DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-112382)

Number of enzymes:	5
Number of disease:	8
Number of reactomes:	33
Number of reactions:	145

Search results (Reactome ID: R-HSA-112382)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008586	POLR2B	P30876	2.7.7.6	R-HSA-6803529 R-HSA-6803529 Reactome Name: FGFR2 alternative splicing See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-203927 R-HSA-203927 Reactome Name: MicroRNA (miRNA) biogenesis See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-5601884 R-HSA-5601884 Reactome Name: PIWI-interacting RNA (piRNA) biogenesis See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-9670095 R-HSA-9670095 Reactome Name: Inhibition of DNA recombination at telomere See in Reactome R-HSA-72165 R-HSA-72165 Reactome Name: mRNA Splicing - Minor Pathway See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome R-HSA-6807505 R-HSA-6807505 Reactome Name: RNA polymerase II transcribes snRNA genes See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-5578749 R-HSA-5578749 Reactome Name: Transcriptional regulation by small RNAs See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-211000 R-HSA-211000 Reactome Name: Gene Silencing by RNA See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA DNA Repair Signal Transduction Cell Cycle Developmental Biology	R-HSA-5621002 ( R-HSA-5617472 ) R-HSA-5621002 Reaction Name: HOXB1 activates HOXB2 expression See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-6803838 ( R-HSA-6803529 ) R-HSA-6803838 Reaction Name: FGFR2c-specific alternative splicing produces FGFR2c transcript See in Reactome R-HSA-109638 ( R-HSA-73779 ) R-HSA-109638 Reaction Name: Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-72139 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-9012319 ( R-HSA-9018519 ) R-HSA-9012319 Reaction Name: p-TEFb phosphorylates serine 2 in RNA polymerase II CTD See in Reactome R-HSA-72095 ( R-HSA-72203 ) R-HSA-72095 Reaction Name: Internal Methylation of mRNA See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6810235 ( R-HSA-6807505 ) R-HSA-6810235 Reaction Name: RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain See in Reactome R-HSA-72107 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72107 Reaction Name: Formation of the Spliceosomal E complex See in Reactome R-HSA-113407 ( R-HSA-113418; R-HSA-75955 ) R-HSA-113407 Reaction Name: DSIF complex binds to RNA Pol II (hypophosphorylated) See in Reactome R-HSA-75095 ( R-HSA-73779 ) R-HSA-75095 Reaction Name: Binding of TFIIE to the growing preinitiation complex See in Reactome R-HSA-72124 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72124 Reaction Name: Formation of the Spliceosomal A Complex See in Reactome R-HSA-113414 ( R-HSA-674695 ) R-HSA-113414 Reaction Name: 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617661 ( R-HSA-5617472 ) R-HSA-5617661 Reaction Name: MAFB:JUN and EGR2 activate HOXB3 expression See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-75081 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75081 Reaction Name: Formation of AT-AC B Complex See in Reactome R-HSA-203901 ( R-HSA-203927 ) R-HSA-203901 Reaction Name: Pol II mediated transcription of microRNA genes See in Reactome R-HSA-9670149 ( R-HSA-9670095 ) R-HSA-9670149 Reaction Name: TERRA transcription See in Reactome R-HSA-72130 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-5617672 ( R-HSA-5617472 ) R-HSA-5617672 Reaction Name: HOXB3 gene is transcribed See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-6810233 ( R-HSA-6807505 ) R-HSA-6810233 Reaction Name: CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter See in Reactome R-HSA-5617462 ( R-HSA-5617472 ) R-HSA-5617462 Reaction Name: HOXD1 gene is transcribed See in Reactome R-HSA-6814554 ( R-HSA-6807505 ) R-HSA-6814554 Reaction Name: Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene See in Reactome R-HSA-6803523 ( R-HSA-6803529 ) R-HSA-6803523 Reaction Name: PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA See in Reactome R-HSA-112381 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112381 Reaction Name: Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex See in Reactome R-HSA-5617486 ( R-HSA-5617472 ) R-HSA-5617486 Reaction Name: HOXB2 gene is transcribed See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-9012315 ( R-HSA-9018519 ) R-HSA-9012315 Reaction Name: ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene See in Reactome R-HSA-77095 ( R-HSA-72086 ) R-HSA-77095 Reaction Name: Recognition and binding of the mRNA cap by the cap-binding complex See in Reactome R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-6810238 ( R-HSA-6807505 ) R-HSA-6810238 Reaction Name: RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) See in Reactome R-HSA-5578742 ( R-HSA-5578749 ) R-HSA-5578742 Reaction Name: AGO1,2:small RNA complexes interact with chromatin See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-6814549 ( R-HSA-6807505 ) R-HSA-6814549 Reaction Name: Pre-snRNA transcript initiation, Integrator binding, LEC binding See in Reactome R-HSA-75082 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75082 Reaction Name: ATAC spliceosome mediated Lariat formation,5' splice site cleavage See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-72160 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-5601926 ( R-HSA-5601884 ) R-HSA-5601926 Reaction Name: RNA polymerase II polymerizes primary piRNA transcript See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-9011971 ( R-HSA-9018519 ) R-HSA-9011971 Reaction Name: Estrogen-responsive MYB gene expression See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-5617866 ( R-HSA-5617472 ) R-HSA-5617866 Reaction Name: HOXC4 gene is transcribed See in Reactome R-HSA-5617641 ( R-HSA-5617472 ) R-HSA-5617641 Reaction Name: MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-5617492 ( R-HSA-5617472 ) R-HSA-5617492 Reaction Name: EGR2 (KROX20) activates HOXB2 expression See in Reactome R-HSA-5617484 ( R-HSA-5617472 ) R-HSA-5617484 Reaction Name: EGR2 (KROX20) activates HOXA2 expression See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-6814559 ( R-HSA-6807505 ) R-HSA-6814559 Reaction Name: Pre-snRNA is elongated and capped with 7-methylguanosine See in Reactome R-HSA-6814885 ( R-HSA-6807505 ) R-HSA-6814885 Reaction Name: CBCAP complex binds 7-methylguanosine cap of snRNA See in Reactome R-HSA-5617483 ( R-HSA-5617472 ) R-HSA-5617483 Reaction Name: HOXA2 gene is transcribed See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-72127 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72127 Reaction Name: Formation of the Spliceosomal B Complex See in Reactome R-HSA-72103 ( R-HSA-72203 ) R-HSA-72103 Reaction Name: Formation of pre-mRNPs See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-113413 ( R-HSA-674695 ) R-HSA-113413 Reaction Name: TFIIS-mediated recovery of elongation from arrest See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-112396 ( R-HSA-75955 ) R-HSA-112396 Reaction Name: Separation of elongating transcript from template See in Reactome R-HSA-5617445 ( R-HSA-5617472 ) R-HSA-5617445 Reaction Name: HOXD1 chromatin is activated See in Reactome R-HSA-6803836 ( R-HSA-6803529 ) R-HSA-6803836 Reaction Name: FGFR2b-specific alternative splicing produces FGFR2b transcript See in Reactome R-HSA-75079 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75079 Reaction Name: Formation of AT-AC C complex See in Reactome R-HSA-113429 ( R-HSA-674695 ) R-HSA-113429 Reaction Name: Elongating transcript encounters a lesion in the template See in Reactome R-HSA-5621010 ( R-HSA-5617472 ) R-HSA-5621010 Reaction Name: HOXB1 activates HOXA2 expression See in Reactome R-HSA-113412 ( R-HSA-75955 ) R-HSA-113412 Reaction Name: Pol II elongation complex moves on the template as transcript elongates See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-75083 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75083 Reaction Name: ATAC spliceosome mediated 3' splice site cleavage, exon ligation See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-5617642 ( R-HSA-5617472 ) R-HSA-5617642 Reaction Name: HOXD3 gene is transcribed See in Reactome R-HSA-6814555 ( R-HSA-6807505 ) R-HSA-6814555 Reaction Name: Integrator complex processes the 3' end of snRNA See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-5617887 ( R-HSA-5617472 ) R-HSA-5617887 Reaction Name: HOXC4 chromatin is activated See in Reactome R-HSA-112392 ( R-HSA-674695 ) R-HSA-112392 Reaction Name: Resumption of elongation after recovery from pausing See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-156661 ( R-HSA-72163; R-HSA-72203 