DAR - Bologna Biocomputing Group

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008438	SPAST	Q9UBP0	5.6.1.1	R-HSA-9668328 R-HSA-9668328 Reactome Name: Sealing of the nuclear envelope (NE) by ESCRT-III See in Reactome	R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-2995410 R-HSA-2995410 Reactome Name: Nuclear Envelope (NE) Reassembly See in Reactome	Cell Cycle	R-HSA-9668389 ( R-HSA-9668328 ) R-HSA-9668389 Reaction Name: VPS4 binds ESCRT-III assemblies at nuclear envelope (NE) fenestrations See in Reactome R-HSA-9668405 ( R-HSA-9668328 ) R-HSA-9668405 Reaction Name: SPAST (spastin) binds the IST1 subunit of ESCRT-III at the sites of microtubule attachment to chromatin See in Reactome R-HSA-9668415 ( R-HSA-9668328 ) R-HSA-9668415 Reaction Name: VPS4 mediates disassembly of ESCRTIII subunits to promote sealing of holes in the nuclear envelope See in Reactome R-HSA-9668419 ( R-HSA-9668328 ) R-HSA-9668419 Reaction Name: SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites See in Reactome