DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q06187)

Number of enzymes:	1
Number of disease:	3
Number of reactomes:	10
Number of reactions:	42

Search results (UniProt accession: Q06187)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010421	BTK	Q06187	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-8964315 R-HSA-8964315 Reactome Name: G beta:gamma signalling through BTK See in Reactome	R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-166072 ( R-HSA-166058 ) R-HSA-166072 Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4 See in Reactome R-HSA-166082 ( R-HSA-166058 ) R-HSA-166082 Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex See in Reactome R-HSA-166091 ( R-HSA-166058 ) R-HSA-166091 Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex See in Reactome R-HSA-166119 ( R-HSA-166058 ) R-HSA-166119 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal See in Reactome R-HSA-166284 ( R-HSA-166058 ) R-HSA-166284 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP See in Reactome R-HSA-166286 ( R-HSA-166058 ) R-HSA-166286 Reaction Name: Multiple IRAK1 autophosphorylation steps See in Reactome R-HSA-166362 ( R-HSA-166058 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-2197698 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197698 Reaction Name: Src phosphorylate WASP,N-WASP See in Reactome R-HSA-2201322 ( R-HSA-166058 ) R-HSA-2201322 Reaction Name: TIRAP is phosphorylated by BTK See in Reactome R-HSA-2262775 ( R-HSA-166058 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2559414 ( R-HSA-166058 ) R-HSA-2559414 Reaction Name: Activated TLR2/4:TIRAP interacts with BTK See in Reactome R-HSA-2730833 ( R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730847 ( R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730858 ( R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-8964241 ( R-HSA-8964315 ) R-HSA-8964241 Reaction Name: G beta-gamma complex and PIP3 recruit BTK to membrane See in Reactome R-HSA-8964246 ( R-HSA-416482 ) R-HSA-8964246 Reaction Name: BTK in G alpha (12)-BTK complex is activated See in Reactome R-HSA-8964271 ( R-HSA-8964315 ) R-HSA-8964271 Reaction Name: BTK in PIP3:BTK:G beta-gamma complex is activated See in Reactome R-HSA-8964274 ( R-HSA-416482 ) R-HSA-8964274 Reaction Name: G alpha (12) binds BTK See in Reactome R-HSA-8964280 ( R-HSA-416476 ) R-HSA-8964280 Reaction Name: Active Gq binds BTK See in Reactome R-HSA-8964284 ( R-HSA-416476 ) R-HSA-8964284 Reaction Name: BTK in active Gq-BTK complex is activated See in Reactome R-HSA-8964317 ( R-HSA-8964315 ) R-HSA-8964317 Reaction Name: PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex See in Reactome R-HSA-8964333 ( R-HSA-416482 ) R-HSA-8964333 Reaction Name: G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) See in Reactome R-HSA-8964340 ( R-HSA-416476 ) R-HSA-8964340 Reaction Name: Gq-BTK complex dissociates to Active BTK and Gq See in Reactome R-HSA-937022 ( R-HSA-166058 ) R-HSA-937022 Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP See in Reactome R-HSA-937059 ( R-HSA-166058 ) R-HSA-937059 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex See in Reactome R-HSA-937079 ( R-HSA-166058 ) R-HSA-937079 Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome
MONDO:0020729	BTK	Q06187	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-8964315 R-HSA-8964315 Reactome Name: G beta:gamma signalling through BTK See in Reactome	R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-166072 ( R-HSA-166058 ) R-HSA-166072 Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4 See in Reactome R-HSA-166082 ( R-HSA-166058 ) R-HSA-166082 Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex See in Reactome R-HSA-166091 ( R-HSA-166058 ) R-HSA-166091 Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex See in Reactome R-HSA-166119 ( R-HSA-166058 ) R-HSA-166119 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal See in Reactome R-HSA-166284 ( R-HSA-166058 ) R-HSA-166284 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP See in Reactome R-HSA-166286 ( R-HSA-166058 ) R-HSA-166286 Reaction Name: Multiple IRAK1 autophosphorylation steps See in Reactome R-HSA-166362 ( R-HSA-166058 