DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q15910)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	6
Number of reactions:	23

Search results (UniProt accession: Q15910)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010193	EZH2	Q15910	2.1.1.356	R-HSA-2559580 R-HSA-2559580 Reactome Name: Oxidative Stress Induced Senescence See in Reactome R-HSA-5617472 R-HSA-5617472 Reactome Name: Activation of anterior HOX genes in hindbrain development during early embryogenesis See in Reactome R-HSA-212300 R-HSA-212300 Reactome Name: PRC2 methylates histones and DNA See in Reactome R-HSA-8953750 R-HSA-8953750 Reactome Name: Transcriptional Regulation by E2F6 See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome	R-HSA-8953897 R-HSA-8953897 Reactome Name: Cellular responses to stimuli See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-2559583 R-HSA-2559583 Reactome Name: Cellular Senescence See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5619507 R-HSA-5619507 Reactome Name: Activation of HOX genes during differentiation See in Reactome R-HSA-2262752 R-HSA-2262752 Reactome Name: Cellular responses to stress See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Cellular responses to stimuli Chromatin organization Signal Transduction Gene expression (Transcription) Developmental Biology	R-HSA-212222 ( R-HSA-212300 ) R-HSA-212222 Reaction Name: PRC2 recruits DNA methyltransferases See in Reactome R-HSA-212252 ( R-HSA-212300 ) R-HSA-212252 Reaction Name: Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin See in Reactome R-HSA-212263 ( R-HSA-212300 ) R-HSA-212263 Reaction Name: PRC2 trimethylates histone H3 at lysine-27 See in Reactome R-HSA-212269 ( R-HSA-212300 ) R-HSA-212269 Reaction Name: DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 See in Reactome R-HSA-3240295 ( R-HSA-2559580 ) R-HSA-3240295 Reaction Name: PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter See in Reactome R-HSA-3240783 ( R-HSA-2559580 ) R-HSA-3240783 Reaction Name: E2F1/2/3 stimulates EZH2 transcription See in Reactome R-HSA-3240957 ( R-HSA-2559580 ) R-HSA-3240957 Reaction Name: Formation of PRC2-EZH2 complex See in Reactome R-HSA-5617431 ( R-HSA-5617472 ) R-HSA-5617431 Reaction Name: Retinoic acid activates HOXA1 chromatin See in Reactome R-HSA-5617445 ( R-HSA-5617472 ) R-HSA-5617445 Reaction Name: HOXD1 chromatin is activated See in Reactome R-HSA-5617452 ( R-HSA-5617472 ) R-HSA-5617452 Reaction Name: Retinoic acid activates HOXB1 chromatin See in Reactome R-HSA-5617650 ( R-HSA-5617472 ) R-HSA-5617650 Reaction Name: HOXD3 chromatin is activated See in Reactome R-HSA-5617859 ( R-HSA-5617472 ) R-HSA-5617859 Reaction Name: Retinoic acid activates HOXB4 chromatin See in Reactome R-HSA-5617862 ( R-HSA-5617472 ) R-HSA-5617862 Reaction Name: Retinoic acid activates HOXA4 chromatin See in Reactome R-HSA-5617887 ( R-HSA-5617472 ) R-HSA-5617887 Reaction Name: HOXC4 chromatin is activated See in Reactome R-HSA-5617896 ( R-HSA-5617472 ) R-HSA-5617896 Reaction Name: Retinoic acid activates HOXD4 chromatin See in Reactome R-HSA-5638332 ( R-HSA-3214841 ) R-HSA-5638332 Reaction Name: PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27) See in Reactome R-HSA-6810139 ( R-HSA-5617472 ) R-HSA-6810139 Reaction Name: HOXA2 chromatin is activated See in Reactome R-HSA-6810158 ( R-HSA-5617472 ) R-HSA-6810158 Reaction Name: HOXB3 chromatin is activated See in Reactome R-HSA-6810159 ( R-HSA-5617472 ) R-HSA-6810159 Reaction Name: HOXB2 chromatin is activated See in Reactome R-HSA-6810161 ( R-HSA-5617472 ) R-HSA-6810161 Reaction Name: HOXA3 chromatin is activated See in Reactome R-HSA-8943817 ( R-HSA-8943724 ) R-HSA-8943817 Reaction Name: MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter See in Reactome R-HSA-8944104 ( R-HSA-8943724 ) R-HSA-8944104 Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN See in Reactome R-HSA-8954110 ( R-HSA-8953750 ) R-HSA-8954110 Reaction Name: E2F6:TFDP1:EPC1 binds the PRC2 complex See in Reactome