DAR - Bologna Biocomputing Group

Search summary (Reactome ID: R-HSA-111465)

Number of enzymes:	3
Number of disease:	7
Number of reactomes:	44
Number of reactions:	79

Search results (Reactome ID: R-HSA-111465)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005138	ROCK1	Q13464	2.7.11.1	R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013422 R-HSA-9013422 Reactome Name: RHOBTB1 GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-9706574 R-HSA-9706574 Reactome Name: RHOBTB GTPase Cycle See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Immune System Programmed Cell Death Developmental Biology	R-HSA-201611 ( R-HSA-111465 ) R-HSA-201611 Reaction Name: Caspase-mediated cleavage of Rock-1 See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018778 ( R-HSA-9013422 ) R-HSA-9018778 Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane See in Reactome R-HSA-9680443 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-9680443 Reaction Name: ROCK1,2 bind ROCKi See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome
MONDO:0011804	CASP8	Q14790	3.4.22.61	R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-75158 R-HSA-75158 Reactome Name: TRAIL signaling See in Reactome R-HSA-75108 R-HSA-75108 Reactome Name: Activation, myristolyation of BID and translocation to mitochondria See in Reactome R-HSA-9686347 R-HSA-9686347 Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis See in Reactome R-HSA-264870 R-HSA-264870 Reactome Name: Caspase-mediated cleavage of cytoskeletal proteins See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5660668 R-HSA-5660668 Reactome Name: CLEC7A/inflammasome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5218900 R-HSA-5218900 Reactome Name: CASP8 activity is inhibited See in Reactome R-HSA-140534 R-HSA-140534 Reactome Name: Caspase activation via Death Receptors in the presence of ligand See in Reactome R-HSA-2562578 R-HSA-2562578 Reactome Name: TRIF-mediated programmed cell death See in Reactome R-HSA-75157 R-HSA-75157 Reactome Name: FasL/ CD95L signaling See in Reactome R-HSA-69416 R-HSA-69416 Reactome Name: Dimerization of procaspase-8 See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-3371378 R-HSA-3371378 Reactome Name: Regulation by c-FLIP See in Reactome R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-9013957 R-HSA-9013957 Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5357769 R-HSA-5357769 Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Signal Transduction	R-HSA-139898 ( R-HSA-75108 ) R-HSA-139898 Reaction Name: Caspase-8 activates BID by cleavage See in Reactome R-HSA-139952 ( R-HSA-140534 ) R-HSA-139952 Reaction Name: Caspase-8 processing in the DISC See in Reactome R-HSA-141156 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141156 Reaction Name: TRAIL-mediated dimerization of procaspase-8 See in Reactome R-HSA-141159 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141159 Reaction Name: TNF-mediated dimerization of procaspase-8 See in Reactome R-HSA-201637 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-201637 Reaction Name: Caspase-mediated cleavage of plectin-1 See in Reactome R-HSA-2562541 ( R-HSA-2562578 ) R-HSA-2562541 Reaction Name: TLR4-induced ripoptosome assembly See in Reactome R-HSA-2562564 ( R-HSA-140534; R-HSA-2562578 ) R-HSA-2562564 Reaction Name: Caspase-8 processing within TLR4 complex See in Reactome R-HSA-2672196 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5357905; R-HSA-5675482; R-HSA-9686347 ) R-HSA-2672196 Reaction Name: Viral serpin blocks caspase-8 activity See in Reactome R-HSA-3371359 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3371359 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling See in Reactome R-HSA-3371360 ( R-HSA-140534; R-HSA-3371378; R-HSA-5357905 ) R-HSA-3371360 