MONDO:0005387 |
NOS3 |
P29474 |
1.14.13.39
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-203754
R-HSA-203754
Reactome Name: NOSIP mediated eNOS trafficking
See in Reactome
R-HSA-392154
R-HSA-392154
Reactome Name: Nitric oxide stimulates guanylate cyclase
See in Reactome
R-HSA-203615
R-HSA-203641
R-HSA-203641
Reactome Name: NOSTRIN mediated eNOS trafficking
See in Reactome
R-HSA-1474151
R-HSA-1474151
Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
See in Reactome
R-HSA-9009391
R-HSA-9009391
Reactome Name: Extra-nuclear estrogen signaling
See in Reactome
R-HSA-5218920
R-HSA-5218920
Reactome Name: VEGFR2 mediated vascular permeability
See in Reactome
|
R-HSA-4420097
R-HSA-8978934
R-HSA-194138
R-HSA-196854
R-HSA-196854
Reactome Name: Metabolism of vitamins and cofactors
See in Reactome
R-HSA-168256
R-HSA-202131
R-HSA-202131
Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation
See in Reactome
R-HSA-9006931
R-HSA-9006931
Reactome Name: Signaling by Nuclear Receptors
See in Reactome
R-HSA-1430728
R-HSA-418346
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-8939211
R-HSA-168249
R-HSA-109582
R-HSA-162582
|
Immune System
Metabolism
Hemostasis
Signal Transduction
|
R-HSA-1497784
(
R-HSA-1474151;
R-HSA-203615;
R-HSA-5218920
)
R-HSA-1497784
Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle
See in Reactome
R-HSA-1497796
(
R-HSA-1474151;
R-HSA-203615
)
R-HSA-1497796
Reaction Name: BH2 binding can lead to eNOS uncoupling
See in Reactome
R-HSA-1497810
(
R-HSA-203615
)
R-HSA-1497810
Reaction Name: Uncoupled eNOS favours the formation of superoxide
See in Reactome
R-HSA-202110
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202110
Reaction Name: eNOS:Caveolin-1 complex binds to CaM
See in Reactome
R-HSA-202111
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202127
(
R-HSA-203615;
R-HSA-5218920;
R-HSA-9009391
)
R-HSA-202129
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202129
Reaction Name: HSP90 binds eNOS:Caveolin-1:CaM complex
See in Reactome
R-HSA-202132
(
R-HSA-203615
)
R-HSA-202132
Reaction Name: depalmitoylated eNOS translocates from plasma membrane
See in Reactome
R-HSA-202137
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202137
Reaction Name: AKT1 binds eNOS complex via HSP90
See in Reactome
R-HSA-202144
(
R-HSA-203615;
R-HSA-5218920
)
R-HSA-202144
Reaction Name: Caveolin-1 dissociates from eNOS:CaM:HSP90 complex
See in Reactome
R-HSA-203553
(
R-HSA-203754
)
R-HSA-203565
(
R-HSA-203641
)
R-HSA-203565
Reaction Name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP
See in Reactome
R-HSA-203567
(
R-HSA-203615
)
R-HSA-203611
(
R-HSA-203615
)
R-HSA-203613
(
R-HSA-203615
)
R-HSA-203625
(
R-HSA-203641
)
R-HSA-203625
Reaction Name: NOSTRIN mediated translocation of eNOS from plasma membrane
See in Reactome
R-HSA-203662
(
R-HSA-203641
)
R-HSA-203662
Reaction Name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2
See in Reactome
R-HSA-203680
(
R-HSA-203754
)
R-HSA-203680
Reaction Name: eNOS:NOSIP translocation from caveolae to intracellular compartments
See in Reactome
R-HSA-203700
(
R-HSA-203615
)
R-HSA-203700
Reaction Name: eNOS translocation from Golgi to Caveolae
See in Reactome
R-HSA-203712
(
R-HSA-203615
)
R-HSA-203712
Reaction Name: eNOS associates with Caveolin-1
See in Reactome
R-HSA-203716
(
R-HSA-203641
)
R-HSA-203716
Reaction Name: eNOS:Caveolin-1 complex binds to Nostrin
See in Reactome
