DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P08246)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	7
Number of reactions:	12

Search results (UniProt accession: P08246)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008090	ELANE	P08246	3.4.21.37	R-HSA-5620971 R-HSA-5620971 Reactome Name: Pyroptosis See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6803157 R-HSA-6803157 Reactome Name: Antimicrobial peptides See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System Programmed Cell Death Extracellular matrix organization	R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-2482180 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2482180 Reaction Name: Collagen type VIII degradation by ELANE See in Reactome R-HSA-2514823 ( R-HSA-1474228 ) R-HSA-2514823 Reaction Name: Fibrillin-1 degradation by ELANE See in Reactome R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6813659 ( R-HSA-6803157 ) R-HSA-6813659 Reaction Name: ELANE, CTSG or PRTN3 binds bacteria See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9710106 ( R-HSA-5620971 ) R-HSA-9710106 Reaction Name: ELANE cleaves GSDMD See in Reactome
MONDO:0042490	ELANE	P08246	3.4.21.37	R-HSA-5620971 R-HSA-5620971 Reactome Name: Pyroptosis See in Reactome R-HSA-977606 R-HSA-977606 Reactome Name: Regulation of Complement cascade See in Reactome R-HSA-1474228 R-HSA-1474228 Reactome Name: Degradation of the extracellular matrix See in Reactome R-HSA-1442490 R-HSA-1442490 Reactome Name: Collagen degradation See in Reactome R-HSA-1592389 R-HSA-1592389 Reactome Name: Activation of Matrix Metalloproteinases See in Reactome R-HSA-6803157 R-HSA-6803157 Reactome Name: Antimicrobial peptides See in Reactome R-HSA-6798695 R-HSA-6798695 Reactome Name: Neutrophil degranulation See in Reactome	R-HSA-168249 R-HSA-168249 Reactome Name: Innate Immune System See in Reactome R-HSA-168256 R-HSA-168256 Reactome Name: Immune System See in Reactome R-HSA-5218859 R-HSA-5218859 Reactome Name: Regulated Necrosis See in Reactome R-HSA-5357801 R-HSA-5357801 Reactome Name: Programmed Cell Death See in Reactome R-HSA-1474244 R-HSA-1474244 Reactome Name: Extracellular matrix organization See in Reactome R-HSA-166658 R-HSA-166658 Reactome Name: Complement cascade See in Reactome	Immune System Programmed Cell Death Extracellular matrix organization	R-HSA-1566962 ( R-HSA-1474228 ) R-HSA-1566962 Reaction Name: Elastin degradation by elastin-degrading extracellular proteinases See in Reactome R-HSA-1592270 ( R-HSA-1474228 ) R-HSA-1592270 Reaction Name: NID1 degradation by MMP1, 9, 12, ELANE See in Reactome R-HSA-1592316 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592316 Reaction Name: Initial activation of proMMP1 See in Reactome R-HSA-1592398 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1592398 Reaction Name: Activation of proMMP8 See in Reactome R-HSA-1604712 ( R-HSA-1474228; R-HSA-1592389 ) R-HSA-1604712 Reaction Name: Initial activation of proMMP7 by trypsin See in Reactome R-HSA-2482180 ( R-HSA-1442490; R-HSA-1474228 ) R-HSA-2482180 Reaction Name: Collagen type VIII degradation by ELANE See in Reactome R-HSA-2514823 ( R-HSA-1474228 ) R-HSA-2514823 Reaction Name: Fibrillin-1 degradation by ELANE See in Reactome R-HSA-6798749 ( R-HSA-6798695 ) R-HSA-6798749 Reaction Name: Exocytosis of specific granule lumen proteins See in Reactome R-HSA-6798751 ( R-HSA-6798695 ) R-HSA-6798751 Reaction Name: Exocytosis of azurophil granule lumen proteins See in Reactome R-HSA-6813659 ( R-HSA-6803157 ) R-HSA-6813659 Reaction Name: ELANE, CTSG or PRTN3 binds bacteria See in Reactome R-HSA-8852716 ( R-HSA-977606 ) R-HSA-8852716 Reaction Name: Thrombin, ELANE cleave C5 See in Reactome R-HSA-9710106 ( R-HSA-5620971 ) R-HSA-9710106 Reaction Name: ELANE cleaves GSDMD See in Reactome