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-5617650 ( R-HSA-5617472 ) R-HSA-5617650 Reaction Name: HOXD3 chromatin is activated See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-113409 ( R-HSA-674695 ) R-HSA-113409 Reaction Name: Abortive termination of early transcription elongation by DSIF:NELF See in Reactome R-HSA-72143 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-75080 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75080 Reaction Name: Formation of AT-AC A complex See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-6803527 ( R-HSA-6803529 ) R-HSA-6803527 Reaction Name: ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression See in Reactome R-HSA-5617676 ( R-HSA-5617472 ) R-HSA-5617676 Reaction Name: HOXA3 gene is transcribed See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-113402 ( R-HSA-113418; R-HSA-75955 ) R-HSA-113402 Reaction Name: Formation of DSIF:NELF:early elongation complex See in Reactome R-HSA-113411 ( R-HSA-674695 ) R-HSA-113411 Reaction Name: 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112395 ( R-HSA-674695 ) R-HSA-112395 Reaction Name: Abortive termination of elongation after arrest See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome
MONDO:0010212	ERCC2	P18074	3.6.4.12	R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA Metabolism DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0011125	ERCC2	P18074	3.6.4.12	R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA Metabolism DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0011402	CTDP1	Q9Y5B0	3.1.3.16	R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome	R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome	Gene expression (Transcription)	R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112381 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112381 Reaction Name: Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-112392 ( R-HSA-674695 ) R-HSA-112392 Reaction Name: Resumption of elongation after recovery from pausing See in Reactome R-HSA-112395 ( R-HSA-674695 ) R-HSA-112395 Reaction Name: Abortive termination of elongation after arrest See in Reactome R-HSA-112396 ( R-HSA-75955 ) R-HSA-112396 Reaction Name: Separation of elongating transcript from template See in Reactome R-HSA-113402 ( R-HSA-113418; R-HSA-75955 ) R-HSA-113402 Reaction Name: Formation of DSIF:NELF:early elongation complex See in Reactome R-HSA-113407 ( R-HSA-113418; R-HSA-75955 ) R-HSA-113407 Reaction Name: DSIF complex binds to RNA Pol II (hypophosphorylated) See in Reactome R-HSA-113409 ( R-HSA-674695 ) R-HSA-113409 Reaction Name: Abortive termination of early transcription elongation by DSIF:NELF See in Reactome R-HSA-113411 ( R-HSA-674695 ) R-HSA-113411 Reaction Name: 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing See in Reactome R-HSA-113412 ( R-HSA-75955 ) R-HSA-113412 Reaction Name: Pol II elongation complex moves on the template as transcript elongates See in Reactome R-HSA-113413 ( R-HSA-674695 ) R-HSA-113413 Reaction Name: TFIIS-mediated recovery of elongation from arrest See in Reactome R-HSA-113414 ( R-HSA-674695 ) R-HSA-113414 Reaction Name: 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest See in Reactome R-HSA-113429 ( R-HSA-674695 ) R-HSA-113429 Reaction Name: Elongating transcript encounters a lesion in the template See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome
MONDO:0012531	ERCC3	P19447	3.6.4.12	R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0012553	ERCC2	P18074	3.6.4.12	R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-2564830 R-HSA-2564830 Reactome Name: Cytosolic iron-sulfur cluster assembly See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA Metabolism DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-2564828 ( R-HSA-2564830 ) R-HSA-2564828 Reaction Name: CIA Targeting Complex transfers 4Fe-4S cluster to apoproteins See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0014615	ERCC3	P19447	3.6.4.12	R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-5696395 R-HSA-5696395 Reactome Name: Formation of Incision Complex in GG-NER See in Reactome R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-5696400 R-HSA-5696400 Reactome Name: Dual Incision in GG-NER See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-73863 R-HSA-73863 Reactome Name: RNA Polymerase I Transcription Termination