DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q7Z6Z7)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	2
Number of reactions:	6

Search results (UniProt accession: Q7Z6Z7)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010407	HUWE1	Q7Z6Z7	2.3.2.26	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome
MONDO:0060596	HUWE1	Q7Z6Z7	2.3.2.26	R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome R-HSA-983168 R-HSA-983168 Reactome Name: Antigen processing: Ubiquitination & Proteasome degradation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome	Immune System	R-HSA-6798748 ( R-HSA-6798695 ) R-HSA-6798748 Reaction Name: Exocytosis of secretory granule lumen proteins See in Reactome R-HSA-6800434 ( R-HSA-6798695 ) R-HSA-6800434 Reaction Name: Exocytosis of ficolin-rich granule lumen proteins See in Reactome R-HSA-983140 ( R-HSA-983168 ) R-HSA-983140 Reaction Name: Transfer of Ub from E2 to substrate and release of E2 See in Reactome R-HSA-983147 ( R-HSA-983168 ) R-HSA-983147 Reaction Name: Release of E3 from polyubiquitinated substrate See in Reactome R-HSA-983156 ( R-HSA-983168 ) R-HSA-983156 Reaction Name: Polyubiquitination of substrate See in Reactome R-HSA-983157 ( R-HSA-983168 ) R-HSA-983157 Reaction Name: Interaction of E3 with substrate and E2-Ub complex See in Reactome