DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P78527)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	4
Number of reactions:	13

Search results (UniProt accession: P78527)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0014423	PRKDC	P78527	2.7.11.1	R-HSA-3270619 R-HSA-3270619 Reactome Name: IRF3-mediated induction of type I IFN See in Reactome R-HSA-1834949 R-HSA-1834949 Reactome Name: Cytosolic sensors of pathogen-associated DNA See in Reactome R-HSA-8866654 R-HSA-8866654 Reactome Name: E3 ubiquitin ligases ubiquitinate target proteins See in Reactome R-HSA-5693571 R-HSA-5693571 Reactome Name: Nonhomologous End-Joining (NHEJ) See in Reactome	R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-8852135 R-HSA-8852135 Reactome Name: Protein ubiquitination See in Reactome R-HSA-73894 R-HSA-73894 Reactome Name: DNA Repair See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-5693532 R-HSA-5693532 Reactome Name: DNA Double-Strand Break Repair See in Reactome R-HSA-1834941 R-HSA-1834941 Reactome Name: STING mediated induction of host immune responses See in Reactome	Immune System Metabolism of proteins DNA Repair	R-HSA-1834939 ( R-HSA-1834949; R-HSA-3270619 ) R-HSA-1834939 Reaction Name: STING recruits TBK1 and IRF3 See in Reactome R-HSA-3134821 ( R-HSA-1834949 ) R-HSA-3134821 Reaction Name: DNA-PK binds microbial dsDNA See in Reactome R-HSA-5686924 ( R-HSA-5693571 ) R-HSA-5686924 Reaction Name: DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs See in Reactome R-HSA-5687183 ( R-HSA-5693571 ) R-HSA-5687183 Reaction Name: PRKDC phosphorylates DCLRE1C at DNA DSBs See in Reactome R-HSA-5687360 ( R-HSA-5693571 ) R-HSA-5687360 Reaction Name: POLL or POLM extends aligned DNA DSB ends to fill gaps See in Reactome R-HSA-5693533 ( R-HSA-5693571 ) R-HSA-5693533 Reaction Name: DCLRE1C (ARTEMIS) processes DNA DSB ends See in Reactome R-HSA-5693574 ( R-HSA-5693571 ) R-HSA-5693574 Reaction Name: XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ See in Reactome R-HSA-5693575 ( R-HSA-5693571 ) R-HSA-5693575 Reaction Name: DNA-PKcs autophosphorylates See in Reactome R-HSA-5693578 ( R-HSA-5693571 ) R-HSA-5693578 Reaction Name: TDP1 and TDP2 process unligatable DSB ends See in Reactome R-HSA-5693604 ( R-HSA-5693571 ) R-HSA-5693604 Reaction Name: XRCC4:LIG4 ligates DNA DSB ends during NHEJ See in Reactome R-HSA-5693615 ( R-HSA-5693571 ) R-HSA-5693615 Reaction Name: Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis See in Reactome R-HSA-8938770 ( R-HSA-8866654 ) R-HSA-8938770 Reaction Name: RNF144A binds PRKDC and Ubiquitin:UBE2L3 See in Reactome R-HSA-8938773 ( R-HSA-8866654 ) R-HSA-8938773 Reaction Name: RNF144A polyubiquitinates PRKDC See in Reactome