DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P42338)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	22
Number of reactions:	37

Search results (UniProt accession: P42338)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0016996	PIK3CB	P42338	2.7.1.153	R-HSA-1660499 R-HSA-1660499 Reactome Name: Synthesis of PIPs at the plasma membrane See in Reactome R-HSA-198203 R-HSA-198203 Reactome Name: PI3K/AKT activation See in Reactome R-HSA-4420097 R-HSA-4420097 Reactome Name: VEGFA-VEGFR2 Pathway See in Reactome R-HSA-114604 R-HSA-114604 Reactome Name: GPVI-mediated activation cascade See in Reactome R-HSA-186763 R-HSA-186763 Reactome Name: Downstream signal transduction See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-9027276 R-HSA-9027276 Reactome Name: Erythropoietin activates Phosphoinositide-3-kinase (PI3K) See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome R-HSA-912631 R-HSA-912631 Reactome Name: Regulation of signaling by CBL See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-8853659 R-HSA-8853659 Reactome Name: RET signaling See in Reactome R-HSA-2730905 R-HSA-2730905 Reactome Name: Role of LAT2/NTAL/LAB on calcium mobilization See in Reactome R-HSA-2029485 R-HSA-2029485 Reactome Name: Role of phospholipids in phagocytosis See in Reactome R-HSA-202424 R-HSA-202424 Reactome Name: Downstream TCR signaling See in Reactome R-HSA-912526 R-HSA-912526 Reactome Name: Interleukin receptor SHC signaling See in Reactome R-HSA-2424491 R-HSA-2424491 Reactome Name: DAP12 signaling See in Reactome R-HSA-512988 R-HSA-512988 Reactome Name: Interleukin-3, Interleukin-5 and GM-CSF signaling See in Reactome R-HSA-201556 R-HSA-201556 Reactome Name: Signaling by ALK See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-210993 R-HSA-210993 Reactome Name: Tie2 Signaling See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-373753 R-HSA-373753 Reactome Name: Nephrin family interactions See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-1500931 R-HSA-1500931 Reactome Name: Cell-Cell communication See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-1266738 R-HSA-1266738 Reactome Name: Developmental Biology See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-166520 R-HSA-166520 Reactome Name: Signaling by NTRKs See in Reactome R-HSA-194138 R-HSA-194138 Reactome Name: Signaling by VEGF See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-76002 R-HSA-76002 Reactome Name: Platelet activation, signaling and aggregation See in Reactome R-HSA-9675108 R-HSA-9675108 Reactome Name: Nervous system development See in Reactome R-HSA-1483255 R-HSA-1483255 Reactome Name: PI Metabolism See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-1483257 R-HSA-1483257 Reactome Name: Phospholipid metabolism See in Reactome R-HSA-556833 R-HSA-556833 Reactome Name: Metabolism of lipids See in Reactome R-HSA-202403 R-HSA-202403 Reactome Name: TCR signaling See in Reactome R-HSA-9006335 R-HSA-9006335 Reactome Name: Signaling by Erythropoietin See in Reactome R-HSA-2029480 R-HSA-2029480 Reactome Name: Fcgamma receptor (FCGR) dependent phagocytosis See in Reactome R-HSA-2454202 R-HSA-2454202 Reactome Name: Fc epsilon receptor (FCERI) signaling See in Reactome R-HSA-451927 R-HSA-451927 Reactome Name: Interleukin-2 family signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-187037 R-HSA-187037 Reactome Name: Signaling by NTRK1 (TRKA) See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-2172127 R-HSA-2172127 Reactome Name: DAP12 interactions See in Reactome R-HSA-186797 R-HSA-186797 Reactome Name: Signaling by PDGF See in Reactome R-HSA-1430728 R-HSA-1430728 Reactome Name: Metabolism See in Reactome R-HSA-422475 R-HSA-422475 Reactome Name: Axon guidance See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Cell-Cell communication Developmental Biology Metabolism Hemostasis Signal Transduction	R-HSA-109699 ( R-HSA-109704; R-HSA-112399 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-1676048 ( R-HSA-1660499 ) R-HSA-1676048 Reaction Name: PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane See in Reactome R-HSA-1676109 ( R-HSA-1660499 ) R-HSA-1676109 Reaction Name: PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane See in Reactome R-HSA-186780 ( R-HSA-186763 ) R-HSA-186780 Reaction Name: PI3-kinase binds to the active receptor See in Reactome R-HSA-186800 ( R-HSA-186763 ) R-HSA-186800 Reaction Name: PI3K catalyses the phosphorylation of PIP2 to PIP3 See in Reactome R-HSA-198266 ( R-HSA-198203 ) R-HSA-198266 Reaction Name: PI3K produces PIP3 and other phosphatidyl inositides See in Reactome R-HSA-198315 ( R-HSA-198203 ) R-HSA-198315 Reaction Name: Active IRS recruits PI3K to the plasma membrane and activates it See in Reactome R-HSA-201510 ( R-HSA-201556 ) R-HSA-201510 Reaction Name: PI3K synthesizes PIP3 downstream of ALK See in Reactome R-HSA-201515 ( R-HSA-201556 ) R-HSA-201515 Reaction Name: Active ALK recruits PI3K See in Reactome R-HSA-202203 ( R-HSA-202424 ) R-HSA-202203 Reaction Name: Recruitment of PI3K to plasma membrane See in Reactome R-HSA-202365 ( R-HSA-202424 ) R-HSA-202365 Reaction Name: PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029271 ( R-HSA-2029485 ) R-HSA-2029271 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2029273 ( R-HSA-2029485 ) R-HSA-2029273 Reaction Name: PI3K binds to p-6Y-SYK See in Reactome R-HSA-204798 ( R-HSA-210993 ) R-HSA-204798 Reaction Name: Interaction of Tie2 and p85 of PI3K See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424480 ( R-HSA-2424491 ) R-HSA-2424480 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-2424482 ( R-HSA-2424491 ) R-HSA-2424482 Reaction Name: p85 regulatory unit of PI3K binds p-6Y-SYK See in Reactome R-HSA-2730842 ( R-HSA-2730905 ) R-HSA-2730842 Reaction Name: PI3K associates with phosphorylated GAB2 See in Reactome R-HSA-2730870 ( R-HSA-2730905 ) R-HSA-2730870 Reaction Name: Phosphorylation of PIP2 to PIP3 by PI3K See in Reactome R-HSA-437118 ( R-HSA-114604 ) R-HSA-437118 Reaction Name: GPVI stimulates PI3K beta, gamma See in Reactome R-HSA-437162 ( R-HSA-114604 ) R-HSA-437162 Reaction Name: PI3K alpha, beta, gamma convert PIP2 to PIP3 See in Reactome R-HSA-451758 ( R-HSA-373753 ) R-HSA-451758 Reaction Name: p85 associates with both p-Nephrin and CD2AP See in Reactome R-HSA-508247 ( R-HSA-512988; R-HSA-912526 ) R-HSA-508247 Reaction Name: Gab2 binds the p85 subunit of Class 1A PI3 kinases See in Reactome R-HSA-5218819 ( R-HSA-4420097 ) R-HSA-5218819 Reaction Name: VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5218852 ( R-HSA-4420097 ) R-HSA-5218852 Reaction Name: p-6Y-VEGFR2 binds PI3K See in Reactome R-HSA-5357479 ( R-HSA-4420097 ) R-HSA-5357479 Reaction Name: p-AXL binds PI3K See in Reactome R-HSA-74737 ( R-HSA-112399 ) R-HSA-74737 Reaction Name: p-Y-IRS1,p-Y-IRS2 bind PI3K See in Reactome R-HSA-879917 ( R-HSA-512988; R-HSA-912631 ) R-HSA-879917 Reaction Name: CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated See in Reactome R-HSA-8854905 ( R-HSA-8853659 ) R-HSA-8854905 Reaction Name: p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K See in Reactome R-HSA-9012657 ( R-HSA-9027276 ) R-HSA-9012657 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K See in Reactome R-HSA-9021627 ( R-HSA-9027276 ) R-HSA-9021627 Reaction Name: EPOR-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-9027275 ( R-HSA-9027276 ) R-HSA-9027275 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K See in Reactome R-HSA-9027280 ( R-HSA-9027276 ) R-HSA-9027280 Reaction Name: EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K See in Reactome R-HSA-912627 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912627 Reaction Name: CBL ubiquitinates PI3K See in Reactome R-HSA-912629 ( R-HSA-512988; R-HSA-912631 ) R-HSA-912629 Reaction Name: CBL is tyrosine phosphorylated See in Reactome R-HSA-914182 ( R-HSA-512988 ) R-HSA-914182 Reaction Name: 14-3-3 zeta binding allows recruitment of PI3K See in Reactome R-HSA-9658253 ( R-HSA-5673001 ) R-HSA-9658253 Reaction Name: RAS:GTP binds PI3K See in Reactome