DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P56524)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	6
Number of reactions:	9

Search results (UniProt accession: P56524)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010886	HDAC4	P56524	3.5.1.98	R-HSA-8951936 R-HSA-8951936 Reactome Name: RUNX3 regulates p14-ARF See in Reactome R-HSA-4551638 R-HSA-4551638 Reactome Name: SUMOylation of chromatin organization proteins See in Reactome R-HSA-2122947 R-HSA-2122947 Reactome Name: NOTCH1 Intracellular Domain Regulates Transcription See in Reactome R-HSA-8941284 R-HSA-8941284 Reactome Name: RUNX2 regulates chondrocyte maturation See in Reactome R-HSA-4090294 R-HSA-4090294 Reactome Name: SUMOylation of intracellular receptors See in Reactome R-HSA-350054 R-HSA-350054 Reactome Name: Notch-HLH transcription pathway See in Reactome	R-HSA-1980143 R-HSA-1980143 Reactome Name: Signaling by NOTCH1 See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-157118 R-HSA-157118 Reactome Name: Signaling by NOTCH See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8878159 R-HSA-8878159 Reactome Name: Transcriptional regulation by RUNX3 See in Reactome R-HSA-8941326 R-HSA-8941326 Reactome Name: RUNX2 regulates bone development See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8878166 R-HSA-8878166 Reactome Name: Transcriptional regulation by RUNX2 See in Reactome	Gene expression (Transcription) Metabolism of proteins Signal Transduction	R-HSA-1912388 ( R-HSA-2122947 ) R-HSA-1912388 Reaction Name: NICD1 displaces co-repressor complex from RBPJ (CSL) See in Reactome R-HSA-350058 ( R-HSA-350054 ) R-HSA-350058 Reaction Name: Formation of CSL NCOR corepressor complex See in Reactome R-HSA-4615872 ( R-HSA-4551638 ) R-HSA-4615872 Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO1 See in Reactome R-HSA-4615987 ( R-HSA-4551638 ) R-HSA-4615987 Reaction Name: RANBP2 SUMOylates HDAC4 with SUMO2,3 See in Reactome R-HSA-4720432 ( R-HSA-4090294 ) R-HSA-4720432 Reaction Name: HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 See in Reactome R-HSA-4720446 ( R-HSA-4090294 ) R-HSA-4720446 Reaction Name: HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 See in Reactome R-HSA-8952062 ( R-HSA-8951936 ) R-HSA-8952062 Reaction Name: CCND1 recruits HDAC4 to RUNX3 See in Reactome R-HSA-8952069 ( R-HSA-8951936 ) R-HSA-8952069 Reaction Name: HDAC4 deacetylates RUNX3 See in Reactome R-HSA-9008326 ( R-HSA-8941284 ) R-HSA-9008326 Reaction Name: RUNX2 binds HDAC4 See in Reactome