MONDO:0001056 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0005105 |
ERBB4 |
Q15303 |
2.7.10.1
|
R-HSA-9620244
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-6785631
R-HSA-9018519
R-HSA-9018519
Reactome Name: Estrogen-dependent gene expression
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-1227986
R-HSA-1236394
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1251985
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-8939211
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-112316
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5684996
R-HSA-162582
|
Neuronal System
Signal Transduction
|
R-HSA-1236398
(
R-HSA-1236394
)
R-HSA-1236398
Reaction Name: ERBB4 binds NRGs or EGF-like ligands
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250220
(
R-HSA-1236394
)
R-HSA-1250315
(
R-HSA-1236394
)
R-HSA-1250315
Reaction Name: Trans-autophosphorylation of ERBB4 homodimers
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250348
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250348
Reaction Name: Phosphorylation of SHC1 by ERBB4 homodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250357
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250357
Reaction Name: SHC1 binds P-ERBB4 isoform dimers
See in Reactome
R-HSA-1250370
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250380
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250380
Reaction Name: Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1251992
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1251992
Reaction Name: Cleavage of P-ERBB4jmA isoforms by ADAM17
See in Reactome
R-HSA-1251997
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1251997
Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex
See in Reactome
R-HSA-1252013
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-1253282
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1253282
Reaction Name: ERBB4 ubiquitination by WWP1/ITCH
See in Reactome
R-HSA-1253300
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1253300
Reaction Name: ERBB4 binds WWP1/ITCH ubiquitin ligases
See in Reactome
R-HSA-1253319
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253319
Reaction Name: ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus
See in Reactome
R-HSA-1253321
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253321
Reaction Name: GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1
See in Reactome
R-HSA-1253325
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253325
Reaction Name: ERBB4s80 binds TAB2:NCOR1 complex
See in Reactome
R-HSA-1253343
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254248
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254248
Reaction Name: Translocation of ERBB4s80:YAP1 complex to the nucleus
See in Reactome
R-HSA-1254251
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254285
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254285
Reaction Name: ERBB4s80:STAT5A complex translocates to the nucleus
See in Reactome
R-HSA-1254290
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254290
Reaction Name: CSN2 gene expression is stimulated by ERBB4s80:STAT5A
See in Reactome
R-HSA-1254291
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254376
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254376
Reaction Name: Translocation of cytosolic ERBB4s80 to mitochondrial matrix
See in Reactome
R-HSA-1254386
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-1254386
Reaction Name: ERBB4s80 forms a complex with estrogen receptor ESR1
See in Reactome
R-HSA-1254392
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-1254392
Reaction Name: PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen
See in Reactome
R-HSA-1306969
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306969
Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1973956
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1973956
Reaction Name: NEDD4 binds ERBB4jmAcyt1s80 dimer
See in Reactome
R-HSA-1977296
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1977296
Reaction Name: NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
See in Reactome
R-HSA-1977958
(
R-HSA-1236394
)
R-HSA-1977958
Reaction Name: ERBB4 forms heterodimers with ERBB3
See in Reactome
R-HSA-1977959
(
R-HSA-1236394
)
R-HSA-1977959
Reaction Name: ERBB4 forms heterodimers with EGFR
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8954179
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954179
Reaction Name: S100B gene expression is inhibited by ERBB4:TAB2:NCOR1
See in Reactome
R-HSA-8954182
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954182
Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter
See in Reactome
R-HSA-8954185
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954185
Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter
See in Reactome
R-HSA-8954199
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954199
Reaction Name: CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen
See in Reactome
R-HSA-8954207
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954207
Reaction Name: ERBB4s80:ESR1 binds CXCL12 gene promoter
See in Reactome
R-HSA-8954208
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954208
Reaction Name: ERBB4s80:ESR1 binds PGR gene promoter
See in Reactome
R-HSA-8954224
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954224
Reaction Name: ERBB4s80:STAT5A binds CSN2 gene promoter
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-9612243
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612243
Reaction Name: APOE gene transcription is stimulated by ERBB4s80
See in Reactome
R-HSA-9612246
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612255
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612257
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612257
Reaction Name: ADAP1 gene expression is inhibited by ERBB4s80
See in Reactome
R-HSA-9612277
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612277
Reaction Name: SPARC gene transcription is stimulated by ERBB4s80
See in Reactome
R-HSA-9612278
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612440
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612444
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612445
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612445
Reaction Name: STMN1 gene expression is stimulated by ERBB4s80
See in Reactome
R-HSA-9612448
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612448
Reaction Name: MXD4 gene expression is stimulated by ERBB4s80
See in Reactome
R-HSA-9612593
(
R-HSA-1236394
)
R-HSA-9612639
(
R-HSA-1236394
)
R-HSA-9612639
Reaction Name: NRG2-activated ERBB4 binds GABA receptors through GABRA1
See in Reactome
R-HSA-9612671
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612671
Reaction Name: ERBB4 gene expression is stimulated by ERBB4s80:ESR1
See in Reactome
R-HSA-9612672
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612672
Reaction Name: ERBB4s80:ESR1 binds ERBB4 gene promoter
See in Reactome
|
MONDO:0005575 |
MONDO:0005575
Disease Name: colorectal cancer
OMIM id: OMIM:615083
Orphanet id: Orphanet:466667
All associated enzymes in DAR:
AKT1
ALOX12
BUB1
EPHA3
NRAS
RAD54B
RET
BRAF
WRN
MTHFD1
EP300
SRC
PTPRJ
MT-CO1
PTPN12
BUB1B
PIK3CA
FGFR3
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0007962 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008093 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008170 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008420 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0008903 |
MONDO:0008903
Disease Name: lung cancer
OMIM id: OMIM:614210
All associated enzymes in DAR:
ERBB2
MAP3K8
PIK3CA
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0011240 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0013038 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0013125 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0014047 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0014223 |
ERBB4 |
Q15303 |
2.7.10.1
|
R-HSA-9620244
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-6785631
R-HSA-9018519
R-HSA-9018519
Reactome Name: Estrogen-dependent gene expression
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-1227986
R-HSA-1236394
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1251985
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-8939211
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-112316
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5684996
R-HSA-162582
|
Neuronal System
Signal Transduction
|
R-HSA-1236398
(
R-HSA-1236394
)
R-HSA-1236398
Reaction Name: ERBB4 binds NRGs or EGF-like ligands
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250220
(
R-HSA-1236394
)
R-HSA-1250315
(
R-HSA-1236394
)
R-HSA-1250315
Reaction Name: Trans-autophosphorylation of ERBB4 homodimers
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250348
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250348
Reaction Name: Phosphorylation of SHC1 by ERBB4 homodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250357
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250357
Reaction Name: SHC1 binds P-ERBB4 isoform dimers
See in Reactome
R-HSA-1250370
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250380
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250380
