DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P22455)

Number of enzymes:	1
Number of disease:	3
Number of reactomes:	11
Number of reactions:	32

Search results (UniProt accession: P22455)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0023122	FGFR4	P22455	2.7.10.1	R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654228 R-HSA-5654228 Reactome Name: Phospholipase C-mediated cascade; FGFR4 See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1307965 R-HSA-1307965 Reactome Name: betaKlotho-mediated ligand binding See in Reactome R-HSA-190322 R-HSA-190322 Reactome Name: FGFR4 ligand binding and activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-1307955 ( R-HSA-1307965; R-HSA-190322 ) R-HSA-1307955 Reaction Name: FGFR4 binds HS:KLB:FGF19 See in Reactome R-HSA-1307963 ( R-HSA-1307965; R-HSA-190322 ) R-HSA-1307963 Reaction Name: Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 See in Reactome R-HSA-190265 ( R-HSA-190322 ) R-HSA-190265 Reaction Name: FGFR4 binds to FGF See in Reactome R-HSA-190326 ( R-HSA-190322 ) R-HSA-190326 Reaction Name: Autocatalytic phosphorylation of FGFR4 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654151 ( R-HSA-5654228 ) R-HSA-5654151 Reaction Name: Activated FGFR4 phosphorylates PLCG1 See in Reactome R-HSA-5654163 ( R-HSA-5654228 ) R-HSA-5654163 Reaction Name: Activated FGFR4 binds PLCG1 See in Reactome R-HSA-5654169 ( R-HSA-5654228 ) R-HSA-5654169 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR4 See in Reactome R-HSA-5654418 ( R-HSA-5654712 ) R-HSA-5654418 Reaction Name: Activated FGFR4 phosphorylates FRS2 See in Reactome R-HSA-5654422 ( R-HSA-5654712 ) R-HSA-5654422 Reaction Name: Activated FGFR4 binds FRS2 See in Reactome R-HSA-5654423 ( R-HSA-5654719 ) R-HSA-5654423 Reaction Name: Activated FGFR4:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654425 ( R-HSA-5654719 ) R-HSA-5654425 Reaction Name: Activated FGFR4 binds SHC1 See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654428 ( R-HSA-5654719 ) R-HSA-5654428 Reaction Name: Activated FGFR4 phosphorylates SHC1 See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5654651 ( R-HSA-5654712 ) R-HSA-5654651 Reaction Name: Activated FGFR4 binds FRS3 See in Reactome R-HSA-5654653 ( R-HSA-5654712 ) R-HSA-5654653 Reaction Name: Activated FGFR4 phosphorylates FRS3 See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654659 ( R-HSA-5654720 ) R-HSA-5654659 Reaction Name: Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654664 ( R-HSA-5654712 ) R-HSA-5654664 Reaction Name: Activated FGFR4:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0005212	FGFR4	P22455	2.7.10.1	R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654228 R-HSA-5654228 Reactome Name: Phospholipase C-mediated cascade; FGFR4 See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1307965 R-HSA-1307965 Reactome Name: betaKlotho-mediated ligand binding See in Reactome R-HSA-190322 R-HSA-190322 Reactome Name: FGFR4 ligand binding and activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-1307955 ( R-HSA-1307965; R-HSA-190322 ) R-HSA-1307955 Reaction Name: FGFR4 binds HS:KLB:FGF19 See in Reactome R-HSA-1307963 ( R-HSA-1307965; R-HSA-190322 ) R-HSA-1307963 Reaction Name: Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 See in Reactome R-HSA-190265 ( R-HSA-190322 ) R-HSA-190265 Reaction Name: FGFR4 binds to FGF See in Reactome R-HSA-190326 ( R-HSA-190322 ) R-HSA-190326 Reaction Name: Autocatalytic phosphorylation of FGFR4 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654151 ( R-HSA-5654228 ) R-HSA-5654151 Reaction Name: Activated FGFR4 phosphorylates PLCG1 See in Reactome R-HSA-5654163 ( R-HSA-5654228 ) R-HSA-5654163 Reaction Name: Activated FGFR4 binds PLCG1 See in Reactome R-HSA-5654169 ( R-HSA-5654228 ) R-HSA-5654169 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR4 See in Reactome R-HSA-5654418 ( R-HSA-5654712 ) R-HSA-5654418 Reaction Name: Activated FGFR4 phosphorylates FRS2 See in Reactome R-HSA-5654422 ( R-HSA-5654712 ) R-HSA-5654422 Reaction Name: Activated FGFR4 binds FRS2 See in Reactome R-HSA-5654423 ( R-HSA-5654719 ) R-HSA-5654423 Reaction Name: Activated FGFR4:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654425 ( R-HSA-5654719 ) R-HSA-5654425 Reaction Name: Activated FGFR4 binds SHC1 See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654428 ( R-HSA-5654719 ) R-HSA-5654428 Reaction Name: Activated FGFR4 phosphorylates SHC1 See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5654651 ( R-HSA-5654712 ) R-HSA-5654651 Reaction Name: Activated FGFR4 binds FRS3 See in Reactome R-HSA-5654653 ( R-HSA-5654712 ) R-HSA-5654653 Reaction Name: Activated FGFR4 phosphorylates FRS3 See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654659 ( R-HSA-5654720 ) R-HSA-5654659 Reaction Name: Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654664 ( R-HSA-5654712 ) R-HSA-5654664 Reaction Name: Activated FGFR4:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome
MONDO:0021100	FGFR4	P22455	2.7.10.1	R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-5654720 R-HSA-5654720 Reactome Name: PI-3K cascade:FGFR4 See in Reactome R-HSA-5654228 R-HSA-5654228 Reactome Name: Phospholipase C-mediated cascade; FGFR4 See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-1307965 R-HSA-1307965 Reactome Name: betaKlotho-mediated ligand binding See in Reactome R-HSA-190322 R-HSA-190322 Reactome Name: FGFR4 ligand binding and activation See in Reactome R-HSA-109704 R-HSA-109704 Reactome Name: PI3K Cascade See in Reactome R-HSA-5654712 R-HSA-5654712 Reactome Name: FRS-mediated FGFR4 signaling See in Reactome R-HSA-5654733 R-HSA-5654733 Reactome Name: Negative regulation of FGFR4 signaling See in Reactome R-HSA-5654719 R-HSA-5654719 Reactome Name: SHC-mediated cascade:FGFR4 See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-112399 R-HSA-112399 Reactome Name: IRS-mediated signalling See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-5654716 R-HSA-5654716 Reactome Name: Downstream signaling of activated FGFR4 See in Reactome R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-190236 R-HSA-190236 Reactome Name: Signaling by FGFR See in Reactome R-HSA-74752 R-HSA-74752 Reactome Name: Signaling by Insulin receptor See in Reactome R-HSA-5654743 R-HSA-5654743 Reactome Name: Signaling by FGFR4 See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-74751 R-HSA-74751 Reactome Name: Insulin receptor signalling cascade See in Reactome	Signal Transduction	R-HSA-109699 ( R-HSA-109704 ) R-HSA-109699 Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3 See in Reactome R-HSA-1307955 ( R-HSA-1307965; R-HSA-190322 ) R-HSA-1307955 Reaction Name: FGFR4 binds HS:KLB:FGF19 See in Reactome R-HSA-1307963 ( R-HSA-1307965; R-HSA-190322 ) R-HSA-1307963 Reaction Name: Autocatalytic phosphorylation of BetaKlotho-bound FGFR4 See in Reactome R-HSA-190265 ( R-HSA-190322 ) R-HSA-190265 Reaction Name: FGFR4 binds to FGF See in Reactome R-HSA-190326 ( R-HSA-190322 ) R-HSA-190326 Reaction Name: Autocatalytic phosphorylation of FGFR4 See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654151 ( R-HSA-5654228 ) R-HSA-5654151 Reaction Name: Activated FGFR4 phosphorylates PLCG1 See in Reactome R-HSA-5654163 ( R-HSA-5654228 ) R-HSA-5654163 Reaction Name: Activated FGFR4 binds PLCG1 See in Reactome R-HSA-5654169 ( R-HSA-5654228 ) R-HSA-5654169 Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR4 See in Reactome R-HSA-5654418 ( R-HSA-5654712 ) R-HSA-5654418 Reaction Name: Activated FGFR4 phosphorylates FRS2 See in Reactome R-HSA-5654422 ( R-HSA-5654712 ) R-HSA-5654422 Reaction Name: Activated FGFR4 binds FRS2 See in Reactome R-HSA-5654423 ( R-HSA-5654719 ) R-HSA-5654423 Reaction Name: Activated FGFR4:p-SHC1 binds GRB2:SOS1 See in Reactome R-HSA-5654425 ( R-HSA-5654719 ) R-HSA-5654425 Reaction Name: Activated FGFR4 binds SHC1 See in Reactome R-HSA-5654426 ( R-HSA-5654719 ) R-HSA-5654426 Reaction Name: Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654428 ( R-HSA-5654719 ) R-HSA-5654428 Reaction Name: Activated FGFR4 phosphorylates SHC1 See in Reactome R-HSA-5654566 ( R-HSA-5654733 ) R-HSA-5654566 Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2. See in Reactome R-HSA-5654651 ( R-HSA-5654712 ) R-HSA-5654651 Reaction Name: Activated FGFR4 binds FRS3 See in Reactome R-HSA-5654653 ( R-HSA-5654712 ) R-HSA-5654653 Reaction Name: Activated FGFR4 phosphorylates FRS3 See in Reactome R-HSA-5654655 ( R-HSA-5654712 ) R-HSA-5654655 Reaction Name: Activated FGFR4 phosphorylates PPTN11 See in Reactome R-HSA-5654658 ( R-HSA-5654712 ) R-HSA-5654658 Reaction Name: Activated FGFR4:p-FRS bind to PPTN11 See in Reactome R-HSA-5654659 ( R-HSA-5654720 ) R-HSA-5654659 Reaction Name: Activated FGFR4:p-FRS2 binds GRB2:GAB1:PIK3R1 See in Reactome R-HSA-5654662 ( R-HSA-5654720 ) R-HSA-5654662 Reaction Name: Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA See in Reactome R-HSA-5654663 ( R-HSA-5654712 ) R-HSA-5654663 Reaction Name: Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange See in Reactome R-HSA-5654664 ( R-HSA-5654712 ) R-HSA-5654664 Reaction Name: Activated FGFR4:p-FRS binds GRB2:SOS1 See in Reactome R-HSA-5654667 ( R-HSA-5654720 ) R-HSA-5654667 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 See in Reactome R-HSA-5654669 ( R-HSA-5654720 ) R-HSA-5654669 Reaction Name: Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA See in Reactome R-HSA-5654684 ( R-HSA-5654733 ) R-HSA-5654684 Reaction Name: CBL ubiquitinates FRS2 and FGFR4 See in Reactome R-HSA-5654714 ( R-HSA-5654720 ) R-HSA-5654714 Reaction Name: FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654717 ( R-HSA-5654720 ) R-HSA-5654717 Reaction Name: FGFR4-associated PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5654734 ( R-HSA-5654733 ) R-HSA-5654734 Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR4 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8941613 ( R-HSA-5654712 ) R-HSA-8941613 Reaction Name: Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange See in Reactome