DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P08069)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	4
Number of reactions:	10

Search results (UniProt accession: P08069)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0016996	IGF1R	P08069	2.7.10.1	R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome	R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome	Signal Transduction	R-HSA-2404193 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-2404193 Reaction Name: IGF1R phosphorylates SHC1 See in Reactome R-HSA-2404195 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-2404195 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 See in Reactome R-HSA-2404199 ( R-HSA-2404192 ) R-HSA-2404199 Reaction Name: IGF1,2:IGF1R autophosphorylates See in Reactome R-HSA-2404200 ( R-HSA-2404192 ) R-HSA-2404200 Reaction Name: IGF1,2 binds IGF1R See in Reactome R-HSA-2428922 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428922 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 See in Reactome R-HSA-2428926 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428926 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 See in Reactome R-HSA-2428930 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428930 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 See in Reactome R-HSA-5686072 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-5686072 Reaction Name: p-3Y-SHC1 dissociates from IGF1R See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome R-HSA-9634584 ( R-HSA-9009391 ) R-HSA-9634584 Reaction Name: Estrogen receptor binds IGF1R and SHC1 in response to estrogen See in Reactome
MONDO:0010038	IGF1R	P08069	2.7.10.1	R-HSA-2428928 R-HSA-2428928 Reactome Name: IRS-related events triggered by IGF1R See in Reactome R-HSA-2404192 R-HSA-2404192 Reactome Name: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) See in Reactome R-HSA-9009391 R-HSA-9009391 Reactome Name: Extra-nuclear estrogen signaling See in Reactome R-HSA-2428933 R-HSA-2428933 Reactome Name: SHC-related events triggered by IGF1R See in Reactome	R-HSA-2428924 R-HSA-2428924 Reactome Name: IGF1R signaling cascade See in Reactome R-HSA-9006931 R-HSA-9006931 Reactome Name: Signaling by Nuclear Receptors See in Reactome R-HSA-9006934 R-HSA-9006934 Reactome Name: Signaling by Receptor Tyrosine Kinases See in Reactome R-HSA-162582 R-HSA-162582 Reactome Name: Signal Transduction See in Reactome R-HSA-8939211 R-HSA-8939211 Reactome Name: ESR-mediated signaling See in Reactome	Signal Transduction	R-HSA-2404193 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-2404193 Reaction Name: IGF1R phosphorylates SHC1 See in Reactome R-HSA-2404195 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-2404195 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds SHC1 See in Reactome R-HSA-2404199 ( R-HSA-2404192 ) R-HSA-2404199 Reaction Name: IGF1,2:IGF1R autophosphorylates See in Reactome R-HSA-2404200 ( R-HSA-2404192 ) R-HSA-2404200 Reaction Name: IGF1,2 binds IGF1R See in Reactome R-HSA-2428922 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428922 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS2 See in Reactome R-HSA-2428926 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428926 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4 See in Reactome R-HSA-2428930 ( R-HSA-2404192; R-HSA-2428928 ) R-HSA-2428930 Reaction Name: IGF1,2:p-Y1161,1165,1166-IGF1R binds IRS1,4 See in Reactome R-HSA-5686072 ( R-HSA-2404192; R-HSA-2428933 ) R-HSA-5686072 Reaction Name: p-3Y-SHC1 dissociates from IGF1R See in Reactome R-HSA-9624272 ( R-HSA-9009391 ) R-HSA-9624272 Reaction Name: MMPs cleave HB-EGF See in Reactome R-HSA-9634584 ( R-HSA-9009391 ) R-HSA-9634584 Reaction Name: Estrogen receptor binds IGF1R and SHC1 in response to estrogen See in Reactome