DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P62140)

Number of enzymes:	1
Number of disease:	3
Number of reactomes:	9
Number of reactions:	12

Search results (UniProt accession: P62140)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0054588	PPP1CB	P62140	3.1.3.16 3.1.3.53	R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Circadian Clock Metabolism Signal Transduction Cell Cycle	R-HSA-163568 ( R-HSA-163560 ) R-HSA-163568 Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate See in Reactome R-HSA-178178 ( R-HSA-2173788 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-3002811 ( R-HSA-2565942 ) R-HSA-3002811 Reaction Name: Myosin phosphatase dephosphorylates PLK1 See in Reactome R-HSA-400382 ( R-HSA-400253 ) R-HSA-400382 Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668978 ( R-HSA-5627123 ) R-HSA-5668978 Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex See in Reactome R-HSA-5671772 ( R-HSA-5625740 ) R-HSA-5671772 Reaction Name: p-T38-PPP1R14A binds MLCP See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0009072	PPP1CB	P62140	3.1.3.16 3.1.3.53	R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Circadian Clock Metabolism Signal Transduction Cell Cycle	R-HSA-163568 ( R-HSA-163560 ) R-HSA-163568 Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate See in Reactome R-HSA-178178 ( R-HSA-2173788 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-3002811 ( R-HSA-2565942 ) R-HSA-3002811 Reaction Name: Myosin phosphatase dephosphorylates PLK1 See in Reactome R-HSA-400382 ( R-HSA-400253 ) R-HSA-400382 Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668978 ( R-HSA-5627123 ) R-HSA-5668978 Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex See in Reactome R-HSA-5671772 ( R-HSA-5625740 ) R-HSA-5671772 Reaction Name: p-T38-PPP1R14A binds MLCP See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome
MONDO:0018997	PPP1CB	P62140	3.1.3.16 3.1.3.53	R-HSA-400253 R-HSA-400253 Reactome Name: Circadian Clock See in Reactome R-HSA-5625900 R-HSA-5625900 Reactome Name: RHO GTPases activate CIT See in Reactome R-HSA-5625740 R-HSA-5625740 Reactome Name: RHO GTPases activate PKNs See in Reactome R-HSA-2565942 R-HSA-2565942 Reactome Name: Regulation of PLK1 Activity at G2/M Transition See in Reactome R-HSA-163560 R-HSA-163560 Reactome Name: Triglyceride catabolism See in Reactome R-HSA-5627117 R-HSA-5627117 Reactome Name: RHO GTPases Activate ROCKs See in Reactome R-HSA-2173788 R-HSA-2173788 Reactome Name: Downregulation of TGF-beta receptor signaling See in Reactome R-HSA-5673000 R-HSA-5673000 Reactome Name: RAF activation See in Reactome R-HSA-5627123 R-HSA-5627123 Reactome Name: RHO GTPases activate PAKs See in Reactome	R-HSA-195258 R-HSA-195258 Reactome Name: RHO GTPase Effectors See in Reactome R-HSA-2173789 R-HSA-2173789 Reactome Name: TGF-beta receptor signaling activates SMADs See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-170834 R-HSA-170834 Reactome Name: Signaling by TGF-beta Receptor Complex See in Reactome R-HSA-194315 R-HSA-194315 Reactome Name: Signaling by Rho GTPases See in Reactome R-HSA-453274 R-HSA-453274 Reactome Name: Mitotic G2-G2/M phases See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-69278 R-HSA-69278 Reactome Name: Cell Cycle, Mitotic See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-9006936 R-HSA-9006936 Reactome Name: Signaling by TGFB family members See in Reactome R-HSA-8979227 R-HSA-8979227 Reactome Name: Triglyceride metabolism See in Reactome R-HSA-1640170 R-HSA-1640170 Reactome Name: Cell Cycle See in Reactome R-HSA-9716542 R-HSA-9716542 Reactome Name: Signaling by Rho GTPases, Miro GTPases and RHOBTB3 See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-69275 R-HSA-69275 Reactome Name: G2/M Transition See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	Circadian Clock Metabolism Signal Transduction Cell Cycle	R-HSA-163568 ( R-HSA-163560 ) R-HSA-163568 Reaction Name: phosphorylated perilipin + H2O -> perilipin + orthophosphate See in Reactome R-HSA-178178 ( R-HSA-2173788 ) R-HSA-178178 Reaction Name: PP1 dephosphorylates TGFBR1 See in Reactome R-HSA-178189 ( R-HSA-2173788 ) R-HSA-178189 Reaction Name: SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR See in Reactome R-HSA-3002811 ( R-HSA-2565942 ) R-HSA-3002811 Reaction Name: Myosin phosphatase dephosphorylates PLK1 See in Reactome R-HSA-400382 ( R-HSA-400253 ) R-HSA-400382 Reaction Name: CSNK1E,CSNK1D phosphorylate CRY and PER proteins See in Reactome R-HSA-419083 ( R-HSA-5627117 ) R-HSA-419083 Reaction Name: Myosin phosphatase inactivation by ROCK See in Reactome R-HSA-419232 ( R-HSA-5625740; R-HSA-5627117; R-HSA-5627123 ) R-HSA-419232 Reaction Name: Myosin phosphatase dephosphorylates myosin regulatory light chain See in Reactome R-HSA-5668947 ( R-HSA-5627123 ) R-HSA-5668947 Reaction Name: PAK1 phosphorylates myosin phosphatase See in Reactome R-HSA-5668978 ( R-HSA-5627123 ) R-HSA-5668978 Reaction Name: MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex See in Reactome R-HSA-5671772 ( R-HSA-5625740 ) R-HSA-5671772 Reaction Name: p-T38-PPP1R14A binds MLCP See in Reactome R-HSA-5671919 ( R-HSA-5625900 ) R-HSA-5671919 Reaction Name: Activated CIT phosphorylates MRLCs See in Reactome R-HSA-9658445 ( R-HSA-5673000 ) R-HSA-9658445 Reaction Name: MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs See in Reactome