-1306953
Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1358790
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
Reaction Name: RNF41 ubiquitinates activated ERBB3
See in Reactome
R-HSA-1358798
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358798
Reaction Name: RNF41 binds neuregulin-activated ERBB3
See in Reactome
R-HSA-1358801
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358801
Reaction Name: ERBB3 binds RNF41 ubiquitin ligase
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1977958
(
R-HSA-1236394
)
R-HSA-1977958
Reaction Name: ERBB4 forms heterodimers with ERBB3
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
|
MONDO:0018416 |
USP8 |
P40818 |
3.4.19.12
|
R-HSA-6807004
R-HSA-6807004
Reactome Name: Negative regulation of MET activity
See in Reactome
R-HSA-4641263
R-HSA-4641263
Reactome Name: Regulation of FZD by ubiquitination
See in Reactome
R-HSA-5689880
R-HSA-5689880
Reactome Name: Ub-specific processing proteases
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
|
R-HSA-6806834
R-HSA-195721
R-HSA-5688426
R-HSA-392499
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-597592
R-HSA-597592
Reactome Name: Post-translational protein modification
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-162582
|
Metabolism of proteins
Signal Transduction
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1358795
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358795
Reaction Name: Deubiquitination of RNF41 by P-USP8
See in Reactome
R-HSA-1358797
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358797
Reaction Name: Ubiquitinated RNF41 binds P-USP8
See in Reactome
R-HSA-4641236
(
R-HSA-4641263
)
R-HSA-4641236
Reaction Name: USP8 deubiquitinates FZD to potentiate WNT signaling
See in Reactome
R-HSA-5690196
(
R-HSA-5689880
)
R-HSA-6782628
(
R-HSA-5689880
)
R-HSA-6782628
Reaction Name: USP8 deubiquitinates STAM2:HGS
See in Reactome
R-HSA-8875443
(
R-HSA-6807004
)
|
MONDO:0019192 |
AKT2 |
P31751 |
2.7.11.1
|
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-3769402
R-HSA-3769402
Reactome Name: Deactivation of the beta-catenin transactivating complex
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-165160
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-165181
R-HSA-165181
Reactome Name: Inhibition of TSC complex formation by PKB
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-1445148
R-HSA-1445148
Reactome Name: Translocation of SLC2A4 (GLUT4) to the plasma membrane
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-165158
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-201681
R-HSA-201681
Reactome Name: TCF dependent signaling in response to WNT
See in Reactome
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-1640170
R-HSA-74752
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5633007
R-HSA-109704
R-HSA-212436
R-HSA-74160
R-HSA-112399
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-1280218
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-73857
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109581
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-195721
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-165159
R-HSA-69242
R-HSA-194138
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-109703
R-HSA-9007101
R-HSA-1227986
R-HSA-8939211
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-162582
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Vesicle-mediated transport
Programmed Cell Death
Signal Transduction
|
R-HSA-109700
(
R-HSA-165158
)
R-HSA-109702
(
R-HSA-165158
)
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-1445144
(
R-HSA-1445148
)
R-HSA-1445144
Reaction Name: p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
See in Reactome
R-HSA-1449597
(
R-HSA-1445148
)
R-HSA-1449597
Reaction Name: p-AKT2 phosphorylates Myosin 5A
See in Reactome
R-HSA-1458463
(
R-HSA-1445148
)
R-HSA-162363
(
R-HSA-165160
)
R-HSA-162363
Reaction Name: p-T309,S474-AKT2:PIP3 phosphorylates PDE3B
See in Reactome
R-HSA-165162
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
(
R-HSA-165159;
R-HSA-165181
)
R-HSA-165182
Reaction Name: Phosphorylation of complexed TSC2 by PKB
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-3769394
(
R-HSA-3769402
)
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-5260201
(
R-HSA-1445148
)
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0020492 |
AKT3 |
Q9Y243 |
2.7.11.1
|
R-HSA-9634638
R-HSA-9634638
Reactome Name: Estrogen-dependent nuclear events downstream of ESR-membrane signaling
See in Reactome
R-HSA-9607240
R-HSA-198693
R-HSA-198693
Reactome Name: AKT phosphorylates targets in the nucleus
See in Reactome
R-HSA-8948751
R-HSA-8948751
Reactome Name: Regulation of PTEN stability and activity
See in Reactome
R-HSA-111447
R-HSA-111447
Reactome Name: Activation of BAD and translocation to mitochondria
See in Reactome
R-HSA-1257604
R-HSA-389513
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-211163
R-HSA-211163
Reactome Name: AKT-mediated inactivation of FOXO1A
