DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q96GD4)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	10
Number of reactions:	22

Search results (UniProt accession: Q96GD4)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0016996	AURKB	Q96GD4	2.7.11.1	R-HSA-5663220 R-HSA-5663220 Reactome Name: RHO GTPases Activate Formins See in Reactome R-HSA-2500257 R-HSA-2500257 Reactome Name: Resolution of Sister Chromatid Cohesion See in Reactome R-HSA-2467813 R-HSA-2467813 Reactome Name: Separation of Sister Chromatids See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-9022692 R-HSA-9022692 Reactome Name: Regulation of MECP2 expression and activity See in Reactome R-HSA-4615885 R-HSA-4615885 Reactome Name: SUMOylation of DNA replication proteins See in Reactome R-HSA-9648025 R-HSA-9648025 Reactome Name: EML4 and NUDC in mitotic spindle formation See in Reactome R-HSA-174178 R-HSA-174178 Reactome Name: APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 See in Reactome R-HSA-141444 R-HSA-141444 Reactome Name: Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal See in Reactome R-HSA-68877 R-HSA-68877 Reactome Name: Mitotic Prometaphase See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-174143 R-HSA-174143 Reactome Name: APC/C-mediated degradation of cell cycle proteins See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-2555396 R-HSA-2555396 Reactome Name: Mitotic Metaphase and Anaphase See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-141424 R-HSA-141424 Reactome Name: Amplification of signal from the kinetochores See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-453276 R-HSA-453276 Reactome Name: Regulation of mitotic cell cycle See in Reactome R-HSA-68886 R-HSA-68886 Reactome Name: M Phase See in Reactome R-HSA-68882 R-HSA-68882 Reactome Name: Mitotic Anaphase See in Reactome R-HSA-8986944 R-HSA-8986944 Reactome Name: Transcriptional Regulation by MECP2 See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-69618 R-HSA-69618 Reactome Name: Mitotic Spindle Checkpoint See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Cell Cycle Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-141409 ( R-HSA-141444 ) R-HSA-141409 Reaction Name: Mad1 binds kinetochore See in Reactome R-HSA-141422 ( R-HSA-141444 ) R-HSA-141422 Reaction Name: MAD2 converted to an inhibitory state via interaction with Mad1 See in Reactome R-HSA-141431 ( R-HSA-141444 ) R-HSA-141431 Reaction Name: MAD2 associates with the Mad1 kinetochore complex See in Reactome R-HSA-141439 ( R-HSA-141444 ) R-HSA-141439 Reaction Name: Release of activated MAD2 from kinetochores See in Reactome R-HSA-1638803 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638803 Reaction Name: Phosphorylation of cohesin by PLK1 at centromeres See in Reactome R-HSA-1638821 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-1638821 Reaction Name: PP2A-B56 dephosphorylates centromeric cohesin See in Reactome R-HSA-174088 ( R-HSA-174178 ) R-HSA-174088 Reaction Name: Association of cell cycle proteins with the APC/C:Cdh1 complex See in Reactome R-HSA-174105 ( R-HSA-174178 ) R-HSA-174105 Reaction Name: Degradation of multiubiquitinated cell cycle proteins See in Reactome R-HSA-174195 ( R-HSA-174178 ) R-HSA-174195 Reaction Name: Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex See in Reactome R-HSA-2467809 ( R-HSA-2467813 ) R-HSA-2467809 Reaction Name: ESPL1 (Separase) cleaves centromeric cohesin See in Reactome R-HSA-2467811 ( R-HSA-2467813 ) R-HSA-2467811 Reaction Name: Separation of sister chromatids See in Reactome R-HSA-2468287 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2468287 Reaction Name: CDK1 phosphorylates CDCA5 (Sororin) at centromeres See in Reactome R-HSA-2484822 ( R-HSA-2500257; R-HSA-68877 ) R-HSA-2484822 Reaction Name: Kinetochore assembly See in Reactome R-HSA-375302 ( R-HSA-68877 ) R-HSA-375302 Reaction Name: Kinetochore capture of astral microtubules See in Reactome R-HSA-4655355 ( R-HSA-4615885 ) R-HSA-4655355 Reaction Name: RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) See in Reactome R-HSA-5666129 ( R-HSA-5663220 ) R-HSA-5666129 Reaction Name: CDC42:GTP recruits DIAPH2-2 to kinetochores See in Reactome R-HSA-5666160 ( R-HSA-5663220 ) R-HSA-5666160 Reaction Name: AURKB phosphorylates DIAPH2-2 at kinetochores See in Reactome R-HSA-5666169 ( R-HSA-5663220 ) R-HSA-5666169 Reaction Name: Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 See in Reactome R-HSA-6805122 ( R-HSA-6804756 ) R-HSA-6805122 Reaction Name: AURKB binds TP53 See in Reactome R-HSA-6805126 ( R-HSA-6804756 ) R-HSA-6805126 Reaction Name: AURKB phosphorylates TP53 See in Reactome R-HSA-9023132 ( R-HSA-9022692 ) R-HSA-9023132 Reaction Name: AURKB phosphorylates MECP2 at S423 See in Reactome R-HSA-9648114 ( R-HSA-68877; R-HSA-9648025 ) R-HSA-9648114 Reaction Name: EML4 recruits NUDC to mitotic spindle See in Reactome