Reaction Name: Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1251992
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1251992
Reaction Name: Cleavage of P-ERBB4jmA isoforms by ADAM17
See in Reactome
R-HSA-1251997
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1251997
Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex
See in Reactome
R-HSA-1252013
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-1253282
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1253282
Reaction Name: ERBB4 ubiquitination by WWP1/ITCH
See in Reactome
R-HSA-1253300
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1253300
Reaction Name: ERBB4 binds WWP1/ITCH ubiquitin ligases
See in Reactome
R-HSA-1253319
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253319
Reaction Name: ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus
See in Reactome
R-HSA-1253321
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253321
Reaction Name: GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1
See in Reactome
R-HSA-1253325
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253325
Reaction Name: ERBB4s80 binds TAB2:NCOR1 complex
See in Reactome
R-HSA-1253343
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254248
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254248
Reaction Name: Translocation of ERBB4s80:YAP1 complex to the nucleus
See in Reactome
R-HSA-1254251
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254285
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254285
Reaction Name: ERBB4s80:STAT5A complex translocates to the nucleus
See in Reactome
R-HSA-1254290
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254290
Reaction Name: CSN2 gene expression is stimulated by ERBB4s80:STAT5A
See in Reactome
R-HSA-1254291
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254376
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254376
Reaction Name: Translocation of cytosolic ERBB4s80 to mitochondrial matrix
See in Reactome
R-HSA-1254386
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-1254386
Reaction Name: ERBB4s80 forms a complex with estrogen receptor ESR1
See in Reactome
R-HSA-1254392
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-1254392
Reaction Name: PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen
See in Reactome
R-HSA-1306969
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306969
Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1973956
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1973956
Reaction Name: NEDD4 binds ERBB4jmAcyt1s80 dimer
See in Reactome
R-HSA-1977296
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1977296
Reaction Name: NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
See in Reactome
R-HSA-1977958
(
R-HSA-1236394
)
R-HSA-1977958
Reaction Name: ERBB4 forms heterodimers with ERBB3
See in Reactome
R-HSA-1977959
(
R-HSA-1236394
)
R-HSA-1977959
Reaction Name: ERBB4 forms heterodimers with EGFR
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8954179
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954179
Reaction Name: S100B gene expression is inhibited by ERBB4:TAB2:NCOR1
See in Reactome
R-HSA-8954182
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954182
Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter
See in Reactome
R-HSA-8954185
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954185
Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter
See in Reactome
R-HSA-8954199
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954199
Reaction Name: CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen
See in Reactome
R-HSA-8954207
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954207
Reaction Name: ERBB4s80:ESR1 binds CXCL12 gene promoter
See in Reactome
R-HSA-8954208
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954208
Reaction Name: ERBB4s80:ESR1 binds PGR gene promoter
See in Reactome
R-HSA-8954224
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954224
Reaction Name: ERBB4s80:STAT5A binds CSN2 gene promoter
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-9612243
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612243
Reaction Name: APOE gene transcription is stimulated by ERBB4s80
See in Reactome
R-HSA-9612246
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612255
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612257
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612257
Reaction Name: ADAP1 gene expression is inhibited by ERBB4s80
See in Reactome
R-HSA-9612277
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612277
Reaction Name: SPARC gene transcription is stimulated by ERBB4s80
See in Reactome
R-HSA-9612278
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612440
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612444
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612445
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612445
Reaction Name: STMN1 gene expression is stimulated by ERBB4s80
See in Reactome
R-HSA-9612448
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612448
Reaction Name: MXD4 gene expression is stimulated by ERBB4s80
See in Reactome
R-HSA-9612593
(
R-HSA-1236394
)
R-HSA-9612639
(
R-HSA-1236394
)
R-HSA-9612639
Reaction Name: NRG2-activated ERBB4 binds GABA receptors through GABRA1
See in Reactome
R-HSA-9612671
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612671
Reaction Name: ERBB4 gene expression is stimulated by ERBB4s80:ESR1
See in Reactome
R-HSA-9612672
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612672
Reaction Name: ERBB4s80:ESR1 binds ERBB4 gene promoter
See in Reactome
|
MONDO:0016216 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0016419 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0016642 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0016996 |
ERBB4 |
Q15303 |
2.7.10.1
|
R-HSA-9620244
R-HSA-1963640
R-HSA-1963640
Reactome Name: GRB2 events in ERBB2 signaling
See in Reactome
R-HSA-1257604
R-HSA-1250347
R-HSA-1250347
Reactome Name: SHC1 events in ERBB4 signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-6785631
R-HSA-9018519
R-HSA-9018519
Reactome Name: Estrogen-dependent gene expression
See in Reactome
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-1250196
R-HSA-1250196
Reactome Name: SHC1 events in ERBB2 signaling
See in Reactome
R-HSA-1227986
R-HSA-1236394
R-HSA-1253288
R-HSA-1253288
Reactome Name: Downregulation of ERBB4 signaling
See in Reactome
R-HSA-8847993
R-HSA-8847993
Reactome Name: ERBB2 Activates PTK6 Signaling
See in Reactome
R-HSA-8863795
R-HSA-8863795
Reactome Name: Downregulation of ERBB2 signaling
See in Reactome
R-HSA-1251985
R-HSA-5673001
|
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-8848021
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006927
R-HSA-9006927
Reactome Name: Signaling by Non-Receptor Tyrosine Kinases
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-8939211
R-HSA-438064
R-HSA-438064
Reactome Name: Post NMDA receptor activation events
See in Reactome
R-HSA-112316
R-HSA-442755
R-HSA-442755
Reactome Name: Activation of NMDA receptors and postsynaptic events
See in Reactome
R-HSA-112314
R-HSA-112314
Reactome Name: Neurotransmitter receptors and postsynaptic signal transmission
See in Reactome
R-HSA-112315
R-HSA-112315
Reactome Name: Transmission across Chemical Synapses
See in Reactome
R-HSA-5684996
R-HSA-162582
|
Neuronal System
Signal Transduction
|
R-HSA-1236398
(
R-HSA-1236394
)
R-HSA-1236398
Reaction Name: ERBB4 binds NRGs or EGF-like ligands
See in Reactome
R-HSA-1250195
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250195
Reaction Name: SHC1 phosphorylation by ERBB2 heterodimers
See in Reactome
R-HSA-1250220
(
R-HSA-1236394
)
R-HSA-1250315
(
R-HSA-1236394
)
R-HSA-1250315
Reaction Name: Trans-autophosphorylation of ERBB4 homodimers
See in Reactome
R-HSA-1250346
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250348
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250348
Reaction Name: Phosphorylation of SHC1 by ERBB4 homodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250357
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250357
Reaction Name: SHC1 binds P-ERBB4 isoform dimers
See in Reactome
R-HSA-1250370
(
R-HSA-1236394;
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250380
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250380
Reaction Name: Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349
See in Reactome
R-HSA-1250383
(
R-HSA-1236394;
R-HSA-1250347
)
R-HSA-1250383
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
See in Reactome
R-HSA-1250463
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250463
Reaction Name: RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1250486
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1250486
Reaction Name: Recruitment of GRB2:SOS1 to p-SHC1 in complex with phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1251992
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1251992
Reaction Name: Cleavage of P-ERBB4jmA isoforms by ADAM17
See in Reactome
R-HSA-1251997
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1251997
Reaction Name: Cleavage of ERBB4m80 by gamma-scretase complex
See in Reactome
R-HSA-1252013
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1252013
Reaction Name: Translocation of ERBB4s80 to the nucleus
