MONDO:0013815 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007872 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007405 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0005061 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0021100 |
MONDO:0021100
Disease Name: breast neoplasm
All associated enzymes in DAR:
FGFR2
MTOR
FGFR4
ROCK1
RHOA
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007400 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0005036 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0019660 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007412 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0019661 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0019086 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0021251 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007042 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0007041 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
Reaction Name: Activated FGFR2 phosphorylates PLCG1
See in Reactome
R-HSA-5654157
(
R-HSA-5654221
)
R-HSA-5654157
Reaction Name: p-4Y-PLCG1 dissociates from activated FGFR2
See in Reactome
R-HSA-5654159
(
R-HSA-5654221
)
R-HSA-5654397
(
R-HSA-5654700
)
R-HSA-5654397
Reaction Name: Activated FGFR2 phosphorylates FRS2
See in Reactome
R-HSA-5654399
(
R-HSA-5654700
)
R-HSA-5654402
(
R-HSA-5654699
)
R-HSA-5654402
Reaction Name: Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654404
(
R-HSA-5654699
)
R-HSA-5654406
(
R-HSA-5654699
)
R-HSA-5654406
Reaction Name: Activated FGFR2:p-SHC1 binds GRB2:SOS1
See in Reactome
R-HSA-5654407
(
R-HSA-5654699
)
R-HSA-5654407
Reaction Name: Activated FGFR2 phosphorylates SHC1
See in Reactome
R-HSA-5654562
(
R-HSA-5654727
)
R-HSA-5654562
Reaction Name: Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2
See in Reactome
R-HSA-5654603
(
R-HSA-5654700
)
R-HSA-5654605
(
R-HSA-5654700
)
R-HSA-5654605
Reaction Name: Activated FGFR2 phosphorylates FRS3
See in Reactome
R-HSA-5654607
(
R-HSA-5654700
)
R-HSA-5654607
Reaction Name: Activated FGFR2 phosphorylates PPTN11
See in Reactome
R-HSA-5654608
(
R-HSA-5654700
)
R-HSA-5654608
Reaction Name: Activated FGFR2:p-FRS bind to PPTN11
See in Reactome
R-HSA-5654612
(
R-HSA-5654695
)
R-HSA-5654612
Reaction Name: Activated FGFR2:p-FRS2 binds GRB2:GAB1:PIK3R1
See in Reactome
R-HSA-5654614
(
R-HSA-5654695
)
R-HSA-5654614
Reaction Name: Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
See in Reactome
R-HSA-5654615
(
R-HSA-5654700
)
R-HSA-5654615
Reaction Name: Activated FGFR2:pFRS binds GRB2:SOS1
See in Reactome
R-HSA-5654618
(
R-HSA-5654700
)
R-HSA-5654618
Reaction Name: Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
See in Reactome
R-HSA-5654620
(
R-HSA-5654695
)
R-HSA-5654620
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
See in Reactome
R-HSA-5654622
(
R-HSA-5654695
)
R-HSA-5654622
Reaction Name: Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
See in Reactome
R-HSA-5654677
(
R-HSA-5654727
)
R-HSA-5654677
Reaction Name: CBL ubiquitinates FRS2 and FGFR2
See in Reactome
R-HSA-5654697
(
R-HSA-5654695
)
R-HSA-5654697
Reaction Name: FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654701
(
R-HSA-5654695
)
R-HSA-5654701
Reaction Name: FGFR2-associated PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654729
(
R-HSA-5654727
)
R-HSA-5654729
Reaction Name: p-CBL:GRB2 binds p-FRS2:activated FGFR2
See in Reactome
R-HSA-5672965
(
R-HSA-5673001
)
R-HSA-5672965
Reaction Name: RAS GEFs promote RAS nucleotide exchange
See in Reactome
R-HSA-8941618
(
R-HSA-5654700
)
R-HSA-8941618
Reaction Name: Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange
See in Reactome
|
MONDO:0020667 |
FGFR2 |
P21802 |
2.7.10.1
|
R-HSA-5654221
R-HSA-5654221
Reactome Name: Phospholipase C-mediated cascade; FGFR2
See in Reactome
R-HSA-190377
R-HSA-190377
Reactome Name: FGFR2b ligand binding and activation
See in Reactome
R-HSA-190375
R-HSA-190375
Reactome Name: FGFR2c ligand binding and activation
See in Reactome
R-HSA-1257604
R-HSA-6811558
R-HSA-6811558
Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
See in Reactome
R-HSA-5654727
R-HSA-5654727
Reactome Name: Negative regulation of FGFR2 signaling
See in Reactome
R-HSA-109704
R-HSA-5654700
R-HSA-5654699
R-HSA-5654695
R-HSA-5673001
|
R-HSA-2404192
R-HSA-2404192
Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
See in Reactome
R-HSA-5683057
R-HSA-5683057
Reactome Name: MAPK family signaling cascades
See in Reactome
R-HSA-5654738
R-HSA-74752
R-HSA-190241
R-HSA-190241
Reactome Name: FGFR2 ligand binding and activation
See in Reactome
R-HSA-112399
R-HSA-199418
R-HSA-199418
Reactome Name: Negative regulation of the PI3K/AKT network
See in Reactome
R-HSA-9006925
R-HSA-9006925
Reactome Name: Intracellular signaling by second messengers
See in Reactome
R-HSA-2428924
R-HSA-2428928
R-HSA-2428928
Reactome Name: IRS-related events triggered by IGF1R
See in Reactome
R-HSA-9006934
R-HSA-9006934
Reactome Name: Signaling by Receptor Tyrosine Kinases
See in Reactome
R-HSA-190236
R-HSA-5684996
R-HSA-5654696
R-HSA-5654696
Reactome Name: Downstream signaling of activated FGFR2
See in Reactome
R-HSA-162582
R-HSA-74751
R-HSA-74751
Reactome Name: Insulin receptor signalling cascade
See in Reactome
|
Signal Transduction
|
R-HSA-109699
(
R-HSA-109704
)
R-HSA-109699
Reaction Name: PI3K-containing complexes phosphorylate PIP2 to PIP3
See in Reactome
R-HSA-190258
(
R-HSA-190375
)
R-HSA-190260
(
R-HSA-190377
)
R-HSA-190408
(
R-HSA-190377
)
R-HSA-190408
Reaction Name: Autocatalytic phosphorylation of FGFR2b
See in Reactome
R-HSA-190413
(
R-HSA-190375
)
R-HSA-190413
Reaction Name: Autocatalytic phosphorylation of FGFR2c
See in Reactome
R-HSA-2316434
(
R-HSA-1257604;
R-HSA-6811558
)
R-HSA-2316434
Reaction Name: PI3K phosphorylates PIP2 to PIP3
See in Reactome
R-HSA-5654147
(
R-HSA-5654221
)
R-HSA-5654147
R |