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-2197698 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197698 Reaction Name: Src phosphorylate WASP,N-WASP See in Reactome R-HSA-2201322 ( R-HSA-166058 ) R-HSA-2201322 Reaction Name: TIRAP is phosphorylated by BTK See in Reactome R-HSA-2262775 ( R-HSA-166058 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2559414 ( R-HSA-166058 ) R-HSA-2559414 Reaction Name: Activated TLR2/4:TIRAP interacts with BTK See in Reactome R-HSA-2730833 ( R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730847 ( R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730858 ( R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-8964241 ( R-HSA-8964315 ) R-HSA-8964241 Reaction Name: G beta-gamma complex and PIP3 recruit BTK to membrane See in Reactome R-HSA-8964246 ( R-HSA-416482 ) R-HSA-8964246 Reaction Name: BTK in G alpha (12)-BTK complex is activated See in Reactome R-HSA-8964271 ( R-HSA-8964315 ) R-HSA-8964271 Reaction Name: BTK in PIP3:BTK:G beta-gamma complex is activated See in Reactome R-HSA-8964274 ( R-HSA-416482 ) R-HSA-8964274 Reaction Name: G alpha (12) binds BTK See in Reactome R-HSA-8964280 ( R-HSA-416476 ) R-HSA-8964280 Reaction Name: Active Gq binds BTK See in Reactome R-HSA-8964284 ( R-HSA-416476 ) R-HSA-8964284 Reaction Name: BTK in active Gq-BTK complex is activated See in Reactome R-HSA-8964317 ( R-HSA-8964315 ) R-HSA-8964317 Reaction Name: PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex See in Reactome R-HSA-8964333 ( R-HSA-416482 ) R-HSA-8964333 Reaction Name: G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) See in Reactome R-HSA-8964340 ( R-HSA-416476 ) R-HSA-8964340 Reaction Name: Gq-BTK complex dissociates to Active BTK and Gq See in Reactome R-HSA-937022 ( R-HSA-166058 ) R-HSA-937022 Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP See in Reactome R-HSA-937059 ( R-HSA-166058 ) R-HSA-937059 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex See in Reactome R-HSA-937079 ( R-HSA-166058 ) R-HSA-937079 Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome
MONDO:0018967	BTK	Q06187	2.7.10.2	R-HSA-983695 R-HSA-983695 Reactome Name: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers See in Reactome R-HSA-5663213 R-HSA-5663213 Reactome Name: RHO GTPases Activate WASPs and WAVEs See in Reactome R-HSA-2029482 R-HSA-2029482 Reactome Name: Regulation of actin dynamics for phagocytic cup formation See in Reactome R-HSA-416482 R-HSA-416482 Reactome Name: G alpha (12/13) signalling events See in Reactome R-HSA-2871809 R-HSA-2871809 Reactome Name: FCERI mediated Ca+2 mobilization See in Reactome R-HSA-1236974 R-HSA-1236974 Reactome Name: ER-Phagosome pathway See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-8964315 R-HSA-8964315 Reactome Name: G beta:gamma signalling through BTK See in Reactome	R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-1236975 R-HSA-1236975 Reactome Name: Antigen processing-Cross presentation See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-397795 R-HSA-397795 Reactome Name: G-protein beta:gamma signalling See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-983169 R-HSA-983169 Reactome Name: Class I MHC mediated antigen processing & presentation See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-983705 R-HSA-983705 Reactome Name: Signaling by the B Cell Receptor (BCR) See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Signal Transduction	R-HSA-1112666 ( R-HSA-983695 ) R-HSA-1112666 Reaction Name: BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate See in Reactome R-HSA-166072 ( R-HSA-166058 ) R-HSA-166072 Reaction Name: MyD88 forms a complex with TIRAP:activated TLR2/4 See in Reactome R-HSA-166082 ( R-HSA-166058 ) R-HSA-166082 Reaction Name: IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex See in Reactome R-HSA-166091 ( R-HSA-166058 ) R-HSA-166091 Reaction Name: IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex See in Reactome R-HSA-166119 ( R-HSA-166058 ) R-HSA-166119 Reaction Name: First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal See in Reactome R-HSA-166284 ( R-HSA-166058 ) R-HSA-166284 Reaction Name: Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP See in Reactome R-HSA-166286 ( R-HSA-166058 ) R-HSA-166286 Reaction Name: Multiple IRAK1 autophosphorylation steps See in Reactome R-HSA-166362 ( R-HSA-166058 ) R-HSA-166362 Reaction Name: Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-166363 ( R-HSA-166058 ) R-HSA-166363 Reaction Name: TRAF6 binds to hp- IRAK1 See in Reactome R-HSA-2197698 ( R-HSA-2029482; R-HSA-5663213 ) R-HSA-2197698 Reaction Name: Src phosphorylate WASP,N-WASP See in Reactome R-HSA-2201322 ( R-HSA-166058 ) R-HSA-2201322 Reaction Name: TIRAP is phosphorylated by BTK See in Reactome R-HSA-2262775 ( R-HSA-166058 ) R-HSA-2262775 Reaction Name: Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex See in Reactome R-HSA-2262777 ( R-HSA-166058 ) R-HSA-2262777 Reaction Name: TRAF6 binds to p-IRAK2 See in Reactome R-HSA-2424476 ( R-HSA-2424491 ) R-HSA-2424476 Reaction Name: Activation of RAC1 by VAV2/3 See in Reactome R-HSA-2424481 ( R-HSA-2424491 ) R-HSA-2424481 Reaction Name: Recruitment of VAV and BTK to p-SLP-76 See in Reactome R-HSA-2424484 ( R-HSA-2424491 ) R-HSA-2424484 Reaction Name: Phosphorylation of BTK by p-SYK See in Reactome R-HSA-2424485 ( R-HSA-2424491 ) R-HSA-2424485 Reaction Name: Release of p-PLCG1 See in Reactome R-HSA-2424486 ( R-HSA-2424491 ) R-HSA-2424486 Reaction Name: Phosphorylation and activation of VAV2/VAV3 by SYK See in Reactome R-HSA-2424487 ( R-HSA-2424491 ) R-HSA-2424487 Reaction Name: Phosphorylation of PLC-gamma by p-BTK/p-SYK See in Reactome R-HSA-2559414 ( R-HSA-166058 ) R-HSA-2559414 Reaction Name: Activated TLR2/4:TIRAP interacts with BTK See in Reactome R-HSA-2730833 ( R-HSA-2871809 ) R-HSA-2730833 Reaction Name: Phosphorylation of TEC kinases by p-SYK See in Reactome R-HSA-2730847 ( R-HSA-2871809 ) R-HSA-2730847 Reaction Name: Hydrolysis of PIP2 by PLCG See in Reactome R-HSA-2730858 ( R-HSA-2871809 ) R-HSA-2730858 Reaction Name: Autophosphorylation of BTK/ITK See in Reactome R-HSA-2730885 ( R-HSA-2871809 ) R-HSA-2730885 Reaction Name: Recruitment of TEC kinases to p-SLP-76 See in Reactome R-HSA-2730888 ( R-HSA-2871809 ) R-HSA-2730888 Reaction Name: Phosphorylation of PLC-gamma See in Reactome R-HSA-8863895 ( R-HSA-1236974 ) R-HSA-8863895 Reaction Name: IKKB phosphorylates SNAP23 See in Reactome R-HSA-8964241 ( R-HSA-8964315 ) R-HSA-8964241 Reaction Name: G beta-gamma complex and PIP3 recruit BTK to membrane See in Reactome R-HSA-8964246 ( R-HSA-416482 ) R-HSA-8964246 Reaction Name: BTK in G alpha (12)-BTK complex is activated See in Reactome R-HSA-8964271 ( R-HSA-8964315 ) R-HSA-8964271 Reaction Name: BTK in PIP3:BTK:G beta-gamma complex is activated See in Reactome R-HSA-8964274 ( R-HSA-416482 ) R-HSA-8964274 Reaction Name: G alpha (12) binds BTK See in Reactome R-HSA-8964280 ( R-HSA-416476 ) R-HSA-8964280 Reaction Name: Active Gq binds BTK See in Reactome R-HSA-8964284 ( R-HSA-416476 ) R-HSA-8964284 Reaction Name: BTK in active Gq-BTK complex is activated See in Reactome R-HSA-8964317 ( R-HSA-8964315 ) R-HSA-8964317 Reaction Name: PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex See in Reactome R-HSA-8964333 ( R-HSA-416482 ) R-HSA-8964333 Reaction Name: G alpha (12)-BTK complex dissociates to Active BTK and G alpha (12) See in Reactome R-HSA-8964340 ( R-HSA-416476 ) R-HSA-8964340 Reaction Name: Gq-BTK complex dissociates to Active BTK and Gq See in Reactome R-HSA-937022 ( R-HSA-166058 ) R-HSA-937022 Reaction Name: IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP See in Reactome R-HSA-937059 ( R-HSA-166058 ) R-HSA-937059 Reaction Name: Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex See in Reactome R-HSA-937079 ( R-HSA-166058 ) R-HSA-937079 Reaction Name: MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88 See in Reactome R-HSA-9606151 ( R-HSA-983695 ) R-HSA-9606151 Reaction Name: Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 See in Reactome R-HSA-9606159 ( R-HSA-983695 ) R-HSA-9606159 Reaction Name: BTK autophosphorylates See in Reactome R-HSA-9606162 ( R-HSA-983695 ) R-HSA-9606162 Reaction Name: Phosphorylated BTK phosphorylates PLCG2 See in Reactome R-HSA-9606163 ( R-HSA-983695 ) R-HSA-9606163 Reaction Name: p-SYK and LYN phosphorylate BTK See in Reactome