See in Reactome
R-HSA-1253282
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1253282
Reaction Name: ERBB4 ubiquitination by WWP1/ITCH
See in Reactome
R-HSA-1253300
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1253300
Reaction Name: ERBB4 binds WWP1/ITCH ubiquitin ligases
See in Reactome
R-HSA-1253319
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253319
Reaction Name: ERBB4s80:TAB2:NCOR1 complex translocates to the nucleus
See in Reactome
R-HSA-1253321
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253321
Reaction Name: GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1
See in Reactome
R-HSA-1253325
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1253325
Reaction Name: ERBB4s80 binds TAB2:NCOR1 complex
See in Reactome
R-HSA-1253343
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254248
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254248
Reaction Name: Translocation of ERBB4s80:YAP1 complex to the nucleus
See in Reactome
R-HSA-1254251
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254285
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254285
Reaction Name: ERBB4s80:STAT5A complex translocates to the nucleus
See in Reactome
R-HSA-1254290
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254290
Reaction Name: CSN2 gene expression is stimulated by ERBB4s80:STAT5A
See in Reactome
R-HSA-1254291
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254376
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-1254376
Reaction Name: Translocation of cytosolic ERBB4s80 to mitochondrial matrix
See in Reactome
R-HSA-1254386
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-1254386
Reaction Name: ERBB4s80 forms a complex with estrogen receptor ESR1
See in Reactome
R-HSA-1254392
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-1254392
Reaction Name: PGR gene expression is stimulated by ERBB4s80:ESR1:estrogen
See in Reactome
R-HSA-1306969
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306969
Reaction Name: GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306972
(
R-HSA-1227986;
R-HSA-1963640
)
R-HSA-1306972
Reaction Name: RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers
See in Reactome
R-HSA-1306979
(
R-HSA-1227986;
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1963563
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-1963563
Reaction Name: MATK (CSK homologous kinase) binds phosphorylated ERBB2
See in Reactome
R-HSA-1963578
(
R-HSA-1227986;
R-HSA-1250196
)
R-HSA-1963578
Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers
See in Reactome
R-HSA-1963581
(
R-HSA-1227986
)
R-HSA-1963581
Reaction Name: Trans-autophosphorylation of p-Y877-ERBB2 heterodimers
See in Reactome
R-HSA-1963582
(
R-HSA-1227986
)
R-HSA-1963582
Reaction Name: Trans-autophosphorylation of ERBB2 heterodimers
See in Reactome
R-HSA-1963586
(
R-HSA-1227986
)
R-HSA-1963586
Reaction Name: SRC family kinases phosphorylate ERBB2
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR
See in Reactome
R-HSA-1963589
(
R-HSA-1227986
)
R-HSA-1963589
Reaction Name: ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4
See in Reactome
R-HSA-1973956
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1973956
Reaction Name: NEDD4 binds ERBB4jmAcyt1s80 dimer
See in Reactome
R-HSA-1977296
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-1977296
Reaction Name: NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
See in Reactome
R-HSA-1977958
(
R-HSA-1236394
)
R-HSA-1977958
Reaction Name: ERBB4 forms heterodimers with ERBB3
See in Reactome
R-HSA-1977959
(
R-HSA-1236394
)
R-HSA-1977959
Reaction Name: ERBB4 forms heterodimers with EGFR
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-6785636
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-6785636
Reaction Name: Phosphorylated ERBB2 heterodimers bind MEMO1
See in Reactome
R-HSA-6785648
(
R-HSA-1227986;
R-HSA-6785631
)
R-HSA-8847995
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8847995
Reaction Name: Activated ERBB2 binds PTK6 (BRK)
See in Reactome
R-HSA-8848005
(
R-HSA-1227986;
R-HSA-8847993
)
R-HSA-8848005
Reaction Name: ERBB2 promotes PTK6 autophosphorylation
See in Reactome
R-HSA-8863804
(
R-HSA-1227986;
R-HSA-8863795
)
R-HSA-8863804
Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248
See in Reactome
R-HSA-8954179
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954179
Reaction Name: S100B gene expression is inhibited by ERBB4:TAB2:NCOR1
See in Reactome
R-HSA-8954182
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954182
Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds S100B gene promoter
See in Reactome
R-HSA-8954185
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954185
Reaction Name: ERBB4s80:TAB2:NCOR1 complex binds GFAP gene promoter
See in Reactome
R-HSA-8954199
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954199
Reaction Name: CXCL12 gene expression is stimulated by ERBB4s80:ESR1:estrogen
See in Reactome
R-HSA-8954207
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954207
Reaction Name: ERBB4s80:ESR1 binds CXCL12 gene promoter
See in Reactome
R-HSA-8954208
(
R-HSA-1236394;
R-HSA-1251985;
R-HSA-9018519
)
R-HSA-8954208
Reaction Name: ERBB4s80:ESR1 binds PGR gene promoter
See in Reactome
R-HSA-8954224
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-8954224
Reaction Name: ERBB4s80:STAT5A binds CSN2 gene promoter
See in Reactome
R-HSA-9612085
(
R-HSA-9620244
)
R-HSA-9612085
Reaction Name: SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs
See in Reactome
R-HSA-9612219
(
R-HSA-1236394;
R-HSA-1253288
)
R-HSA-9612243
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612243
Reaction Name: APOE gene transcription is stimulated by ERBB4s80
See in Reactome
R-HSA-9612246
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612255
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612257
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612257
Reaction Name: ADAP1 gene expression is inhibited by ERBB4s80
See in Reactome
R-HSA-9612277
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612277
Reaction Name: SPARC gene transcription is stimulated by ERBB4s80
See in Reactome
R-HSA-9612278
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612440
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612444
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612445
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612445
Reaction Name: STMN1 gene expression is stimulated by ERBB4s80
See in Reactome
R-HSA-9612448
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612448
Reaction Name: MXD4 gene expression is stimulated by ERBB4s80
See in Reactome
R-HSA-9612593
(
R-HSA-1236394
)
R-HSA-9612639
(
R-HSA-1236394
)
R-HSA-9612639
Reaction Name: NRG2-activated ERBB4 binds GABA receptors through GABRA1
See in Reactome
R-HSA-9612671
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612671
Reaction Name: ERBB4 gene expression is stimulated by ERBB4s80:ESR1
See in Reactome
R-HSA-9612672
(
R-HSA-1236394;
R-HSA-1251985
)
R-HSA-9612672
Reaction Name: ERBB4s80:ESR1 binds ERBB4 gene promoter
See in Reactome
|
MONDO:0017177 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017564 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017566 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0017812 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|
MONDO:0020492 |
PIK3CA |
P42336 |
2.7.1.137
2.7.11.1
2.7.1.153
|
R-HSA-1660499
R-HSA-1660499
Reactome Name: Synthesis of PIPs at the plasma membrane
See in Reactome
R-HSA-198203
R-HSA-4420097
R-HSA-114604
R-HSA-114604
Reactome Name: GPVI-mediated activation cascade
See in Reactome
R-HSA-1963642
R-HSA-1963642
Reactome Name: PI3K events in ERBB2 signaling
See in Reactome
R-HSA-9607240
R-HSA-186763
R-HSA-180292
R-HSA-8853659
R-HSA-9027276
R-HSA-9027276
Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
See in Reactome
R-HSA-2730905
R-HSA-2730905
Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization
See in Reactome
R-HSA-912631
R-HSA-1257604
R-HSA-5654710
R-HSA-5654720
R-HSA-5654689
R-HSA-112399
R-HSA-389357
R-HSA-389357
Reactome Name: CD28 dependent PI3K/Akt signaling
See in Reactome
R-HSA-388841
R-HSA-388841
Reactome Name: Costimulation by the CD28 family
See in Reactome
R-HSA-5673001
R-HSA-2029485
R-HSA-2029485
Reactome Name: Role of phospholipids in phagocytosis
See in Reactome
R-HSA-202424
R-HSA-912526
R-HSA-912526
Reactome Name: Interleukin receptor SHC signaling
See in Reactome
R-HSA-1433557
R-HSA-2424491
R-HSA-512988
R-HSA-512988
Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling
See in Reactome
R-HSA-5654695
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-9013149
R-HSA-8851907
R-HSA-8851907
Reactome Name: MET activates PI3K/AKT signaling
See in Reactome
R-HSA-1250342
R-HSA-1250342
Reactome Name: PI3K events in ERBB4 signaling
See in Reactome
R-HSA-416476
R-HSA-201556
R-HSA-109704
R-HSA-210993
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-9028335
R-HSA-9028335
Reactome Name: Activated NTRK2 signals through PI3K
See in Reactome
R-HSA-9013404
R-HSA-9603381
R-HSA-9603381
Reactome Name: Activated NTRK3 signals through PI3K
See in Reactome
R-HSA-373753
|
R-HSA-186797
R-HSA-9012999
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-168256
R-HSA-194315
R-HSA-202733
R-HSA-202733
Reactome Name: Cell surface interactions at the vascular wall