See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-73772 R-HSA-73772 Reactome Name: RNA Polymerase I Promoter Escape See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5696399 R-HSA-5696399 Reactome Name: Global Genome Nucleotide Excision Repair (GG-NER) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA DNA Repair	R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-427366 ( R-HSA-427413 ) R-HSA-427366 Reaction Name: Transcription of intergenic spacer of the rRNA gene See in Reactome R-HSA-5689317 ( R-HSA-5696395 ) R-HSA-5689317 Reaction Name: Formation of the pre-incision complex in GG-NER See in Reactome R-HSA-5689861 ( R-HSA-5696395 ) R-HSA-5689861 Reaction Name: Recruitment of XPA and release of CAK See in Reactome R-HSA-5690213 ( R-HSA-5696400 ) R-HSA-5690213 Reaction Name: DNA polymerases delta, epsilon or kappa bind the GG-NER site See in Reactome R-HSA-5690988 ( R-HSA-5696400 ) R-HSA-5690988 Reaction Name: 3'-incision of DNA by ERCC5 (XPG) in GG-NER See in Reactome R-HSA-5690990 ( R-HSA-5696400 ) R-HSA-5690990 Reaction Name: 5'- incision of DNA by ERCC1:ERCC4 in GG-NER See in Reactome R-HSA-5690991 ( R-HSA-5696395 ) R-HSA-5690991 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER See in Reactome R-HSA-5690996 ( R-HSA-5696395 ) R-HSA-5690996 Reaction Name: ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA See in Reactome R-HSA-5691000 ( R-HSA-5696395 ) R-HSA-5691000 Reaction Name: TFIIH binds GG-NER site to form a verification complex See in Reactome R-HSA-5696670 ( R-HSA-5696395 ) R-HSA-5696670 Reaction Name: CHD1L is recruited to GG-NER site See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-6790454 ( R-HSA-5696395 ) R-HSA-6790454 Reaction Name: SUMOylation of XPC See in Reactome R-HSA-6790487 ( R-HSA-5696395 ) R-HSA-6790487 Reaction Name: RNF111 ubiquitinates SUMOylated XPC See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-73758 ( R-HSA-73762 ) R-HSA-73758 Reaction Name: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter See in Reactome R-HSA-73769 ( R-HSA-73772 ) R-HSA-73769 Reaction Name: Loss of Rrn3 from RNA Polymerase I promoter escape complex See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-74986 ( R-HSA-73772 ) R-HSA-74986 Reaction Name: Elongation of pre-rRNA transcript See in Reactome R-HSA-74992 ( R-HSA-73863 ) R-HSA-74992 Reaction Name: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box See in Reactome R-HSA-74993 ( R-HSA-73863 ) R-HSA-74993 Reaction Name: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box See in Reactome R-HSA-74994 ( R-HSA-73863 ) R-HSA-74994 Reaction Name: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome
MONDO:0032829	POLR2A	P24928	2.7.7.48 2.7.7.6	R-HSA-6803529 R-HSA-6803529 Reactome Name: FGFR2 alternative splicing See in Reactome R-HSA-6796648 R-HSA-6796648 Reactome Name: TP53 Regulates Transcription of DNA Repair Genes See in Reactome R-HSA-203927 R-HSA-203927 Reactome Name: MicroRNA (miRNA) biogenesis See in Reactome R-HSA-6782135 R-HSA-6782135 Reactome Name: Dual incision in TC-NER See in Reactome R-HSA-6782210 R-HSA-6782210 Reactome Name: Gap-filling DNA repair synthesis and ligation in TC-NER See in Reactome R-HSA-72203 R-HSA-72203 Reactome Name: Processing of Capped Intron-Containing Pre-mRNA See in Reactome R-HSA-73776 R-HSA-73776 Reactome Name: RNA Polymerase II Promoter Escape See in Reactome R-HSA-73779 R-HSA-73779 Reactome Name: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening See in Reactome R-HSA-674695 R-HSA-674695 Reactome Name: RNA Polymerase II Pre-transcription Events See in Reactome R-HSA-76042 R-HSA-76042 Reactome Name: RNA Polymerase II Transcription Initiation And Promoter Clearance See in Reactome R-HSA-5601884 R-HSA-5601884 Reactome Name: PIWI-interacting RNA (piRNA) biogenesis See in Reactome R-HSA-6781827 R-HSA-6781827 Reactome Name: Transcription-Coupled Nucleotide Excision Repair (TC-NER) See in Reactome R-HSA-6781823 R-HSA-6781823 Reactome Name: Formation of TC-NER Pre-Incision Complex See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-72086 R-HSA-72086 Reactome Name: mRNA Capping See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-75953 R-HSA-75953 Reactome Name: RNA Polymerase II Transcription Initiation See in Reactome R-HSA-77075 R-HSA-77075 Reactome Name: RNA Pol II CTD phosphorylation and interaction with CE See in Reactome R-HSA-9670095 