DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q15746)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	2
Number of reactions:	4

Search results (UniProt accession: Q15746)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013418	MYLK	Q15746	2.7.11.18	R-HSA-445355 R-HSA-445355 Reactome Name: Smooth Muscle Contraction See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Muscle contraction Signal Transduction	R-HSA-445797 ( R-HSA-445355; R-HSA-5627123 ) R-HSA-445797 Reaction Name: MYLK (MLCK) Active Calmodulin Binding See in Reactome R-HSA-445813 ( R-HSA-445355 ) R-HSA-445813 Reaction Name: Phosphorylation of Smooth Muscle Myosin Light Chains See in Reactome R-HSA-5668978 ( R-HSA-5627123 ) R-HSA-5668978 Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex See in Reactome R-HSA-5668984 ( R-HSA-5627123 ) R-HSA-5668984 Reaction Name: PAK1 or PAK2 phosphorylates MYLK See in Reactome
MONDO:0100354	MYLK	Q15746	2.7.11.18	R-HSA-445355 R-HSA-445355 Reactome Name: Smooth Muscle Contraction See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-397014 R-HSA-397014 Reactome Name: Muscle contraction See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Muscle contraction Signal Transduction	R-HSA-445797 ( R-HSA-445355; R-HSA-5627123 ) R-HSA-445797 Reaction Name: MYLK (MLCK) Active Calmodulin Binding See in Reactome R-HSA-445813 ( R-HSA-445355 ) R-HSA-445813 Reaction Name: Phosphorylation of Smooth Muscle Myosin Light Chains See in Reactome R-HSA-5668978 ( R-HSA-5627123 ) R-HSA-5668978 Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex See in Reactome R-HSA-5668984 ( R-HSA-5627123 ) R-HSA-5668984 Reaction Name: PAK1 or PAK2 phosphorylates MYLK See in Reactome