DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-1222556)

Number of enzymes:	4
Number of disease:	8
Number of reactomes:	21
Number of reactions:	51

Search results (Reactome ID: R-HSA-1222556)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005387	NOS3	P29474	1.14.13.39	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-203754 R-HSA-203754 Reactome Name: NOSIP mediated eNOS trafficking See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome R-HSA-203615 R-HSA-203615 Reactome Name: eNOS activation See in Reactome R-HSA-203641 R-HSA-203641 Reactome Name: NOSTRIN mediated eNOS trafficking See in Reactome R-HSA-1474151 R-HSA-1474151 Reactome Name: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-5218920 R-HSA-5218920 Reactome Name: VEGFR2 mediated vascular permeability See in Reactome	R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-8978934 R-HSA-8978934 Reactome Name: Metabolism of cofactors See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-196854 R-HSA-196854 Reactome Name: Metabolism of vitamins and cofactors See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202131 R-HSA-202131 Reactome Name: Metabolism of nitric oxide: NOS3 activation and regulation See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism Hemostasis Signal Transduction	R-HSA-1497784 ( R-HSA-1474151; R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-1497784 Reaction Name: The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle See in Reactome R-HSA-1497796 ( R-HSA-1474151; R-HSA-203615 ) R-HSA-1497796 Reaction Name: BH2 binding can lead to eNOS uncoupling See in Reactome R-HSA-1497810 ( R-HSA-203615 ) R-HSA-1497810 Reaction Name: Uncoupled eNOS favours the formation of superoxide See in Reactome R-HSA-202110 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202110 Reaction Name: eNOS:Caveolin-1 complex binds to CaM See in Reactome R-HSA-202111 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202111 Reaction Name: AKT1 phosphorylates eNOS See in Reactome R-HSA-202127 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920; R-HSA-9009391 ) R-HSA-202127 Reaction Name: eNOS synthesizes NO See in Reactome R-HSA-202129 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202129 Reaction Name: HSP90 binds eNOS:Caveolin-1:CaM complex See in Reactome R-HSA-202132 ( R-HSA-203615 ) R-HSA-202132 Reaction Name: depalmitoylated eNOS translocates from plasma membrane See in Reactome R-HSA-202137 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202137 Reaction Name: AKT1 binds eNOS complex via HSP90 See in Reactome R-HSA-202144 ( R-HSA-203615; R-HSA-4420097; R-HSA-5218920 ) R-HSA-202144 Reaction Name: Caveolin-1 dissociates from eNOS:CaM:HSP90 complex See in Reactome R-HSA-203553 ( R-HSA-203754 ) R-HSA-203553 Reaction Name: eNOS binds NOSIP See in Reactome R-HSA-203565 ( R-HSA-203641 ) R-HSA-203565 Reaction Name: eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP See in Reactome R-HSA-203567 ( R-HSA-203615 ) R-HSA-203567 Reaction Name: palmitoylation of eNOS See in Reactome R-HSA-203611 ( R-HSA-203615 ) R-HSA-203611 Reaction Name: N-myristoylation of eNOS See in Reactome R-HSA-203613 ( R-HSA-203615 ) R-HSA-203613 Reaction Name: depalmitoylation of eNOS See in Reactome R-HSA-203625 ( R-HSA-203641 ) R-HSA-203625 Reaction Name: NOSTRIN mediated translocation of eNOS from plasma membrane See in Reactome R-HSA-203662 ( R-HSA-203641 ) R-HSA-203662 Reaction Name: eNOS:Caveolin-1:NOSTRIN complex binds dynamin-2 See in Reactome R-HSA-203680 ( R-HSA-203754 ) R-HSA-203680 Reaction Name: eNOS:NOSIP translocation from caveolae to intracellular compartments See in Reactome R-HSA-203700 ( R-HSA-203615 ) R-HSA-203700 Reaction Name: eNOS translocation from Golgi to Caveolae See in Reactome R-HSA-203712 ( R-HSA-203615 ) R-HSA-203712 Reaction Name: eNOS associates with Caveolin-1 See in Reactome R-HSA-203716 ( R-HSA-203641 ) R-HSA-203716 Reaction Name: eNOS:Caveolin-1 complex binds to Nostrin See in Reactome R-HSA-418436 ( R-HSA-1222556; R-HSA-392154 ) R-HSA-418436 Reaction Name: Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) See in Reactome
MONDO:0009054	ATP6V1A	P38606	7.1.2.2	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-917977 R-HSA-917977 Reactome Name: Transferrin endocytosis and recycling See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cellular responses to stimuli Transport of small molecules Signal Transduction	R-HSA-1222516 ( R-HSA-1222556 ) R-HSA-1222516 Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase See in Reactome R-HSA-5252133 ( R-HSA-77387; R-HSA-917977; R-HSA-983712 ) R-HSA-5252133 Reaction Name: ATP6AP1 binds V-ATPase See in Reactome R-HSA-74723 ( R-HSA-77387 ) R-HSA-74723 Reaction Name: Endosome acidification See in Reactome R-HSA-917841 ( R-HSA-917977 ) R-HSA-917841 Reaction Name: Acidification of Tf:TfR1 containing endosome See in Reactome R-HSA-9639286 ( R-HSA-9639288 ) R-HSA-9639286 Reaction Name: RRAGC,D exchanges GTP for GDP See in Reactome R-HSA-9640167 ( R-HSA-9639288 ) R-HSA-9640167 Reaction Name: RRAGA,B exchanges GDP for GTP See in Reactome R-HSA-9640168 ( R-HSA-9639288 ) R-HSA-9640168 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine See in Reactome R-HSA-9640175 ( R-HSA-9639288 ) R-HSA-9640175 Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645598 ( R-HSA-9639288 ) R-HSA-9645598 Reaction Name: RRAGC,D hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0010389	CYBB	P04839	1.-.-.-	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-1236973 R-HSA-1236973 Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes) See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cellular responses to stimuli Immune System Signal Transduction	R-HSA-1222376 ( R-HSA-3299685 ) R-HSA-1222376 Reaction Name: NOX2 generates superoxide from oxygen See in Reactome R-HSA-1236967 ( R-HSA-1236973 ) R-HSA-1236967 Reaction Name: Alkalization of the phagosomal lumen by NOX2 See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5668605 ( R-HSA-5668599 ) R-HSA-5668605 Reaction Name: RAC2:GTP binds NOX2 complex See in Reactome R-HSA-5668629 ( R-HSA-5668599 ) R-HSA-5668629 Reaction Name: Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP See in Reactome R-HSA-6789092 ( R-HSA-1222556 ) R-HSA-6789092 Reaction Name: NOX2 generates superoxide anion from oxygen See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-6807557 ( R-HSA-3299685 ) R-HSA-6807557 Reaction Name: NOX4, NOX5 reduce O2 to O2.- See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014424 ( R-HSA-9013404 ) R-HSA-9014424 Reaction Name: RAC2 binds effectors at the phagocytic vesicle membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9626848 ( R-HSA-5668599 ) R-HSA-9626848 Reaction Name: S100A8:S100A9:AA:Ca(2+) binds NOX2 complex See in Reactome
MONDO:0010600	CYBB	P04839	1.-.-.-	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-1236973 R-HSA-1236973 Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes) See in Reactome R-HSA-9013423 R-HSA-9013423 Reactome Name: RAC3 GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013404 R-HSA-9013404 Reactome Name: RAC2 GTPase cycle See in Reactome R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-9013149 R-HSA-9013149 Reactome Name: RAC1 GTPase cycle See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cellular responses to stimuli Immune System Signal Transduction	R-HSA-1222376 ( R-HSA-3299685 ) R-HSA-1222376 Reaction Name: NOX2 generates superoxide from oxygen See in Reactome R-HSA-1236967 ( R-HSA-1236973 ) R-HSA-1236967 Reaction Name: Alkalization of the phagosomal lumen by NOX2 See in Reactome R-HSA-5218827 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218827 Reaction Name: NADPH oxidase 2 (NOX2) complex binds RAC1 See in Reactome R-HSA-5218841 ( R-HSA-4420097; R-HSA-5668599 ) R-HSA-5218841 Reaction Name: NADPH oxidase 2 generates superoxide from oxygen See in Reactome R-HSA-5668605 ( R-HSA-5668599 ) R-HSA-5668605 Reaction Name: RAC2:GTP binds NOX2 complex See in Reactome R-HSA-5668629 ( R-HSA-5668599 ) R-HSA-5668629 Reaction Name: Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP See in Reactome R-HSA-6789092 ( R-HSA-1222556 ) R-HSA-6789092 Reaction Name: NOX2 generates superoxide anion from oxygen See in Reactome R-HSA-6798747 ( R-HSA-6798695 ) R-HSA-6798747 Reaction Name: Exocytosis of tertiary granule membrane proteins See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-6807557 ( R-HSA-3299685 ) R-HSA-6807557 Reaction Name: NOX4, NOX5 reduce O2 to O2.- See in Reactome R-HSA-9013145 ( R-HSA-9013149 ) R-HSA-9013145 Reaction Name: RAC1 binds effectors at the plasma membrane See in Reactome R-HSA-9014424 ( R-HSA-9013404 ) R-HSA-9014424 Reaction Name: RAC2 binds effectors at the phagocytic vesicle membrane See in Reactome R-HSA-9018808 ( R-HSA-9013423 ) R-HSA-9018808 Reaction Name: RAC3 binds effectors at the plasma membrane See in Reactome R-HSA-9626848 ( R-HSA-5668599 ) R-HSA-9626848 Reaction Name: S100A8:S100A9:AA:Ca(2+) binds NOX2 complex See in Reactome
MONDO:0018614	ATP6V1A	P38606	7.1.2.2	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-917977 R-HSA-917977 Reactome Name: Transferrin endocytosis and recycling See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cellular responses to stimuli Transport of small molecules Signal Transduction	R-HSA-1222516 ( R-HSA-1222556 ) R-HSA-1222516 Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase See in Reactome R-HSA-5252133 ( R-HSA-77387; R-HSA-917977; R-HSA-983712 ) R-HSA-5252133 Reaction Name: ATP6AP1 binds V-ATPase See in Reactome R-HSA-74723 ( R-HSA-77387 ) R-HSA-74723 Reaction Name: Endosome acidification See in Reactome R-HSA-917841 ( R-HSA-917977 ) R-HSA-917841 Reaction Name: Acidification of Tf:TfR1 containing endosome See in Reactome R-HSA-9639286 ( R-HSA-9639288 ) R-HSA-9639286 Reaction Name: RRAGC,D exchanges GTP for GDP See in Reactome R-HSA-9640167 ( R-HSA-9639288 ) R-HSA-9640167 Reaction Name: RRAGA,B exchanges GDP for GTP See in Reactome R-HSA-9640168 ( R-HSA-9639288 ) R-HSA-9640168 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine See in Reactome R-HSA-9640175 ( R-HSA-9639288 ) R-HSA-9640175 Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645598 ( R-HSA-9639288 ) R-HSA-9645598 Reaction Name: RRAGC,D hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0019635	NOS1	P29475	1.14.13.39	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-5578775 R-HSA-5578775 Reactome Name: Ion homeostasis See in Reactome R-HSA-392154 R-HSA-392154 Reactome Name: Nitric oxide stimulates guanylate cyclase See in Reactome	R-HSA-5576891 R-HSA-5576891 Reactome Name: Cardiac conduction See in Reactome R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-418346 R-HSA-418346 Reactome Name: Platelet homeostasis See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Immune System Hemostasis	R-HSA-418436 ( R-HSA-1222556; R-HSA-392154 ) R-HSA-418436 Reaction Name: Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO) See in Reactome R-HSA-5617178 ( R-HSA-5578775 ) R-HSA-5617178 Reaction Name: ATP2B4 binds to NOS1, inhibiting it See in Reactome R-HSA-5617179 ( R-HSA-5578775 ) R-HSA-5617179 Reaction Name: PRKACA phosphorylates TNNI3 See in Reactome R-HSA-5617182 ( R-HSA-5578775 ) R-HSA-5617182 Reaction Name: PRKACA phosphorylates PLN See in Reactome
