DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P41279)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	2
Number of reactions:	10

Search results (UniProt accession: P41279)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008903	MAP3K8	P41279	2.7.11.25	R-HSA-5684264 R-HSA-5684264 Reactome Name: MAP3K8 (TPL2)-dependent MAPK1/3 activation See in Reactome R-HSA-389357 R-HSA-389357 Reactome Name: CD28 dependent PI3K/Akt signaling See in Reactome	R-HSA-937061 R-HSA-937061 Reactome Name: TRIF(TICAM1)-mediated TLR4 signaling See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-181438 R-HSA-181438 Reactome Name: Toll Like Receptor 2 (TLR2) Cascade See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-975871 R-HSA-975871 Reactome Name: MyD88 cascade initiated on plasma membrane See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-1280218 R-HSA-1280218 Reactome Name: Adaptive Immune System See in Reactome R-HSA-9020702 R-HSA-9020702 Reactome Name: Interleukin-1 signaling See in Reactome R-HSA-168142 R-HSA-168142 Reactome Name: Toll Like Receptor 10 (TLR10) Cascade See in Reactome R-HSA-168164 R-HSA-168164 Reactome Name: Toll Like Receptor 3 (TLR3) Cascade See in Reactome R-HSA-168898 R-HSA-168898 Reactome Name: Toll-like Receptor Cascades See in Reactome R-HSA-389356 R-HSA-389356 Reactome Name: CD28 co-stimulation See in Reactome R-HSA-166166 R-HSA-166166 Reactome Name: MyD88-independent TLR4 cascade See in Reactome R-HSA-388841 R-HSA-388841 Reactome Name: Costimulation by the CD28 family See in Reactome R-HSA-446652 R-HSA-446652 Reactome Name: Interleukin-1 family signaling See in Reactome R-HSA-168188 R-HSA-168188 Reactome Name: Toll Like Receptor TLR6:TLR2 Cascade See in Reactome R-HSA-166016 R-HSA-166016 Reactome Name: Toll Like Receptor 4 (TLR4) Cascade See in Reactome R-HSA-168181 R-HSA-168181 Reactome Name: Toll Like Receptor 7/8 (TLR7/8) Cascade See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168179 R-HSA-168179 Reactome Name: Toll Like Receptor TLR1:TLR2 Cascade See in Reactome R-HSA-450294 R-HSA-450294 Reactome Name: MAP kinase activation See in Reactome R-HSA-975138 R-HSA-975138 Reactome Name: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation See in Reactome R-HSA-448424 R-HSA-448424 Reactome Name: Interleukin-17 signaling See in Reactome R-HSA-168176 R-HSA-168176 Reactome Name: Toll Like Receptor 5 (TLR5) Cascade See in Reactome R-HSA-975155 R-HSA-975155 Reactome Name: MyD88 dependent cascade initiated on endosome See in Reactome R-HSA-166058 R-HSA-166058 Reactome Name: MyD88:MAL(TIRAP) cascade initiated on plasma membrane See in Reactome R-HSA-168138 R-HSA-168138 Reactome Name: Toll Like Receptor 9 (TLR9) Cascade See in Reactome	Immune System	R-HSA-389756 ( R-HSA-389357 ) R-HSA-389756 Reaction Name: AKT interacts and phosphorylates Cot See in Reactome R-HSA-392530 ( R-HSA-389357 ) R-HSA-392530 Reaction Name: p-S400-Cot phosphorylates NIK See in Reactome R-HSA-451634 ( R-HSA-5684264 ) R-HSA-451634 Reaction Name: NFKB p105, TPL2 (COT) and ABIN2 form a stable complex See in Reactome R-HSA-451649 ( R-HSA-5684264 ) R-HSA-451649 Reaction Name: TPL2 phosphorylates MEK1, SEK1 See in Reactome R-HSA-5684248 ( R-HSA-5684264 ) R-HSA-5684248 Reaction Name: SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 See in Reactome R-HSA-5684250 ( R-HSA-5684264 ) R-HSA-5684250 Reaction Name: SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 See in Reactome R-HSA-5684261 ( R-HSA-5684264 ) R-HSA-5684261 Reaction Name: MAP3K8 is phosphorylated See in Reactome R-HSA-5684267 ( R-HSA-5684264 ) R-HSA-5684267 Reaction Name: IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex See in Reactome R-HSA-5684273 ( R-HSA-5684264 ) R-HSA-5684273 Reaction Name: 3xUb,p-S-NFkB p105:TPL2:ABIN2 dissociates due to degradation of p105 See in Reactome R-HSA-5684275 ( R-HSA-5684264 ) R-HSA-5684275 Reaction Name: IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 See in Reactome