DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q05209)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	5
Number of reactions:	6

Search results (UniProt accession: Q05209)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0005575	PTPN12	Q05209	3.1.3.48	R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-1250196 R-HSA-1250196 Reactome Name: SHC1 events in ERBB2 signaling See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-182971 R-HSA-182971 Reactome Name: EGFR downregulation See in Reactome R-HSA-9008059 R-HSA-9008059 Reactome Name: Interleukin-37 signaling See in Reactome	R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-177929 R-HSA-177929 Reactome Name: Signaling by EGFR See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome	Immune System Signal Transduction	R-HSA-1963578 ( R-HSA-1250196 ) R-HSA-1963578 Reaction Name: SHC1 binds phosphorylated ERBB2 heterodimers See in Reactome R-HSA-8863804 ( R-HSA-8863795 ) R-HSA-8863804 Reaction Name: PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 See in Reactome R-HSA-8864029 ( R-HSA-182971 ) R-HSA-8864029 Reaction Name: PTPN12 dephosphorylates EGFR at Y1148 (Y1172) See in Reactome R-HSA-8864036 ( R-HSA-186797 ) R-HSA-8864036 Reaction Name: PTPN12 dephosphorylates PDGFRB at Y1021 See in Reactome R-HSA-8934465 ( R-HSA-1250196 ) R-HSA-8934465 Reaction Name: SHC1 binds PTPN12 See in Reactome R-HSA-9008894 ( R-HSA-9008059 ) R-HSA-9008894 Reaction Name: PTPNs gene transcription and translation See in Reactome