DAR - Bologna Biocomputing Group

Search summary (UniProt accession: P04070)

Number of enzymes:	1
Number of disease:	2
Number of reactomes:	8
Number of reactions:	19

Search results (UniProt accession: P04070)

DiseaseID	Gene	UniProt	EC numbers	Reactomes	Expanded Reactomes	Reactome roots	Reactions
MONDO:0008316	PROC	P04070	3.4.21.69	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-141026 ( R-HSA-140875 ) R-HSA-141026 Reaction Name: Activated protein C cleaves factor Va to factor Vi intermediate form See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159762 ( R-HSA-159763 ) R-HSA-159762 Reaction Name: Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159771 ( R-HSA-159782 ) R-HSA-159771 Reaction Name: Furin cleaves pro-protein C to protein C See in Reactome R-HSA-159795 ( R-HSA-159740 ) R-HSA-159795 Reaction Name: GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) See in Reactome R-HSA-5591040 ( R-HSA-140875 ) R-HSA-5591040 Reaction Name: Activated protein C cleaves Factor Va intermediate form for Factor Va See in Reactome R-HSA-5591052 ( R-HSA-140875 ) R-HSA-5591052 Reaction Name: PROCR binds Protein C See in Reactome R-HSA-5591086 ( R-HSA-140875 ) R-HSA-5591086 Reaction Name: SERPINA5 binds activated protein C See in Reactome R-HSA-5603467 ( R-HSA-140875 ) R-HSA-5603467 Reaction Name: Activated protein C is released from PROCR See in Reactome R-HSA-5604929 ( R-HSA-140875 ) R-HSA-5604929 Reaction Name: Activated protein C binds Protein S See in Reactome R-HSA-5606996 ( R-HSA-140875 ) R-HSA-5606996 Reaction Name: Soluble PROCR binds activated protein C See in Reactome R-HSA-5607002 ( R-HSA-140875 ) R-HSA-5607002 Reaction Name: Activated protein C cleaves factor VIIIa See in Reactome R-HSA-5607058 ( R-HSA-140875 ) R-HSA-5607058 Reaction Name: Activated protein C:PROCR binds F2R See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome
MONDO:0012860	PROC	P04070	3.4.21.69	R-HSA-159740 R-HSA-159740 Reactome Name: Gamma-carboxylation of protein precursors See in Reactome R-HSA-381426 R-HSA-381426 Reactome Name: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) See in Reactome R-HSA-202733 R-HSA-202733 Reactome Name: Cell surface interactions at the vascular wall See in Reactome R-HSA-159782 R-HSA-159782 Reactome Name: Removal of aminoterminal propeptides from gamma-carboxylated proteins See in Reactome R-HSA-140837 R-HSA-140837 Reactome Name: Intrinsic Pathway of Fibrin Clot Formation See in Reactome R-HSA-140875 R-HSA-140875 Reactome Name: Common Pathway of Fibrin Clot Formation See in Reactome R-HSA-159763 R-HSA-159763 Reactome Name: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-8957275 R-HSA-8957275 Reactome Name: Post-translational protein phosphorylation See in Reactome	R-HSA-163841 R-HSA-163841 Reactome Name: Gamma carboxylation, hypusine formation and arylsulfatase activation See in Reactome R-HSA-392499 R-HSA-392499 Reactome Name: Metabolism of proteins See in Reactome R-HSA-159854 R-HSA-159854 Reactome Name: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins See in Reactome R-HSA-597592 R-HSA-597592 Reactome Name: Post-translational protein modification See in Reactome R-HSA-140877 R-HSA-140877 Reactome Name: Formation of Fibrin Clot (Clotting Cascade) See in Reactome R-HSA-109582 R-HSA-109582 Reactome Name: Hemostasis See in Reactome	Metabolism of proteins Hemostasis	R-HSA-140599 ( R-HSA-140875 ) R-HSA-140599 Reaction Name: factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides See in Reactome R-HSA-140696 ( R-HSA-140875 ) R-HSA-140696 Reaction Name: factor V -> factor Va + factor V activation peptide See in Reactome R-HSA-140840 ( R-HSA-140875 ) R-HSA-140840 Reaction Name: fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B See in Reactome R-HSA-141026 ( R-HSA-140875 ) R-HSA-141026 Reaction Name: Activated protein C cleaves factor Va to factor Vi intermediate form See in Reactome R-HSA-141040 ( R-HSA-140875; R-HSA-202733 ) R-HSA-141040 Reaction Name: Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C See in Reactome R-HSA-158137 ( R-HSA-140837 ) R-HSA-158137 Reaction Name: factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer See in Reactome R-HSA-158419 ( R-HSA-140837 ) R-HSA-158419 Reaction Name: factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) See in Reactome R-HSA-159762 ( R-HSA-159763 ) R-HSA-159762 Reaction Name: Gamma-carboxy pro-protein C transport from the endoplasmic reticulum to the Golgi apparatus See in Reactome R-HSA-159771 ( R-HSA-159782 ) R-HSA-159771 Reaction Name: Furin cleaves pro-protein C to protein C See in Reactome R-HSA-159795 ( R-HSA-159740 ) R-HSA-159795 Reaction Name: GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain) See in Reactome R-HSA-5591040 ( R-HSA-140875 ) R-HSA-5591040 Reaction Name: Activated protein C cleaves Factor Va intermediate form for Factor Va See in Reactome R-HSA-5591052 ( R-HSA-140875 ) R-HSA-5591052 Reaction Name: PROCR binds Protein C See in Reactome R-HSA-5591086 ( R-HSA-140875 ) R-HSA-5591086 Reaction Name: SERPINA5 binds activated protein C See in Reactome R-HSA-5603467 ( R-HSA-140875 ) R-HSA-5603467 Reaction Name: Activated protein C is released from PROCR See in Reactome R-HSA-5604929 ( R-HSA-140875 ) R-HSA-5604929 Reaction Name: Activated protein C binds Protein S See in Reactome R-HSA-5606996 ( R-HSA-140875 ) R-HSA-5606996 Reaction Name: Soluble PROCR binds activated protein C See in Reactome R-HSA-5607002 ( R-HSA-140875 ) R-HSA-5607002 Reaction Name: Activated protein C cleaves factor VIIIa See in Reactome R-HSA-5607058 ( R-HSA-140875 ) R-HSA-5607058 Reaction Name: Activated protein C:PROCR binds F2R See in Reactome R-HSA-8952289 ( R-HSA-381426; R-HSA-8957275 ) R-HSA-8952289 Reaction Name: FAM20C phosphorylates FAM20C substrates See in Reactome