DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q8N6T7)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	2
Number of reactions:	4

Search results (UniProt accession: Q8N6T7)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005387	SIRT6	Q8N6T7	2.3.1.286	R-HSA-1912408 R-HSA-1912408 Reactome Name: Pre-NOTCH Transcription and Translation See in Reactome R-HSA-5693607 R-HSA-5693607 Reactome Name: Processing of DNA double-strand break ends See in Reactome	R-HSA-5693567 R-HSA-5693567 Reactome Name: HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-5693538 R-HSA-5693538 Reactome Name: Homology Directed Repair See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-1912422 R-HSA-1912422 Reactome Name: Pre-NOTCH Expression and Processing See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	DNA Repair Signal Transduction	R-HSA-5685953 ( R-HSA-5693607 ) R-HSA-5685953 Reaction Name: SIRT6 deacetylates RBBP8 See in Reactome R-HSA-9604829 ( R-HSA-1912408 ) R-HSA-9604829 Reaction Name: SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters See in Reactome R-HSA-9604831 ( R-HSA-1912408 ) R-HSA-9604831 Reaction Name: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 See in Reactome R-HSA-9604834 ( R-HSA-1912408 ) R-HSA-9604834 Reaction Name: SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters See in Reactome