DAR - Bologna Biocomputing Group

Search summary (UniProt accession: Q03112)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	2
Number of reactions:	4

Search results (UniProt accession: Q03112)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0014758	MECOM	Q03112	2.1.1.367	R-HSA-8943724 R-HSA-8943724 Reactome Name: Regulation of PTEN gene transcription See in Reactome R-HSA-3214841 R-HSA-3214841 Reactome Name: PKMTs methylate histone lysines See in Reactome	R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-4839726 R-HSA-4839726 Reactome Name: Chromatin organization See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-3247509 R-HSA-3247509 Reactome Name: Chromatin modifying enzymes See in Reactome	Chromatin organization Signal Transduction	R-HSA-5634802 ( R-HSA-3214841 ) R-HSA-5634802 Reaction Name: MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9) See in Reactome R-HSA-8943811 ( R-HSA-8943724 ) R-HSA-8943811 Reaction Name: MECOM (EVI1) binds the PTEN gene promoter See in Reactome R-HSA-8943817 ( R-HSA-8943724 ) R-HSA-8943817 Reaction Name: MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter See in Reactome R-HSA-8944104 ( R-HSA-8943724 ) R-HSA-8944104 Reaction Name: PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN See in Reactome