DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P40818)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	4
Number of reactions:	7

Search results (UniProt accession: P40818)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0009050	USP8	P40818	3.4.19.12	R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-4641263 R-HSA-4641263 Reactome Name: Regulation of FZD by ubiquitination See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1358795 ( R-HSA-1358803 ) R-HSA-1358795 Reaction Name: Deubiquitination of RNF41 by P-USP8 See in Reactome R-HSA-1358797 ( R-HSA-1358803 ) R-HSA-1358797 Reaction Name: Ubiquitinated RNF41 binds P-USP8 See in Reactome R-HSA-4641236 ( R-HSA-4641263 ) R-HSA-4641236 Reaction Name: USP8 deubiquitinates FZD to potentiate WNT signaling See in Reactome R-HSA-5690196 ( R-HSA-5689880 ) R-HSA-5690196 Reaction Name: USP8 deubiquitinates RNF128 See in Reactome R-HSA-6782628 ( R-HSA-5689880 ) R-HSA-6782628 Reaction Name: USP8 deubiquitinates STAM2:HGS See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome
MONDO:0018416	USP8	P40818	3.4.19.12	R-HSA-6807004 R-HSA-6807004 Reactome Name: Negative regulation of MET activity See in Reactome R-HSA-4641263 R-HSA-4641263 Reactome Name: Regulation of FZD by ubiquitination See in Reactome R-HSA-5689880 R-HSA-5689880 Reactome Name: Ub-specific processing proteases See in Reactome R-HSA-1358803 R-HSA-1358803 Reactome Name: Downregulation of ERBB2:ERBB3 signaling See in Reactome	R-HSA-6806834 R-HSA-6806834 Reactome Name: Signaling by MET See in Reactome R-HSA-195721 R-HSA-195721 Reactome Name: Signaling by WNT See in Reactome R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-1227986 R-HSA-1227986 Reactome Name: Signaling by ERBB2 See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-201681 R-HSA-201681 Reactome Name: TCF dependent signaling in response to WNT See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-8863795 R-HSA-8863795 Reactome Name: Downregulation of ERBB2 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Metabolism of proteins Signal Transduction	R-HSA-1358791 ( R-HSA-1358803 ) R-HSA-1358791 Reaction Name: Phosphorylation of USP8 by P-AKT See in Reactome R-HSA-1358795 ( R-HSA-1358803 ) R-HSA-1358795 Reaction Name: Deubiquitination of RNF41 by P-USP8 See in Reactome R-HSA-1358797 ( R-HSA-1358803 ) R-HSA-1358797 Reaction Name: Ubiquitinated RNF41 binds P-USP8 See in Reactome R-HSA-4641236 ( R-HSA-4641263 ) R-HSA-4641236 Reaction Name: USP8 deubiquitinates FZD to potentiate WNT signaling See in Reactome R-HSA-5690196 ( R-HSA-5689880 ) R-HSA-5690196 Reaction Name: USP8 deubiquitinates RNF128 See in Reactome R-HSA-6782628 ( R-HSA-5689880 ) R-HSA-6782628 Reaction Name: USP8 deubiquitinates STAM2:HGS See in Reactome R-HSA-8875443 ( R-HSA-6807004 ) R-HSA-8875443 Reaction Name: USP8 deubiquitinates LRIG1 See in Reactome