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling See in Reactome R-HSA-3465429 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-3465429 Reaction Name: FLIP(S) and procaspase-8 form heterodimer See in Reactome R-HSA-3465448 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465448 Reaction Name: Caspase-8 and FLIP(L) processing at DISC See in Reactome R-HSA-3465459 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465459 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling See in Reactome R-HSA-350319 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-350319 Reaction Name: Caspase mediated cleavage of vimentin at IDVD (259) See in Reactome R-HSA-351863 ( R-HSA-75153 ) R-HSA-351863 Reaction Name: Translocation of active caspase-8 to the mitochondrial membrane See in Reactome R-HSA-351894 ( R-HSA-111465; R-HSA-75153 ) R-HSA-351894 Reaction Name: Caspase mediated cleavage of BAP31 See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-5357828 ( R-HSA-5213460; R-HSA-5357905; R-HSA-5675482 ) R-HSA-5357828 Reaction Name: RIPK1 is cleaved by CASP8 See in Reactome R-HSA-5634228 ( R-HSA-5357905 ) R-HSA-5634228 Reaction Name: TRAF1 is cleaved by caspases See in Reactome R-HSA-5660662 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660662 Reaction Name: ASC binds Caspase-8 complex See in Reactome R-HSA-5660663 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660663 Reaction Name: Caspase-8 cleaves IL1B precursor See in Reactome R-HSA-5660665 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660665 Reaction Name: Caspase-8 binds MALT See in Reactome R-HSA-5675456 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-5675456 Reaction Name: FLIP(L) and procaspase-8 form heterodimer See in Reactome R-HSA-5692550 ( R-HSA-5357905 ) R-HSA-5692550 Reaction Name: Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 See in Reactome R-HSA-622420 ( R-HSA-168638 ) R-HSA-622420 Reaction Name: NOD1 induced apoptosis is mediated by RIP2 and CARD8 See in Reactome R-HSA-73945 ( R-HSA-140534; R-HSA-69416 ) R-HSA-73945 Reaction Name: FAS-mediated dimerization of procaspase-8 See in Reactome R-HSA-75146 ( R-HSA-75158 ) R-HSA-75146 Reaction Name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 See in Reactome R-HSA-75240 ( R-HSA-5357786 ) R-HSA-75240 Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 See in Reactome R-HSA-83586 ( R-HSA-75157 ) R-HSA-83586 Reaction Name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 See in Reactome R-HSA-9013889 ( R-HSA-9013957 ) R-HSA-9013889 Reaction Name: TLR3-induced ripoptosome assembly See in Reactome R-HSA-9013895 ( R-HSA-9013957 ) R-HSA-9013895 Reaction Name: Caspase-8 processing within TLR3 complex See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-9686930 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686930 Reaction Name: RIPK3 is cleaved by CASP8 See in Reactome R-HSA-9687458 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9687458 Reaction Name: HSV1 RIR1 binds CASP8 See in Reactome R-HSA-9697747 ( R-HSA-5357905 ) R-HSA-9697747 Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex See in Reactome R-HSA-9697750 ( R-HSA-5357905 ) R-HSA-9697750 Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L) See in Reactome