See in Reactome
R-HSA-1500931
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-1236394
R-HSA-74752
R-HSA-1280218
R-HSA-1266738
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
R-HSA-5654687
R-HSA-5654687
Reactome Name: Downstream signaling of activated FGFR1
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-166520
R-HSA-194138
R-HSA-5684996
R-HSA-1430728
R-HSA-449147
R-HSA-1483257
R-HSA-1483255
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-389356
R-HSA-388396
R-HSA-556833
R-HSA-5654708
R-HSA-5654708
Reactome Name: Downstream signaling of activated FGFR3
See in Reactome
R-HSA-109582
R-HSA-202403
R-HSA-5654741
R-HSA-9006335
R-HSA-2029480
R-HSA-2029480
Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis
See in Reactome
R-HSA-190236
R-HSA-2454202
R-HSA-2454202
Reactome Name: Fc epsilon receptor (FCERI) signaling
See in Reactome
R-HSA-451927
R-HSA-9034015
R-HSA-168249
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-8939211
R-HSA-9006115
R-HSA-9675108
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-177929
R-HSA-187037
R-HSA-1280215
R-HSA-1280215
Reactome Name: Cytokine Signaling in Immune system
See in Reactome
R-HSA-6806834
R-HSA-372790
R-HSA-5654738
R-HSA-5654736
R-HSA-5654743
R-HSA-2172127
R-HSA-5654716
R-HSA-5654716
Reactome Name: Downstream signaling of activated FGFR4
See in Reactome
R-HSA-1227986
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-422475
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-76002
R-HSA-76002
Reactome Name: Platelet activation, signaling and aggregation
See in Reactome
R-HSA-162582
|
Immune System
Cell-Cell communication
Developmental Biology
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704;
R-HSA-112399
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-114542
(
R-HSA-1257604
)
R-HSA-1250189
(
R-HSA-1963642
)
R-HSA-1250189
Reaction Name: Binding of PI3K to ERBB2:p-ERBB3 heterodimer
See in Reactome
R-HSA-1250346
(
R-HSA-1963642
)
R-HSA-1250346
Reaction Name: Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers
See in Reactome
R-HSA-1250353
(
R-HSA-1250342
)
R-HSA-1250353
Reaction Name: Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250370
(
R-HSA-1250342
)
R-HSA-1250370
Reaction Name: Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers
See in Reactome
R-HSA-1250462
(
R-HSA-1963642
)
R-HSA-1250462
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3
See in Reactome
R-HSA-1306957
(
R-HSA-1963642
)
R-HSA-1306957
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR
See in Reactome
R-HSA-1306965
(
R-HSA-1963642
)
R-HSA-1306965
Reaction Name: Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR.
See in Reactome
R-HSA-1306979
(
R-HSA-1963642
)
R-HSA-1306979
Reaction Name: PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1
See in Reactome
R-HSA-1433514
(
R-HSA-1433557
)
R-HSA-1433514
Reaction Name: Synthesis of PIP3 from PIP2 by PI3K
See in Reactome
R-HSA-1562641
(
R-HSA-1433557
)
R-HSA-1562641
Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2
See in Reactome
R-HSA-1676048
(
R-HSA-1660499
)
R-HSA-1676048
Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
See in Reactome
R-HSA-1676109
(
R-HSA-1660499
)
R-HSA-1676109
Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
See in Reactome
R-HSA-177927
(
R-HSA-180292
)
R-HSA-177927
Reaction Name: PI3K binds to EGF:EGFR:GRB2:GAB1
See in Reactome
R-HSA-177939
(
R-HSA-180292
)
R-HSA-177939
Reaction Name: PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
See in Reactome
R-HSA-186780
(
R-HSA-186763
)
R-HSA-186780
Reaction Name: PI3-kinase binds to the active receptor
See in Reactome
R-HSA-186800
(
R-HSA-186763
)
R-HSA-186800
Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3
See in Reactome
R-HSA-198266
(
R-HSA-198203
)
R-HSA-198266
Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides
See in Reactome
R-HSA-198315
(
R-HSA-198203
)
R-HSA-198315
Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it
See in Reactome
R-HSA-201510
(
R-HSA-201556
)
R-HSA-201510
Reaction Name: PI3K synthesizes PIP3 downstream of ALK
See in Reactome
R-HSA-201515
(
R-HSA-201556
)
R-HSA-202203
(
R-HSA-202424
)
R-HSA-202203
Reaction Name: Recruitment of PI3K to plasma membrane
See in Reactome
R-HSA-202365
(
R-HSA-202424
)
R-HSA-202365
Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029271
(
R-HSA-2029485
)
R-HSA-2029271
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2029273
(
R-HSA-2029485
)
R-HSA-204798
(
R-HSA-210993
)
R-HSA-204798
Reaction Name: Interaction of Tie2 and p85 of PI3K
See in Reactome
R-HSA-205262
(
R-HSA-1433557
)
R-HSA-205262
Reaction Name: Direct recruitment of PI3K to p-KIT
