DAR - Bologna Biocomputing Group

Search results (Reactome ID: R-HSA-114608)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0000468	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0007103	SOD1	P00441	1.15.1.1	R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8950505 R-HSA-8950505 Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Cellular responses to stimuli Immune System Hemostasis	R-HSA-3299691 ( R-HSA-3299685 ) R-HSA-3299691 Reaction Name: SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) See in Reactome R-HSA-3299753 ( R-HSA-3299685 ) R-HSA-3299753 Reaction Name: CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 See in Reactome R-HSA-3697860 ( R-HSA-3299685 ) R-HSA-3697860 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ See in Reactome R-HSA-3777112 ( R-HSA-3299685 ) R-HSA-3777112 Reaction Name: SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) See in Reactome R-HSA-3780958 ( R-HSA-3299685 ) R-HSA-3780958 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) See in Reactome R-HSA-3780979 ( R-HSA-3299685 ) R-HSA-3780979 Reaction Name: CCS transfers Cu to SOD1 (mitochondrial) See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome R-HSA-8950771 ( R-HSA-8950505 ) R-HSA-8950771 Reaction Name: Expression of SOD1 See in Reactome R-HSA-8951723 ( R-HSA-3299685 ) R-HSA-8951723 Reaction Name: 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates See in Reactome
MONDO:0009009	PLG	P00747	3.4.21.7	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-75205 R-HSA-75205 Reactome Name: Dissolution of Fibrin Clot See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome	R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Extracellular matrix organization Hemostasis Signal Transduction	R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-158721 ( R-HSA-75205 ) R-HSA-158721 Reaction Name: histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen See in Reactome R-HSA-158722 ( R-HSA-75205 ) R-HSA-158722 Reaction Name: histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen See in Reactome R-HSA-158744 ( R-HSA-75205 ) R-HSA-158744 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin See in Reactome R-HSA-158747 ( R-HSA-75205 ) R-HSA-158747 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) See in Reactome R-HSA-158750 ( R-HSA-75205 ) R-HSA-158750 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin See in Reactome R-HSA-158756 ( R-HSA-75205 ) R-HSA-158756 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen See in Reactome R-HSA-158766 ( R-HSA-75205 ) R-HSA-158766 Reaction Name: fibrin multimer, crosslinked -> fibrin digestion products (plasmin) See in Reactome R-HSA-158784 ( R-HSA-75205 ) R-HSA-158784 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen See in Reactome R-HSA-158893 ( R-HSA-75205 ) R-HSA-158893 Reaction Name: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin See in Reactome R-HSA-158925 ( R-HSA-75205 ) R-HSA-158925 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) See in Reactome R-HSA-158941 ( R-HSA-75205 ) R-HSA-158941 Reaction Name: plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein See in Reactome R-HSA-158942 ( R-HSA-75205 ) R-HSA-158942 Reaction Name: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR See in Reactome R-HSA-158982 ( R-HSA-75205 ) R-HSA-158982 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1602458 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602458 Reaction Name: Activation of proMMP10 See in Reactome R-HSA-1602488 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-381461 ( R-HSA-381426 ) R-HSA-381461 Reaction Name: Plasmin proteolyzes IGF:IGFBP-3:ALS See in Reactome R-HSA-382061 ( R-HSA-186797 ) R-HSA-382061 Reaction Name: Extracellular processing of novel PDGFs See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome
MONDO:0010870	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0011362	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0011400	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0012031	CD36	P16671	-	R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-434313 R-HSA-434313 Reactome Name: Intracellular metabolism of fatty acids regulates insulin secretion See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1236973 R-HSA-1236973 Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-3000471 R-HSA-3000471 Reactome Name: Scavenging by Class B Receptors See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5686938 R-HSA-5686938 Reactome Name: Regulation of TLR by endogenous ligand See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-2173782 R-HSA-2173782 Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors See in Reactome	Immune System Metabolism Developmental Biology Vesicle-mediated transport Hemostasis	R-HSA-1236956 ( R-HSA-1236973 ) R-HSA-1236956 Reaction Name: Engulfment of particulate antigen into phagocytic vesicle See in Reactome R-HSA-1236958 ( R-HSA-1236973 ) R-HSA-1236958 Reaction Name: Interaction of particulate antigens with dendritic cell receptors See in Reactome R-HSA-166072 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166072 Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4 See in Reactome R-HSA-166082 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166082 Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex See in Reactome R-HSA-166091 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166091 Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex See in Reactome R-HSA-166119 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166119 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal See in Reactome R-HSA-166284 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166284 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP See in Reactome R-HSA-166286 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166286 Reaction Name: Multiple IRAK1 autophosphorylation steps See in Reactome R-HSA-166362 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-168950 ( R-HSA-168188 ) R-HSA-168950 Reaction Name: TLR6:TLR2 is recruited to ligand:CD14:CD36 See in Reactome R-HSA-2187264 ( R-HSA-3000471 ) R-HSA-2187264 Reaction Name: Platelet glycoprotein IV (CD36) binds ligands See in Reactome R-HSA-2201316 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201316 Reaction Name: Activated TLR2/4 interacts with MAL (TIRAP) See in Reactome R-HSA-2201322 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201322 Reaction Name: TIRAP is phosphorylated by BTK See in Reactome R-HSA-2247512 ( R-HSA-3000471 ) R-HSA-2247512 Reaction Name: Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed See in Reactome R-HSA-2262775 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2559414 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2559414 Reaction Name: Activated TLR2/4:TIRAP interacts with BTK See in Reactome R-HSA-2559464 ( R-HSA-168188 ) R-HSA-2559464 Reaction Name: TLR6/2 ligand associates with CD14 and CD36 within lipid rafts See in Reactome R-HSA-434381 ( R-HSA-434313 ) R-HSA-434381 Reaction Name: CD36 (FAT) translocates palmitate from the extracellular region to the cytosol See in Reactome R-HSA-481044 ( R-HSA-114608 ) R-HSA-481044 Reaction Name: Surface deployment of platelet alpha granule membrane components See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-6797267 ( R-HSA-6785807 ) R-HSA-6797267 Reaction Name: Expression of CD36 See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-8869667 ( R-HSA-5686938 ) R-HSA-8869667 Reaction Name: oxLDL:CD36 binds TLR4:TLR6 See in Reactome R-HSA-937022 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937022 Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP See in Reactome R-HSA-937059 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937059 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex See in Reactome R-HSA-937079 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937079 Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 See in Reactome
MONDO:0012127	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0012585	CD36	P16671	-	R-HSA-1989781 R-HSA-1989781 Reactome Name: PPARA activates gene expression See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-434313 R-HSA-434313 Reactome Name: Intracellular metabolism of fatty acids regulates insulin secretion See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1236973 R-HSA-1236973 Reactome Name: Cross-presentation of particulate exogenous antigens (phagosomes) See in Reactome R-HSA-381340 R-HSA-381340 Reactome Name: Transcriptional regulation of white adipocyte differentiation See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-3000471 R-HSA-3000471 Reactome Name: Scavenging by Class B Receptors See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5686938 R-HSA-5686938 Reactome Name: Regulation of TLR by endogenous ligand See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-400451 R-HSA-400451 Reactome Name: Free fatty acids regulate insulin secretion See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-163685 R-HSA-163685 Reactome Name: Integration of energy metabolism See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-400206 R-HSA-400206 Reactome Name: Regulation of lipid metabolism by PPARalpha See in Reactome R-HSA-5653656 R-HSA-5653656 Reactome Name: Vesicle-mediated transport See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-422356 R-HSA-422356 Reactome Name: Regulation of insulin secretion See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-2173782 R-HSA-2173782 Reactome Name: Binding and Uptake of Ligands by Scavenger Receptors See in Reactome	Immune System Metabolism Developmental Biology Vesicle-mediated transport Hemostasis	R-HSA-1236956 ( R-HSA-1236973 ) R-HSA-1236956 Reaction Name: Engulfment of particulate antigen into phagocytic vesicle See in Reactome R-HSA-1236958 ( R-HSA-1236973 ) R-HSA-1236958 Reaction Name: Interaction of particulate antigens with dendritic cell receptors See in Reactome R-HSA-166072 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166072 Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4 See in Reactome R-HSA-166082 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166082 Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex See in Reactome R-HSA-166091 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166091 Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex See in Reactome R-HSA-166119 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166119 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal See in Reactome R-HSA-166284 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166284 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP See in Reactome R-HSA-166286 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166286 Reaction Name: Multiple IRAK1 autophosphorylation steps See in Reactome R-HSA-166362 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058; R-HSA-168188 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-168950 ( R-HSA-168188 ) R-HSA-168950 Reaction Name: TLR6:TLR2 is recruited to ligand:CD14:CD36 See in Reactome R-HSA-2187264 ( R-HSA-3000471 ) R-HSA-2187264 Reaction Name: Platelet glycoprotein IV (CD36) binds ligands See in Reactome R-HSA-2201316 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201316 Reaction Name: Activated TLR2/4 interacts with MAL (TIRAP) See in Reactome R-HSA-2201322 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2201322 Reaction Name: TIRAP is phosphorylated by BTK See in Reactome R-HSA-2247512 ( R-HSA-3000471 ) R-HSA-2247512 Reaction Name: Platelet glycoprotein IV:ligand (CD36:ligand) is endocytosed See in Reactome R-HSA-2262775 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2559414 ( R-HSA-166058; R-HSA-168188 ) R-HSA-2559414 Reaction Name: Activated TLR2/4:TIRAP interacts with BTK See in Reactome R-HSA-2559464 ( R-HSA-168188 ) R-HSA-2559464 Reaction Name: TLR6/2 ligand associates with CD14 and CD36 within lipid rafts See in Reactome R-HSA-434381 ( R-HSA-434313 ) R-HSA-434381 Reaction Name: CD36 (FAT) translocates palmitate from the extracellular region to the cytosol See in Reactome R-HSA-481044 ( R-HSA-114608 ) R-HSA-481044 Reaction Name: Surface deployment of platelet alpha granule membrane components See in Reactome R-HSA-560517 ( R-HSA-1989781; R-HSA-381340 ) R-HSA-560517 Reaction Name: Expression of CD36 (platelet glycoprotein IV, FAT) See in Reactome R-HSA-6797267 ( R-HSA-6785807 ) R-HSA-6797267 Reaction Name: Expression of CD36 See in Reactome R-HSA-6799350 ( R-HSA-6798695 ) R-HSA-6799350 Reaction Name: Exocytosis of specific granule membrane proteins See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-8869667 ( R-HSA-5686938 ) R-HSA-8869667 Reaction Name: oxLDL:CD36 binds TLR4:TLR6 See in Reactome R-HSA-937022 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937022 Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP See in Reactome R-HSA-937059 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937059 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex See in Reactome R-HSA-937079 ( R-HSA-166058; R-HSA-168188 ) R-HSA-937079 Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 See in Reactome
MONDO:0012714	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0012747	ALDOA	P04075	4.1.2.13	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-70171 R-HSA-70171 Reactome Name: Glycolysis See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-70263 R-HSA-70263 Reactome Name: Gluconeogenesis See in Reactome	R-HSA-70326 R-HSA-70326 Reactome Name: Glucose metabolism See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-71387 R-HSA-71387 Reactome Name: Metabolism of carbohydrates See in Reactome	Immune System Metabolism Hemostasis	R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome R-HSA-6798745 ( R-HSA-6798695 ) R-HSA-6798745 Reaction Name: Exocytosis of tertiary granule lumen proteins See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-71495 ( R-HSA-70263 ) R-HSA-71495 Reaction Name: dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate See in Reactome R-HSA-71496 ( R-HSA-70171 ) R-HSA-71496 Reaction Name: D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate See in Reactome
MONDO:0013187	F13A1	P00488	2.3.2.13	R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Immune System Hemostasis	R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140847 ( R-HSA-140875 ) R-HSA-140847 Reaction Name: factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain See in Reactome R-HSA-140851 ( R-HSA-140875 ) R-HSA-140851 Reaction Name: fibrin multimer -> fibrin multimer, crosslinked + NH4+ See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome R-HSA-6785895 ( R-HSA-6785807 ) R-HSA-6785895 Reaction Name: Expression of IL4, IL13-upregulated extracellular proteins See in Reactome
MONDO:0013412	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0013487	CFD	P00746	3.4.21.46	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-173736 R-HSA-173736 Reactome Name: Alternative complement activation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome R-HSA-166663 R-HSA-166663 Reactome Name: Initial triggering of complement See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Immune System Hemostasis	R-HSA-173745 ( R-HSA-173736 ) R-HSA-173745 Reaction Name: Factor D cleaves C3(H2O)-bound Factor B See in Reactome R-HSA-183122 ( R-HSA-173736 ) R-HSA-183122 Reaction Name: Factor D cleaves C3b-bound Factor B See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome
MONDO:0015705	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0017401	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0017402	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0017403	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0017939	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0018759	TTN	Q8WZ42	2.7.11.1	R-HSA-390522 R-HSA-390522 Reactome Name: Striated Muscle Contraction See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Muscle contraction Hemostasis	R-HSA-390593 ( R-HSA-390522 ) R-HSA-390593 Reaction Name: ATP Hydrolysis By Myosin See in Reactome R-HSA-390595 ( R-HSA-390522 ) R-HSA-390595 Reaction Name: Calcium Binds Troponin-C See in Reactome R-HSA-390597 ( R-HSA-390522 ) R-HSA-390597 Reaction Name: Release Of ADP From Myosin See in Reactome R-HSA-390598 ( R-HSA-390522 ) R-HSA-390598 Reaction Name: Myosin Binds ATP See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome
MONDO:0019623	PLG	P00747	3.4.21.7	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-75205 R-HSA-75205 Reactome Name: Dissolution of Fibrin Clot See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome	R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Extracellular matrix organization Hemostasis Signal Transduction	R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-158721 ( R-HSA-75205 ) R-HSA-158721 Reaction Name: histidine-rich glycoprotein:plasminogen <-> histidine-rich glycoprotein + plasminogen See in Reactome R-HSA-158722 ( R-HSA-75205 ) R-HSA-158722 Reaction Name: histidine-rich glycoprotein + plasminogen <-> histidine-rich glycoprotein:plasminogen See in Reactome R-HSA-158744 ( R-HSA-75205 ) R-HSA-158744 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin See in Reactome R-HSA-158747 ( R-HSA-75205 ) R-HSA-158747 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) See in Reactome R-HSA-158750 ( R-HSA-75205 ) R-HSA-158750 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin See in Reactome R-HSA-158756 ( R-HSA-75205 ) R-HSA-158756 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen See in Reactome R-HSA-158766 ( R-HSA-75205 ) R-HSA-158766 Reaction Name: fibrin multimer, crosslinked -> fibrin digestion products (plasmin) See in Reactome R-HSA-158784 ( R-HSA-75205 ) R-HSA-158784 Reaction Name: crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen See in Reactome R-HSA-158893 ( R-HSA-75205 ) R-HSA-158893 Reaction Name: alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin See in Reactome R-HSA-158925 ( R-HSA-75205 ) R-HSA-158925 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst) See in Reactome R-HSA-158941 ( R-HSA-75205 ) R-HSA-158941 Reaction Name: plasminogen + histidine-rich glycoprotein -> plasminogen:histidine-rich glycoprotein See in Reactome R-HSA-158942 ( R-HSA-75205 ) R-HSA-158942 Reaction Name: urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR See in Reactome R-HSA-158982 ( R-HSA-75205 ) R-HSA-158982 Reaction Name: plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst) See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1602458 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602458 Reaction Name: Activation of proMMP10 See in Reactome R-HSA-1602488 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602488 Reaction Name: Initial activation of proMMP13 by plasmin and trypsin See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-381461 ( R-HSA-381426 ) R-HSA-381461 Reaction Name: Plasmin proteolyzes IGF:IGFBP-3:ALS See in Reactome R-HSA-382061 ( R-HSA-186797 ) R-HSA-382061 Reaction Name: Extracellular processing of novel PDGFs See in Reactome R-HSA-481007 ( R-HSA-114608 ) R-HSA-481007 Reaction Name: Exocytosis of platelet alpha granule contents See in Reactome
MONDO:0032828	SOD1	P00441	1.15.1.1	R-HSA-3299685 R-HSA-3299685 Reactome Name: Detoxification of Reactive Oxygen Species See in Reactome R-HSA-8950505 R-HSA-8950505 Reactome Name: Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation See in Reactome R-HSA-114608 R-HSA-114608 Reactome Name: Platelet degranulation See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-447115 R-HSA-447115 Reactome Name: Interleukin-12 family signaling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-76005 R-HSA-76005 Reactome Name: Response to elevated platelet cytosolic Ca2+ See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9711123 R-HSA-9711123 Reactome Name: Cellular response to chemical stress See in Reactome R-HSA-9020591 R-HSA-9020591 Reactome Name: Interleukin-12 signaling See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Cellular responses to stimuli Immune System Hemostasis	R-HSA-3299691 ( R-HSA-3299685 ) R-HSA-3299691 Reaction Name: SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) See in Reactome R-HSA-3299753 ( R-HSA-3299685 ) R-HSA-3299753 Reaction Name: CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 See in Reactome R-HSA-3697860 ( R-HSA-3299685 ) R-HSA-3697860 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ See in Reactome R-HSA-3777112 ( R-HSA-3299685 ) R-HSA-3777112 Reaction Name: SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space) See in Reactome R-HSA-3780958 ( R-HSA-3299685 ) R-HSA-3780958 Reaction Name: SOD1:Zn2+ apoenzyme binds CCS:Cu1+ (mitochondrial) See in Reactome R-HSA-3780979 ( R-HSA-3299685 ) R-HSA-3780979 Reaction Name: CCS transfers Cu to SOD1 (mitochondrial) See in Reactome R-HSA-482772 ( R-HSA-114608 ) R-HSA-482772 Reaction Name: Release of platelet cytosolic components See in Reactome R-HSA-8950771 ( R-HSA-8950505 ) R-HSA-8950771 Reaction Name: Expression of SOD1 See in Reactome R-HSA-8951723 ( R-HSA-3299685 ) R-HSA-8951723 Reaction Name: 2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates See in Reactome

Number of enzymes:	7
Number of disease:	22
Number of reactomes:	24
Number of reactions:	78

Search summary (Reactome ID: R-HSA-114608)

Search results (Reactome ID: R-HSA-114608)

MONDO:0000468

R-HSA-390522

R-HSA-114608

R-HSA-397014

R-HSA-76002

R-HSA-76005

R-HSA-109582

R-HSA-390593

R-HSA-390595

R-HSA-390597

R-HSA-390598

R-HSA-482772

MONDO:0007103

R-HSA-3299685

R-HSA-8950505

R-HSA-114608

R-HSA-8953897

R-HSA-449147

R-HSA-447115

R-HSA-76002

R-HSA-168256

R-HSA-2262752

R-HSA-76005

R-HSA-1280215

R-HSA-9711123

R-HSA-9020591

R-HSA-109582

R-HSA-3299691

R-HSA-3299753

R-HSA-3697860

R-HSA-3777112

R-HSA-3780958

R-HSA-3780979

R-HSA-482772

R-HSA-8950771

R-HSA-8951723

MONDO:0009009

R-HSA-381426

R-HSA-75205

R-HSA-114608

R-HSA-1474228

R-HSA-1592389

R-HSA-186797

R-HSA-76002

R-HSA-76005

R-HSA-392499

R-HSA-1474244

R-HSA-9006934

R-HSA-109582

R-HSA-162582

R-HSA-1454843

R-HSA-1566979

R-HSA-158721

R-HSA-158722

R-HSA-158744

R-HSA-158747

R-HSA-158750

R-HSA-158756

R-HSA-158766

R-HSA-158784

R-HSA-158893

R-HSA-158925

R-HSA-158941

R-HSA-158942

R-HSA-158982

R-HSA-1592314

R-HSA-1592316

R-HSA-1592371

R-HSA-1592398

R-HSA-1602458

R-HSA-1602488

R-HSA-1604712

R-HSA-381461

R-HSA-382061

R-HSA-481007

MONDO:0010870

R-HSA-390522

R-HSA-114608