DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P10721)

Number of enzymes:	1
Number of disease:	14
Number of reactomes:	6
Number of reactions:	39

Search results (UniProt accession: P10721)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008244	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0019576	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0017244	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0020332	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0020320	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0011719	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0015558	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0003669	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0019314	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0017243	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0015556	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0015557	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0015554	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome
MONDO:0015555	KIT	P10721	2.7.10.1	R-HSA-1433559 R-HSA-1433559 Reactome Name: Regulation of KIT signaling See in Reactome R-HSA-1257604 R-HSA-1257604 Reactome Name: PIP3 activates AKT signaling See in Reactome R-HSA-1433557 R-HSA-1433557 Reactome Name: Signaling by SCF-KIT See in Reactome R-HSA-8866910 R-HSA-8866910 Reactome Name: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors See in Reactome R-HSA-6811558 R-HSA-6811558 Reactome Name: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling See in Reactome R-HSA-5673001 R-HSA-5673001 Reactome Name: RAF/MAP kinase cascade See in Reactome	R-HSA-5683057 R-HSA-5683057 Reactome Name: MAPK family signaling cascades See in Reactome R-HSA-212436 R-HSA-212436 Reactome Name: Generic Transcription Pathway See in Reactome R-HSA-74160 R-HSA-74160 Reactome Name: Gene expression (Transcription) See in Reactome R-HSA-199418 R-HSA-199418 Reactome Name: Negative regulation of the PI3K/AKT network See in Reactome R-HSA-9006925 R-HSA-9006925 Reactome Name: Intracellular signaling by second messengers See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-73857 R-HSA-73857 Reactome Name: RNA Polymerase II Transcription See in Reactome R-HSA-5684996 R-HSA-5684996 Reactome Name: MAPK1/MAPK3 signaling See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8864260 R-HSA-8864260 Reactome Name: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors See in Reactome	Gene expression (Transcription) Signal Transduction	R-HSA-1433410 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433410 Reaction Name: SOCS1 as a regulator of KIT signaling See in Reactome R-HSA-1433418 ( R-HSA-1433557 ) R-HSA-1433418 Reaction Name: Phosphorylation of JAK2 See in Reactome R-HSA-1433423 ( R-HSA-1433557 ) R-HSA-1433423 Reaction Name: PTP-RO interacts with p-c-Kit complex See in Reactome R-HSA-1433428 ( R-HSA-1433557 ) R-HSA-1433428 Reaction Name: GRB2 is indirectly recruited to p-KIT through SHP2 See in Reactome R-HSA-1433451 ( R-HSA-1433557 ) R-HSA-1433451 Reaction Name: JAK2 binds to p-KIT See in Reactome R-HSA-1433454 ( R-HSA-1433557 ) R-HSA-1433454 Reaction Name: Phosphorylation of GAB2 by SFKs See in Reactome R-HSA-1433456 ( R-HSA-1433557 ) R-HSA-1433456 Reaction Name: Recruitment of STATs See in Reactome R-HSA-1433471 ( R-HSA-1433557 ) R-HSA-1433471 Reaction Name: Activation of RAS by p-KIT bound SOS1 See in Reactome R-HSA-1433488 ( R-HSA-1433557 ) R-HSA-1433488 Reaction Name: Phosphorylation of SHP2 by SFKs See in Reactome R-HSA-1433501 ( R-HSA-1433557 ) R-HSA-1433501 Reaction Name: Interaction of other adapter proteins with p-KIT See in Reactome R-HSA-1433506 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433506 Reaction Name: Phosphorylation of APS See in Reactome R-HSA-1433508 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1433508 Reaction Name: PKC alpha interacts with and phosphorylates KIT See in Reactome R-HSA-1433514 ( R-HSA-1433557 ) R-HSA-1433514 Reaction Name: Synthesis of PIP3 from PIP2 by PI3K See in Reactome R-HSA-1433542 ( R-HSA-1433557 ) R-HSA-1433542 Reaction Name: Phosphorylation and activation of VAV1 See in Reactome R-HSA-1470009 ( R-HSA-1433557 ) R-HSA-1470009 Reaction Name: Phosphorylation of STATs See in Reactome R-HSA-1470010 ( R-HSA-1433557 ) R-HSA-1470010 Reaction Name: Dimerization of STATs See in Reactome R-HSA-1470011 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1470011 Reaction Name: Downregulation of c-Kit signaling by SOCS6 See in Reactome R-HSA-1470012 ( R-HSA-1433557 ) R-HSA-1470012 Reaction Name: Disassociation and translocation of STATs to the nucleus See in Reactome R-HSA-1472121 ( R-HSA-1433557 ) R-HSA-1472121 Reaction Name: Phosphorylation of p-KIT on Y900 by Src kinases See in Reactome R-HSA-1562640 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-1562640 Reaction Name: LNK binds to p-KIT and inhibit downstream signaling See in Reactome R-HSA-1562641 ( R-HSA-1433557 ) R-HSA-1562641 Reaction Name: Indirect recruitment of PI3K to KIT via p(Y)-GAB2 See in Reactome R-HSA-205205 ( R-HSA-1433557 ) R-HSA-205205 Reaction Name: Interaction of Src family kinases with p-KIT See in Reactome R-HSA-205231 ( R-HSA-1433557 ) R-HSA-205231 Reaction Name: Dimerization of KIT upon SCF binding See in Reactome R-HSA-205234 ( R-HSA-1433557 ) R-HSA-205234 Reaction Name: Indirect recruitment of GAB2 to p-KIT See in Reactome R-HSA-205238 ( R-HSA-1433557 ) R-HSA-205238 Reaction Name: SHP2 interacts with p-KIT See in Reactome R-HSA-205244 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205244 Reaction Name: Recruitment of CBL to KIT See in Reactome R-HSA-205262 ( R-HSA-1433557 ) R-HSA-205262 Reaction Name: Direct recruitment of PI3K to p-KIT See in Reactome R-HSA-205286 ( R-HSA-1433557 ) R-HSA-205286 Reaction Name: GRB2:SOS interacts with p-KIT See in Reactome R-HSA-205289 ( R-HSA-1433557 ) R-HSA-205289 Reaction Name: Autophosphorylation of KIT See in Reactome R-HSA-205306 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205306 Reaction Name: Interaction of SHP1 and KIT See in Reactome R-HSA-205319 ( R-HSA-1433557; R-HSA-1433559 ) R-HSA-205319 Reaction Name: Interaction of APS and p-KIT See in Reactome R-HSA-205321 ( R-HSA-1433557 ) R-HSA-205321 Reaction Name: Interaction of KIT and sSCF See in Reactome R-HSA-205328 ( R-HSA-1433557 ) R-HSA-205328 Reaction Name: Interaction of other tyrosine kinases with p-KIT See in Reactome R-HSA-2316434 ( R-HSA-1257604; R-HSA-6811558 ) R-HSA-2316434 Reaction Name: PI3K phosphorylates PIP2 to PIP3 See in Reactome R-HSA-5672965 ( R-HSA-5673001 ) R-HSA-5672965 Reaction Name: RAS GEFs promote RAS nucleotide exchange See in Reactome R-HSA-8864698 ( R-HSA-8866910 ) R-HSA-8864698 Reaction Name: KIT gene expression is stimulated by TFAP2A,(TFAP2B) homodimers See in Reactome R-HSA-9669854 ( R-HSA-1433557 ) R-HSA-9669854 Reaction Name: KIT binds type II TKIs See in Reactome R-HSA-9669893 ( R-HSA-1433557 ) R-HSA-9669893 Reaction Name: KIT binds type I TKIs See in Reactome R-HSA-9681375 ( R-HSA-1433557 ) R-HSA-9681375 Reaction Name: KIT binds ripretinib See in Reactome