R-HSA-9670095 Reactome Name: Inhibition of DNA recombination at telomere See in Reactome R-HSA-72165 R-HSA-72165 Reactome Name: mRNA Splicing - Minor Pathway See in Reactome R-HSA-112382 R-HSA-112382 Reactome Name: Formation of RNA Pol II elongation complex See in Reactome R-HSA-72163 R-HSA-72163 Reactome Name: mRNA Splicing - Major Pathway See in Reactome R-HSA-6807505 R-HSA-6807505 Reactome Name: RNA polymerase II transcribes snRNA genes See in Reactome R-HSA-113418 R-HSA-113418 Reactome Name: Formation of the Early Elongation Complex See in Reactome R-HSA-5578749 R-HSA-5578749 Reactome Name: Transcriptional regulation by small RNAs See in Reactome R-HSA-75955 R-HSA-75955 Reactome Name: RNA Polymerase II Transcription Elongation See in Reactome	R-HSA-5654738 R-HSA-5654738 Reactome Name: Signaling by FGFR2 See in Reactome R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-5696398 R-HSA-5696398 Reactome Name: Nucleotide Excision Repair See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-72172 R-HSA-72172 Reactome Name: mRNA Splicing See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-157579 R-HSA-157579 Reactome Name: Telomere Maintenance See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73886 R-HSA-73886 Reactome Name: Chromosome Maintenance See in Reactome R-HSA-211000 R-HSA-211000 Reactome Name: Gene Silencing by RNA See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Metabolism of RNA DNA Repair Signal Transduction Cell Cycle Developmental Biology	R-HSA-5621002 ( R-HSA-5617472 ) R-HSA-5621002 Reaction Name: HOXB1 activates HOXB2 expression See in Reactome R-HSA-77090 ( R-HSA-72086 ) R-HSA-77090 Reaction Name: Methylation of GMP-cap by RNA Methyltransferase See in Reactome R-HSA-6803838 ( R-HSA-6803529 ) R-HSA-6803838 Reaction Name: FGFR2c-specific alternative splicing produces FGFR2c transcript See in Reactome R-HSA-109638 ( R-HSA-73779 ) R-HSA-109638 Reaction Name: Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex See in Reactome R-HSA-75866 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75866 Reaction Name: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP See in Reactome R-HSA-72139 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72139 Reaction Name: Formation of the active Spliceosomal C complex See in Reactome R-HSA-9012319 ( R-HSA-9018519 ) R-HSA-9012319 Reaction Name: p-TEFb phosphorylates serine 2 in RNA polymerase II CTD See in Reactome R-HSA-72095 ( R-HSA-72203 ) R-HSA-72095 Reaction Name: Internal Methylation of mRNA See in Reactome R-HSA-6782211 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782211 Reaction Name: DNA polymerases delta, epsilon or kappa bind the TC-NER site See in Reactome R-HSA-6810235 ( R-HSA-6807505 ) R-HSA-6810235 Reaction Name: RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain See in Reactome R-HSA-72107 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72107 Reaction Name: Formation of the Spliceosomal E complex See in Reactome R-HSA-113407 ( R-HSA-113418; R-HSA-75955 ) R-HSA-113407 Reaction Name: DSIF complex binds to RNA Pol II (hypophosphorylated) See in Reactome R-HSA-75095 ( R-HSA-73779 ) R-HSA-75095 Reaction Name: Binding of TFIIE to the growing preinitiation complex See in Reactome R-HSA-72124 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72124 Reaction Name: Formation of the Spliceosomal A Complex See in Reactome R-HSA-113414 ( R-HSA-674695 ) R-HSA-113414 Reaction Name: 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest See in Reactome R-HSA-75864 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75864 Reaction Name: Newly Formed Phosphodiester Bond Stabilized and PPi Released See in Reactome R-HSA-6782204 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782204 Reaction Name: 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER See in Reactome R-HSA-5617661 ( R-HSA-5617472 ) R-HSA-5617661 Reaction Name: MAFB:JUN and EGR2 activate HOXB3 expression See in Reactome R-HSA-5617867 ( R-HSA-5617472 ) R-HSA-5617867 Reaction Name: HOXB4 gene is transcribed See in Reactome R-HSA-75081 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75081 Reaction Name: Formation of AT-AC B Complex See in Reactome R-HSA-203901 ( R-HSA-203927 ) R-HSA-203901 Reaction Name: Pol II mediated transcription of microRNA genes See in Reactome R-HSA-9670149 ( R-HSA-9670095 ) R-HSA-9670149 Reaction Name: TERRA transcription See in Reactome R-HSA-72130 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72130 Reaction Name: Formation of an intermediate Spliceosomal C complex See in Reactome R-HSA-6797712 ( R-HSA-6796648 ) R-HSA-6797712 Reaction Name: CDK12 stimulates expression of DNA repair genes See in Reactome R-HSA-6781818 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781818 Reaction Name: RNA Pol II initiates transcription from damaged DNA template See in Reactome R-HSA-5617672 ( R-HSA-5617472 ) R-HSA-5617672 Reaction Name: HOXB3 gene is transcribed See in Reactome R-HSA-73946 ( R-HSA-674695 ) R-HSA-73946 Reaction Name: Abortive initiation after formation of the first phosphodiester bond See in Reactome R-HSA-77083 ( R-HSA-72086 ) R-HSA-77083 Reaction Name: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA See in Reactome R-HSA-6810233 ( R-HSA-6807505 ) R-HSA-6810233 Reaction Name: CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter See in Reactome R-HSA-5617462 ( R-HSA-5617472 ) R-HSA-5617462 Reaction Name: HOXD1 gene is transcribed See in Reactome R-HSA-6814554 ( R-HSA-6807505 ) R-HSA-6814554 Reaction Name: Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene See in Reactome R-HSA-6803523 ( R-HSA-6803529 ) R-HSA-6803523 Reaction Name: PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA See in Reactome R-HSA-112381 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112381 Reaction Name: Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex See in Reactome R-HSA-5617486 ( R-HSA-5617472 ) R-HSA-5617486 Reaction Name: HOXB2 gene is transcribed See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-6781833 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781833 Reaction Name: ERCC8 (CSA) binds stalled RNA Pol II See in Reactome R-HSA-9012315 ( R-HSA-9018519 ) R-HSA-9012315 Reaction Name: ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene See in Reactome R-HSA-77095 ( R-HSA-72086 ) R-HSA-77095 Reaction Name: Recognition and binding of the mRNA cap by the cap-binding complex See in Reactome R-HSA-109639 ( R-HSA-73779 ) R-HSA-109639 Reaction Name: Formation of the closed pre-initiation complex See in Reactome R-HSA-6810238 ( R-HSA-6807505 ) R-HSA-6810238 Reaction Name: RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) See in Reactome R-HSA-5578742 ( R-HSA-5578749 ) R-HSA-5578742 Reaction Name: AGO1,2:small RNA complexes interact with chromatin See in Reactome R-HSA-77085 ( R-HSA-72086 ) R-HSA-77085 Reaction Name: Dissociation of transcript with 5'-GMP from GT See in Reactome R-HSA-77073 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77073 Reaction Name: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) See in Reactome R-HSA-5617454 ( R-HSA-5617472 ) R-HSA-5617454 Reaction Name: HOXB1 gene is transcribed See in Reactome R-HSA-113430 ( R-HSA-77075 ) R-HSA-113430 Reaction Name: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex See in Reactome R-HSA-75891 ( R-HSA-674695 ) R-HSA-75891 Reaction Name: Abortive Initiation After Second Transition See in Reactome R-HSA-6814549 ( R-HSA-6807505 ) R-HSA-6814549 Reaction Name: Pre-snRNA transcript initiation, Integrator binding, LEC binding See in Reactome R-HSA-75082 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75082 Reaction Name: ATAC spliceosome mediated Lariat formation,5' splice site cleavage See in Reactome R-HSA-77068 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77068 Reaction Name: Activation of GT See in Reactome R-HSA-72160 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72160 Reaction Name: Cleavage at the 3'-Splice Site and Exon Ligation See in Reactome R-HSA-6782004 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782004 Reaction Name: Assembly of the pre-incision complex in TC-NER See in Reactome R-HSA-77077 ( R-HSA-72086 ) R-HSA-77077 Reaction Name: Capping complex formation See in Reactome R-HSA-6782138 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782138 Reaction Name: ERCC5 and RPA bind TC-NER site See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-5601926 ( R-HSA-5601884 ) R-HSA-5601926 Reaction Name: RNA polymerase II polymerizes primary piRNA transcript See in Reactome R-HSA-6781840 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781840 Reaction Name: ERCC6 binds stalled RNA Pol II See in Reactome R-HSA-9011971 ( R-HSA-9018519 ) R-HSA-9011971 Reaction Name: Estrogen-responsive MYB gene expression See in Reactome R-HSA-77078 ( R-HSA-72086 ) R-HSA-77078 Reaction Name: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme See in Reactome R-HSA-5617866 ( R-HSA-5617472 ) R-HSA-5617866 Reaction Name: HOXC4 gene is transcribed See in Reactome R-HSA-5617641 ( R-HSA-5617472 ) R-HSA-5617641 Reaction Name: MAFB (KREISLER) and HOXB1:PBX1:PKNOX1 (HOXB1:PBX1:PREP1) activate HOXA3 expression See in Reactome R-HSA-9613497 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613497 Reaction Name: Unwinding DNA for the nascent transcript See in Reactome R-HSA-5693644 ( R-HSA-5617472 ) R-HSA-5693644 Reaction Name: HOXB1 maintains activation of HOXB1 chromatin See in Reactome R-HSA-5617492 ( R-HSA-5617472 ) R-HSA-5617492 Reaction Name: EGR2 (KROX20) activates HOXB2 expression See in Reactome R-HSA-5617484 ( R-HSA-5617472 ) R-HSA-5617484 Reaction Name: EGR2 (KROX20) activates HOXA2 expression See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-6814559 ( R-HSA-6807505 ) R-HSA-6814559 Reaction Name: Pre-snRNA is elongated and capped with 7-methylguanosine See in Reactome R-HSA-6814885 ( R-HSA-6807505 ) R-HSA-6814885 Reaction Name: CBCAP complex binds 7-methylguanosine cap of snRNA See in Reactome R-HSA-5617483 ( R-HSA-5617472 ) R-HSA-5617483 Reaction Name: HOXA2 gene is transcribed See in Reactome R-HSA-6782208 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782208 Reaction Name: Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER See in Reactome R-HSA-77069 ( R-HSA-72086; R-HSA-77075 ) R-HSA-77069 Reaction Name: RNA Polymerase II CTD (phosphorylated) binds to CE See in Reactome R-HSA-72127 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72127 Reaction Name: Formation of the Spliceosomal B Complex See in Reactome R-HSA-72103 ( R-HSA-72203 ) R-HSA-72103 Reaction Name: Formation of pre-mRNPs See in Reactome R-HSA-6782227 ( R-HSA-6781827; R-HSA-6782210 ) R-HSA-6782227 Reaction Name: Ligation of newly synthesized repair patch to incised DNA in TC-NER See in Reactome R-HSA-113413 ( R-HSA-674695 ) R-HSA-113413 Reaction Name: TFIIS-mediated recovery of elongation from arrest See in Reactome R-HSA-75869 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75869 Reaction Name: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition See in Reactome R-HSA-112396 ( R-HSA-75955 ) R-HSA-112396 Reaction Name: Separation of elongating transcript from template See in Reactome R-HSA-5617445 ( R-HSA-5617472 ) R-HSA-5617445 Reaction Name: HOXD1 chromatin is activated See in Reactome R-HSA-6803836 ( R-HSA-6803529 ) R-HSA-6803836 Reaction Name: FGFR2b-specific alternative splicing produces FGFR2b transcript See in Reactome R-HSA-75079 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75079 Reaction Name: Formation of AT-AC C complex See in Reactome R-HSA-113429 ( R-HSA-674695 ) R-HSA-113429 Reaction Name: Elongating transcript encounters a lesion in the template See in Reactome R-HSA-5621010 ( R-HSA-5617472 ) R-HSA-5621010 Reaction Name: HOXB1 activates HOXA2 expression See in Reactome R-HSA-113412 ( R-HSA-75955 ) R-HSA-113412 Reaction Name: Pol II elongation complex moves on the template as transcript elongates See in Reactome R-HSA-77081 ( R-HSA-72086 ) R-HSA-77081 Reaction Name: Formation of the CE:GMP intermediate complex See in Reactome R-HSA-77071 ( R-HSA-77075 ) R-HSA-77071 Reaction Name: Phosphorylation (Ser5) of RNA pol II CTD See in Reactome R-HSA-6781867 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781867 Reaction Name: ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II See in Reactome R-HSA-112383 ( R-HSA-113418; R-HSA-75955 ) R-HSA-112383 Reaction Name: Hypophosphorylation of RNA Pol II CTD by FCP1P protein See in Reactome R-HSA-5617877 ( R-HSA-5617472 ) R-HSA-5617877 Reaction Name: HOXA4 gene is transcribed See in Reactome R-HSA-75949 ( R-HSA-76042 ) R-HSA-75949 Reaction Name: RNA Polymerase II Promoter Opening: First Transition See in Reactome R-HSA-6782234 ( R-HSA-6781827 ) R-HSA-6782234 Reaction Name: Recovery of RNA synthesis after TC-NER See in Reactome R-HSA-75083 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75083 Reaction Name: ATAC spliceosome mediated 3' splice site cleavage, exon ligation See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-5617642 ( R-HSA-5617472 ) R-HSA-5617642 Reaction Name: HOXD3 gene is transcribed See in Reactome R-HSA-6814555 ( R-HSA-6807505 ) R-HSA-6814555 Reaction Name: Integrator complex processes the 3' end of snRNA See in Reactome R-HSA-111264 ( R-HSA-73776; R-HSA-76042 ) R-HSA-111264 Reaction Name: Addition of nucleotides between position +11 and +30 See in Reactome R-HSA-5617887 ( R-HSA-5617472 ) R-HSA-5617887 Reaction Name: HOXC4 chromatin is activated See in Reactome R-HSA-112392 ( R-HSA-674695 ) R-HSA-112392 Reaction Name: Resumption of elongation after recovery from pausing See in Reactome R-HSA-6781824 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6781824 Reaction Name: Active RNA Pol II complex transcribes lesion-containing DNA template See in Reactome R-HSA-6797606 ( R-HSA-6796648 ) R-HSA-6797606 Reaction Name: CDK12 phosphorylates RNA Pol II CTD at DNA repair genes See in Reactome R-HSA-156661 ( R-HSA-72163; R-HSA-72203 ) R-HSA-156661 Reaction Name: Formation of Exon Junction Complex See in Reactome R-HSA-5617650 ( R-HSA-5617472 ) R-HSA-5617650 Reaction Name: HOXD3 chromatin is activated See in Reactome R-HSA-75856 ( R-HSA-674695 ) R-HSA-75856 Reaction Name: Abortive Initiation Before Second Transition See in Reactome R-HSA-113409 ( R-HSA-674695 ) R-HSA-113409 Reaction Name: Abortive termination of early transcription elongation by DSIF:NELF See in Reactome R-HSA-72143 ( R-HSA-72163; R-HSA-72203 ) R-HSA-72143 Reaction Name: Lariat Formation and 5'-Splice Site Cleavage See in Reactome R-HSA-75080 ( R-HSA-72165; R-HSA-72203 ) R-HSA-75080 Reaction Name: Formation of AT-AC A complex See in Reactome R-HSA-75862 ( R-HSA-674695 ) R-HSA-75862 Reaction Name: Fall Back to Closed Pre-initiation Complex See in Reactome R-HSA-5617471 ( R-HSA-5617472 ) R-HSA-5617471 Reaction Name: HOXA1 gene is transcribed See in Reactome R-HSA-75873 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75873 Reaction Name: Addition of Nucleotides 5 through 9 on the growing Transcript See in Reactome R-HSA-5617874 ( R-HSA-5617472 ) R-HSA-5617874 Reaction Name: HOXD4 gene is transcribed See in Reactome R-HSA-112385 ( R-HSA-75955 ) R-HSA-112385 Reaction Name: Addition of nucleotides leads to transcript elongation See in Reactome R-HSA-6803527 ( R-HSA-6803529 ) R-HSA-6803527 Reaction Name: ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression See in Reactome R-HSA-5617676 ( R-HSA-5617472 ) R-HSA-5617676 Reaction Name: HOXA3 gene is transcribed See in Reactome R-HSA-75861 ( R-HSA-75953; R-HSA-76042 ) R-HSA-75861 Reaction Name: NTP Binds Active Site of RNA Polymerase II See in Reactome R-HSA-6782131 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782131 Reaction Name: ERCC2-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-76576 ( R-HSA-73776; R-HSA-76042 ) R-HSA-76576 Reaction Name: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition See in Reactome R-HSA-6782224 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782224 Reaction Name: 3' incision by ERCC5 (XPG) in TC-NER See in Reactome R-HSA-113402 ( R-HSA-113418; R-HSA-75955 ) R-HSA-113402 Reaction Name: Formation of DSIF:NELF:early elongation complex See in Reactome R-HSA-113411 ( R-HSA-674695 ) R-HSA-113411 Reaction Name: 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing See in Reactome R-HSA-75850 ( R-HSA-73776; R-HSA-76042 ) R-HSA-75850 Reaction Name: Addition of the third nucleotide on the nascent transcript See in Reactome R-HSA-6797616 ( R-HSA-6796648 ) R-HSA-6797616 Reaction Name: CCNK:CDK12 binds RNA Pol II at DNA repair genes See in Reactome R-HSA-6782141 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-6782141 Reaction Name: Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-112379 ( R-HSA-112382; R-HSA-75955 ) R-HSA-112379 Reaction Name: Recruitment of elongation factors to form elongation complex See in Reactome R-HSA-112395 ( R-HSA-674695 ) R-HSA-112395 Reaction Name: Abortive termination of elongation after arrest See in Reactome R-HSA-9684118 ( R-HSA-6781827; R-HSA-6782135 ) R-HSA-9684118 Reaction Name: ERCC3-facilitated RNA Pol II backtracking in TC-NER See in Reactome R-HSA-9613494 ( R-HSA-73776; R-HSA-76042 ) R-HSA-9613494 Reaction Name: Unwinding of DNA for the Nascent Transcript: Second Transition See in Reactome R-HSA-6782069 ( R-HSA-6781823; R-HSA-6781827 ) R-HSA-6782069 Reaction Name: UVSSA:USP7 deubiquitinates ERCC6 See in Reactome