DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P21580)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	6
Number of reactions:	13

Search results (UniProt accession: P21580)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0014761	TNFAIP3	P21580	2.3.2.- 3.4.19.12	R-HSA-5357786 R-HSA-5357786 Reactome Name: TNFR1-induced proapoptotic signaling See in Reactome R-HSA-168638 R-HSA-168638 Reactome Name: NOD1/2 Signaling Pathway See in Reactome R-HSA-5357905 R-HSA-5357905 Reactome Name: Regulation of TNFR1 signaling See in Reactome R-HSA-5357956 R-HSA-5357956 Reactome Name: TNFR1-induced NFkappaB signaling pathway See in Reactome R-HSA-936440 R-HSA-936440 Reactome Name: Negative regulators of DDX58/IFIH1 signaling See in Reactome R-HSA-5689896 R-HSA-5689896 Reactome Name: Ovarian tumor domain proteases See in Reactome	R-HSA-5688426 R-HSA-5688426 Reactome Name: Deubiquitination See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-168643 R-HSA-168643 Reactome Name: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways See in Reactome R-HSA-168928 R-HSA-168928 Reactome Name: DDX58/IFIH1-mediated induction of interferon-alpha/beta See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-73887 R-HSA-73887 Reactome Name: Death Receptor Signalling See in Reactome R-HSA-75893 R-HSA-75893 Reactome Name: TNF signaling See in Reactome R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Metabolism of proteins Signal Transduction	R-HSA-140978 ( R-HSA-5357786 ) R-HSA-140978 Reaction Name: TRADD:TRAF2:RIP1 complex binds FADD See in Reactome R-HSA-5357776 ( R-HSA-5357956 ) R-HSA-5357776 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG See in Reactome R-HSA-5357845 ( R-HSA-5357905 ) R-HSA-5357845 Reaction Name: RIPK1 is deubiquitinated See in Reactome R-HSA-5357860 ( R-HSA-5357956 ) R-HSA-5357860 Reaction Name: TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3 recruits TAK1 complex See in Reactome R-HSA-5690827 ( R-HSA-5689896 ) R-HSA-5690827 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 See in Reactome R-HSA-5690845 ( R-HSA-5689896 ) R-HSA-5690845 Reaction Name: TNIPs bind TNFAIP3 (A20) See in Reactome R-HSA-5690856 ( R-HSA-5689896 ) R-HSA-5690856 Reaction Name: TNFAIP3 (A20) deubiquitinates K63polyUb-RIPK1 See in Reactome R-HSA-5690870 ( R-HSA-5689896 ) R-HSA-5690870 Reaction Name: OTUD7B,TNFAIP3 deubiquitinate TRAF6 See in Reactome R-HSA-5693055 ( R-HSA-5357905 ) R-HSA-5693055 Reaction Name: TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes See in Reactome R-HSA-5693108 ( R-HSA-5357905 ) R-HSA-5693108 Reaction Name: TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains See in Reactome R-HSA-688136 ( R-HSA-168638; R-HSA-5689896 ) R-HSA-688136 Reaction Name: TNFAIP3 (A20) deubiquitinates RIP2 See in Reactome R-HSA-8869506 ( R-HSA-5689896 ) R-HSA-8869506 Reaction Name: TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6 See in Reactome R-HSA-937337 ( R-HSA-936440 ) R-HSA-937337 Reaction Name: TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination See in Reactome