DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q9BYM8)

Number of enzymes:	1
Number of disease:	4
Number of reactomes:	3
Number of reactions:	7

Search results (UniProt accession: Q9BYM8)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0017992	RBCK1	Q9BYM8	2.3.2.31	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357904 ( R-HSA-5357956 ) R-HSA-5357904 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC See in Reactome R-HSA-5661517 ( R-HSA-5357905 ) R-HSA-5661517 Reaction Name: LUBAC comlex binds OTULIN See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0018348	RBCK1	Q9BYM8	2.3.2.31	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357904 ( R-HSA-5357956 ) R-HSA-5357904 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC See in Reactome R-HSA-5661517 ( R-HSA-5357905 ) R-HSA-5661517 Reaction Name: LUBAC comlex binds OTULIN See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0014389	RBCK1	Q9BYM8	2.3.2.31	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357904 ( R-HSA-5357956 ) R-HSA-5357904 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC See in Reactome R-HSA-5661517 ( R-HSA-5357905 ) R-HSA-5661517 Reaction Name: LUBAC comlex binds OTULIN See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0009292	RBCK1	Q9BYM8	2.3.2.31	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357904 ( R-HSA-5357956 ) R-HSA-5357904 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC See in Reactome R-HSA-5661517 ( R-HSA-5357905 ) R-HSA-5661517 Reaction Name: LUBAC comlex binds OTULIN See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome