DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P50281)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	3
Number of reactions:	18

Search results (UniProt accession: P50281)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0010201	MMP14	P50281	3.4.24.80	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-1458433 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1458433 Reaction Name: Collagen type I degradation by MMP14 See in Reactome R-HSA-1474196 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474196 Reaction Name: Collagen type II degradation by MMP14 See in Reactome R-HSA-1474210 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474210 Reaction Name: Collagen type III degradation by MMP14 See in Reactome R-HSA-1592349 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592349 Reaction Name: MMP14 (MT1-MMP) binds TIMP2 See in Reactome R-HSA-1602466 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602466 Reaction Name: Activation of MT-MMPs by FURIN See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604741 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604741 Reaction Name: Initial activation of proMMP13 by MMP14 (MT1-MMP) See in Reactome R-HSA-1605825 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1605825 Reaction Name: MT-MMPs are sorted to the plasma membrane See in Reactome R-HSA-2514790 ( R-HSA-1474228 ) R-HSA-2514790 Reaction Name: Elastin degradation by MMP14 See in Reactome R-HSA-2514831 ( R-HSA-1474228 ) R-HSA-2514831 Reaction Name: Fibrillin-1 degradation by MMP14 See in Reactome R-HSA-2533874 ( R-HSA-1474228 ) R-HSA-2533874 Reaction Name: Laminin-511 degradation by MMP14 See in Reactome R-HSA-2533950 ( R-HSA-1474228 ) R-HSA-2533950 Reaction Name: Fibronectin degradation by MMP14, TMPRSS6 See in Reactome R-HSA-2533965 ( R-HSA-1474228 ) R-HSA-2533965 Reaction Name: NID1 degradation by MMP14, MMP15 See in Reactome R-HSA-2534240 ( R-HSA-1474228 ) R-HSA-2534240 Reaction Name: HSPG2 (perlecan) degradation by MMP14, MMP15 See in Reactome R-HSA-3791155 ( R-HSA-1474228 ) R-HSA-3791155 Reaction Name: Laminin-322 degradation by MMP14 See in Reactome R-HSA-3828025 ( R-HSA-1474228 ) R-HSA-3828025 Reaction Name: DCN (decorin) degradation by MMP14 See in Reactome
MONDO:0018298	MMP14	P50281	3.4.24.80	R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome	R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome	Extracellular matrix organization	R-HSA-1458433 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1458433 Reaction Name: Collagen type I degradation by MMP14 See in Reactome R-HSA-1474196 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474196 Reaction Name: Collagen type II degradation by MMP14 See in Reactome R-HSA-1474210 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474210 Reaction Name: Collagen type III degradation by MMP14 See in Reactome R-HSA-1592349 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592349 Reaction Name: MMP14 (MT1-MMP) binds TIMP2 See in Reactome R-HSA-1602466 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1602466 Reaction Name: Activation of MT-MMPs by FURIN See in Reactome R-HSA-1604350 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604350 Reaction Name: MMP14:TIMP2 binds proMMP2 See in Reactome R-HSA-1604360 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604360 Reaction Name: Initial activation of proMMP2 by MMP14 See in Reactome R-HSA-1604368 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604368 Reaction Name: Autocatalytic activation of bound proMMP2 See in Reactome R-HSA-1604741 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604741 Reaction Name: Initial activation of proMMP13 by MMP14 (MT1-MMP) See in Reactome R-HSA-1605825 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1605825 Reaction Name: MT-MMPs are sorted to the plasma membrane See in Reactome R-HSA-2514790 ( R-HSA-1474228 ) R-HSA-2514790 Reaction Name: Elastin degradation by MMP14 See in Reactome R-HSA-2514831 ( R-HSA-1474228 ) R-HSA-2514831 Reaction Name: Fibrillin-1 degradation by MMP14 See in Reactome R-HSA-2533874 ( R-HSA-1474228 ) R-HSA-2533874 Reaction Name: Laminin-511 degradation by MMP14 See in Reactome R-HSA-2533950 ( R-HSA-1474228 ) R-HSA-2533950 Reaction Name: Fibronectin degradation by MMP14, TMPRSS6 See in Reactome R-HSA-2533965 ( R-HSA-1474228 ) R-HSA-2533965 Reaction Name: NID1 degradation by MMP14, MMP15 See in Reactome R-HSA-2534240 ( R-HSA-1474228 ) R-HSA-2534240 Reaction Name: HSPG2 (perlecan) degradation by MMP14, MMP15 See in Reactome R-HSA-3791155 ( R-HSA-1474228 ) R-HSA-3791155 Reaction Name: Laminin-322 degradation by MMP14 See in Reactome R-HSA-3828025 ( R-HSA-1474228 ) R-HSA-3828025 Reaction Name: DCN (decorin) degradation by MMP14 See in Reactome