DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q92993)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	16
Number of reactions:	76

Search results (UniProt accession: Q92993)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0030852	KAT5	Q92993	2.3.1.- 2.3.1.48	R-HSA-5685942 R-HSA-5685942 Reactome Name: HDR through Homologous Recombination (HRR) See in Reactome R-HSA-2559586 R-HSA-2559586 Reactome Name: DNA Damage/Telomere Stress Induced Senescence See in Reactome R-HSA-201722 R-HSA-201722 Reactome Name: Formation of the beta-catenin:TCF transactivating complex See in Reactome R-HSA-5693548 R-HSA-5693548 Reactome Name: Sensing of DNA Double Strand Breaks See in Reactome R-HSA-5693554 R-HSA-5693554 Reactome Name: Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) See in Reactome R-HSA-6804756 R-HSA-6804756 Reactome Name: Regulation of TP53 Activity through Phosphorylation See in Reactome R-HSA-5693579 R-HSA-5693579 Reactome Name: Homologous DNA Pairing and Strand Exchange See in Reactome R-HSA-5693565 R-HSA-5693565 Reactome Name: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome R-HSA-3214847 R-HSA-3214847 Reactome Name: HATs acetylate histones See in Reactome R-HSA-5693568 R-HSA-5693568 Reactome Name: Resolution of D-loop Structures through Holliday Junction Intermediates See in Reactome R-HSA-5685938 R-HSA-5685938 Reactome Name: HDR through Single Strand Annealing (SSA) See in Reactome R-HSA-9018519 R-HSA-9018519 Reactome Name: Estrogen-dependent gene expression See in Reactome R-HSA-5693616 R-HSA-5693616 Reactome Name: Presynaptic phase of homologous DNA pairing and strand exchange See in Reactome R-HSA-69473 R-HSA-69473 Reactome Name: G2/M DNA damage checkpoint See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-5693606 R-HSA-5693606 Reactome Name: DNA Double Strand Break Response See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-69620 R-HSA-69620 Reactome Name: Cell Cycle Checkpoints See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-69481 R-HSA-69481 Reactome Name: G2/M Checkpoints See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-5693537 R-HSA-5693537 Reactome Name: Resolution of D-Loop Structures See in Reactome	Cell Cycle Gene expression (Transcription) DNA Repair Cellular responses to stimuli Chromatin organization Signal Transduction	R-HSA-3321975 ( R-HSA-3214847 ) R-HSA-3321975 Reaction Name: NuA4 complex acetylates histone H2A, HIST1H4 See in Reactome R-HSA-3451147 ( R-HSA-201722 ) R-HSA-3451147 Reaction Name: KAT5 HAT complex acetylates TCF4 gene at histone H4 See in Reactome R-HSA-3451153 ( R-HSA-201722 ) R-HSA-3451153 Reaction Name: Beta-catenin recruits TRRAP/KAT5 HAT components See in Reactome R-HSA-5682018 ( R-HSA-2559586 ) R-HSA-5682018 Reaction Name: MRN complex bound to shortened telomeres recruits ATM See in Reactome R-HSA-5682026 ( R-HSA-2559586 ) R-HSA-5682026 Reaction Name: MRN bound to shortened telomeres activates ATM See in Reactome R-HSA-5682044 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5682044 Reaction Name: KAT5 acetylates ATM at DNA DSBs See in Reactome R-HSA-5682586 ( R-HSA-5693565 ) R-HSA-5682586 Reaction Name: HERC2 and PIAS4 are recruited to DNA DSBs See in Reactome R-HSA-5682588 ( R-HSA-5693565 ) R-HSA-5682588 Reaction Name: RNF8 binds phosphorylated MDC1 at DNA DSBs See in Reactome R-HSA-5682598 ( R-HSA-5693565 ) R-HSA-5682598 Reaction Name: ATM phosphorylates HERC2 See in Reactome R-HSA-5682607 ( R-HSA-5693565 ) R-HSA-5682607 Reaction Name: PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs See in Reactome R-HSA-5682629 ( R-HSA-5693565 ) R-HSA-5682629 Reaction Name: HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 See in Reactome R-HSA-5682858 ( R-HSA-5693565 ) R-HSA-5682858 Reaction Name: RNF8 and RNF168 ubiquitinate H2AFX See in Reactome R-HSA-5682863 ( R-HSA-5693565 ) R-HSA-5682863 Reaction Name: RNF168 binds