R-HSA-418436
(
R-HSA-1222556;
R-HSA-392154
)
R-HSA-418436
Reaction Name: Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
See in Reactome
|
MONDO:0009054 |
ATP6V1A |
P38606 |
7.1.2.2
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-917977
R-HSA-917977
Reactome Name: Transferrin endocytosis and recycling
See in Reactome
R-HSA-983712
R-HSA-9639288
R-HSA-77387
|
R-HSA-168256
R-HSA-8953897
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-168249
R-HSA-2262752
R-HSA-917937
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-382551
R-HSA-74752
R-HSA-162582
|
Immune System
Cellular responses to stimuli
Transport of small molecules
Signal Transduction
|
R-HSA-1222516
(
R-HSA-1222556
)
R-HSA-1222516
Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase
See in Reactome
R-HSA-5252133
(
R-HSA-77387;
R-HSA-917977;
R-HSA-983712
)
R-HSA-74723
(
R-HSA-77387
)
R-HSA-917841
(
R-HSA-917977
)
R-HSA-917841
Reaction Name: Acidification of Tf:TfR1 containing endosome
See in Reactome
R-HSA-9639286
(
R-HSA-9639288
)
R-HSA-9640167
(
R-HSA-9639288
)
R-HSA-9640168
(
R-HSA-9639288
)
R-HSA-9640168
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine
See in Reactome
R-HSA-9640175
(
R-HSA-9639288
)
R-HSA-9640175
Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645598
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0010389 |
CYBB |
P04839 |
1.-.-.-
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-4420097
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-1236973
R-HSA-1236973
Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes)
See in Reactome
R-HSA-9013423
R-HSA-6798695
R-HSA-9013404
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-9013149
|
R-HSA-195258
R-HSA-8953897
R-HSA-9012999
R-HSA-194138
R-HSA-168256
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-194315
R-HSA-2262752
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168249
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Cellular responses to stimuli
Immune System
Signal Transduction
|
R-HSA-1222376
(
R-HSA-3299685
)
R-HSA-1222376
Reaction Name: NOX2 generates superoxide from oxygen
See in Reactome
R-HSA-1236967
(
R-HSA-1236973
)
R-HSA-1236967
Reaction Name: Alkalization of the phagosomal lumen by NOX2
See in Reactome
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5668605
(
R-HSA-5668599
)
R-HSA-5668629
(
R-HSA-5668599
)
R-HSA-5668629
Reaction Name: Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP
See in Reactome
R-HSA-6789092
(
R-HSA-1222556
)
R-HSA-6789092
Reaction Name: NOX2 generates superoxide anion from oxygen
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-6807557
(
R-HSA-3299685
)
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014424
(
R-HSA-9013404
)
R-HSA-9014424
Reaction Name: RAC2 binds effectors at the phagocytic vesicle membrane
See in Reactome
R-HSA-9018808
(
R-HSA-9013423
)
R-HSA-9018808
Reaction Name: RAC3 binds effectors at the plasma membrane
See in Reactome
R-HSA-9626848
(
R-HSA-5668599
)
R-HSA-9626848
Reaction Name: S100A8:S100A9:AA:Ca(2+) binds NOX2 complex
See in Reactome
|
MONDO:0010600 |
CYBB |
P04839 |
1.-.-.-
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-4420097
R-HSA-5668599
R-HSA-5668599
Reactome Name: RHO GTPases Activate NADPH Oxidases
See in Reactome
R-HSA-1236973
R-HSA-1236973
Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes)
See in Reactome
R-HSA-9013423
R-HSA-6798695
R-HSA-9013404
R-HSA-3299685
