DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q8NBP7)

Number of enzymes:	1
Number of disease:	3
Number of reactomes:	4
Number of reactions:	8

Search results (UniProt accession: Q8NBP7)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0018328	PCSK9	Q8NBP7	3.4.21.-	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-8866427 R-HSA-8866427 Reactome Name: VLDLR internalisation and degradation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Transport of small molecules Metabolism of proteins	R-HSA-6784729 ( R-HSA-8964038 ) R-HSA-6784729 Reaction Name: PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome See in Reactome R-HSA-6784734 ( R-HSA-8964038 ) R-HSA-6784734 Reaction Name: PCSK9 binds LDLR See in Reactome R-HSA-6784735 ( R-HSA-8964038 ) R-HSA-6784735 Reaction Name: PCSK9:LDLR bind to Clathrin See in Reactome R-HSA-6784738 ( R-HSA-8964038 ) R-HSA-6784738 Reaction Name: Degradation of PCSK9:LDLR:Clathrin-coated vesicle See in Reactome R-HSA-8855111 ( R-HSA-8866427 ) R-HSA-8855111 Reaction Name: VLDLR binds PCSK9 See in Reactome R-HSA-8855130 ( R-HSA-8866427 ) R-HSA-8855130 Reaction Name: VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane See in Reactome R-HSA-8855131 ( R-HSA-8866427 ) R-HSA-8855131 Reaction Name: VLDLR:PCSK9 binds Clathrin-coated vesicles See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0011369	PCSK9	Q8NBP7	3.4.21.-	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-8866427 R-HSA-8866427 Reactome Name: VLDLR internalisation and degradation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Transport of small molecules Metabolism of proteins	R-HSA-6784729 ( R-HSA-8964038 ) R-HSA-6784729 Reaction Name: PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome See in Reactome R-HSA-6784734 ( R-HSA-8964038 ) R-HSA-6784734 Reaction Name: PCSK9 binds LDLR See in Reactome R-HSA-6784735 ( R-HSA-8964038 ) R-HSA-6784735 Reaction Name: PCSK9:LDLR bind to Clathrin See in Reactome R-HSA-6784738 ( R-HSA-8964038 ) R-HSA-6784738 Reaction Name: Degradation of PCSK9:LDLR:Clathrin-coated vesicle See in Reactome R-HSA-8855111 ( R-HSA-8866427 ) R-HSA-8855111 Reaction Name: VLDLR binds PCSK9 See in Reactome R-HSA-8855130 ( R-HSA-8866427 ) R-HSA-8855130 Reaction Name: VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane See in Reactome R-HSA-8855131 ( R-HSA-8866427 ) R-HSA-8855131 Reaction Name: VLDLR:PCSK9 binds Clathrin-coated vesicles See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0007750	PCSK9	Q8NBP7	3.4.21.-	R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome R-HSA-8866427 R-HSA-8866427 Reactome Name: VLDLR internalisation and degradation See in Reactome R-HSA-8964038 R-HSA-8964038 Reactome Name: LDL clearance See in Reactome	R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-382551 R-HSA-382551 Reactome Name: Transport of small molecules See in Reactome R-HSA-174824 R-HSA-174824 Reactome Name: Plasma lipoprotein assembly, remodeling, and clearance See in Reactome R-HSA-8964043 R-HSA-8964043 Reactome Name: Plasma lipoprotein clearance See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome	Transport of small molecules Metabolism of proteins	R-HSA-6784729 ( R-HSA-8964038 ) R-HSA-6784729 Reaction Name: PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome See in Reactome R-HSA-6784734 ( R-HSA-8964038 ) R-HSA-6784734 Reaction Name: PCSK9 binds LDLR See in Reactome R-HSA-6784735 ( R-HSA-8964038 ) R-HSA-6784735 Reaction Name: PCSK9:LDLR bind to Clathrin See in Reactome R-HSA-6784738 ( R-HSA-8964038 ) R-HSA-6784738 Reaction Name: Degradation of PCSK9:LDLR:Clathrin-coated vesicle See in Reactome R-HSA-8855111 ( R-HSA-8866427 ) R-HSA-8855111 Reaction Name: VLDLR binds PCSK9 See in Reactome R-HSA-8855130 ( R-HSA-8866427 ) R-HSA-8855130 Reaction Name: VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane See in Reactome R-HSA-8855131 ( R-HSA-8866427 ) R-HSA-8855131 Reaction Name: VLDLR:PCSK9 binds Clathrin-coated vesicles See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome