DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q14839)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	6
Number of reactions:	12

Search results (UniProt accession: Q14839)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0014946	CHD4	Q14839	3.6.4.12	R-HSA-6804758 R-HSA-6804758 Reactome Name: Regulation of TP53 Activity through Acetylation See in Reactome R-HSA-427389 R-HSA-427389 Reactome Name: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression See in Reactome R-HSA-9031628 R-HSA-9031628 Reactome Name: NGF-stimulated transcription See in Reactome R-HSA-73762 R-HSA-73762 Reactome Name: RNA Polymerase I Transcription Initiation See in Reactome R-HSA-3214815 R-HSA-3214815 Reactome Name: HDACs deacetylate histones See in Reactome R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome	R-HSA-3700989 R-HSA-3700989 Reactome Name: Transcriptional Regulation by TP53 See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-5633007 R-HSA-5633007 Reactome Name: Regulation of TP53 Activity See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5250913 R-HSA-5250913 Reactome Name: Positive epigenetic regulation of rRNA expression See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-73864 R-HSA-73864 Reactome Name: RNA Polymerase I Transcription See in Reactome R-HSA-198725 R-HSA-198725 Reactome Name: Nuclear Events (kinase and transcription factor activation) See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome R-HSA-73854 R-HSA-73854 Reactome Name: RNA Polymerase I Promoter Clearance See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome	Gene expression (Transcription) Chromatin organization Signal Transduction	R-HSA-3769447 ( R-HSA-3214815 ) R-HSA-3769447 Reaction Name: HDAC1:2-containing complex deacetylate histones See in Reactome R-HSA-427336 ( R-HSA-427389 ) R-HSA-427336 Reaction Name: TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. See in Reactome R-HSA-427404 ( R-HSA-427389 ) R-HSA-427404 Reaction Name: Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene See in Reactome R-HSA-6805650 ( R-HSA-6804758 ) R-HSA-6805650 Reaction Name: MTA2-NuRD complex deacetylates TP53 See in Reactome R-HSA-73739 ( R-HSA-73762 ) R-HSA-73739 Reaction Name: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter See in Reactome R-HSA-8943780 ( R-HSA-8943724 ) R-HSA-8943780 Reaction Name: SALL4 recruits NuRD to PTEN gene See in Reactome R-HSA-8944104 ( R-HSA-8943724 ) R-HSA-8944104 Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN See in Reactome R-HSA-9612534 ( R-HSA-9031628 ) R-HSA-9612534 Reaction Name: Expression of ID2 and ID4 is repressed by EGR2:NAB See in Reactome R-HSA-9613213 ( R-HSA-9031628 ) R-HSA-9613213 Reaction Name: NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression See in Reactome R-HSA-9613219 ( R-HSA-9031628 ) R-HSA-9613219 Reaction Name: RRAD gene expression See in Reactome R-HSA-9613476 ( R-HSA-9031628 ) R-HSA-9613476 Reaction Name: EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions See in Reactome R-HSA-9679787 ( R-HSA-3214815 ) R-HSA-9679787 Reaction Name: HDAC1:2-containing complex binds HDAC2 Inhibitors See in Reactome