R-HSA-3299685
Reactome Name: Detoxification of Reactive Oxygen Species
See in Reactome
R-HSA-9013149
|
R-HSA-195258
R-HSA-8953897
R-HSA-9012999
R-HSA-194138
R-HSA-168256
R-HSA-1236975
R-HSA-1236975
Reactome Name: Antigen processing-Cross presentation
See in Reactome
R-HSA-194315
R-HSA-2262752
R-HSA-983169
R-HSA-983169
Reactome Name: Class I MHC mediated antigen processing & presentation
See in Reactome
R-HSA-168249
R-HSA-9711123
R-HSA-9711123
Reactome Name: Cellular response to chemical stress
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-9716542
R-HSA-9716542
Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3
See in Reactome
R-HSA-1280218
R-HSA-162582
|
Cellular responses to stimuli
Immune System
Signal Transduction
|
R-HSA-1222376
(
R-HSA-3299685
)
R-HSA-1222376
Reaction Name: NOX2 generates superoxide from oxygen
See in Reactome
R-HSA-1236967
(
R-HSA-1236973
)
R-HSA-1236967
Reaction Name: Alkalization of the phagosomal lumen by NOX2
See in Reactome
R-HSA-5218827
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218827
Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1
See in Reactome
R-HSA-5218841
(
R-HSA-4420097;
R-HSA-5668599
)
R-HSA-5218841
Reaction Name: NADPH oxidase 2 generates superoxide from oxygen
See in Reactome
R-HSA-5668605
(
R-HSA-5668599
)
R-HSA-5668629
(
R-HSA-5668599
)
R-HSA-5668629
Reaction Name: Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP
See in Reactome
R-HSA-6789092
(
R-HSA-1222556
)
R-HSA-6789092
Reaction Name: NOX2 generates superoxide anion from oxygen
See in Reactome
R-HSA-6798747
(
R-HSA-6798695
)
R-HSA-6798747
Reaction Name: Exocytosis of tertiary granule membrane proteins
See in Reactome
R-HSA-6799350
(
R-HSA-6798695
)
R-HSA-6799350
Reaction Name: Exocytosis of specific granule membrane proteins
See in Reactome
R-HSA-6807557
(
R-HSA-3299685
)
R-HSA-9013145
(
R-HSA-9013149
)
R-HSA-9013145
Reaction Name: RAC1 binds effectors at the plasma membrane
See in Reactome
R-HSA-9014424
(
R-HSA-9013404
)
R-HSA-9014424
Reaction Name: RAC2 binds effectors at the phagocytic vesicle membrane
See in Reactome
R-HSA-9018808
(
R-HSA-9013423
)
R-HSA-9018808
Reaction Name: RAC3 binds effectors at the plasma membrane
See in Reactome
R-HSA-9626848
(
R-HSA-5668599
)
R-HSA-9626848
Reaction Name: S100A8:S100A9:AA:Ca(2+) binds NOX2 complex
See in Reactome
|
MONDO:0018614 |
ATP6V1A |
P38606 |
7.1.2.2
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-917977
R-HSA-917977
Reactome Name: Transferrin endocytosis and recycling
See in Reactome
R-HSA-983712
R-HSA-9639288
R-HSA-77387
|
R-HSA-168256
R-HSA-8953897
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-168249
R-HSA-2262752
R-HSA-917937
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-382551
R-HSA-74752
R-HSA-162582
|
Immune System
Cellular responses to stimuli
Transport of small molecules
Signal Transduction
|
R-HSA-1222516
(
R-HSA-1222556
)
R-HSA-1222516
Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase
See in Reactome
R-HSA-5252133
(
R-HSA-77387;
R-HSA-917977;
R-HSA-983712
)
R-HSA-74723
(
R-HSA-77387
)
R-HSA-917841
(
R-HSA-917977
)
R-HSA-917841
Reaction Name: Acidification of Tf:TfR1 containing endosome
See in Reactome
R-HSA-9639286
(
R-HSA-9639288
)
R-HSA-9640167
(
R-HSA-9639288
)
R-HSA-9640168
(
R-HSA-9639288
)
R-HSA-9640168
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine
See in Reactome
R-HSA-9640175
(
R-HSA-9639288
)
R-HSA-9640175
Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645598
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0019635 |
NOS1 |
P29475 |
1.14.13.39
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-5578775
R-HSA-392154
R-HSA-392154
Reactome Name: Nitric oxide stimulates guanylate cyclase
See in Reactome
|
R-HSA-5576891
R-HSA-397014
R-HSA-168256
R-HSA-168249
R-HSA-418346
R-HSA-109582
|
Muscle contraction
Immune System
Hemostasis
|
R-HSA-418436
(
R-HSA-1222556;
R-HSA-392154
)
R-HSA-418436
Reaction Name: Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)
See in Reactome
R-HSA-5617178
(
R-HSA-5578775
)
R-HSA-5617178
Reaction Name: ATP2B4 binds to NOS1, inhibiting it
See in Reactome
R-HSA-5617179
(
R-HSA-5578775
)
R-HSA-5617182
(
R-HSA-5578775
)
|
MONDO:0020632 |
ATP6V1A |
P38606 |
7.1.2.2
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-917977
R-HSA-917977
Reactome Name: Transferrin endocytosis and recycling
See in Reactome
R-HSA-983712
R-HSA-9639288
R-HSA-77387
|
R-HSA-168256
R-HSA-8953897
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-168249
R-HSA-2262752
R-HSA-917937
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-382551
R-HSA-74752
R-HSA-162582
|
Immune System
Cellular responses to stimuli
Transport of small molecules
Signal Transduction
|
R-HSA-1222516
(
R-HSA-1222556
)
R-HSA-1222516
Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase
See in Reactome
R-HSA-5252133
(
R-HSA-77387;
R-HSA-917977;
R-HSA-983712
)
R-HSA-74723
(
R-HSA-77387
)
R-HSA-917841
(
R-HSA-917977
)
R-HSA-917841
Reaction Name: Acidification of Tf:TfR1 containing endosome
See in Reactome
R-HSA-9639286
(
R-HSA-9639288
)
R-HSA-9640167
(
R-HSA-9639288
)
R-HSA-9640168
(
R-HSA-9639288
)
R-HSA-9640168
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine
See in Reactome
R-HSA-9640175
(
R-HSA-9639288
)
R-HSA-9640175
Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645598
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|
MONDO:0027451 |
ATP6V1A |
P38606 |
7.1.2.2
|
R-HSA-1222556
R-HSA-1222556
Reactome Name: ROS and RNS production in phagocytes
See in Reactome
R-HSA-917977
R-HSA-917977
Reactome Name: Transferrin endocytosis and recycling
See in Reactome
R-HSA-983712
R-HSA-9639288
R-HSA-77387
|
R-HSA-168256
R-HSA-8953897
R-HSA-9711097
R-HSA-9711097
Reactome Name: Cellular response to starvation
See in Reactome
R-HSA-168249
R-HSA-2262752
R-HSA-917937
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-382551
R-HSA-74752
R-HSA-162582
|
Immune System
Cellular responses to stimuli
Transport of small molecules
Signal Transduction
|
R-HSA-1222516
(
R-HSA-1222556
)
R-HSA-1222516
Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase
See in Reactome
R-HSA-5252133
(
R-HSA-77387;
R-HSA-917977;
R-HSA-983712
)
R-HSA-74723
(
R-HSA-77387
)
R-HSA-917841
(
R-HSA-917977
)
R-HSA-917841
Reaction Name: Acidification of Tf:TfR1 containing endosome
See in Reactome
R-HSA-9639286
(
R-HSA-9639288
)
R-HSA-9640167
(
R-HSA-9639288
)
R-HSA-9640168
(
R-HSA-9639288
)
R-HSA-9640168
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine
See in Reactome
R-HSA-9640175
(
R-HSA-9639288
)
R-HSA-9640175
Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine
See in Reactome
R-HSA-9640195
(
R-HSA-9639288
)
R-HSA-9645598
(
R-HSA-9639288
)
R-HSA-9645608
(
R-HSA-9639288
)
R-HSA-9645608
Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1
See in Reactome
R-HSA-9646468
(
R-HSA-9639288
)
|