DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q96PU5)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	4
Number of reactions:	11

Search results (UniProt accession: Q96PU5)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0014966	NEDD4L	Q96PU5	2.3.2.26	R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome R-HSA-2672351 R-HSA-2672351 Reactome Name: Stimuli-sensing channels See in Reactome R-HSA-2173795 R-HSA-2173795 Reactome Name: Downregulation of SMAD2/3:SMAD4 transcriptional activity See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome	R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-983712 R-HSA-983712 Reactome Name: Ion channel transport See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-2173793 R-HSA-2173793 Reactome Name: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Immune System Transport of small molecules Signal Transduction	R-HSA-178218 ( R-HSA-2173788 ) R-HSA-178218 Reaction Name: SMAD7:SMURF complex binds to phosphorylated TGFBR1 See in Reactome R-HSA-2169050 ( R-HSA-2173788 ) R-HSA-2169050 Reaction Name: SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 See in Reactome R-HSA-2176416 ( R-HSA-2173788 ) R-HSA-2176416 Reaction Name: NEDD4L ubiquitin ligase binds SMAD7 See in Reactome R-HSA-2176417 ( R-HSA-2173788 ) R-HSA-2176417 Reaction Name: SMAD7:NEDD4L complex translocates to the cytosol See in Reactome R-HSA-2176491 ( R-HSA-2173795 ) R-HSA-2176491 Reaction Name: NEDD4L binds phosphorylated linker region of SMAD2/3 See in Reactome R-HSA-2176502 ( R-HSA-2173795 ) R-HSA-2176502 Reaction Name: NEDD4L ubiquitinates SMAD2/3 See in Reactome R-HSA-2682349 ( R-HSA-2672351 ) R-HSA-2682349 Reaction Name: RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome