DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q08209)

Number of enzymes:	1
Number of disease:	4
Number of reactomes:	5
Number of reactions:	9

Search results (UniProt accession: Q08209)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0015802	PPP3CA	Q08209	3.1.3.16	R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-180024 R-HSA-180024 Reactome Name: DARPP-32 events See in Reactome R-HSA-2025928 R-HSA-2025928 Reactome Name: Calcineurin activates NFAT See in Reactome R-HSA-5607763 R-HSA-5607763 Reactome Name: CLEC7A (Dectin-1) induces NFAT activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-201783 ( R-HSA-180024 ) R-HSA-201783 Reaction Name: Inactive catalytic PP2B is activated by the binding of calmodulin See in Reactome R-HSA-201787 ( R-HSA-180024 ) R-HSA-201787 Reaction Name: PPP3 complex dephosphorylates DARPP-32 on Thr34 See in Reactome R-HSA-2025882 ( R-HSA-2025928 ) R-HSA-2025882 Reaction Name: Calcineurin dephosphorylates NFATC1,2,3 See in Reactome R-HSA-2025890 ( R-HSA-2025928 ) R-HSA-2025890 Reaction Name: Calcineurin binds NFATC1,2,3 See in Reactome R-HSA-2730849 ( R-HSA-2871809; R-HSA-5607763 ) R-HSA-2730849 Reaction Name: Calcineurin binds and dephosphorylates NFAT See in Reactome R-HSA-2730867 ( R-HSA-2871809; R-HSA-5607763 ) R-HSA-2730867 Reaction Name: Translocation of CaN:CaM:NFAT to nucleus See in Reactome R-HSA-2730872 ( R-HSA-2871809; R-HSA-4086398; R-HSA-5607763 ) R-HSA-2730872 Reaction Name: Activation of Calcineurin See in Reactome R-HSA-4551451 ( R-HSA-4086398 ) R-HSA-4551451 Reaction Name: Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling See in Reactome R-HSA-4551465 ( R-HSA-4086398 ) R-HSA-4551465 Reaction Name: Translocation of NFATC1:CaN:CaM to nucleus See in Reactome
MONDO:0020630	PPP3CA	Q08209	3.1.3.16	R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-180024 R-HSA-180024 Reactome Name: DARPP-32 events See in Reactome R-HSA-2025928 R-HSA-2025928 Reactome Name: Calcineurin activates NFAT See in Reactome R-HSA-5607763 R-HSA-5607763 Reactome Name: CLEC7A (Dectin-1) induces NFAT activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-201783 ( R-HSA-180024 ) R-HSA-201783 Reaction Name: Inactive catalytic PP2B is activated by the binding of calmodulin See in Reactome R-HSA-201787 ( R-HSA-180024 ) R-HSA-201787 Reaction Name: PPP3 complex dephosphorylates DARPP-32 on Thr34 See in Reactome R-HSA-2025882 ( R-HSA-2025928 ) R-HSA-2025882 Reaction Name: Calcineurin dephosphorylates NFATC1,2,3 See in Reactome R-HSA-2025890 ( R-HSA-2025928 ) R-HSA-2025890 Reaction Name: Calcineurin binds NFATC1,2,3 See in Reactome R-HSA-2730849 ( R-HSA-2871809; R-HSA-5607763 ) R-HSA-2730849 Reaction Name: Calcineurin binds and dephosphorylates NFAT See in Reactome R-HSA-2730867 ( R-HSA-2871809; R-HSA-5607763 ) R-HSA-2730867 Reaction Name: Translocation of CaN:CaM:NFAT to nucleus See in Reactome R-HSA-2730872 ( R-HSA-2871809; R-HSA-4086398; R-HSA-5607763 ) R-HSA-2730872 Reaction Name: Activation of Calcineurin See in Reactome R-HSA-4551451 ( R-HSA-4086398 ) R-HSA-4551451 Reaction Name: Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling See in Reactome R-HSA-4551465 ( R-HSA-4086398 ) R-HSA-4551465 Reaction Name: Translocation of NFATC1:CaN:CaM to nucleus See in Reactome
MONDO:0018614	PPP3CA	Q08209	3.1.3.16	R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-180024 R-HSA-180024 Reactome Name: DARPP-32 events See in Reactome R-HSA-2025928 R-HSA-2025928 Reactome Name: Calcineurin activates NFAT See in Reactome R-HSA-5607763 R-HSA-5607763 Reactome Name: CLEC7A (Dectin-1) induces NFAT activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-201783 ( R-HSA-180024 ) R-HSA-201783 Reaction Name: Inactive catalytic PP2B is activated by the binding of calmodulin See in Reactome R-HSA-201787 ( R-HSA-180024 ) R-HSA-201787 Reaction Name: PPP3 complex dephosphorylates DARPP-32 on Thr34 See in Reactome R-HSA-2025882 ( R-HSA-2025928 ) R-HSA-2025882 Reaction Name: Calcineurin dephosphorylates NFATC1,2,3 See in Reactome R-HSA-2025890 ( R-HSA-2025928 ) R-HSA-2025890 Reaction Name: Calcineurin binds NFATC1,2,3 See in Reactome R-HSA-2730849 ( R-HSA-2871809; R-HSA-5607763 ) R-HSA-2730849 Reaction Name: Calcineurin binds and dephosphorylates NFAT See in Reactome R-HSA-2730867 ( R-HSA-2871809; R-HSA-5607763 ) R-HSA-2730867 Reaction Name: Translocation of CaN:CaM:NFAT to nucleus See in Reactome R-HSA-2730872 ( R-HSA-2871809; R-HSA-4086398; R-HSA-5607763 ) R-HSA-2730872 Reaction Name: Activation of Calcineurin See in Reactome R-HSA-4551451 ( R-HSA-4086398 ) R-HSA-4551451 Reaction Name: Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling See in Reactome R-HSA-4551465 ( R-HSA-4086398 ) R-HSA-4551465 Reaction Name: Translocation of NFATC1:CaN:CaM to nucleus See in Reactome
MONDO:0032642	PPP3CA	Q08209	3.1.3.16	R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-4086398 R-HSA-4086398 Reactome Name: Ca2+ pathway See in Reactome R-HSA-180024 R-HSA-180024 Reactome Name: DARPP-32 events See in Reactome R-HSA-2025928 R-HSA-2025928 Reactome Name: Calcineurin activates NFAT See in Reactome R-HSA-5607763 R-HSA-5607763 Reactome Name: CLEC7A (Dectin-1) induces NFAT activation See in Reactome	R-HSA-5621481 R-HSA-5621481 Reactome Name: C-type lectin receptors (CLRs) See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-418594 R-HSA-418594 Reactome Name: G alpha (i) signalling events See in Reactome R-HSA-3858494 R-HSA-3858494 Reactome Name: Beta-catenin independent WNT signaling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-1168372 R-HSA-1168372 Reactome Name: Downstream signaling events of B Cell Receptor (BCR) See in Reactome R-HSA-5607764 R-HSA-5607764 Reactome Name: CLEC7A (Dectin-1) signaling See in Reactome R-HSA-111885 R-HSA-111885 Reactome Name: Opioid Signalling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-201783 ( R-HSA-180024 ) R-HSA-201783 Reaction Name: Inactive catalytic PP2B is activated by the binding of calmodulin See in Reactome R-HSA-201787 ( R-HSA-180024 ) R-HSA-201787 Reaction Name: PPP3 complex dephosphorylates DARPP-32 on Thr34 See in Reactome R-HSA-2025882 ( R-HSA-2025928 ) R-HSA-2025882 Reaction Name: Calcineurin dephosphorylates NFATC1,2,3 See in Reactome R-HSA-2025890 ( R-HSA-2025928 ) R-HSA-2025890 Reaction Name: Calcineurin binds NFATC1,2,3 See in Reactome R-HSA-2730849 ( R-HSA-2871809; R-HSA-5607763 ) R-HSA-2730849 Reaction Name: Calcineurin binds and dephosphorylates NFAT See in Reactome R-HSA-2730867 ( R-HSA-2871809; R-HSA-5607763 ) R-HSA-2730867 Reaction Name: Translocation of CaN:CaM:NFAT to nucleus See in Reactome R-HSA-2730872 ( R-HSA-2871809; R-HSA-4086398; R-HSA-5607763 ) R-HSA-2730872 Reaction Name: Activation of Calcineurin See in Reactome R-HSA-4551451 ( R-HSA-4086398 ) R-HSA-4551451 Reaction Name: Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling See in Reactome R-HSA-4551465 ( R-HSA-4086398 ) R-HSA-4551465 Reaction Name: Translocation of NFATC1:CaN:CaM to nucleus See in Reactome