MONDO:0020632	ATP6V1A	P38606	7.1.2.2	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-917977 R-HSA-917977 Reactome Name: Transferrin endocytosis and recycling See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cellular responses to stimuli Transport of small molecules Signal Transduction	R-HSA-1222516 ( R-HSA-1222556 ) R-HSA-1222516 Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase See in Reactome R-HSA-5252133 ( R-HSA-77387; R-HSA-917977; R-HSA-983712 ) R-HSA-5252133 Reaction Name: ATP6AP1 binds V-ATPase See in Reactome R-HSA-74723 ( R-HSA-77387 ) R-HSA-74723 Reaction Name: Endosome acidification See in Reactome R-HSA-917841 ( R-HSA-917977 ) R-HSA-917841 Reaction Name: Acidification of Tf:TfR1 containing endosome See in Reactome R-HSA-9639286 ( R-HSA-9639288 ) R-HSA-9639286 Reaction Name: RRAGC,D exchanges GTP for GDP See in Reactome R-HSA-9640167 ( R-HSA-9639288 ) R-HSA-9640167 Reaction Name: RRAGA,B exchanges GDP for GTP See in Reactome R-HSA-9640168 ( R-HSA-9639288 ) R-HSA-9640168 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine See in Reactome R-HSA-9640175 ( R-HSA-9639288 ) R-HSA-9640175 Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645598 ( R-HSA-9639288 ) R-HSA-9645598 Reaction Name: RRAGC,D hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome
MONDO:0027451	ATP6V1A	P38606	7.1.2.2	R-HSA-1222556 R-HSA-1222556 Reactome Name: ROS and RNS production in phagocytes See in Reactome R-HSA-917977 R-HSA-917977 Reactome Name: Transferrin endocytosis and recycling See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-9639288 R-HSA-9639288 Reactome Name: Amino acids regulate mTORC1 See in Reactome R-HSA-77387 R-HSA-77387 Reactome Name: Insulin receptor recycling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-9711097 R-HSA-9711097 Reactome Name: Cellular response to starvation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-917937 R-HSA-917937 Reactome Name: Iron uptake and transport See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cellular responses to stimuli Transport of small molecules Signal Transduction	R-HSA-1222516 ( R-HSA-1222556 ) R-HSA-1222516 Reaction Name: Intraphagosomal pH is lowered to 5 by V-ATPase See in Reactome R-HSA-5252133 ( R-HSA-77387; R-HSA-917977; R-HSA-983712 ) R-HSA-5252133 Reaction Name: ATP6AP1 binds V-ATPase See in Reactome R-HSA-74723 ( R-HSA-77387 ) R-HSA-74723 Reaction Name: Endosome acidification See in Reactome R-HSA-917841 ( R-HSA-917977 ) R-HSA-917841 Reaction Name: Acidification of Tf:TfR1 containing endosome See in Reactome R-HSA-9639286 ( R-HSA-9639288 ) R-HSA-9639286 Reaction Name: RRAGC,D exchanges GTP for GDP See in Reactome R-HSA-9640167 ( R-HSA-9639288 ) R-HSA-9640167 Reaction Name: RRAGA,B exchanges GDP for GTP See in Reactome R-HSA-9640168 ( R-HSA-9639288 ) R-HSA-9640168 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine See in Reactome R-HSA-9640175 ( R-HSA-9639288 ) R-HSA-9640175 Reaction Name: v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine See in Reactome R-HSA-9640195 ( R-HSA-9639288 ) R-HSA-9640195 Reaction Name: RRAGA,B hydrolyzes GTP See in Reactome R-HSA-9645598 ( R-HSA-9639288 ) R-HSA-9645598 Reaction Name: RRAGC,D hydrolyzes GTP See in Reactome R-HSA-9645608 ( R-HSA-9639288 ) R-HSA-9645608 Reaction Name: v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 See in Reactome R-HSA-9646468 ( R-HSA-9639288 ) R-HSA-9646468 Reaction Name: mTORC1 binds RHEB:GTP See in Reactome