DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q13705)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	4
Number of reactions:	18

Search results (UniProt accession: Q13705)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013403	ACVR2B	Q13705	2.7.11.30	R-HSA-1433617 R-HSA-1433617 Reactome Name: Regulation of signaling by NODAL See in Reactome R-HSA-1181150 R-HSA-1181150 Reactome Name: Signaling by NODAL See in Reactome R-HSA-201451 R-HSA-201451 Reactome Name: Signaling by BMP See in Reactome R-HSA-1502540 R-HSA-1502540 Reactome Name: Signaling by Activin See in Reactome	R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome	Signal Transduction Developmental Biology	R-HSA-1181149 ( R-HSA-1502540 ) R-HSA-1181149 Reaction Name: ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin See in Reactome R-HSA-1181153 ( R-HSA-1502540 ) R-HSA-1181153 Reaction Name: Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B See in Reactome R-HSA-1181155 ( R-HSA-1181150 ) R-HSA-1181155 Reaction Name: The NODAL Receptor binds NODAL ligands See in Reactome R-HSA-1181156 ( R-HSA-1181150 ) R-HSA-1181156 Reaction Name: Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL See in Reactome R-HSA-1181351 ( R-HSA-1181150; R-HSA-1433617 ) R-HSA-1181351 Reaction Name: LEFTY binds the EGF-CFC coreceptor in the NODAL receptor See in Reactome R-HSA-1181355 ( R-HSA-1181150 ) R-HSA-1181355 Reaction Name: Phosphorylation of R-SMAD2/3 by NODAL receptor See in Reactome R-HSA-1225894 ( R-HSA-1181150 ) R-HSA-1225894 Reaction Name: Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL See in Reactome R-HSA-1549526 ( R-HSA-1502540 ) R-HSA-1549526 Reaction Name: Phosphorylation of SMAD2,3 by Activin:Activin Receptor See in Reactome R-HSA-201443 ( R-HSA-201451 ) R-HSA-201443 Reaction Name: Type II receptor phosphorylates type I receptor See in Reactome R-HSA-201453 ( R-HSA-201451 ) R-HSA-201453 Reaction Name: Phospho-R-Smad1/5/8 dissociates from the receptor complex See in Reactome R-HSA-201457 ( R-HSA-201451 ) R-HSA-201457 Reaction Name: BMP2 binds to the receptor complex See in Reactome R-HSA-201475 ( R-HSA-201451 ) R-HSA-201475 Reaction Name: I-Smad competes with R-Smad1/5/8 for type I receptor See in Reactome R-HSA-201476 ( R-HSA-201451 ) R-HSA-201476 Reaction Name: Activated type I receptor phosphorylates R-Smad1/5/8 directly See in Reactome R-HSA-201648 ( R-HSA-201451 ) R-HSA-201648 Reaction Name: An anchoring protein, Endofin, recruits R-Smad1/5/8 See in Reactome R-HSA-201821 ( R-HSA-201451 ) R-HSA-201821 Reaction Name: I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated See in Reactome R-HSA-202604 ( R-HSA-201451 ) R-HSA-202604 Reaction Name: Formation of a heteromeric BMP receptor complex See in Reactome R-HSA-2470483 ( R-HSA-1502540 ) R-HSA-2470483 Reaction Name: Activin AB,B binds Activin Receptor ACVR2A,B:ACVR1C See in Reactome R-HSA-2470508 ( R-HSA-1502540 ) R-HSA-2470508 Reaction Name: ACVR2A,B (ActRIIA,B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin See in Reactome