DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P98170)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	12
Number of reactions:	29

Search results (UniProt accession: P98170)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010385	XIAP	P98170	2.3.2.27	R-HSA-111469 R-HSA-111469 Reactome Name: SMAC, XIAP-regulated apoptotic response See in Reactome R-HSA-5675482 R-HSA-5675482 Reactome Name: Regulation of necroptotic cell death See in Reactome R-HSA-9627069 R-HSA-9627069 Reactome Name: Regulation of the apoptosome activity See in Reactome R-HSA-111464 R-HSA-111464 Reactome Name: SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes See in Reactome R-HSA-5213460 R-HSA-5213460 Reactome Name: RIPK1-mediated regulated necrosis See in Reactome R-HSA-111463 R-HSA-111463 Reactome Name: SMAC (DIABLO) binds to IAPs See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-3769402 R-HSA-3769402 Reactome Name: Deactivation of the beta-catenin transactivating complex See in Reactome R-HSA-8948747 R-HSA-8948747 Reactome Name: Regulation of PTEN localization See in Reactome R-HSA-8948751 R-HSA-8948751 Reactome Name: Regulation of PTEN stability and activity See in Reactome R-HSA-111459 R-HSA-111459 Reactome Name: Activation of caspases through apoptosome-mediated cleavage See in Reactome	R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-6807070 R-HSA-6807070 Reactome Name: PTEN Regulation See in Reactome R-HSA-111461 R-HSA-111461 Reactome Name: Cytochrome c-mediated apoptotic response See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-111471 R-HSA-111471 Reactome Name: Apoptotic factor-mediated response See in Reactome R-HSA-109581 R-HSA-109581 Reactome Name: Apoptosis See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-109606 R-HSA-109606 Reactome Name: Intrinsic Pathway for Apoptosis See in Reactome R-HSA-111458 R-HSA-111458 Reactome Name: Formation of apoptosome See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Programmed Cell Death Signal Transduction	R-HSA-114252 ( R-HSA-111459 ) R-HSA-114252 Reaction Name: Cleavage of Procaspase-3 by the apoptosome See in Reactome R-HSA-114261 ( R-HSA-111459 ) R-HSA-114261 Reaction Name: Cleavage of Procaspase-7 by the apoptosome See in Reactome R-HSA-114306 ( R-HSA-111463; R-HSA-111469 ) R-HSA-114306 Reaction Name: SMAC binds XIAP:Caspase-3 See in Reactome R-HSA-114354 ( R-HSA-111463; R-HSA-111469 ) R-HSA-114354 Reaction Name: SMAC binds XIAP:Caspase-7 See in Reactome R-HSA-114361 ( R-HSA-111463; R-HSA-111469 ) R-HSA-114361 Reaction Name: SMAC binds XIAP within apoptosome See in Reactome R-HSA-114392 ( R-HSA-111464; R-HSA-111469 ) R-HSA-114392 Reaction Name: Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7 See in Reactome R-HSA-114419 ( R-HSA-111464; R-HSA-111469 ) R-HSA-114419 Reaction Name: Dissociation of Caspase-3 from DIABLO:XIAP:Caspase-3 See in Reactome R-HSA-114440 ( R-HSA-111464; R-HSA-111469 ) R-HSA-114440 Reaction Name: Dissociation of DIABLO:XIAP from the apoptosome complex See in Reactome R-HSA-3322429 ( R-HSA-3769402 ) R-HSA-3322429 Reaction Name: XIAP monoubiquinates TLE See in Reactome R-HSA-3322431 ( R-HSA-3769402 ) R-HSA-3322431 Reaction Name: XIAP binds TLE See in Reactome R-HSA-3322434 ( R-HSA-3769402 ) R-HSA-3322434 Reaction Name: XIAP dissociates from ub-TLE See in Reactome R-HSA-5213462 ( R-HSA-5213460 ) R-HSA-5213462 Reaction Name: RIPK3 binds RIPK1 See in Reactome R-HSA-5357757 ( R-HSA-5357956 ) R-HSA-5357757 Reaction Name: BIRC(cIAP1/2) ubiquitinates RIPK1 See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357780 ( R-HSA-5357956 ) R-HSA-5357780 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) See in Reactome R-HSA-5357845 ( R-HSA-5357905 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5357904 ( R-HSA-5357956 ) R-HSA-5357904 Reaction Name: TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC See in Reactome R-HSA-5357928 ( R-HSA-5357905 ) R-HSA-5357928 Reaction Name: CLIP3 and CYLD bind TNF signaling complex See in Reactome R-HSA-5675470 ( R-HSA-5213460; R-HSA-5675482 ) R-HSA-5675470 Reaction Name: BIRC2/3 (cIAP1/2) is autoubiquitinated See in Reactome R-HSA-5693055 ( R-HSA-5357905 ) R-HSA-5693055 Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes See in Reactome R-HSA-5693108 ( R-HSA-5357905 ) R-HSA-5693108 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains See in Reactome R-HSA-6807106 ( R-HSA-8948747 ) R-HSA-6807106 Reaction Name: PTEN undergoes monoubiquitination See in Reactome R-HSA-6807134 ( R-HSA-8948751 ) R-HSA-6807134 Reaction Name: NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN See in Reactome R-HSA-9627078 ( R-HSA-9627069 ) R-HSA-9627078 Reaction Name: XIAP binds CASP9 See in Reactome R-HSA-9627104 ( R-HSA-111469 ) R-HSA-9627104 Reaction Name: XIAP binds CASP3 See in Reactome R-HSA-9627107 ( R-HSA-111469 ) R-HSA-9627107 Reaction Name: XIAP binds CASP7 See in Reactome R-HSA-9627350 ( R-HSA-111463; R-HSA-111469 ) R-HSA-9627350 Reaction Name: SMAC (DIABLO) binds XIAP See in Reactome R-HSA-9627369 ( R-HSA-111469 ) R-HSA-9627369 Reaction Name: SEPT4 binds XIAP See in Reactome