DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q5S007)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	1
Number of reactions:	4

Search results (UniProt accession: Q5S007)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0018466	LRRK2	Q5S007	3.6.5.- 2.7.11.1	R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome	R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome
MONDO:0011764	LRRK2	Q5S007	3.6.5.- 2.7.11.1	R-HSA-8857538 R-HSA-8857538 Reactome Name: PTK6 promotes HIF1A stabilization See in Reactome	R-HSA-9006927 R-HSA-9006927 Reactome Name: Signaling by Non-Receptor Tyrosine Kinases See in Reactome R-HSA-8848021 R-HSA-8848021 Reactome Name: Signaling by PTK6 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Signal Transduction	R-HSA-8857565 ( R-HSA-8857538 ) R-HSA-8857565 Reaction Name: Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 See in Reactome R-HSA-8857577 ( R-HSA-8857538 ) R-HSA-8857577 Reaction Name: LINC01139 facilitates PTK6 autophosphorylation See in Reactome R-HSA-8857583 ( R-HSA-8857538 ) R-HSA-8857583 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by PTK6 See in Reactome R-HSA-9634702 ( R-HSA-8857538 ) R-HSA-9634702 Reaction Name: LINC01139 promotes phosphorylation of HIF1A by LRRK2 See in Reactome