DAR - Bologna Biocomputing Group

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0014912	OTULIN	Q96BN8	3.4.19.12	R-HSA-8866652 R-HSA-8866652 Reactome Name: Synthesis of active ubiquitin: roles of E1 and E2 enzymes See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome	R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-5661517 ( R-HSA-5357905 ) R-HSA-5661517 Reaction Name: LUBAC comlex binds OTULIN See in Reactome R-HSA-8853515 ( R-HSA-8866652 ) R-HSA-8853515 Reaction Name: OTULIN,USP5 cleaves UBC yielding ubiquitin See in Reactome R-HSA-8853529 ( R-HSA-8866652 ) R-HSA-8853529 Reaction Name: OTULIN,USP5 cleaves UBB yielding ubiquitin See in Reactome