MONDO:0013743	PRKCD	Q05655	2.7.11.13 2.7.10.2	R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-450520 R-HSA-450520 Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-114508 R-HSA-114508 Reactome Name: Effects of PIP2 hydrolysis See in Reactome	R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Metabolism of RNA Programmed Cell Death Signal Transduction Hemostasis	R-HSA-111966 ( R-HSA-111933; R-HSA-1489509 ) R-HSA-111966 Reaction Name: GRK2 binds CALM1:4Ca2+ See in Reactome R-HSA-111970 ( R-HSA-111933; R-HSA-1489509 ) R-HSA-111970 Reaction Name: PKC phosphorylates GRK2 See in Reactome R-HSA-198314 ( R-HSA-1489509; R-HSA-2029485 ) R-HSA-198314 Reaction Name: DAG stimulates protein kinase C-delta See in Reactome R-HSA-212552 ( R-HSA-111465 ) R-HSA-212552 Reaction Name: Caspase 3-mediated cleavage of PKC delta See in Reactome R-HSA-425861 ( R-HSA-114508 ) R-HSA-425861 Reaction Name: Activation of Protein Kinase C novel isoforms See in Reactome R-HSA-450533 ( R-HSA-450520 ) R-HSA-450533 Reaction Name: PKCdelta phosphorylates HuR See in Reactome R-HSA-5218805 ( R-HSA-5218921 ) R-HSA-5218805 Reaction Name: PKC autophosphorylates See in Reactome R-HSA-5218813 ( R-HSA-5218921 ) R-HSA-5218813 Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane See in Reactome R-HSA-5218821 ( R-HSA-5218921 ) R-HSA-5218821 Reaction Name: PDK1 phosphorylates PKC See in Reactome R-HSA-5218823 ( R-HSA-5218921 ) R-HSA-5218823 Reaction Name: PKC phosphorylates sphingosine kinase 1 See in Reactome R-HSA-5607734 ( R-HSA-5607764 ) R-HSA-5607734 Reaction Name: PKC-delta translocates to plasma membrane See in Reactome R-HSA-5607740 ( R-HSA-5607764 ) R-HSA-5607740 Reaction Name: PKC-delta phosphorylates CARD9 See in Reactome R-HSA-5607746 ( R-HSA-5607764 ) R-HSA-5607746 Reaction Name: PKC-delta is activated See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-751040 ( R-HSA-418597 ) R-HSA-751040 Reaction Name: PKC phosphorylates G alpha (z) See in Reactome R-HSA-8932284 () R-HSA-8932284 Reaction Name: PKC phosphorylates NFE2L2 See in Reactome R-HSA-8934446 ( R-HSA-1250196 ) R-HSA-8934446 Reaction Name: Activated PKC phosphorylates SHC1 See in Reactome R-HSA-8982703 ( R-HSA-418597 ) R-HSA-8982703 Reaction Name: PKC binds active G alpha (z) See in Reactome R-HSA-8982709 ( R-HSA-418597 ) R-HSA-8982709 Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-9626817 ( R-HSA-5668599 ) R-HSA-9626817 Reaction Name: PKC phosphorylates NCF1 See in Reactome
MONDO:0014253	PRKCD	Q05655	2.7.11.13 2.7.10.2	R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-450520 R-HSA-450520 Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-114508 R-HSA-114508 Reactome Name: Effects of PIP2 hydrolysis See in Reactome	R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Metabolism of RNA Programmed Cell Death Signal Transduction Hemostasis	R-HSA-111966 ( R-HSA-111933; R-HSA-1489509 ) R-HSA-111966 Reaction Name: GRK2 binds CALM1:4Ca2+ See in Reactome R-HSA-111970 ( R-HSA-111933; R-HSA-1489509 ) R-HSA-111970 Reaction Name: PKC phosphorylates GRK2 See in Reactome R-HSA-198314 ( R-HSA-1489509; R-HSA-2029485 ) R-HSA-198314 Reaction Name: DAG stimulates protein kinase C-delta See in Reactome R-HSA-212552 ( R-HSA-111465 ) R-HSA-212552 Reaction Name: Caspase 3-mediated cleavage of PKC delta See in Reactome R-HSA-425861 ( R-HSA-114508 ) R-HSA-425861 Reaction Name: Activation of Protein Kinase C novel isoforms See in Reactome R-HSA-450533 ( R-HSA-450520 ) R-HSA-450533 Reaction Name: PKCdelta phosphorylates HuR See in Reactome R-HSA-5218805 ( R-HSA-5218921 ) R-HSA-5218805 Reaction Name: PKC autophosphorylates See in Reactome R-HSA-5218813 ( R-HSA-5218921 ) R-HSA-5218813 Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane See in Reactome R-HSA-5218821 ( R-HSA-5218921 ) R-HSA-5218821 Reaction Name: PDK1 phosphorylates PKC See in Reactome R-HSA-5218823 ( R-HSA-5218921 ) R-HSA-5218823 Reaction Name: PKC phosphorylates sphingosine kinase 1 See in Reactome R-HSA-5607734 ( R-HSA-5607764 ) R-HSA-5607734 Reaction Name: PKC-delta translocates to plasma membrane See in Reactome R-HSA-5607740 ( R-HSA-5607764 ) R-HSA-5607740 Reaction Name: PKC-delta phosphorylates CARD9 See in Reactome R-HSA-5607746 ( R-HSA-5607764 ) R-HSA-5607746 Reaction Name: PKC-delta is activated See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-751040 ( R-HSA-418597 ) R-HSA-751040 Reaction Name: PKC phosphorylates G alpha (z) See in Reactome R-HSA-8932284 () R-HSA-8932284 Reaction Name: PKC phosphorylates NFE2L2 See in Reactome R-HSA-8934446 ( R-HSA-1250196 ) R-HSA-8934446 Reaction Name: Activated PKC phosphorylates SHC1 See in Reactome R-HSA-8982703 ( R-HSA-418597 ) R-HSA-8982703 Reaction Name: PKC binds active G alpha (z) See in Reactome R-HSA-8982709 ( R-HSA-418597 ) R-HSA-8982709 Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-9626817 ( R-HSA-5668599 ) R-HSA-9626817 Reaction Name: PKC phosphorylates NCF1 See in Reactome
MONDO:0015517	PRKCD	Q05655	2.7.11.13 2.7.10.2	R-HSA-111933 R-HSA-111933 Reactome Name: Calmodulin induced events See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-1489509 R-HSA-1489509 Reactome Name: DAG and IP3 signaling See in Reactome R-HSA-5668599 R-HSA-5668599 Reactome Name: RHO GTPases Activate NADPH Oxidases See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-418597 R-HSA-418597 Reactome Name: G alpha (z) signalling events See in Reactome R-HSA-877300 R-HSA-877300 Reactome Name: Interferon gamma signaling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-450520 R-HSA-450520 Reactome Name: HuR (ELAVL1) binds and stabilizes mRNA See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-5218921 R-HSA-5218921 Reactome Name: VEGFR2 mediated cell proliferation See in Reactome R-HSA-114508 R-HSA-114508 Reactome Name: Effects of PIP2 hydrolysis See in Reactome	R-HSA-111997 R-HSA-111997 Reactome Name: CaM pathway See in Reactome R-HSA-111996 R-HSA-111996 Reactome Name: Ca-dependent events See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-913531 R-HSA-913531 Reactome Name: Interferon Signaling See in Reactome R-HSA-450531 R-HSA-450531 Reactome Name: Regulation of mRNA stability by proteins that bind AU-rich elements See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-8953854 R-HSA-8953854 Reactome Name: Metabolism of RNA See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-112043 R-HSA-112043 Reactome Name: PLC beta mediated events See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-112040 R-HSA-112040 Reactome Name: G-protein mediated events See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Metabolism of RNA Programmed Cell Death Signal Transduction Hemostasis	R-HSA-111966 ( R-HSA-111933; R-HSA-1489509 ) R-HSA-111966 Reaction Name: GRK2 binds CALM1:4Ca2+ See in Reactome R-HSA-111970 ( R-HSA-111933; R-HSA-1489509 ) R-HSA-111970 Reaction Name: PKC phosphorylates GRK2 See in Reactome R-HSA-198314 ( R-HSA-1489509; R-HSA-2029485 ) R-HSA-198314 Reaction Name: DAG stimulates protein kinase C-delta See in Reactome R-HSA-212552 ( R-HSA-111465 ) R-HSA-212552 Reaction Name: Caspase 3-mediated cleavage of PKC delta See in Reactome R-HSA-425861 ( R-HSA-114508 ) R-HSA-425861 Reaction Name: Activation of Protein Kinase C novel isoforms See in Reactome R-HSA-450533 ( R-HSA-450520 ) R-HSA-450533 Reaction Name: PKCdelta phosphorylates HuR See in Reactome R-HSA-5218805 ( R-HSA-5218921 ) R-HSA-5218805 Reaction Name: PKC autophosphorylates See in Reactome R-HSA-5218813 ( R-HSA-5218921 ) R-HSA-5218813 Reaction Name: DAG and Ca+2 bind to PKC and tether it to membrane See in Reactome R-HSA-5218821 ( R-HSA-5218921 ) R-HSA-5218821 Reaction Name: PDK1 phosphorylates PKC See in Reactome R-HSA-5218823 ( R-HSA-5218921 ) R-HSA-5218823 Reaction Name: PKC phosphorylates sphingosine kinase 1 See in Reactome R-HSA-5607734 ( R-HSA-5607764 ) R-HSA-5607734 Reaction Name: PKC-delta translocates to plasma membrane See in Reactome R-HSA-5607740 ( R-HSA-5607764 ) R-HSA-5607740 Reaction Name: PKC-delta phosphorylates CARD9 See in Reactome R-HSA-5607746 ( R-HSA-5607764 ) R-HSA-5607746 Reaction Name: PKC-delta is activated See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-751040 ( R-HSA-418597 ) R-HSA-751040 Reaction Name: PKC phosphorylates G alpha (z) See in Reactome R-HSA-8932284 () R-HSA-8932284 Reaction Name: PKC phosphorylates NFE2L2 See in Reactome R-HSA-8934446 ( R-HSA-1250196 ) R-HSA-8934446 Reaction Name: Activated PKC phosphorylates SHC1 See in Reactome R-HSA-8982703 ( R-HSA-418597 ) R-HSA-8982703 Reaction Name: PKC binds active G alpha (z) See in Reactome R-HSA-8982709 ( R-HSA-418597 ) R-HSA-8982709 Reaction Name: G-alpha(z):PKC dissociates to give phosphorylated G alpha (z) See in Reactome R-HSA-909552 ( R-HSA-877300 ) R-HSA-909552 Reaction Name: Phosphorylation of STAT1 at Ser727 See in Reactome R-HSA-9626817 ( R-HSA-5668599 ) R-HSA-9626817 Reaction Name: PKC phosphorylates NCF1 See in Reactome
MONDO:0016216	CASP8	Q14790	3.4.22.61	R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-933543 R-HSA-933543 Reactome Name: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 See in Reactome R-HSA-75158 R-HSA-75158 Reactome Name: TRAIL signaling See in Reactome R-HSA-75108 R-HSA-75108 Reactome Name: Activation, myristolyation of BID and translocation to mitochondria See in Reactome R-HSA-9686347 R-HSA-9686347 Reactome Name: Microbial modulation of RIPK1-mediated regulated necrosis See in Reactome R-HSA-264870 R-HSA-264870 Reactome Name: Caspase-mediated cleavage of cytoskeletal proteins See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5660668 R-HSA-5660668 Reactome Name: CLEC7A/inflammasome pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5218900 R-HSA-5218900 Reactome Name: CASP8 activity is inhibited See in Reactome R-HSA-140534 R-HSA-140534 Reactome Name: Caspase activation via Death Receptors in the presence of ligand See in Reactome R-HSA-2562578 R-HSA-2562578 Reactome Name: TRIF-mediated programmed cell death See in Reactome R-HSA-75157 R-HSA-75157 Reactome Name: FasL/ CD95L signaling See in Reactome R-HSA-69416 R-HSA-69416 Reactome Name: Dimerization of procaspase-8 See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-3371378 R-HSA-3371378 Reactome Name: Regulation by c-FLIP See in Reactome R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-9013957 R-HSA-9013957 Reactome Name: TLR3-mediated TICAM1-dependent programmed cell death See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5357769 R-HSA-5357769 Reactome Name: Caspase activation via extrinsic apoptotic signalling pathway See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome	Immune System Programmed Cell Death Signal Transduction	R-HSA-139898 ( R-HSA-75108 ) R-HSA-139898 Reaction Name: Caspase-8 activates BID by cleavage See in Reactome R-HSA-139952 ( R-HSA-140534 ) R-HSA-139952 Reaction Name: Caspase-8 processing in the DISC See in Reactome R-HSA-141156 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141156 Reaction Name: TRAIL-mediated dimerization of procaspase-8 See in Reactome R-HSA-141159 ( R-HSA-140534; R-HSA-69416 ) R-HSA-141159 Reaction Name: TNF-mediated dimerization of procaspase-8 See in Reactome R-HSA-201637 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-201637 Reaction Name: Caspase-mediated cleavage of plectin-1 See in Reactome R-HSA-2562541 ( R-HSA-2562578 ) R-HSA-2562541 Reaction Name: TLR4-induced ripoptosome assembly See in Reactome R-HSA-2562564 ( R-HSA-140534; R-HSA-2562578 ) R-HSA-2562564 Reaction Name: Caspase-8 processing within TLR4 complex See in Reactome R-HSA-2672196 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5357905; R-HSA-5675482; R-HSA-9686347 ) R-HSA-2672196 Reaction Name: Viral serpin blocks caspase-8 activity See in Reactome R-HSA-3371359 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3371359 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling See in Reactome R-HSA-3371360 ( R-HSA-140534; R-HSA-3371378; R-HSA-5357905 ) R-HSA-3371360 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in TNF signaling See in Reactome R-HSA-3465429 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-3465429 Reaction Name: FLIP(S) and procaspase-8 form heterodimer See in Reactome R-HSA-3465448 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465448 Reaction Name: Caspase-8 and FLIP(L) processing at DISC See in Reactome R-HSA-3465459 ( R-HSA-140534; R-HSA-3371378 ) R-HSA-3465459 Reaction Name: FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling See in Reactome R-HSA-350319 ( R-HSA-111465; R-HSA-264870; R-HSA-75153 ) R-HSA-350319 Reaction Name: Caspase mediated cleavage of vimentin at IDVD (259) See in Reactome R-HSA-351863 ( R-HSA-75153 ) R-HSA-351863 Reaction Name: Translocation of active caspase-8 to the mitochondrial membrane See in Reactome R-HSA-351894 ( R-HSA-111465; R-HSA-75153 ) R-HSA-351894 Reaction Name: Caspase mediated cleavage of BAP31 See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-5357828 ( R-HSA-5213460; R-HSA-5357905; R-HSA-5675482 ) R-HSA-5357828 Reaction Name: RIPK1 is cleaved by CASP8 See in Reactome R-HSA-5634228 ( R-HSA-5357905 ) R-HSA-5634228 Reaction Name: TRAF1 is cleaved by caspases See in Reactome R-HSA-5660662 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660662 Reaction Name: ASC binds Caspase-8 complex See in Reactome R-HSA-5660663 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660663 Reaction Name: Caspase-8 cleaves IL1B precursor See in Reactome R-HSA-5660665 ( R-HSA-5607764; R-HSA-5660668 ) R-HSA-5660665 Reaction Name: Caspase-8 binds MALT See in Reactome R-HSA-5675456 ( R-HSA-5213460; R-HSA-5218900; R-HSA-5675482 ) R-HSA-5675456 Reaction Name: FLIP(L) and procaspase-8 form heterodimer See in Reactome R-HSA-5692550 ( R-HSA-5357905 ) R-HSA-5692550 Reaction Name: Viral inhibitor of caspase-8 activation (UL36) binds caspase-8 See in Reactome R-HSA-622420 ( R-HSA-168638 ) R-HSA-622420 Reaction Name: NOD1 induced apoptosis is mediated by RIP2 and CARD8 See in Reactome R-HSA-73945 ( R-HSA-140534; R-HSA-69416 ) R-HSA-73945 Reaction Name: FAS-mediated dimerization of procaspase-8 See in Reactome R-HSA-75146 ( R-HSA-75158 ) R-HSA-75146 Reaction Name: TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8 See in Reactome R-HSA-75240 ( R-HSA-5357786 ) R-HSA-75240 Reaction Name: TRADD:TRAF2:RIP1:FADD complex binds Pro-Caspase 8 See in Reactome R-HSA-83586 ( R-HSA-75157 ) R-HSA-83586 Reaction Name: FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 See in Reactome R-HSA-9013889 ( R-HSA-9013957 ) R-HSA-9013889 Reaction Name: TLR3-induced ripoptosome assembly See in Reactome R-HSA-9013895 ( R-HSA-9013957 ) R-HSA-9013895 Reaction Name: Caspase-8 processing within TLR3 complex See in Reactome R-HSA-933523 ( R-HSA-933543 ) R-HSA-933523 Reaction Name: Dimerzation of procaspase-8, procaspase-10 See in Reactome R-HSA-933526 ( R-HSA-933543 ) R-HSA-933526 Reaction Name: Recruitment of caspase-8 and -10 to FADD complex See in Reactome R-HSA-933532 ( R-HSA-933543 ) R-HSA-933532 Reaction Name: Processing of caspases See in Reactome R-HSA-933539 ( R-HSA-933543 ) R-HSA-933539 Reaction Name: Recruitment of IKK complex See in Reactome R-HSA-9686930 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-9686930 Reaction Name: RIPK3 is cleaved by CASP8 See in Reactome R-HSA-9687458 ( R-HSA-5213460; R-HSA-9686347 ) R-HSA-9687458 Reaction Name: HSV1 RIR1 binds CASP8 See in Reactome R-HSA-9697747 ( R-HSA-5357905 ) R-HSA-9697747 Reaction Name: Caspase-8 and FLIP(L) processing at TNFR signaling complex See in Reactome R-HSA-9697750 ( R-HSA-5357905 ) R-HSA-9697750 Reaction Name: RIPK1 is cleaved by CASP8:FLIP(L) See in Reactome
