DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P26358)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	4
Number of reactions:	8

Search results (UniProt accession: P26358)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013584	DNMT1	P26358	2.1.1.37	R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-4655427 R-HSA-4655427 Reactome Name: SUMOylation of DNA methylation proteins See in Reactome R-HSA-212300 R-HSA-212300 Reactome Name: PRC2 methylates histones and DNA See in Reactome R-HSA-5334118 R-HSA-5334118 Reactome Name: DNA methylation See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins Gene expression (Transcription)	R-HSA-212222 ( R-HSA-212300 ) R-HSA-212222 Reaction Name: PRC2 recruits DNA methyltransferases See in Reactome R-HSA-212269 ( R-HSA-212300 ) R-HSA-212269 Reaction Name: DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 See in Reactome R-HSA-427409 ( R-HSA-427413 ) R-HSA-427409 Reaction Name: Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA See in Reactome R-HSA-433672 ( R-HSA-427413 ) R-HSA-433672 Reaction Name: NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 See in Reactome R-HSA-4655431 ( R-HSA-4655427 ) R-HSA-4655431 Reaction Name: SUMOyation of DNMT1 with SUMO1 See in Reactome R-HSA-5227490 ( R-HSA-427413 ) R-HSA-5227490 Reaction Name: NoRC:HDAC:DNMT methylates cytosine of the rRNA genes See in Reactome R-HSA-5334151 ( R-HSA-5334118 ) R-HSA-5334151 Reaction Name: DNMT1 methylates cytosine in hemimethylated DNA See in Reactome R-HSA-5334160 ( R-HSA-5334118 ) R-HSA-5334160 Reaction Name: UHRF1:Chromatin binds DNMT1 See in Reactome
MONDO:0011397	DNMT1	P26358	2.1.1.37	R-HSA-427413 R-HSA-427413 Reactome Name: NoRC negatively regulates rRNA expression See in Reactome R-HSA-4655427 R-HSA-4655427 Reactome Name: SUMOylation of DNA methylation proteins See in Reactome R-HSA-212300 R-HSA-212300 Reactome Name: PRC2 methylates histones and DNA See in Reactome R-HSA-5334118 R-HSA-5334118 Reactome Name: DNA methylation See in Reactome	R-HSA-5250941 R-HSA-5250941 Reactome Name: Negative epigenetic regulation of rRNA expression See in Reactome R-HSA-212165 R-HSA-212165 Reactome Name: Epigenetic regulation of gene expression See in Reactome R-HSA-3108232 R-HSA-3108232 Reactome Name: SUMO E3 ligases SUMOylate target proteins See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-2990846 R-HSA-2990846 Reactome Name: SUMOylation See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome	Metabolism of proteins Gene expression (Transcription)	R-HSA-212222 ( R-HSA-212300 ) R-HSA-212222 Reaction Name: PRC2 recruits DNA methyltransferases See in Reactome R-HSA-212269 ( R-HSA-212300 ) R-HSA-212269 Reaction Name: DNMT1,3A,3B:PRC2 methylates cytosine and histone H3 See in Reactome R-HSA-427409 ( R-HSA-427413 ) R-HSA-427409 Reaction Name: Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA See in Reactome R-HSA-433672 ( R-HSA-427413 ) R-HSA-433672 Reaction Name: NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 See in Reactome R-HSA-4655431 ( R-HSA-4655427 ) R-HSA-4655431 Reaction Name: SUMOyation of DNMT1 with SUMO1 See in Reactome R-HSA-5227490 ( R-HSA-427413 ) R-HSA-5227490 Reaction Name: NoRC:HDAC:DNMT methylates cytosine of the rRNA genes See in Reactome R-HSA-5334151 ( R-HSA-5334118 ) R-HSA-5334151 Reaction Name: DNMT1 methylates cytosine in hemimethylated DNA See in Reactome R-HSA-5334160 ( R-HSA-5334118 ) R-HSA-5334160 Reaction Name: UHRF1:Chromatin binds DNMT1 See in Reactome