DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P48735)

Number of enzymes:	1
Number of disease:	4
Number of reactomes:	2
Number of reactions:	2

Search results (UniProt accession: P48735)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008145	IDH2	P48735	1.1.1.42	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-450984 ( R-HSA-71403 ) R-HSA-450984 Reaction Name: isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] See in Reactome R-HSA-5688289 ( R-HSA-2151201 ) R-HSA-5688289 Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 See in Reactome
MONDO:0013345	IDH2	P48735	1.1.1.42	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-450984 ( R-HSA-71403 ) R-HSA-450984 Reaction Name: isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] See in Reactome R-HSA-5688289 ( R-HSA-2151201 ) R-HSA-5688289 Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 See in Reactome
MONDO:0013808	IDH2	P48735	1.1.1.42	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-450984 ( R-HSA-71403 ) R-HSA-450984 Reaction Name: isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] See in Reactome R-HSA-5688289 ( R-HSA-2151201 ) R-HSA-5688289 Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 See in Reactome
MONDO:0024498	IDH2	P48735	1.1.1.42	R-HSA-71403 R-HSA-71403 Reactome Name: Citric acid cycle (TCA cycle) See in Reactome R-HSA-2151201 R-HSA-2151201 Reactome Name: Transcriptional activation of mitochondrial biogenesis See in Reactome	R-HSA-1428517 R-HSA-1428517 Reactome Name: The citric acid (TCA) cycle and respiratory electron transport See in Reactome R-HSA-1852241 R-HSA-1852241 Reactome Name: Organelle biogenesis and maintenance See in Reactome R-HSA-71406 R-HSA-71406 Reactome Name: Pyruvate metabolism and Citric Acid (TCA) cycle See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-1592230 R-HSA-1592230 Reactome Name: Mitochondrial biogenesis See in Reactome	Organelle biogenesis and maintenance Metabolism	R-HSA-450984 ( R-HSA-71403 ) R-HSA-450984 Reaction Name: isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2] See in Reactome R-HSA-5688289 ( R-HSA-2151201 ) R-HSA-5688289 Reaction Name: SIRT3 deacetylates ACCS2, GLUD, IDH2, SOD2 See in Reactome