MONDO:0021100	ROCK1	Q13464	2.7.11.1	R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-416572 R-HSA-416572 Reactome Name: Sema4D induced cell migration and growth-cone collapse See in Reactome R-HSA-9013106 R-HSA-9013106 Reactome Name: RHOC GTPase cycle See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-111465 R-HSA-111465 Reactome Name: Apoptotic cleavage of cellular proteins See in Reactome R-HSA-9696264 R-HSA-9696264 Reactome Name: RND3 GTPase cycle See in Reactome R-HSA-3928663 R-HSA-3928663 Reactome Name: EPHA-mediated growth cone collapse See in Reactome R-HSA-3928662 R-HSA-3928662 Reactome Name: EPHB-mediated forward signaling See in Reactome R-HSA-9013026 R-HSA-9013026 Reactome Name: RHOB GTPase cycle See in Reactome R-HSA-9013407 R-HSA-9013407 Reactome Name: RHOH GTPase cycle See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-9013422 R-HSA-9013422 Reactome Name: RHOBTB1 GTPase cycle See in Reactome R-HSA-8980692 R-HSA-8980692 Reactome Name: RHOA GTPase cycle See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-400685 R-HSA-400685 Reactome Name: Sema4D in semaphorin signaling See in Reactome R-HSA-9012999 R-HSA-9012999 Reactome Name: RHO GTPase cycle See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-75153 R-HSA-75153 Reactome Name: Apoptotic execution phase See in Reactome R-HSA-9706574 R-HSA-9706574 Reactome Name: RHOBTB GTPase Cycle See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-373755 R-HSA-373755 Reactome Name: Semaphorin interactions See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-2682334 R-HSA-2682334 Reactome Name: EPH-Ephrin signaling See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Immune System Programmed Cell Death Developmental Biology	R-HSA-201611 ( R-HSA-111465 ) R-HSA-201611 Reaction Name: Caspase-mediated cleavage of Rock-1 See in Reactome R-HSA-3928576 ( R-HSA-3928662 ) R-HSA-3928576 Reaction Name: RHOA:GTP binds ROCK, activating it See in Reactome R-HSA-3928577 ( R-HSA-3928662 ) R-HSA-3928577 Reaction Name: ROCK phosphorylates LIMK1,2 See in Reactome R-HSA-3928616 ( R-HSA-3928663 ) R-HSA-3928616 Reaction Name: Activated ROCK phosphorylates MRLCs See in Reactome R-HSA-3928647 ( R-HSA-4420097 ) R-HSA-3928647 Reaction Name: RHOA:GTP:Mg2+ binds ROCK1,ROCK2 See in Reactome R-HSA-419049 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-419049 Reaction Name: ROCK activation by RHO See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419087 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419087 Reaction Name: LIM kinase phosphorylation by ROCK See in Reactome R-HSA-419197 ( R-HSA-416572; R-HSA-5627117 ) R-HSA-419197 Reaction Name: Myosin regulatory light chain phosphorylation by ROCK See in Reactome R-HSA-5218826 ( R-HSA-4420097 ) R-HSA-5218826 Reaction Name: Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732 See in Reactome R-HSA-5228992 ( R-HSA-4420097 ) R-HSA-5228992 Reaction Name: ROCK1,ROCK2 are activated See in Reactome R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-9013009 ( R-HSA-8980692 ) R-HSA-9013009 Reaction Name: RHOA binds effectors at the plasma membrane See in Reactome R-HSA-9013024 ( R-HSA-9013026 ) R-HSA-9013024 Reaction Name: RHOB binds effectors at the plasma membrane See in Reactome R-HSA-9013110 ( R-HSA-9013106 ) R-HSA-9013110 Reaction Name: RHOC binds effectors at the plasma membrane See in Reactome R-HSA-9018758 ( R-HSA-9013407 ) R-HSA-9018758 Reaction Name: RHOH binds effectors at the plasma membrane See in Reactome R-HSA-9018778 ( R-HSA-9013422 ) R-HSA-9018778 Reaction Name: RHOBTB1 binds interacting proteins at the endosome membrane See in Reactome R-HSA-9680443 ( R-HSA-416482; R-HSA-416572; R-HSA-5627117 ) R-HSA-9680443 Reaction Name: ROCK1,2 bind ROCKi See in Reactome R-HSA-9696268 ( R-HSA-9696264 ) R-HSA-9696268 Reaction Name: RND3 binds effectors See in Reactome