See in Reactome
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-5628897
R-HSA-5628897
Reactome Name: TP53 Regulates Metabolic Genes
See in Reactome
R-HSA-8941332
R-HSA-8941332
Reactome Name: RUNX2 regulates genes involved in cell migration
See in Reactome
R-HSA-6804759
R-HSA-6804759
Reactome Name: Regulation of TP53 Activity through Association with Co-factors
See in Reactome
R-HSA-6804758
R-HSA-6804758
Reactome Name: Regulation of TP53 Activity through Acetylation
See in Reactome
R-HSA-6804757
R-HSA-6804757
Reactome Name: Regulation of TP53 Degradation
See in Reactome
R-HSA-9614399
R-HSA-9614399
Reactome Name: Regulation of localization of FOXO transcription factors
See in Reactome
R-HSA-392451
R-HSA-392451
Reactome Name: G beta:gamma signalling through PI3Kgamma
See in Reactome
R-HSA-198323
R-HSA-198323
Reactome Name: AKT phosphorylates targets in the cytosol
See in Reactome
R-HSA-8876198
R-HSA-8876198
Reactome Name: RAB GEFs exchange GTP for GDP on RABs
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-69656
R-HSA-69656
Reactome Name: Cyclin A:Cdk2-associated events at S phase entry
See in Reactome
R-HSA-69202
R-HSA-69202
Reactome Name: Cyclin E associated events during G1/S transition
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-3700989
R-HSA-3700989
Reactome Name: Transcriptional Regulation by TP53
See in Reactome
R-HSA-210745
R-HSA-210745
Reactome Name: Regulation of gene expression in beta cells
See in Reactome
R-HSA-6806003
R-HSA-6806003
Reactome Name: Regulation of TP53 Expression and Degradation
See in Reactome
R-HSA-168256
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-1640170
R-HSA-1280218
R-HSA-1266738
R-HSA-73857
R-HSA-5633007
R-HSA-194138
R-HSA-74160
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-9614085
R-HSA-69278
R-HSA-389356
R-HSA-162582
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-9007101
R-HSA-453279
R-HSA-453279
Reactome Name: Mitotic G1 phase and G1/S transition
See in Reactome
R-HSA-4420097
R-HSA-388396
R-HSA-199991
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5653656
R-HSA-186712
R-HSA-186712
Reactome Name: Regulation of beta-cell development
See in Reactome
R-HSA-372790
R-HSA-114452
R-HSA-114452
Reactome Name: Activation of BH3-only proteins
See in Reactome
R-HSA-69206
R-HSA-6807070
R-HSA-5357801
R-HSA-397795
R-HSA-397795
Reactome Name: G-protein beta:gamma signalling
See in Reactome
R-HSA-69242
R-HSA-212436
R-HSA-8878166
R-HSA-8878166
Reactome Name: Transcriptional regulation by RUNX2
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-109606
R-HSA-109606
Reactome Name: Intrinsic Pathway for Apoptosis
See in Reactome
R-HSA-109581
|
Immune System
Cell Cycle
Developmental Biology
Gene expression (Transcription)
Signal Transduction
Vesicle-mediated transport
Programmed Cell Death
|
R-HSA-1358791
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358791
Reaction Name: Phosphorylation of USP8 by P-AKT
See in Reactome
R-HSA-198270
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198270
Reaction Name: PDPK1 phosphorylates AKT at T308
See in Reactome
R-HSA-198298
(
R-HSA-1257604
)
R-HSA-198298
Reaction Name: AKT translocates to the nucleus
See in Reactome
R-HSA-198347
(
R-HSA-111447;
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198371
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198599
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-6804757
)
R-HSA-198609
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-5628897
)
R-HSA-198609
Reaction Name: AKT phosphorylates TSC2, inhibiting it
See in Reactome
R-HSA-198611
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198613
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-69202;
R-HSA-69656
)
R-HSA-198613
Reaction Name: AKT phosphorylates p21Cip1 and p27Kip1
See in Reactome
R-HSA-198621
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-198640
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-198640
Reaction Name: TORC2 (mTOR) phosphorylates AKT at S473
See in Reactome
R-HSA-199298
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-199299
(
R-HSA-1257604;
R-HSA-198693;
R-HSA-9614399
)
R-HSA-199299
Reaction Name: AKT phosphorylates FOXO transcription factors
See in Reactome
R-HSA-199425
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199425
Reaction Name: PHLPP dephosphorylates S473 in AKT
See in Reactome
R-HSA-199443
(
R-HSA-1257604;
R-HSA-199418
)
R-HSA-199443
Reaction Name: THEM4 (CTMP) and/or TRIB3 inhibit AKT phosphorylation
See in Reactome
R-HSA-199839
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
(
R-HSA-1257604;
R-HSA-198693
)
R-HSA-199863
Reaction Name: AKT can phosphorylate NR4A1 (NUR77)
See in Reactome
R-HSA-200143
(
R-HSA-1257604;
R-HSA-198323
)
R-HSA-200143
Reaction Name: AKT phosphorylates AKT1S1 (PRAS40)
See in Reactome
R-HSA-211164
(
R-HSA-211163
)
R-HSA-2317314
(
R-HSA-1257604;
R-HSA-389357;
R-HSA-5218920
)
R-HSA-2317332
(
R-HSA-1257604;
R-HSA-389357
)
R-HSA-2317332
Reaction Name: PIP3 recruits AKT to the membrane