DNA DSBs See in Reactome R-HSA-5682965 ( R-HSA-5693565 ) R-HSA-5682965 Reaction Name: WHSC1 dimethylates histone H4 on lysine K21 at DSBs See in Reactome R-HSA-5682967 ( R-HSA-5693565 ) R-HSA-5682967 Reaction Name: WHSC1 binds DNA DSBs See in Reactome R-HSA-5682983 ( R-HSA-5693565 ) R-HSA-5682983 Reaction Name: ATM phosphorylates WHSC1 See in Reactome R-HSA-5682992 ( R-HSA-5693565 ) R-HSA-5682992 Reaction Name: KDM4A,B bind H4K20Me2 See in Reactome R-HSA-5683077 ( R-HSA-5693565 ) R-HSA-5683077 Reaction Name: RNF8 and RNF168 ubiquitinate KDM4A,B See in Reactome R-HSA-5683384 ( R-HSA-5693565 ) R-HSA-5683384 Reaction Name: UIMC1 and FAM175A bind DNA DSBs See in Reactome R-HSA-5683385 ( R-HSA-5693565 ) R-HSA-5683385 Reaction Name: Formation of BRCA1-A complex at DNA DSBs See in Reactome R-HSA-5683405 ( R-HSA-5693565 ) R-HSA-5683405 Reaction Name: PPP5C dephosphorylates TP53BP1 See in Reactome R-HSA-5683425 ( R-HSA-5693565 ) R-HSA-5683425 Reaction Name: ATM phosphorylates TP53BP1 at DNA DSBs See in Reactome R-HSA-5683735 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-5683735 Reaction Name: CHEK2 is recruited to DNA DSBs See in Reactome R-HSA-5683801 ( R-HSA-5693565 ) R-HSA-5683801 Reaction Name: CHEK2 phosphorylates BRCA1 See in Reactome R-HSA-5683964 ( R-HSA-5693565 ) R-HSA-5683964 Reaction Name: ATM phosphorylates EYA1-4 See in Reactome R-HSA-5683967 ( R-HSA-5693565 ) R-HSA-5683967 Reaction Name: EYA1-4 dephosphorylates tyrosine Y142 of H2AFX See in Reactome R-HSA-5683986 ( R-HSA-5693565 ) R-HSA-5683986 Reaction Name: APBB1 and MAPK8 bind diphosphorylated H2AFX See in Reactome R-HSA-5684052 ( R-HSA-5693607 ) R-HSA-5684052 Reaction Name: PIAS4 SUMOylates MDC1 See in Reactome R-HSA-5684071 ( R-HSA-5693607 ) R-HSA-5684071 Reaction Name: RNF4 ubiquitinates MDC1 See in Reactome R-HSA-5684081 ( R-HSA-5693607 ) R-HSA-5684081 Reaction Name: MRN complex binds CDK2 and RBBP8 See in Reactome R-HSA-5684096 ( R-HSA-5693607 ) R-HSA-5684096 Reaction Name: CDK2 phosphorylates RBBP8 See in Reactome R-HSA-5684108 ( R-HSA-5693607 ) R-HSA-5684108 Reaction Name: BRCA1 binds phosphorylated RBBP8 See in Reactome R-HSA-5684140 ( R-HSA-5693607 ) R-HSA-5684140 Reaction Name: ATM phosphorylates RBBP8 See in Reactome R-HSA-5684875 ( R-HSA-5693607 ) R-HSA-5684875 Reaction Name: Binding of ATR:ATRIP to RPA at resected DNA DSBs See in Reactome R-HSA-5684882 ( R-HSA-5693607 ) R-HSA-5684882 Reaction Name: CHEK1 is recruited to resected DNA DSBs See in Reactome R-HSA-5684887 ( R-HSA-5693607 ) R-HSA-5684887 Reaction Name: Activation of CHEK1 at resected DNA DSBs See in Reactome R-HSA-5685011 ( R-HSA-5693607 ) R-HSA-5685011 Reaction Name: ATR activation at DNA DSBs See in Reactome R-HSA-5685156 ( R-HSA-5693607 ) R-HSA-5685156 Reaction Name: ATR phosphorylates RPA2 See in Reactome R-HSA-5685341 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5685341 Reaction Name: BCDX2 complex stabilizes RAD51 filament See in Reactome R-HSA-5685838 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5685838 Reaction Name: CX3 complex binds D-loop structures See in Reactome R-HSA-5685985 ( R-HSA-5693607 ) R-HSA-5685985 Reaction Name: EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment See in Reactome R-HSA-5685994 ( R-HSA-5693607 ) R-HSA-5685994 Reaction Name: Long-range resection of DNA DSBs by EXO1 or DNA2 See in Reactome R-HSA-5686410 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686410 Reaction Name: BLM mediates dissolution of double Holliday junction See in Reactome R-HSA-5686440 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686440 Reaction Name: MUS81:EME1,EME2 cleaves D-loop See in Reactome R-HSA-5686469 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686469 Reaction Name: Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 See in Reactome R-HSA-5686483 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5686483 Reaction Name: Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5686642 ( R-HSA-5685938 ) R-HSA-5686642 Reaction Name: RAD52 promotes single strand annealing at resected DNA DSBs See in Reactome R-HSA-5686657 ( R-HSA-5685938 ) R-HSA-5686657 Reaction Name: ERCC1:XPF cleaves flaps generated by SSA See in Reactome R-HSA-5686685 ( R-HSA-5693571 ) R-HSA-5686685 Reaction Name: RIF1 and PAX1IP bind TP53BP1 at DNA DSBs See in Reactome R-HSA-5686704 ( R-HSA-5693571 ) R-HSA-5686704 Reaction Name: Activated ATM phosphorylates DCLRE1C See in Reactome R-HSA-5686900 ( R-HSA-5693571 ) R-HSA-5686900 Reaction Name: TP53BP1 recruits DCLRE1C to ATM See in Reactome R-HSA-5693536 ( R-HSA-5693565 ) R-HSA-5693536 Reaction Name: ATM phosphorylates MDC1 See in Reactome R-HSA-5693539 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693539 Reaction Name: Ligation of DNA and formation of Holliday structures following repair synthesis See in Reactome R-HSA-5693540 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693540 Reaction Name: MRN activates ATM See in Reactome R-HSA-5693542 ( R-HSA-5693607 ) R-HSA-5693542 Reaction Name: Association of RPA complexes with ssDNA at resected DNA DSBs See in Reactome R-HSA-5693549 ( R-HSA-5693565 ) R-HSA-5693549 Reaction Name: ATM phosphorylates histone H2AFX on S139 at DNA DSBs See in Reactome R-HSA-5693551 ( R-HSA-5693565 ) R-HSA-5693551 Reaction Name: Phosphorylation of BRCA1-A complex at multiple sites by ATM See in Reactome R-HSA-5693561 ( R-HSA-5685942; R-HSA-5693579; R-HSA-5693616 ) R-HSA-5693561 Reaction Name: RAD51 binds BRCA2 at resected DNA DSBs See in Reactome R-HSA-5693564 ( R-HSA-5685938 ) R-HSA-5693564 Reaction Name: Association of RAD51 with RAD52:DNA double-strand break ends See in Reactome R-HSA-5693566 ( R-HSA-5693565 ) R-HSA-5693566 Reaction Name: TP53BP1 associates with H4K20Me2 at DNA DSBs See in Reactome R-HSA-5693580 ( R-HSA-5685938 ) R-HSA-5693580 Reaction Name: Association of RAD52 with the RPA complex at resected DNA DSBs See in Reactome R-HSA-5693583 ( R-HSA-5693565 ) R-HSA-5693583 Reaction Name: MDC1 associates with gamma-H2AFX at nuclear foci See in Reactome R-HSA-5693584 ( R-HSA-5685942; R-HSA-5693568 ) R-HSA-5693584 Reaction Name: Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) See in Reactome R-HSA-5693589 ( R-HSA-5685942; R-HSA-5693554 ) R-HSA-5693589 Reaction Name: D-loop dissociation and strand annealing See in Reactome R-HSA-5693593 ( R-HSA-5685942 ) R-HSA-5693593 Reaction Name: D-loop extension by DNA polymerases See in Reactome R-HSA-5693598 ( R-HSA-5693565 ) R-HSA-5693598 Reaction Name: ATM phosphorylates NBN See in Reactome R-HSA-5693599 ( R-HSA-5693571 ) R-HSA-5693599 Reaction Name: Association of Ku heterodimer with ends of DNA double-strand break See in Reactome R-HSA-5693602 ( R-HSA-5693565 ) R-HSA-5693602 Reaction Name: ATM recognizes H2AFX-Nucleosomes See in Reactome R-HSA-5693608 ( R-HSA-5693607 ) R-HSA-5693608 Reaction Name: Initial resection of double-strand break ends See in Reactome R-HSA-5693612 ( R-HSA-2559586; R-HSA-5693548 ) R-HSA-5693612 Reaction Name: MRN complex bound to DNA ends recruits ATM See in Reactome R-HSA-5693620 ( R-HSA-5685942; R-HSA-5693579 ) R-HSA-5693620 Reaction Name: D-loop formation mediated by PALB2, BRCA2 and RAD51 See in Reactome R-HSA-6792712 ( R-HSA-2559586 ) R-HSA-6792712 Reaction Name: KAT5 acetylates ATM at shortened telomeres See in Reactome R-HSA-6799332 ( R-HSA-6804756; R-HSA-69473 ) R-HSA-6799332 Reaction Name: ATR phosphorylates TP53 See in Reactome R-HSA-69891 ( R-HSA-5693565; R-HSA-69473 ) R-HSA-69891 Reaction Name: Phosphorylation and activation of CHEK2 by ATM See in Reactome R-HSA-9023859 ( R-HSA-9018519 ) R-HSA-9023859 Reaction Name: Estrogen-responsive TFF1 gene expression See in Reactome R-HSA-9023860 ( R-HSA-9018519 ) R-HSA-9023860 Reaction Name: Histone acetyltransferases are recruited to the TFF1 gene See in Reactome