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424480
(
R-HSA-2424491
)
R-HSA-2424480
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-2424482
(
R-HSA-2424491
)
R-HSA-2424482
Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK
See in Reactome
R-HSA-2730842
(
R-HSA-2730905
)
R-HSA-2730842
Reaction Name: PI3K associates with phosphorylated GAB2
See in Reactome
R-HSA-2730870
(
R-HSA-2730905
)
R-HSA-2730870
Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K
See in Reactome
R-HSA-388830
(
R-HSA-388841
)
R-HSA-388832
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
(
R-HSA-388841;
R-HSA-389357
)
R-HSA-389158
Reaction Name: CD28 bound PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-416358
(
R-HSA-416476
)
R-HSA-416358
Reaction Name: G alpha (q) inhibits PI3K alpha
See in Reactome
R-HSA-437162
(
R-HSA-114604
)
R-HSA-437162
Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3
See in Reactome
R-HSA-451758
(
R-HSA-373753
)
R-HSA-451758
Reaction Name: p85 associates with both p-Nephrin and CD2AP
See in Reactome
R-HSA-508247
(
R-HSA-512988;
R-HSA-912526
)
R-HSA-508247
Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases
See in Reactome
R-HSA-5218819
(
R-HSA-4420097
)
R-HSA-5218819
Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5218852
(
R-HSA-4420097
)
R-HSA-5357479
(
R-HSA-4420097
)
R-HSA-5654591
(
R-HSA-5654689
)
R-HSA-5654591
Reaction Name: Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654596
(
R-HSA-5654689
)
R-HSA-5654596
Reaction Name: Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654640
(
R-HSA-5654710
)
R-HSA-5654640
Reaction Name: Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654643
(
R-HSA-5654710
)
R-HSA-5654643
Reaction Name: Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654662
(
R-HSA-5654720
)
R-HSA-5654662
Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654669
(
R-HSA-5654720
)
R-HSA-5654669
Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA
See in Reactome
R-HSA-5654690
(
R-HSA-5654689
)
R-HSA-5654690
Reaction Name: FGFR1-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654692
(
R-HSA-5654689
)
R-HSA-5654692
Reaction Name: FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654705
(
R-HSA-5654710
)
R-HSA-5654705
Reaction Name: FGFR3-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654709
(
R-HSA-5654710
)
R-HSA-5654709
Reaction Name: FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654714
(
R-HSA-5654720
)
R-HSA-5654714
Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654717
(
R-HSA-5654720
)
R-HSA-5654717
Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-74737
(
R-HSA-112399
)
R-HSA-879917
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-879917
Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
See in Reactome
R-HSA-8851954
(
R-HSA-8851907
)
R-HSA-8851954
Reaction Name: Phosphorylated GAB1 recruits PI3K to MET
See in Reactome
R-HSA-8852019
(
R-HSA-8851907
)
R-HSA-8854905
(
R-HSA-8853659
)
R-HSA-8854905
Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K
See in Reactome
R-HSA-9012657
(
R-HSA-9027276
)
R-HSA-9012657
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
See in Reactome
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014294
(
R-HSA-9013404
)
R-HSA-9014294
Reaction Name: RAC2 binds effectors at the plasma membrane
See in Reactome
R-HSA-9021627
(
R-HSA-9027276
)
R-HSA-9021627
Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-9021660
(
R-HSA-9009391
)
R-HSA-9021660
Reaction Name: PI3K binds membrane-associated estrogen receptors
See in Reactome
R-HSA-9027275
(
R-HSA-9027276
)
R-HSA-9027275
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K
See in Reactome
R-HSA-9027280
(
R-HSA-9027276
)
R-HSA-9027280
Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K
See in Reactome
R-HSA-9028505
(
R-HSA-9028335
)
R-HSA-9028519
(
R-HSA-9028335
)
R-HSA-9028519
Reaction Name: NTRK2-activated PI3K generates PIP3
See in Reactome
R-HSA-912627
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-912629
(
R-HSA-512988;
R-HSA-912631
)
R-HSA-914182
(
R-HSA-512988
)
R-HSA-914182
Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K
See in Reactome
R-HSA-9603407
(
R-HSA-9603381
)
R-HSA-9603445
(
R-HSA-9603381
)
R-HSA-9603445
Reaction Name: Activated NTRK3 stimulates PI3K activity
See in Reactome
R-HSA-9632412
(
R-HSA-9009391
)
R-HSA-9632412
Reaction Name: PTK2 is recruited to methylated ESR1
See in Reactome
R-HSA-9658253
(
R-HSA-5673001
)
R-HSA-9698170
(
R-HSA-9607240
)
R-HSA-9698170
Reaction Name: Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-9706345
(
R-HSA-9607240
)
R-HSA-9706345
Reaction Name: Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA
See in Reactome
|