See in Reactome
R-HSA-389756
(
R-HSA-389357
)
R-HSA-389756
Reaction Name: AKT interacts and phosphorylates Cot
See in Reactome
R-HSA-390329
(
R-HSA-389513
)
R-HSA-390329
Reaction Name: Dephosphorylation of AKT by PP2A
See in Reactome
R-HSA-6805620
(
R-HSA-6804758
)
R-HSA-6805640
(
R-HSA-6804758
)
R-HSA-6805785
(
R-HSA-6804759
)
R-HSA-8932309
()
R-HSA-8932309
Reaction Name: NFE2L2 translocates from cytosol to nucleoplasm
See in Reactome
R-HSA-8933446
(
R-HSA-8876198
)
R-HSA-8933446
Reaction Name: Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling
See in Reactome
R-HSA-8939963
(
R-HSA-8941332
)
R-HSA-8939963
Reaction Name: Activated AKT phosphorylates RUNX2
See in Reactome
R-HSA-8948757
(
R-HSA-1257604;
R-HSA-198323;
R-HSA-8948751
)
R-HSA-9603279
(
R-HSA-392451
)
R-HSA-9603279
Reaction Name: PIP3 recruits PDK1 and AKT to the membrane
See in Reactome
R-HSA-9624526
(
R-HSA-9009391;
R-HSA-9634638
)
R-HSA-9624526
Reaction Name: AKT phosphorylates FOXO3 downstream of ESR1 and EGFR
See in Reactome
R-HSA-9699579
(
R-HSA-9607240
)
R-HSA-9699579
Reaction Name: AKT phosphorylates FOXO3 downstream of FLT3
See in Reactome
|
MONDO:0024498 |
ERBB2 |
P04626 |
2.7.10.1
|
R-HSA-416572
R-HSA-416572
Reactome Name: Sema4D induced cell migration and growth-cone collapse
See in Reactome
R-HSA-1251932
R-HSA-1251932
Reactome Name: PLCG1 events in ERBB2 signaling
See in Reactome
R-HSA-1358803
R-HSA-1358803
Reactome Name: Downregulation of ERBB2:ERBB3 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1306955
R-HSA-1306955
Reactome Name: GRB7 events in ERBB2 signaling
See in Reactome
R-HSA-8866910
R-HSA-8866910
Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
See in Reactome
R-HSA-9652282
R-HSA-9652282
Reactome Name: Drug-mediated inhibition of ERBB2 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-1227986
R-HSA-6785631
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-8864260
R-HSA-8864260
Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
See in Reactome
R-HSA-212436
R-HSA-74160
R-HSA-9675108
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-162582
R-HSA-373755
R-HSA-422475
R-HSA-73857
R-HSA-5684996
R-HSA-400685
R-HSA-1266738
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
|
Gene expression (Transcription)
Signal Transduction
Developmental Biology
|
R-HSA-1250189
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250488
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250488
Reaction Name: GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer
See in Reactome
R-HSA-1250498
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1250498
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers.
See in Reactome
R-HSA-1251922
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1251922
Reaction Name: PLCG1 phosphorylation by p-EGFR:p-ERBB2
See in Reactome
R-HSA-1251944
(
R-HSA-1227986;
R-HSA-1251932
)
R-HSA-1306953
(
R-HSA-1227986;
R-HSA-1306955
)
R-HSA-1306953
Reaction Name: GRB7 binds phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306963
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306963
Reaction Name: Binding of GRB2:GAB1 to p-ERBB2:p-EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306969
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306969
Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1358792
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358792
Reaction Name: RNF41 ubiquitinates activated ERBB3
See in Reactome
R-HSA-1358798
(
R-HSA-1227986;
R-HSA-1358803;
R-HSA-8863795
)
R-HSA-1358798
Reaction Name: RNF41 binds neuregulin-activated ERBB3
See in Reactome
R-HSA-1918092
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918092
Reaction Name: CHIP (STUB1) mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1918095
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1918095
Reaction Name: CUL5 mediates ubiquitination of ERBB2
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-199418;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-373750
(
R-HSA-416572
)
R-HSA-373750
Reaction Name: SEMA4D interacts with Plexin-B1:ErbB2
See in Reactome
R-HSA-416588
(
R-HSA-416572
)
R-HSA-416588
Reaction Name: Activation of Rho by LARG and PDZ-RhoGEF
See in Reactome
R-HSA-416594
(
R-HSA-416572
)
R-HSA-416594
Reaction Name: LARG and PDZ-RhoGEF binds to Plexin-B1
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8864105
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864105
Reaction Name: PTPN18 binds ERBB2:EGFR heterodimers
See in Reactome
R-HSA-8864125
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8864125
Reaction Name: PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248
See in Reactome
R-HSA-8864466
(
R-HSA-8866910
)
R-HSA-8864466
Reaction Name: TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers and YY1 stimulate ERBB2 gene expression
See in Reactome
R-HSA-9652264
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9652277
(
R-HSA-1227986;
R-HSA-9652282
)
R-HSA-9665726
(
R-HSA-1227986;
R-HSA-9652282
)
|