DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P08254)

Number of enzymes:	1
Number of disease:	1
Number of reactomes:	7
Number of reactions:	32

Search results (UniProt accession: P08254)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0013765	MMP3	P08254	3.4.24.17	R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6785807 R-HSA-6785807 Reactome Name: Interleukin-4 and Interleukin-13 signaling See in Reactome R-HSA-2179392 R-HSA-2179392 Reactome Name: EGFR Transactivation by Gastrin See in Reactome R-HSA-2022090 R-HSA-2022090 Reactome Name: Assembly of collagen fibrils and other multimeric structures See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome	R-HSA-372790 R-HSA-372790 Reactome Name: Signaling by GPCR See in Reactome R-HSA-449147 R-HSA-449147 Reactome Name: Signaling by Interleukins See in Reactome R-HSA-388396 R-HSA-388396 Reactome Name: GPCR downstream signalling See in Reactome R-HSA-881907 R-HSA-881907 Reactome Name: Gastrin-CREB signalling pathway via PKC and MAPK See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-416476 R-HSA-416476 Reactome Name: G alpha (q) signalling events See in Reactome R-HSA-1280215 R-HSA-1280215 Reactome Name: Cytokine Signaling in Immune system See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome R-HSA-1474290 R-HSA-1474290 Reactome Name: Collagen formation See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome	Immune System Extracellular matrix organization Signal Transduction	R-HSA-1454757 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1454757 Reaction Name: Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 See in Reactome R-HSA-1454781 ( R-HSA-1474228 ) R-HSA-1454781 Reaction Name: MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin See in Reactome R-HSA-1454843 ( R-HSA-1474228 ) R-HSA-1454843 Reaction Name: E-cadherin degradation by MMP3, MMP7 and plasmin. See in Reactome R-HSA-1474197 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1474197 Reaction Name: Collagen type II degradation by MMP1,3,8,13,PRSS2 See in Reactome R-HSA-1564120 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564120 Reaction Name: Collagen type VII degradation by MMP1,2,3 See in Reactome R-HSA-1564142 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564142 Reaction Name: Collagen type IV degradation by MMP2,3,4,9,10,12 See in Reactome R-HSA-1564179 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564179 Reaction Name: Collagen type XI degradation by MMP1,2,3,9 See in Reactome R-HSA-1564184 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-1564184 Reaction Name: Collagen type IX degradation by MMP3,13 See in Reactome R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1566979 ( R-HSA-1474228 ) R-HSA-1566979 Reaction Name: Laminin-332 degradation by laminin-322 degrading extracellular proteinases See in Reactome R-HSA-1566981 ( R-HSA-1474228 ) R-HSA-1566981 Reaction Name: Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS See in Reactome R-HSA-1592297 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592297 Reaction Name: Full activation of MMP1 See in Reactome R-HSA-1592314 ( R-HSA-1474228 ) R-HSA-1592314 Reaction Name: HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12) See in Reactome R-HSA-1592362 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592362 Reaction Name: Activation of proMMP7 by MMP3 See in Reactome R-HSA-1592371 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592371 Reaction Name: Initial activation of proMMP3 See in Reactome R-HSA-1592436 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592436 Reaction Name: Initial activation of proMMP9 by MMPs See in Reactome R-HSA-1604690 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604690 Reaction Name: Activation of MMP9 intermediate form by MMPs See in Reactome R-HSA-1604731 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604731 Reaction Name: Autocatalytic activation of MMP3 See in Reactome R-HSA-1604752 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604752 Reaction Name: Initial activation of proMMP13 by MMP3 See in Reactome R-HSA-2168923 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2168923 Reaction Name: Collagen type XVIII endostatin release See in Reactome R-HSA-2179402 ( R-HSA-2179392 ) R-HSA-2179402 Reaction Name: Active MMP3 can cleave pro-HBEGF to form active HBEGF See in Reactome R-HSA-2179413 ( R-HSA-2179392 ) R-HSA-2179413 Reaction Name: Activated PKC-alpha activate MMP3 See in Reactome R-HSA-2213200 ( R-HSA-2022090 ) R-HSA-2213200 Reaction Name: Release of endostatin-like peptides See in Reactome R-HSA-2484882 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2484882 Reaction Name: Collagen type X degradation by MMP3, 13 See in Reactome R-HSA-2514772 ( R-HSA-1474228 ) R-HSA-2514772 Reaction Name: Fibrillin-1 degradation by MMP3, CTSK, CTSL2 See in Reactome R-HSA-2533970 ( R-HSA-1474228 ) R-HSA-2533970 Reaction Name: NID1 degradation by MMP3, 7 See in Reactome R-HSA-2534248 ( R-HSA-1474228 ) R-HSA-2534248 Reaction Name: DCN (decorin) degradation by MMP2, MMP3, MMP7 See in Reactome R-HSA-3791149 ( R-HSA-1474228 ) R-HSA-3791149 Reaction Name: Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 See in Reactome R-HSA-3791295 ( R-HSA-1474228 ) R-HSA-3791295 Reaction Name: Aggrecan degradation by MMP1,2,3,7,9,12,13 See in Reactome R-HSA-4086205 ( R-HSA-1474228 ) R-HSA-4086205 Reaction Name: OPN (osteopontin) degradation by MMP3, MMP7 See in Reactome R-HSA-6789615 ( R-HSA-6785807 ) R-HSA-6789615 Reaction Name: Expression of STAT3-upregulated extracellular proteins See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome